LOCUS       NP_001009637            1178 aa            linear   ROD 26-FEB-2024
DEFINITION  leucine--tRNA ligase, cytoplasmic [Rattus norvegicus].
ACCESSION   NP_001009637 XP_214566
VERSION     NP_001009637.1
DBSOURCE    REFSEQ: accession NM_001009637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1178)
  AUTHORS   Topalidou I, Cattin-Ortola J, Pappas AL, Cooper K, Merrihew GE,
            MacCoss MJ and Ailion M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1178)
  AUTHORS   Ognjenovic J, Wu J, Matthies D, Baxa U, Subramaniam S, Ling J and
            Simonovic M.
  TITLE     The crystal structure of human GlnRS provides basis for the
            development of neurological disorders
  JOURNAL   Nucleic Acids Res 44 (7), 3420-3431 (2016)
   PUBMED   26869582
REFERENCE   3  (residues 1 to 1178)
  AUTHORS   Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH
            and Kim S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   4  (residues 1 to 1178)
  AUTHORS   Kaminska M, Havrylenko S, Decottignies P, Le Marechal P, Negrutskii
            B and Mirande M.
  TITLE     Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the
            Cytoplasm of Human Cells
  JOURNAL   J Biol Chem 284 (20), 13746-13754 (2009)
   PUBMED   19289464
REFERENCE   5  (residues 1 to 1178)
  AUTHORS   Kaminska M, Havrylenko S, Decottignies P, Gillet S, Le Marechal P,
            Negrutskii B and Mirande M.
  TITLE     Dissection of the structural organization of the aminoacyl-tRNA
            synthetase complex
  JOURNAL   J Biol Chem 284 (10), 6053-6060 (2009)
   PUBMED   19131329
REFERENCE   6  (residues 1 to 1178)
  AUTHORS   Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG and Kim S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087655.1.
            
            On Jan 13, 2005 this sequence version replaced XP_214566.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087655.1, FQ212494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     Protein         1..1178
                     /product="leucine--tRNA ligase, cytoplasmic"
                     /EC_number="6.1.1.4"
                     /note="leucyl-tRNA synthetase, cytoplasmic"
                     /calculated_mol_wt=134148
     Region          5..1064
                     /region_name="PLN02959"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:215518"
     CDS             1..1178
                     /gene="Lars1"
                     /gene_synonym="Lars"
                     /coded_by="NM_001009637.1:115..3651"
                     /db_xref="GeneID:291624"
                     /db_xref="RGD:1304962"
ORIGIN      
        1 maerkgtakv dflkkiekev qqkweaekvf evsasslekq kqsskgkyfv tfpypymngr
       61 lhlghtfsls kcefavgyqr lkgksclfpf glhctgmpik acadklkrei elygcppdfp
      121 eeeeeeeess akpgdivmkd kakgkkskaa akagsskyqw nimkslglsd ediakfseae
      181 hwldyfppla vqdlkkiglk vdwrrsfitt dvnpyydsfv rwqfltlrer nkikfgkryt
      241 iyspkdgqpc mdhdrqtgeg vgpqeytlvk lkvldpypsk lsglkgknif lvaatlrpet
      301 mfgqtncwvr pdmkyigfet angdifictq raarnmsyqg ftkhngvvpv vkelmgeeil
      361 gaslsapltc ykviyvlpml tikedkgtgv vtsvpsdspd dfaalrdlkk kqalrakyav
      421 rddmvlpfep vpvleipgig nlpavtvcde lkiqsqndre klaeakekly lrgfydgvml
      481 vdgfkgqkiq hvkktiqknm idagdaliym epekqvvsrs adecvvalcd qwyldygden
      541 wkkqtfqclk nmetfceesr knfeasldwl qehacsrtyg lgtrlpwdeq wlieslsdst
      601 iymafytvah llqggdlqgq aesplgirpq qmtrdvwdyv ffkdapfpkt qipkekldql
      661 kqefefwypv dlrasgkdli pnhlsyyiyn hvamwpeqsd kwpvsvrang hlllnsekms
      721 kstgnfltls qavdkfsadg mrlaladagd tvedanfvea madagilrly twvewvkeml
      781 ancsslrsgp ansfndrvfa semnagiikt dqnyekmmfk ealktgffef qaakdkyrel
      841 ategmhrelv frfievqtil ltpfcphlce hiwtllgkpd simhaswpva gpvdeslirs
      901 sqylmevahd lrlrlknymt pakgkktdkq pvqrpshcti yvaknypvwq hitlttlrsh
      961 feanngklpd nkviacelgs lpelkkymkk vmpfvamike nmekkgprvl dlelefdeqa
     1021 vlmenivylt nslelehidv kfaseaedkv reeccpgkpl nvfrtepgvp vslvnpqpss
     1081 ghfstkidir qgdscesiir rltkmdrgik dlskvklmrf ddpllgprrv pvlgreqnek
     1141 tlisenaifh vdlvskkvhl tenglradig dtivylvh
//
