LOCUS       NM_001044290            2097 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus La ribonucleoprotein 7, transcriptional regulator
            (Larp7), mRNA.
ACCESSION   NM_001044290 XM_001076161
VERSION     NM_001044290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Hasler,D., Meduri,R., Bak,M., Lehmann,G., Heizinger,L., Wang,X.,
            Li,Z.T., Sement,F.M., Bruckmann,A., Dock-Bregeon,A.C., Merkl,R.,
            Kalb,R., Grauer,E., Kunstmann,E., Zavolan,M., Liu,M.F., Fischer,U.
            and Meister,G.
  TITLE     The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small
            Nuclear RNA Modification and Contributes to Splicing Robustness
  JOURNAL   Mol Cell 77 (5), 1014-1031 (2020)
   PUBMED   32017898
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Eichhorn,C.D., Yang,Y., Repeta,L. and Feigon,J.
  TITLE     Structural basis for recognition of human 7SK long noncoding RNA by
            the La-related protein Larp7
  JOURNAL   Proc Natl Acad Sci U S A 115 (28), E6457-E6466 (2018)
   PUBMED   29946027
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Egloff,S., Vitali,P., Tellier,M., Raffel,R., Murphy,S. and Kiss,T.
  TITLE     The 7SK snRNP associates with the little elongation complex to
            promote snRNA gene expression
  JOURNAL   EMBO J 36 (7), 934-948 (2017)
   PUBMED   28254838
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Eichhorn,C.D., Chug,R. and Feigon,J.
  TITLE     hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin
            of 7SK RNA
  JOURNAL   Nucleic Acids Res 44 (20), 9977-9989 (2016)
   PUBMED   27679474
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Okamura,D., Maeda,I., Taniguchi,H., Tokitake,Y., Ikeda,M.,
            Ozato,K., Mise,N., Abe,K., Noce,T., Izpisua Belmonte,J.C. and
            Matsui,Y.
  TITLE     Cell cycle gene-specific control of transcription has a critical
            role in proliferation of primordial germ cells
  JOURNAL   Genes Dev 26 (22), 2477-2482 (2012)
   PUBMED   23154982
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 2097)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 2097)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM031800.1 and BC083898.1.
            
            On Sep 30, 2011 this sequence version replaced NM_001044290.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083898.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                FM031800.1         1-63
            64-2097             BC083898.1         1-2034
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2097
                     /gene="Larp7"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:686883"
                     /db_xref="RGD:1592474"
     exon            1..110
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..298
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1827
                     /gene="Larp7"
                     /note="La ribonucleoprotein domain family, member 7"
                     /codon_start=1
                     /product="la-related protein 7"
                     /protein_id="NP_001037755.2"
                     /db_xref="GeneID:686883"
                     /db_xref="RGD:1592474"
                     /translation="METENQKTMEESTEKRKEEKKKRSRVKQVLADIAKQVDFWFGDA
                     NLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGT
                     RIRRKKPLGERPKDEEERTVYVELLPKNVTHSWIERVFGKCGNVVYISIPHYKSTGDP
                     KGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKK
                     KKGRIKKEESVQAKELVVDSSSSGVSKATKRPRTASEGSEAETPEAPKQPAKKKKKRD
                     KVETGGLPESKAGKRERSSAEDEDCLPPRPKLKKRAQKDGGGPAASEVSKEHRDLEFC
                     STEEEKEPGDRKGDSLSKGKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLAL
                     QKASMASLKKTISQIKLESEMETESKAPPGSGQQCSTQEKVSAQGPQFVTGVIVKILS
                     EDPLPGRKQVKDILATISEVVYIDLLEGDTECHARFKTPEDAQAVMNAQTEIKKKHSW
                     NLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASQHIR
                     FSEYD"
     exon            299..399
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            400..483
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            484..648
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            649..742
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1099
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1247
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1372
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1494
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1654
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1746
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2071
                     /gene="Larp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgcgtc gctggtcgga tgacgcaaat ttccgccgcc tgctagggtc gggagacgga
       61 aagcgtggaa gaacgcaatc gctgaccgtg gatctgagga cgtgcacgga aatggaaact
      121 gaaaaccaaa aaaccatgga agaaagcact gagaagagaa aagaagaaaa aaagaagcga
      181 tcacgggtta agcaggtgct tgcagatatc gctaagcagg tggacttctg gtttggagat
      241 gcaaaccttc acaaggacag gtttctgcga gagcaaattg aaaaatctag agatggatat
      301 gtggacattt cccttctggt gtcttttaac aaaatgaaga agctgacaac tgatgggaag
      361 ctaatagcca gagcactgaa gagctcatct gttgtagagt tggacttaga agggaccaga
      421 atcaggagga aaaaacccct aggagagaga ccaaaggacg aggaagaacg cacggtatat
      481 gtggagttgc tcccaaaaaa cgttactcac agttggattg agagagtatt tgggaaatgt
      541 ggcaatgttg tttacataag tattccacat tacaagtcta ctggggatcc taagggattt
      601 gcctttgtgg agtttgaaac aaaagagcaa gcagcaaaag ccattgagtt tctgaacaac
      661 ccaccagaag aagcacccag aaagcctggc atattcccca agacggtgaa aaacaagccc
      721 atcccttcct tacgagtagc tgaagagaag aaaaagaaga aaaagaaaaa aggcagaata
      781 aagaaggaag agagtgtgca ggctaaggag ctggttgtgg acagcagcag ctcgggtgtg
      841 agtaaagcca cgaagagacc taggacagcc tctgagggct ctgaggcgga aaccccagaa
      901 gctccaaagc aacctgcaaa gaagaagaag aagcgggaca aggtggaaac cggcggctta
      961 cctgagtcaa aggcagggaa gcgggagaga agcagtgctg aggacgaaga ctgcctccca
     1021 ccaaggccaa agctaaagaa gagggctcag aaggatgggg gtggcccagc tgcttctgag
     1081 gtctccaagg agcacagaga cttggaattc tgctctacgg aagaagagaa ggagccggga
     1141 gacaggaaag gcgactcgct ctccaagggg aagaggaagc ataagaagaa gcataaggag
     1201 aggcataaga tgggcgagga ggtgataccg ctgcgagtgc tgtccaagac tgaatggatg
     1261 gatttgaaaa aagagtattt ggcactgcaa aaagctagca tggcttctct aaaaaaaaca
     1321 atatctcaaa taaaattgga gtcggaaatg gagacagagt ccaaagcgcc tccaggcagt
     1381 ggtcagcagt gctccaccca ggagaaggtc agtgcacagg gcccgcagtt cgtgactgga
     1441 gtgatcgtga agatcctgag cgaagaccct ctcccaggca ggaaacaagt caaggatatt
     1501 ttggccacaa tctcagaagt tgtttacatt gatttgctag aaggagatac tgaatgccat
     1561 gcccgattca aaaccccaga ggatgctcag gcagtaatga atgcacagac tgaaattaaa
     1621 aagaagcaca gttggaacct cgagatcctt tctggtgatc atgagcagag gtactggcag
     1681 aagattttgg tagatagaca agccaaactt aatcaacctc gggaaaagaa aagaggcaca
     1741 gaaaagctaa tcaccaaagc tgagaagatt agactggcta agacccagca agccagtcag
     1801 cacattcgat tctccgagta tgactgagaa gactatgact tttgggctcc cttgctgaag
     1861 tattcttagt gctggggctg cttgatggat gttgtgccga gatctgcatt agaaaagaca
     1921 aggaaagacc ttggctcctc agtgtgtcaa taagactttt ctaatgacag gtgcattgtg
     1981 tgtcagaatt ttttcaatga atgcccttac ttgttgaaat tatgtaagtc aacttcaaat
     2041 gatttcataa ataaatgtgt tttgaatata aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
