LOCUS       NM_001009637            3834 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus leucyl-tRNA synthetase 1 (Lars1), mRNA.
ACCESSION   NM_001009637 XM_214566
VERSION     NM_001009637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3834)
  AUTHORS   Topalidou I, Cattin-Ortola J, Pappas AL, Cooper K, Merrihew GE,
            MacCoss MJ and Ailion M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3834)
  AUTHORS   Ognjenovic J, Wu J, Matthies D, Baxa U, Subramaniam S, Ling J and
            Simonovic M.
  TITLE     The crystal structure of human GlnRS provides basis for the
            development of neurological disorders
  JOURNAL   Nucleic Acids Res 44 (7), 3420-3431 (2016)
   PUBMED   26869582
REFERENCE   3  (bases 1 to 3834)
  AUTHORS   Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH
            and Kim S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   4  (bases 1 to 3834)
  AUTHORS   Kaminska M, Havrylenko S, Decottignies P, Le Marechal P, Negrutskii
            B and Mirande M.
  TITLE     Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the
            Cytoplasm of Human Cells
  JOURNAL   J Biol Chem 284 (20), 13746-13754 (2009)
   PUBMED   19289464
REFERENCE   5  (bases 1 to 3834)
  AUTHORS   Kaminska M, Havrylenko S, Decottignies P, Gillet S, Le Marechal P,
            Negrutskii B and Mirande M.
  TITLE     Dissection of the structural organization of the aminoacyl-tRNA
            synthetase complex
  JOURNAL   J Biol Chem 284 (10), 6053-6060 (2009)
   PUBMED   19131329
REFERENCE   6  (bases 1 to 3834)
  AUTHORS   Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG and Kim S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087655.1.
            
            On Jan 13, 2005 this sequence version replaced XM_214566.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087655.1, FQ212494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3834
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /note="leucyl-tRNA synthetase 1"
                     /db_xref="GeneID:291624"
                     /db_xref="RGD:1304962"
     exon            1..120
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3651
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /EC_number="6.1.1.4"
                     /note="leucyl-tRNA synthetase, cytoplasmic"
                     /codon_start=1
                     /product="leucine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001009637.1"
                     /db_xref="GeneID:291624"
                     /db_xref="RGD:1304962"
                     /translation="MAERKGTAKVDFLKKIEKEVQQKWEAEKVFEVSASSLEKQKQSS
                     KGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKAC
                     ADKLKREIELYGCPPDFPEEEEEEEESSAKPGDIVMKDKAKGKKSKAAAKAGSSKYQW
                     NIMKSLGLSDEDIAKFSEAEHWLDYFPPLAVQDLKKIGLKVDWRRSFITTDVNPYYDS
                     FVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLDP
                     YPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETANGDIFICTQRAAR
                     NMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVIYVLPMLTIKEDKGTGVVT
                     SVPSDSPDDFAALRDLKKKQALRAKYAVRDDMVLPFEPVPVLEIPGIGNLPAVTVCDE
                     LKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALI
                     YMEPEKQVVSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEAS
                     LDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLQGQAESP
                     LGIRPQQMTRDVWDYVFFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPN
                     HLSYYIYNHVAMWPEQSDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADG
                     MRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLANCSSLRSGPANSFNDRV
                     FASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELATEGMHRELVFRFIEV
                     QTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLR
                     LKNYMTPAKGKKTDKQPVQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNGKLPDNK
                     VIACELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMENIVYLT
                     NSLELEHIDVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKID
                     IRQGDSCESIIRRLTKMDRGIKDLSKVKLMRFDDPLLGPRRVPVLGREQNEKTLISEN
                     AIFHVDLVSKKVHLTENGLRADIGDTIVYLVH"
     exon            121..245
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            246..333
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            334..414
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            415..552
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            553..714
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            715..827
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            828..891
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            892..959
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1185
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1273
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1350
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1404
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1545
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1623
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1709
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1775
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1858
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1997
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2210
