LOCUS       NM_030853               1188 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus linker for activation of T cells (Lat), mRNA.
ACCESSION   NM_030853
VERSION     NM_030853.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Xuan,J., Zhang,J., He,J., Zhao,K., Miao,S., Chen,G. and Wei,S.
  TITLE     RNA-Sequencing Analysis and Expression of Lymphocyte-Specific
            Protein Tyrosine Kinase, Linker for Activation of T Cells, and
            70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat
            Liver Transplant Rejection
  JOURNAL   Exp Clin Transplant 21 (12), 961-972 (2023)
   PUBMED   38263783
  REMARK    GeneRIF: RNA-Sequencing Analysis and Expression of
            Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation
            of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated
            Protein Kinase in Rat Liver Transplant Rejection.
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Dauphinee,S.M., Clayton,A., Hussainkhel,A., Yang,C., Park,Y.J.,
            Fuller,M.E., Blonder,J., Veenstra,T.D. and Karsan,A.
  TITLE     SASH1 is a scaffold molecule in endothelial TLR4 signaling
  JOURNAL   J Immunol 191 (2), 892-901 (2013)
   PUBMED   23776175
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Halova,I., Draberova,L., Bambouskova,M., Machyna,M., Stegurova,L.,
            Smrz,D. and Draber,P.
  TITLE     Cross-talk between tetraspanin CD9 and transmembrane adaptor
            protein non-T cell activation linker (NTAL) in mast cell activation
            and chemotaxis
  JOURNAL   J Biol Chem 288 (14), 9801-9814 (2013)
   PUBMED   23443658
  REMARK    GeneRIF: chemotaxis toward antigen is controlled in mast cells by a
            cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane
            adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins
            of the ERM family
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Li,C.Y., Peng,J., Ren,L.P., Gan,L.X., Lu,X.J., Liu,Q., Gu,W. and
            Guo,X.J.
  TITLE     Roles of histone hypoacetylation in LAT expression on T cells and
            Th2 polarization in allergic asthma
  JOURNAL   J Transl Med 11, 26 (2013)
   PUBMED   23360572
  REMARK    GeneRIF: Histone hypoacetylation on LAT promoter could inhibit LAT
            expression and enhanced Th2 differentiation, while trichostatin A,
            a histone deacetylase inhibitor, promoted LAT expression and
            inhibited Th2 cytokine production
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Roose,J.P., Diehn,M., Tomlinson,M.G., Lin,J., Alizadeh,A.A.,
            Botstein,D., Brown,P.O. and Weiss,A.
  TITLE     T cell receptor-independent basal signaling via Erk and Abl kinases
            suppresses RAG gene expression
  JOURNAL   PLoS Biol 1 (2), E53 (2003)
   PUBMED   14624253
REFERENCE   7  (bases 1 to 1188)
  AUTHORS   Hartgroves,L.C., Lin,J., Langen,H., Zech,T., Weiss,A. and Harder,T.
  TITLE     Synergistic assembly of linker for activation of T cells signaling
            protein complexes in T cell plasma membrane domains
  JOURNAL   J Biol Chem 278 (22), 20389-20394 (2003)
   PUBMED   12646565
REFERENCE   8  (bases 1 to 1188)
  AUTHORS   Perez-Villar,J.J., Whitney,G.S., Sitnick,M.T., Dunn,R.J.,
            Venkatesan,S., O'Day,K., Schieven,G.L., Lin,T.A. and Kanner,S.B.
  TITLE     Phosphorylation of the linker for activation of T-cells by Itk
            promotes recruitment of Vav
  JOURNAL   Biochemistry 41 (34), 10732-10740 (2002)
   PUBMED   12186560
REFERENCE   9  (bases 1 to 1188)
  AUTHORS   Weber,J.R., Orstavik,S., Torgersen,K.M., Danbolt,N.C., Berg,S.F.,
            Ryan,J.C., Tasken,K., Imboden,J.B. and Vaage,J.T.
