LOCUS       NM_001170590            2483 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LAS1-like, ribosome biogenesis factor (Las1l),
            mRNA.
ACCESSION   NM_001170590
VERSION     NM_001170590.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1, BF554409.1, CB751131.1, CB811034.1, FM042988.1
            and CB322360.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.44178.1,
                                           SRR26643289.44887.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000021.1  64882935-64883109   c
            176-465             BF554409.1         8-297               c
            466-469             JAXUCZ010000021.1  64879144-64879147   c
            470-751             JAXUCZ010000021.1  64877628-64877909   c
            752-798             JAXUCZ010000021.1  64877257-64877303   c
            799-876             JAXUCZ010000021.1  64876333-64876410   c
            877-1258            CB751131.1         57-438
            1259-1348           CB811034.1         316-405
            1349-1631           JAXUCZ010000021.1  64867589-64867871   c
            1632-2114           FM042988.1         1-483
            2115-2482           CB322360.1         19-386              c
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2483
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /note="LAS1-like, ribosome biogenesis factor"
                     /db_xref="GeneID:296865"
                     /db_xref="RGD:1565755"
     CDS             1..2286
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /codon_start=1
                     /product="ribosomal biogenesis protein LAS1L"
                     /protein_id="NP_001164061.1"
                     /db_xref="GeneID:296865"
                     /db_xref="RGD:1565755"
                     /translation="MERVWRAWDGQSVNENQPDSPGVAGMVVSWLSRAEWEQVTVYLF
                     CDDQKLQQYALNRITVWRSRLGNELPLAVASTADLIRCKLLDVAGGLGTDELRLLYGM
                     ALVRFVNLISERKSKSCNLPLKYLAHEVNIPEWIVELRHKLTHKKMPHINDCRRGCYF
                     VLHWLQKTFWSRQLEDSLKETWGMEEDQVEADEPEEEETEIIIDDIIEEIPEFQDDDK
                     GEELAVTDDANTKGNEEVASHPELSPRHKELYEKARELLVSYEEEQFKVLEKYRHLLQ
                     AIKVWNNLSPRVQGILEELKSISWENRDAVLDAFLDDGFLIPTYEQLAALQIEYEENI
                     DLNEVLVPKPFSQFWQPLLRGLHSQTFTQALLERMFSELSTLGRTGIRPTYILRWTVE
                     LIVANTKTGRNARRFSAGQWEARRSWRLFNCSSTLDWPQVIEACLGSPCWASLQLLQV
                     VFKAMGEVLPDEEQEKLLRVCSIYTQNGESGLAKAVEGSSSSSSSSSSTGKAPYTLDT
                     LHQDLQPPATNCESEGNIQQKEQDNLTDVKPEEEEKENVEEEEEEEKEEAEMEEEEKE
                     EEEEQEQEEHQEEEQEEEEEEEEEQKVFQDQMEADAEESDGLGEEEEVDEDEDDDEDD
                     DYDDDDDDDEDGMDMGGFSLLQGSYVLENTRIMSQKREALQGSAWQLSSDDVRWGIFP
                     IGRVPGQTEDPTELMLDNYDTMYLLDQPVLEHRLEPQKSKSSTLGLCCGSNNNGGVGN
                     MEGLLWNQGQMHGLKAGLQLF"
     exon            1..191
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            192..317
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            318..387
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            388..469
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            470..751
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            752..798
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            799..908
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            909..994
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1201