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2268
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2332
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2516
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2607
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2748
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2889
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3000
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3111
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3216
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3312
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3445
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3811
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttggtgtc ctgagagact aggcttctac gagtaggagg gaaaagttgg acccacatct
       61 ctgagggatt cattggggcc atcgtactgg atcttgagtc gtttgggcgg cgccatggcg
      121 gaaagaaaag gaacagccaa agtagacttc ttgaagaaga ttgagaaaga agtccagcag
      181 aaatgggaag cggagaaagt gtttgaagtc agcgcgtctt cactggagaa gcagaagcag
      241 agcagcaagg gcaaatactt tgtcaccttt ccatatccat acatgaatgg acgccttcat
      301 ttgggacaca cgttttcctt atccaagtgt gagtttgcag taggatacca gagattaaaa
      361 ggaaaaagct gtctgttccc cttcgggtta cactgtaccg gtatgcctat taaggcatgt
      421 gctgacaagc tgaaaaggga gatagagctg tatggctgcc ctcctgattt tccagaggag
      481 gaggaggaag aggaagaaag cagtgctaaa cctggagata tagtaatgaa ggataaagcc
      541 aaagggaaaa agagtaaagc cgctgctaaa gcaggatctt ctaagtacca gtggaacatt
      601 atgaaatccc ttgggctctc tgatgaagac atcgcgaagt tttctgaagc agaacattgg
      661 cttgattatt tcccaccact ggctgttcag gatctgaaga aaataggttt gaaggtagac
      721 tggcggcgtt ccttcatcac cacggatgtg aatccttact atgattcttt tgtcaggtgg
      781 caatttttaa ctttaagaga aagaaataaa attaaattcg ggaagcggta cactatttat
      841 tccccaaaag atggacagcc ttgcatggat catgacagac aaaccggaga gggtgttgga
      901 cctcaggaat ataccctagt caaactgaag gtgcttgatc catacccatc aaaattaagt
      961 ggcctgaaag ggaaaaatat cttcctagta gctgccacac tcagacctga gactatgttt
     1021 ggacagacaa attgttgggt tcggcctgat atgaaataca ttgggtttga gacagcaaat
     1081 ggagacatat tcatctgtac ccagagagca gccaggaata tgtcatacca aggcttcacc
     1141 aagcacaatg gcgtggtgcc ggttgtgaag gagttaatgg gagaggaaat ccttggggct
     1201 tcactttctg cacccctgac atgctataag gtgatctatg ttctccctat gctgaccatt
     1261 aaggaggata aaggcactgg ggtggtcaca agcgttcctt ctgattcccc ggatgatttt
     1321 gcggcactca gagacttgaa gaaaaagcaa gccttacgag caaagtatgc agtcagagat
     1381 gacatggtcc tgccctttga accggtgcca gtccttgaaa tcccagggat tggaaatctt
     1441 cctgctgtga ccgtttgtga cgaactgaaa attcagagcc agaatgaccg tgaaaaactt
     1501 gcagaggcaa aggagaaatt gtatctaaga ggattttatg atggtgtaat gctagtggat
     1561 ggatttaaag ggcagaagat ccaacatgta aagaagacta ttcagaaaaa catgattgat
     1621 gctggagatg cgcttatcta catggagcca gaaaaacaag tggtgtcgag gtctgcagat
     1681 gagtgtgttg tggccctgtg tgaccaatgg tacttggatt atggagatga gaactggaag
     1741 aaacagacat ttcagtgcct gaagaacatg gaaacattct gcgaggagag caggaagaat
     1801 tttgaagctt ccttagactg gctgcaagaa catgcctgct caagaactta cggtttaggc
     1861 acgcgtctgc cttgggatga gcagtggttg attgaatccc tctcagactc cactatttac
     1921 atggcgtttt acacagttgc acacctgttg caggggggtg acctgcaggg tcaggcggag
     1981 tctccactgg gcatcagacc ccagcagatg acgagggatg tttgggatta tgtgttcttc
     2041 aaggatgctc catttcccaa gactcagatc ccaaaggaaa agctggatca gctgaagcag
     2101 gaatttgagt tttggtatcc agtggacctt cgagcctctg gcaaggatct gattccaaat
     2161 catctttcat attacattta caatcatgtg gccatgtggc cagaacaaag cgacaagtgg
     2221 cctgtatccg ttcgagcaaa tggacacctg ctgctcaact ccgagaagat gtcaaaatct
     2281 acgggaaact tcctcacttt gagccaagct gttgacaagt tttccgctga tggaatgcgc
     2341 ctggctctgg ctgatgctgg cgacactgtt gaagatgcta actttgtgga agctatggca
     2401 gacgcaggca ttctccgtct gtacacatgg gtagagtggg tcaaagaaat gcttgccaac
     2461 tgcagcagcc tgagaagtgg acctgccaac tcattcaatg atcgtgtgtt tgccagtgaa
     2521 atgaatgcag gaattataaa aacagatcaa aactatgaaa agatgatgtt taaagaagcg
     2581 ttgaaaacag gtttttttga gtttcaggct gcgaaagaca agtaccgtga actggccaca
     2641 gaggggatgc acagagagct tgtgttccgg tttattgaag ttcaaacaat ccttctgact
     2701 ccattctgtc cacatttgtg tgagcacatc tggacactgc tgggaaagcc tgattcaatt
     2761 atgcatgcct catggcctgt ggcaggtccc gtggatgaat ccctgattcg ttcctcacag
     2821 tacctcatgg aagtagcaca cgaccttaga ttacggctca agaattacat gacgccagct
     2881 aaagggaaga agacggacaa gcaaccagtt cagaggccct cacactgcac catctatgtg
     2941 gcaaagaact accctgtctg gcagcacatt accctgacaa ccctacggag ccactttgag
     3001 gctaacaatg gaaaattgcc tgataacaaa gtcatcgctt gtgaactagg cagtttgcca
     3061 gaactgaaga aatatatgaa gaaagttatg ccatttgttg ccatgattaa ggaaaacatg
     3121 gagaagaaag ggccgcgagt cttggattta gagttggaat ttgatgagca ggcagtcctt
     3181 atggagaata tagtctacct aaccaattct cttgagctgg aacatataga cgtcaagttt
     3241 gcctctgaag ctgaagataa agtcagggaa gagtgctgtc ctgggaagcc acttaatgtt
     3301 ttcagaacag aacctggtgt gccagtttcc ctagtaaatc ctcagccatc cagcgggcac
     3361 ttctctacca aaatcgacat cagacaagga gatagctgtg agtccataat cagacgcctg
     3421 acgaaaatgg accgaggaat caaagatctc tccaaagtga aactcatgcg ctttgatgat
     3481 cctctgttgg ggcctcgacg agttccagtc ctggggagag agcagaacga gaagacactc
     3541 atttctgaga atgccatttt ccacgtggac ctagtgagca agaaagttca ccttactgag
     3601 aacgggctgc gcgcagacat cggtgacaca atagtctatc tggttcactg agaccatgca
     3661 aacggaaaag tcaggatggt tataggatgc ttctgctctg agactctcaa gctagatcta
     3721 aacaaacttc atttctaact gctgggttct gtatgtaatc ataattaccc caattctttc
     3781 atttctaatc taataaacta gcagttttca aaaaaaaaaa aaaaaaaaaa aaaa
//
