LOCUS       NM_001013174            1750 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus lysosomal protein transmembrane 4 beta (Laptm4b),
            mRNA.
ACCESSION   NM_001013174 XM_235393
VERSION     NM_001013174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Gu,S., Tan,J., Li,Q., Liu,S., Ma,J., Zheng,Y., Liu,J., Bi,W.,
            Sha,P., Li,X., Wei,M., Cao,N. and Yang,H.T.
  TITLE     Downregulation of LAPTM4B Contributes to the Impairment of the
            Autophagic Flux via Unopposed Activation of mTORC1 Signaling During
            Myocardial Ischemia/Reperfusion Injury
  JOURNAL   Circ Res 127 (7), e148-e165 (2020)
   PUBMED   32693673
  REMARK    GeneRIF: Downregulation of LAPTM4B Contributes to the Impairment of
            the Autophagic Flux via Unopposed Activation of mTORC1 Signaling
            During Myocardial Ischemia/Reperfusion Injury.
            Erratum:[Circ Res. 2023 Mar 3;132(5):e94. doi:
            10.1161/RES.0000000000000597.. PMID: 36862816]
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Blom,T., Li,S., Dichlberger,A., Back,N., Kim,Y.A.,
            Loizides-Mangold,U., Riezman,H., Bittman,R. and Ikonen,E.
  TITLE     LAPTM4B facilitates late endosomal ceramide export to control cell
            death pathways
  JOURNAL   Nat Chem Biol 11 (10), 799-806 (2015)
   PUBMED   26280656
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Huygens,C., Lienart,S., Dedobbeleer,O., Stockis,J., Gauthy,E.,
            Coulie,P.G. and Lucas,S.
  TITLE     Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases
            Transforming Growth Factor beta1 (TGF-beta1) Production in Human
            Regulatory T Cells
  JOURNAL   J Biol Chem 290 (33), 20105-20116 (2015)
   PUBMED   26126825
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Tan,X., Sun,Y., Thapa,N., Liao,Y., Hedman,A.C. and Anderson,R.A.
  TITLE     LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling,
            lysosomal sorting, and degradation
  JOURNAL   EMBO J 34 (4), 475-490 (2015)
   PUBMED   25588945
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Vergarajauregui,S., Martina,J.A. and Puertollano,R.
  TITLE     LAPTMs regulate lysosomal function and interact with mucolipin 1:
            new clues for understanding mucolipidosis type IV
  JOURNAL   J Cell Sci 124 (Pt 3), 459-468 (2011)
   PUBMED   21224396
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Milkereit,R. and Rotin,D.
  TITLE     A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4
            proteins
  JOURNAL   PLoS One 6 (11), e27478 (2011)
   PUBMED   22096579
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086442.1.
            
            On Apr 20, 2005 this sequence version replaced XM_235393.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086442.1, EX488744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1750
                     /gene="Laptm4b"
                     /note="lysosomal protein transmembrane 4 beta"
                     /db_xref="GeneID:315047"
                     /db_xref="RGD:1311853"
     exon            1..171
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..756
                     /gene="Laptm4b"
                     /note="lysosomal-associated protein transmembrane 4B"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 4B"
                     /protein_id="NP_001013192.1"
                     /db_xref="GeneID:315047"
                     /db_xref="RGD:1311853"
                     /translation="MKMVAPWTRFYSHSCCLCCHVRTGTILLGIWYLIINAVVLLILL
                     SALADPDQYHFSGSELGGEFEFMDDANMCIAIAISLLMILICAMATYGAYKQHAAWII
                     PFFCYQIFDFALNTLVAITVLVYPNSIQEYIRQLPPSFPYRDDIMSVNPTCLVLVILL
                     FIGIILTFKGYLISCVWSCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATAVTGTAK
                     EPPPPYVSA"
     exon            172..283
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            284..357
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..480
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            481..579
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            580..675
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1731
                     /gene="Laptm4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaccgtg tgagcggagc ccgggacgaa aagagagaga cggtctcgca aacttgtgcg
       61 agcgcctgag ctatgaagat ggtcgcgccc tggactcggt tctattccca cagctgctgc
      121 ctgtgctgcc atgtccgcac cggcaccatc ctgttgggca tctggtacct gatcatcaat
      181 gccgtggtcc tgttgatcct gctgagtgcc ctggccgatc ccgatcagta tcacttttca
      241 ggctctgaac taggagggga atttgagttc atggacgatg ccaacatgtg cattgctatc
      301 gcgatctctc tcctcatgat cctgatctgt gccatggcta cctacggtgc atacaagcaa
      361 cacgctgcct ggatcatccc gttcttctgt taccagatct ttgatttcgc cctgaatact
      421 ttggttgcaa tcaccgtgct tgtctacccc aactccattc aggagtacat aagacagctg
      481 ccccccagct ttccctacag agatgacata atgtcagtga accctacctg tttggtcctt
      541 gtcatccttc tcttcatagg cattattttg acatttaagg gctacttgat cagctgtgtt
      601 tggagctgct acaggtacat caatggcagg aactcctctg atgttctggt ttacgttacc
      661 agcaacgata ccacggtgct gttgccacca tacgatgatg ccactgctgt gaccggcact
      721 gccaaggagc caccgccacc ttacgtgtct gcctgaacgt ggtgtggagg agcccagagc
      781 gccagtctga gcccacagct gcttgattga ccctgtggtt tcacctctcc tccgtgatga
      841 gctctttgag cctgtttgtt gttaaaatgc catgttttaa aatttagatg ttaagttgaa
      901 gcctctgttg tctgacgtac cctgtaccca agcaccgagt agtaaggctg taggactgtt
      961 ttggtaggag ggggctgtga tgagttctca gagtctttct caaaactatg tacggcgttc
     1021 cctggtctgg tttgtacctg cctggcccca aagccagggg gcagtcatac ttttcctctc
     1081 cattccttct gactgtttga aagtacaaaa taaaaattag atcatactta aactattcca
     1141 gaatccctaa taaaaacaat attaattgtt ctaattatgt agttaggagc ccttatatat
     1201 gtgatataag aatttcccta ctatccccaa gttcagtgat attctgaatt tgctggtcaa
     1261 gaattttctt tgggctaaat aaggactgtg aggtaatagg aacagtgagg gcaagggctg
     1321 cccaggatgt ctgttttgag ctagggctga tgtgtctccc tgtgtgaaag ggggaccagc
     1381 ttgcttggct cagaaaaact cagactcact tttcctcagc gtcctccagc aaataccttg
     1441 ctttgtcaag cagaaccacc cgtgtacgtt tgggaaaagg tgttcacact ctttccttgc
     1501 aaggtacacc ctactttgaa tttctaagta tgcctaatca tttattaaag tgtcaagcag
     1561 tcttcagaaa gataaggagg ctcgttccca tgtggaatgc tctagattgt ctgaattgca
     1621 aacgatgttt gtgtccatgt ctctgaatgt gaacaactct cctgcttgtt cattgctcag
     1681 tgtgctgtac atgaaggctt tgcaattaaa gtttgtctgc atccaagaaa aaaaaaaaaa
     1741 aaaaaaaaaa
//
