LOCUS       NM_001011910            2211 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus leucine aminopeptidase 3 (Lap3), mRNA.
ACCESSION   NM_001011910 XM_214050
VERSION     NM_001011910.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Feng,L., Chen,Y., Xu,K., Li,Y., Riaz,F., Lu,K., Chen,Q., Du,X.,
            Wu,L., Cao,D., Li,C., Lu,S. and Li,D.
  TITLE     Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation
            inhibits cell autophagy in pathogenesis of NAFLD
  JOURNAL   Aging (Albany NY) 14 (7), 3259-3275 (2022)
   PUBMED   35404840
  REMARK    GeneRIF: Cholesterol-induced leucine aminopeptidase 3 (LAP3)
            upregulation inhibits cell autophagy in pathogenesis of NAFLD.
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2211)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2211)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 2211)
  AUTHORS   Rezvani,K., Teng,Y., Pan,Y., Dani,J.A., Lindstrom,J., Garcia
            Gras,E.A., McIntosh,J.M. and De Biasi,M.
  TITLE     UBXD4, a UBX-containing protein, regulates the cell surface number
            and stability of alpha3-containing nicotinic acetylcholine
            receptors
  JOURNAL   J Neurosci 29 (21), 6883-6896 (2009)
   PUBMED   19474315
REFERENCE   7  (bases 1 to 2211)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2211)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2211)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079381.1.
            
            On Feb 11, 2005 this sequence version replaced XM_214050.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079381.1, SRR8487226.11748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..2211
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /note="leucine aminopeptidase 3"
                     /db_xref="GeneID:289668"
                     /db_xref="RGD:1307985"
     exon            1..143
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1601
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /EC_number="3.4.11.5"
                     /EC_number="3.4.11.1"
                     /EC_number="3.4.13.23"
                     /note="LAP; leucyl aminopeptidase; prolyl aminopeptidase;
                     proline aminopeptidase; peptidase S;
                     cysteinylglycine-S-conjugate dipeptidase"
                     /codon_start=1
                     /product="cytosol aminopeptidase"
                     /protein_id="NP_001011910.1"
                     /db_xref="GeneID:289668"
                     /db_xref="RGD:1307985"
                     /translation="MYLLPLPAAARVALRRLGVRGLWDRGLSTADMTKGLVLGIYSKD
                     KDDDVPQFTSAGENFNKLVSGRLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLG
                     KRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAEGAVLGLY
                     EYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARQLMESPANEMTPTRFAEV
                     IEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYTGSPNATEAP
                     LVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPL
                     CENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATL
                     TGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADV
                     NNLGKYRSAGACTAAAFLREFVTHTKWAHLDIAGVMTNKDEIPYLRKGMSGRPTRTLI
                     EFLLRFSKDSS"
     exon            144..259
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..314
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..420
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..580
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..745
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..904
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1029
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1118
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1221
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1301
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1411
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..2187
                     /gene="Lap3"
                     /gene_synonym="LAP-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgctctct ggagggcggc gccgtgggcc gagccgagaa gatgtacttg ctgcctcttc
       61 cggcagccgc gcgagtcgcg ctccgcaggc tgggagtgag aggtctctgg gatcggggtc
      121 tgtccaccgc agacatgacg aagggccttg ttttaggaat ttattccaaa gacaaagatg
      181 atgacgtacc acagtttaca agtgcaggag agaattttaa taagttggtg tctggaaggc
      241 tgagggaaat gttgaacata tcgggacctc ctctcaaggc aggcaaaacc cgaaccttct
      301 atggtctgca tcaggacttc cccagcgtgg tggttgtcgg ccttggcaag agatcggctg
      361 gtgtcgatga ccaggaaaac tggcacgaag gcaaggagaa catccgagct gctgttgcag
      421 cgggatgcag gcaggtccaa gacctggagc tgccgtcggt ggaggtggat ccctgtggag
      481 atgctcaggc tgctgcggaa ggagctgtgc ttggcctcta cgagtatgat gacctaaagc
      541 agaaaaagaa ggtggctgtg tcggccaagc tccatggaag tggtgacctc gaggcctggg
      601 agaaaggggt cctctttgct tctgggcaga acttggcccg ccagctgatg gagtctccag
      661 ccaatgaaat gacaccaacc agatttgccg aagttattga aaaaaatctc aaaagtgcca
      721 gtagtaaaac cgaggtccat atcagaacca aatcctggat agaggaacaa gaaatgggtt
      781 cattcctaag tgtagccaag gggtctgaag aaccaccagt cttcttggaa atccactata
      841 ctggcagccc caatgcaact gaagcacccc tggtgtttgt gggaaagggc attacctttg
      901 acagcggagg tatctccatc aaggcttctg caaatatgga cctcatgagg gctgacatgg
      961 gaggagcagc aacaatatgc tcggccattg tgtctgcagc aaagctcaat ctgcccatta
     1021 atatcatagg tttggcccct ctttgtgaaa acatgcctag cggcaaggcc aacaaaccag
     1081 gggatgttgt cagagccagg aatgggaaga ctatccaggt cgacaacact gatgccgagg
     1141 gcaggctcat cctggccgac gcactctgct atgcacacac cttcaatccc aaggtcatca
     1201 tcaatgctgc cactttaaca ggtgccatgg acgtagccct gggatcaggt gccactggag
     1261 tctttaccaa ttcatcctgg ctgtggaaca aactatttga ggccagtgta gaaactgggg
     1321 accgagtctg gaggatgccc ctctttgagc attatacaag acaagtcata gattgccaac
     1381 ttgctgatgt gaacaatctt ggaaaataca gatctgcagg tgcgtgcaca gctgcggcat
     1441 tcctgcgaga gtttgtgact catacaaagt gggcacattt agacatagcc ggtgtgatga
     1501 ccaacaagga cgagattccc tatctgcgga agggaatgag tgggagaccc acaaggactc
     1561 tgattgagtt cttacttcgc ttcagcaaag acagttctta gttcatacac tcagaaattc
     1621 ttccttctgt cttgaattgg atagttagcc ttcaaaattt ttgaatgaat gaaaatcttt
     1681 taaagacaaa aacggatgtt gttctttttt taatcttaat tcttggaata ttttagtatg
     1741 cttgaatcat ggaaatctaa atgatatatg aattaatata ggtcctttat taaaacatct
     1801 tgtaatagta tgtatttttc aagccatatt tactattttt acaagacagg gaaaatctta
     1861 agtccataaa aacgtacaaa gggagccaga catggcggcg cacaactttg atcccagcac
     1921 ttgggaggca gaggcagctg gatttctgac tttgagacca gcatggtcta tagagtgagt
     1981 tccaggatag ccatggctac acaggaaccc tgtctcggaa aaaacaaaaa caaacaccac
     2041 caccaccaaa atatacaaag gaaaatataa ttaatgactt tgttacattt tctaattttt
     2101 gattcttaag gtagattgtt taagtgttca taaaactttc aaaatccaga tccaatgcag
     2161 taaataaatt acagtatttc cttctgaaaa aaaaaaaaaa aaaaaaaaaa a
//