  TITLE     Molecular cloning of the cDNA encoding pp36, a
            tyrosine-phosphorylated adaptor protein selectively expressed by T
            cells and natural killer cells
  JOURNAL   J Exp Med 187 (7), 1157-1161 (1998)
   PUBMED   9529333
REFERENCE   10 (bases 1 to 1188)
  AUTHORS   Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and
            Samelson,L.E.
  TITLE     LAT: the ZAP-70 tyrosine kinase substrate that links T cell
            receptor to cellular activation
  JOURNAL   Cell 92 (1), 83-92 (1998)
   PUBMED   9489702
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ001184.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1188
                     /gene="Lat"
                     /note="linker for activation of T cells"
                     /db_xref="GeneID:81511"
                     /db_xref="RGD:620802"
     exon            1..338
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..961
                     /gene="Lat"
                     /note="pp36; p36-38; 36 kDa phospho-tyrosine adapter
                     protein; 36 kDa phosphotyrosine adapter protein"
                     /codon_start=1
                     /product="linker for activation of T-cells family member
                     1"
                     /protein_id="NP_110480.1"
                     /db_xref="GeneID:81511"
                     /db_xref="RGD:620802"
                     /translation="MEADALSPVELGLLLLPFVVMLLAALCVRCRELPASYDSASTES
                     LYPRSILIKPPQITVPRTPATSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSRQ
                     NSDDANSVASYENQEPARKNVDEDEDEDDYPEGYLVVLPDSSPAAVPVVSSAPVPSNP
                     DLGDSAFSMESCEDYVNVPESEESAEASLDGSREYVNVSQDAQPVIRAELASVTSQEV
                     EDEEEEDVDGEEAPDYENLQELN"
     exon            339..366
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            367..401
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            402..489
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            490..554
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            555..584
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            585..645
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            646..740
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            741..803
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            804..866
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            867..968
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1188
                     /gene="Lat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcaagaa aggcaggtac agctgggcac agggatcgtg cagctggtgg ctggggcaca
       61 ggccccagcg ctggctccgg gactaacacc tttccggagc caacgctaat ctcaactcag
      121 tcgagcaaga gagcagacgc agctgccggc tgctggatcc caggctgggg cccgcttggt
      181 cccacacccc tccaggggct gcggtgcagc agggcctggg gcaggtgctc tgcagatgga
      241 agcagacgcc ttgagccctg tggagctggg cctcctgctg ctgcccttcg tggtcatgct
      301 cctggctgcc ctatgcgtgc gctgccgtga gttgccagcc tcctatgaca gtgcttccac
      361 agagagtttg tacccaagga gcatcctcat caaaccacct caaataaccg tcccccgaac
      421 acctgctact tcctaccctc ttgtcacttc cttcccaccc ctgaggcagc cagacctgct
      481 ccccattccg agatccccac agcccctcgg gggctcccat cggatgccat cttcccggca
      541 gaattcagat gatgccaaca gtgtggcgag ctacgagaac caggagccag cccgtaagaa
      601 cgtggatgaa gatgaggatg aagatgacta tcctgagggc tacctagtgg tgctgcctga
      661 cagtagtcct gctgccgtcc ctgttgtctc ctctgctccg gtgcccagca accctgacct
      721 tggagacagt gccttctcta tggagtcatg tgaagattac gtgaatgtcc ctgagagcga
      781 ggagagtgca gaggcatctc tggatgggag ccgggagtat gtgaatgtgt cccaggacgc
      841 acagccagtg atcagggctg agctggcctc tgtgacctcc caggaggtgg aagatgaaga
      901 agaggaggat gtggatggag aggaagctcc tgactatgag aacctgcagg aacttaactg
      961 aaagcctgct gcagctatca gtcctggaac tggacttgct gggggtgtcg ctaagggagt
     1021 cccatttgac ctctgccttg cctacagcct gagaatctcc cctaacttat tgtgactttg
     1081 gagctcagtc tgtgtcccca gtattctgca ccttctgatg aagcctgaga atgaatctag
     1141 ttccagccgg actatgtcat agaataaagg ccacgtggcc caaaatct
//
