LOCUS       NM_199107               2399 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus LARGE xylosyl- and glucuronyltransferase 2
            (Large2), mRNA.
ACCESSION   NM_199107 XM_230290
VERSION     NM_199107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Inamori,K., Willer,T., Hara,Y., Venzke,D., Anderson,M.E.,
            Clarke,N.F., Guicheney,P., Bonnemann,C.G., Moore,S.A. and
            Campbell,K.P.
  TITLE     Endogenous glucuronyltransferase activity of LARGE or LARGE2
            required for functional modification of alpha-dystroglycan in cells
            and tissues
  JOURNAL   J Biol Chem 289 (41), 28138-28148 (2014)
   PUBMED   25138275
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Ashikov,A., Buettner,F.F., Tiemann,B., Gerardy-Schahn,R. and
            Bakker,H.
  TITLE     LARGE2 generates the same xylose- and glucuronic acid-containing
            glycan structures as LARGE
  JOURNAL   Glycobiology 23 (3), 303-309 (2013)
   PUBMED   23135544
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Inamori,K., Hara,Y., Willer,T., Anderson,M.E., Zhu,Z.,
            Yoshida-Moriguchi,T. and Campbell,K.P.
  TITLE     Xylosyl- and glucuronyltransferase functions of LARGE in
            alpha-dystroglycan modification are conserved in LARGE2
  JOURNAL   Glycobiology 23 (3), 295-302 (2013)
   PUBMED   23125099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061762.1, SRR26360172.2466169.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000003.1  98797643-98797674   c
            33-188              JAXUCZ010000003.1  98797404-98797559   c
            189-286             JAXUCZ010000003.1  98797231-98797328   c
            287-369             JAXUCZ010000003.1  98796839-98796921   c
            370-493             JAXUCZ010000003.1  98796489-98796612   c
            494-665             JAXUCZ010000003.1  98796131-98796302   c
            666-770             JAXUCZ010000003.1  98795909-98796013   c
            771-883             JAXUCZ010000003.1  98794258-98794370   c
            884-1009            JAXUCZ010000003.1  98794057-98794182   c
            1010-1165           JAXUCZ010000003.1  98793772-98793927   c
            1166-1326           JAXUCZ010000003.1  98793519-98793679   c
            1327-1605           JAXUCZ010000003.1  98792855-98793133   c
            1606-1758           JAXUCZ010000003.1  98792395-98792547   c
            1759-1954           JAXUCZ010000003.1  98792104-98792299   c
            1955-2399           JAXUCZ010000003.1  98791543-98791987   c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2399
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /note="LARGE xylosyl- and glucuronyltransferase 2"
                     /db_xref="GeneID:311202"
                     /db_xref="RGD:735214"
     exon            1..32
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            33..188
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2164
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /note="glycosyltransferase-like protein LARGE2;
                     glycosyltransferase-like 1B"
                     /codon_start=1
                     /product="xylosyl- and glucuronyltransferase LARGE2"
                     /protein_id="NP_954538.1"
                     /db_xref="GeneID:311202"
                     /db_xref="RGD:735214"
                     /translation="MLPRGRPRALGAALLLLLLLVVGFFLFGRDPEYGLGTTATLDGD
                     PYGSRNRSTSSLQLLLPPKCEMLHVAIVCAGYNSSREIITLMKSVLFYRKNPLHLHLI
                     TDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSVL
                     PLSLARVIVLDTDVTFSSDIMELWALFGHFSDKQVVGLVENQSDWYLGNLWKNHRPWP
                     ALGRGFNTGVILLWLDRLQQIGWEQMWKLTAKRELLTLTATSLADQDIFNAVIKEHPE
                     LVHPLPCVWNVQLSDHTLAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRDLHLTFL
                     GFDGKLLCRELFGCPNQFPPGVEQLQQALAQLDEEEPCFEFRQQQLTVHRVHITFLSH
                     QPPPPRPHDVTLVAQLSMDRLQMLEALCRHWRGPMSLALYLTDAEAQQFLRFVETSPV
                     LSARKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASI
                     EQLALGRRQRKAALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHAS
                     TDYTRWREAQAPYRVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYE
                     FLVLPEAFSIHLPHAPSLDISRFRSSPTYRDCLQALKEEFHQDLSRRYGSAALKYLTA
                     LQQSRSRA"
     exon            189..286
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            287..369
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            370..493
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            494..665
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            666..770
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            771..883
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1009
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1165
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1326
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1605
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1758
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1954
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2399
                     /gene="Large2"
                     /gene_synonym="Gyltl1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacagggc cttcccggag ccactggagc agggtccgag atggagcccg cagcccgagg
       61 tcgtgtcccg ccctgactcc cacagacagc catgctgcct cgagggcgcc cccgggcact
      121 gggggccgca ctgctgttgt tgctgctgct agtggttggc ttcttcctat tcggccggga
      181 cccggagtat ggactaggca caaccgccac cctcgatgga gacccgtacg ggagccgcaa
      241 ccgctccacc tccagcctgc agcttctact gccacccaag tgcgagatgt tgcatgtggc
      301 catcgtgtgt gcgggataca actccagccg agagatcatc accctaatga agtccgtgct
      361 attctacagg aaaaatccgc tgcacctcca cctgataacc gatgccgtag ccagaaacat
      421 cctggagaca ctcttccgaa catggatggt accagctgtg gtggtcagct tctatgatgc
      481 tgaagagctc aagcccctgg tttcctggat tcccaacaag cactactctg gcctctatgg
      541 gctcatgaag ctagtacttc ccagcgtcct gcctctcagc ctggcccgag tcattgtcct
      601 ggacaccgat gtcactttct cctctgacat tatggagctc tgggcactct ttggtcattt
      661 ttctgacaag caggtggtcg gtcttgtgga gaaccagagc gactggtacc tgggcaacct
      721 ctggaagaac cataggccct ggcctgcctt gggcagggga tttaacacag gtgtgatcct
      781 gctttggctg gacagattac agcagattgg ctgggagcag atgtggaagc tgacggccaa
      841 acgggagctg cttactttga ctgccacttc cttggctgac caggacatct tcaatgccgt
      901 catcaaggag catcccgagc tggtgcatcc cctgccctgt gtctggaacg tgcagttgtc
      961 agaccacact ctggctgagc gctgctactt ggaagcagct gacctcaaag tgatccactg
     1021 gaattcacca aagaagcttc gagtgaagaa caagcatgca gaattcttcc gtgatctaca
     1081 cttgaccttc ctggggtttg acgggaagct actgtgtaga gagctctttg gttgccccaa
     1141 ccagttccct cctggggttg agcagttgca acaggcccta gcacagctgg atgaggaaga
     1201 gccctgcttt gagttccgcc aacagcagct cactgtgcac cgtgtacaca tcacctttct
     1261 gtctcaccag ccgccacctc ctcggcctca cgatgtcacc ttggtggccc agctctctat
     1321 ggaccggctg cagatgctgg aagccctgtg caggcactgg cggggtccca tgagcctggc
     1381 cttgtacctg acagacgcag aggctcaaca gttcctgcgt ttcgtggaga cgtcaccagt
     1441 actctctgca aggaaggatg tggcctatca tgtagtgtac cgggacggcc ccctctaccc
     1501 agtcaaccag ctccgaaatg tggccttggc ccaggctctc acaccctacg tcttcctcag
     1561 tgatattgac ttcttacctg cctactccct ctatgactac ctcagggcct ctattgagca
     1621 actggcgctg ggcaggcggc agaggaaggc tgctttggta gtgcctgcat ttgagaccct
     1681 gcactaccgt ttcagcttcc caaactctaa ggcagagttg ttgaccttac tggatgctgg
     1741 ctctctccac acctttaggt accacgagtg gccacagggt catgcatcca cagactatac
     1801 ccgctggcgg gaagcccagg caccataccg agtgcagtgg tcagctgact atgagcctta
     1861 cgtggtggta ccccgtgact gtccccgcta tgaccctcgc tttgtgggct ttggctggaa
     1921 caaggtggcc catatcatag agctggatgc tcaggaatat gaattcctgg tacttcctga
     1981 ggccttctct atccacttgc cccatgcccc aagtctggac atctcccgct tccgctccag
     2041 ccccacctac cgcgactgcc tccaggccct caaggaggag ttccaccagg acttgtctag
     2101 gcgctatggg tctgcagccc tcaaatacct cactgccctg cagcagtccc gaagccgggc
     2161 ctgagcttgc cgggacacat acatacactg gagaaactgg ggaccctggt gggtgcctac
     2221 ccttattgct ttctaaatta tttaaagttt ttgtcagaag ggctagagtg gagcatctgt
     2281 ggggttcctg gttccttctc ctgctgttcc acactggggt ccagccctcc tttgcctcag
     2341 ctggtttggg gctagttctc ctaattctct tatataataa aattttttaa ctttttaaa
//