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1349
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2020
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2171
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2483
                     /gene="Las1l"
                     /gene_synonym="RGD1565755"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaacgcg tgtggcgtgc gtgggacgga cagtccgtaa atgagaacca gccagactcg
       61 ccgggagtcg cgggtatggt agtgtcctgg ctcagcaggg ctgagtggga gcaagtgacg
      121 gtttatctgt tctgtgatga tcagaaattg cagcaatacg cgctgaaccg aattacagta
      181 tggaggagca ggttaggcaa cgaactgccc ctggcagtgg cttctacagc tgacctgata
      241 cgatgtaagc tcctggatgt agccggtggc ttgggcaccg atgaacttag attgctctat
      301 ggcatggcat tggtcaggtt tgtgaatctt atctcagaga ggaagtccaa atcttgtaac
      361 cttcccctca aatacctggc tcatgaggtg aacattccag aatggattgt tgaacttcgc
      421 cacaagttga cccacaagaa aatgccccat ataaatgact gccgcagagg ttgctacttt
      481 gtcctccatt ggctccagaa gacattctgg agccgtcaac tagaggacag tctgaaagaa
      541 acctggggga tggaagagga ccaggtagaa gcagatgaac ctgaagaaga ggaaactgaa
      601 attattattg atgatataat tgaagagata ccagagtttc aggatgacga caaaggtgaa
      661 gaattggctg tcacagatga tgcaaacact aaaggcaatg aagaggtggc ttctcatcca
      721 gaactatctc caagacataa ggagttgtat gaaaaagcac gagaattgct ggtatcatat
      781 gaagaggaac agtttaaggt gctggagaaa tataggcatt tacttcaggc tattaaggtg
      841 tggaataacc tttctccacg tgtacaaggt atcctagaag aactcaagag catttcatgg
      901 gagaacaggg atgctgtact ggatgccttt ttagacgatg gcttcctcat tcccacttat
      961 gagcagttgg cagcgttgca gatagagtat gaagaaaaca tcgacttgaa tgaagtgttg
     1021 gtgccaaagc ccttctctca gttctggcag cccctgctca ggggcctgca ctcccagacc
     1081 ttcacacagg ccctgctaga gaggatgttc tctgagttgt ctaccctggg gagaactggg
     1141 atccggccta cctacatcct tagatggacc gttgaactga tcgtggccaa caccaagact
     1201 ggacgaaatg ctcggcggtt ttctgcaggc cagtgggaag caagaaggag ctggaggctg
     1261 ttcaattgct cttccaccct ggactggccc caggtgatcg aggcctgctt gggctcacct
     1321 tgctgggcca gcctccaact ccttcaggta gtcttcaaag ccatgggaga ggtcttgcca
     1381 gatgaggaac aggagaagct gctgcgagtc tgctccattt atactcagaa tggagagagt
     1441 ggcttggcaa aggccgtcga aggctcctcc tcctcctcct cttcctcctc ctccactggg
     1501 aaagctccat acacgctgga taccttacat caggacctcc agccacctgc taccaactgt
     1561 gagtctgaag gaaatattca acagaaggag caagacaacc ttacggatgt caagccagag
     1621 gaggaggaaa aggagaatgt ggaggaggag gaggaggagg agaaggagga ggcagagatg
     1681 gaagaggagg agaaggagga ggaggaagaa caggagcagg aggagcacca ggaggaagaa
     1741 caggaggagg aggaggagga ggaggaggag cagaaggtct ttcaagatca gatggaagca
     1801 gatgcagagg aaagtgacgg cttaggagag gaggaggaag tagatgagga tgaagatgat
     1861 gatgaagatg acgactatga tgatgatgat gatgatgatg aagacggaat ggatatgggt
     1921 gggttctctc tcctacaggg atcctatgtt cttgagaata ctaggatcat gtctcagaaa
     1981 agagaagctt tgcagggttc agcatggcaa ctaagctctg atgatgtacg atggggtata
     2041 ttccctatcg gccgagtacc aggtcagact gaggacccaa cagagcttat gctggataat
     2101 tatgacacca tgtatctttt ggaccaacct gtactagagc accggttaga accccaaaag
     2161 tctaagagta gcactctggg cctatgctgt ggcagcaata acaatggcgg tgttggcaac
     2221 atggagggcc ttctctggaa ccaaggacaa atgcatgggc tcaaagctgg cctgcagctc
     2281 ttctgatggc tgtcctgatg caagtgtcca tgtagccctg ccactgtcac agctcagtcc
     2341 agaatccacc catggtacag agtggacaac ctaagagaca gatcagcctt atcaattccg
     2401 ctgtcgacca caatggaaat tagaatgatt cccccatttt ctgttgtgtt ttgaaaaata
     2461 ataaacagat ttttgtcatg gtg
//
