LOCUS       NM_199384               1387 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus lysosomal protein transmembrane 4 alpha
            (Laptm4a), mRNA.
ACCESSION   NM_199384 XM_216660
VERSION     NM_199384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Milkereit,R. and Rotin,D.
  TITLE     A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4
            proteins
  JOURNAL   PLoS One 6 (11), e27478 (2011)
   PUBMED   22096579
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Hogue,D.L., Nash,C., Ling,V. and Hobman,T.C.
  TITLE     Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha)
            requires two tandemly arranged tyrosine-based signals for sorting
            to lysosomes
  JOURNAL   Biochem J 365 (Pt 3), 721-730 (2002)
   PUBMED   11980562
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 8, 2021 this sequence version replaced NM_199384.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232171.1, FQ212732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               JAXUCZ010000006.1  37438503-37438782
            281-401             JAXUCZ010000006.1  37449635-37449755
            402-478             JAXUCZ010000006.1  37452442-37452518
            479-601             JAXUCZ010000006.1  37452605-37452727
            602-697             JAXUCZ010000006.1  37453848-37453943
            698-796             JAXUCZ010000006.1  37454348-37454446
            797-1387            JAXUCZ010000006.1  37455648-37456238
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1387
                     /gene="Laptm4a"
                     /note="lysosomal protein transmembrane 4 alpha"
                     /db_xref="GeneID:298875"
                     /db_xref="RGD:735179"
     exon            1..280
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..871
                     /gene="Laptm4a"
                     /note="lysosomal-associated protein transmembrane 4A;
                     lysosomal-associated protein transmembrane 4 alpha"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 4A"
                     /protein_id="NP_955416.1"
                     /db_xref="GeneID:298875"
                     /db_xref="RGD:735179"
                     /translation="MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMA
                     ILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAI
                     SYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSC
                     LLFIVLVFFVVFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMA
                     VKIPEKEPPPPYLPA"
     exon            281..401
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            402..478
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            479..601
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            602..697
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            698..796
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1387
                     /gene="Laptm4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgctcag agcgcaggcg cacaggagtt ggcaggggcc cgggccgagg gcgggccaga
       61 agacgcgtcg tttggctttg gacagcgtcg cagagtcgtc tgggttgaac cgctgggccg
      121 aaagcttttg tcaggggcct gggcgagagc gaggcccacg aggttcccga tggtgtccat
      181 gactttcaaa cggagccgca gcgaccggtt ctacagcacc cggtgctgcg gctgttgcca
      241 tgtccgcacc gggacgatca tcctggggac ctggtacatg gtggtcaacc tattgatggc
      301 aattttgctg actgtggagg tgactcatcc aaattccatg ccagctgtca acattcagta
      361 tgaagtcatt ggtaattact attcatctga gagaatggct gataatgcct gcgttctttt
      421 tgccgtctct gttcttatgt ttataatcag ttcaatgctg gtttatggag ccatttctta
      481 tcaagtgggc tggctgattc ctttcttctg ctaccgactt tttgacttcg ttctcagttg
      541 tctggtagcc atcagttctc tcacttactt gccaagaatc aaagaatatc tggatcagtt
      601 gcctgatttc ccctacaaag atgacctcct ggcattggac tccagctgcc ttctgttcat
      661 tgtacttgtg ttctttgtgg tattcatcat ttttaaggct tacctaatca attgtgtttg
      721 gaactgctac aaatacatca acaatagaaa tgtgccagag attgccgtgt atcctgcctt
      781 tgaagcacct ccacagtacg ttttgccaac ctatgaaatg gctgtgaaga ttcctgagaa
      841 agagccacca cctccttacc tgcctgcctg aggacgttct accttgtcaa taaagcctat
      901 accagcttct tgtcttgttt attttacaga aagctgcaat gcagggctct cagactcgtt
      961 tgatgtaaag tgcactgtct tgtctgagca tttattttca aacactaagg agcttttgga
     1021 cattattaaa aattttgtta agaatcacat tgtagaaact tttgaagaca atctaggtta
     1081 agcaagagca aagtgccatt gttagccttt aactgagggt agggagggga agggtctcta
     1141 tgttttcttt tttaactttg cactttcttt gtataatggt ttatgttttg gatgtctgat
     1201 gccctgaata gtttccagag agtgagttgg tcgaagatcc gcagtctcca gctctgtgaa
     1261 acaggagaga gaaagagcat tttgacttga cctggaagat gacggttgca tgcttctcat
     1321 ttgtatgttt tcatctttgt gataaaatgc tttaataaag ctcttaaatt ttaccattgt
     1381 ccttaaa
//
