LOCUS       NM_001014187            1607 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus LanC like glutathione S-transferase 2 (Lancl2),
            mRNA.
ACCESSION   NM_001014187 XM_342699
VERSION     NM_001014187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Sturla L, Fresia C, Guida L, Bruzzone S, Scarfi S, Usai C,
            Fruscione F, Magnone M, Millo E, Basile G, Grozio A, Jacchetti E,
            Allegretti M, De Flora A and Zocchi E.
  TITLE     LANCL2 is necessary for abscisic acid binding and signaling in
            human granulocytes and in rat insulinoma cells
  JOURNAL   J Biol Chem 284 (41), 28045-28057 (2009)
   PUBMED   19667068
  REMARK    GeneRIF: Data show that lanthionine synthetase C-like protein
            (LANCL2) is required for abscisic acid binding on human granulocyte
            membranes and that LANCL2 is necessary for transduction of the ABA
            signal into granulocytes and rat insulinoma cells.
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Landlinger C, Salzer U and Prohaska R.
  TITLE     Myristoylation of human LanC-like protein 2 (LANCL2) is essential
            for the interaction with the plasma membrane and the increase in
            cellular sensitivity to adriamycin
  JOURNAL   Biochim Biophys Acta 1758 (11), 1759-1767 (2006)
   PUBMED   16979580
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Park S and James CD.
  TITLE     Lanthionine synthetase components C-like 2 increases cellular
            sensitivity to adriamycin by decreasing the expression of
            P-glycoprotein through a transcription-mediated mechanism
  JOURNAL   Cancer Res 63 (3), 723-727 (2003)
   PUBMED   12566319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079412.1.
            
            On Apr 1, 2005 this sequence version replaced XM_342699.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079412.1, SRR8487231.98315.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1607
                     /gene="Lancl2"
                     /note="LanC like glutathione S-transferase 2"
                     /db_xref="GeneID:362375"
                     /db_xref="RGD:1310809"
     exon            1..213
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1362
                     /gene="Lancl2"
                     /note="testis-specific adriamycin sensitivity protein;
                     LanC (bacterial lantibiotic synthetase component C)-like
                     2; LanC like 2; LanC lantibiotic synthetase component
                     C-like 2"
                     /codon_start=1
                     /product="lanC-like protein 2"
                     /protein_id="NP_001014209.1"
                     /db_xref="GeneID:362375"
                     /db_xref="RGD:1310809"
                     /translation="MGETMSKRLKFHLGEAEMEERSFPNPFLDYEVAASATGFASGTA
                     EETGRVCPLPTTEDPGLPFHPNGKIVPNLIKRIQTKIKDLLQQMEEGLKTADPHDCSA
                     YTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAV
                     IYHKLKSECESQECITKLLQMHRTIVCQESELPDELLFGRAGYLYALLYLNTEIGPGT
                     VGETAIKEVVTAIIESGKRLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQP
                     EAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLLRA
                     YQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYQLTQDKKYLYR
                     ACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDMLVPETARFPAFELGFVQKD
                     "
     exon            214..331
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..539
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..687
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..834
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1017
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1194
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1267
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1582
                     /gene="Lancl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcggaca tgggcgagac catgtcaaag agactcaagt tccacctagg agaggcggag
       61 atggaggagc ggtcgtttcc taatcccttc ctagactatg aggtcgctgc ctccgccacg
      121 gggttcgcct ctggaactgc ggaggaaaca ggccgtgttt gccctcttcc caccacagaa
      181 gacccgggcc tccctttcca ccccaacggg aagattgttc ctaacttgat aaagcgtatc
      241 cagaccaaaa ttaaagatct tctgcagcaa atggaagaag ggctgaagac agctgatccc
      301 catgattgct ctgcatacac tggttggaca ggcatagcac ttttgtacct gcagctgtac
      361 cgggtcactg gtgaccagac ctacctgctc cgatccctgg attatgtgaa gagaacactc
      421 cgaaatttga gtggacgcag agtcactttc ctttgtggag atgctgggcc ccttgctgtg
      481 ggagctgtga tatatcataa actcaaaagt gaatgtgagt cccaggaatg catcacaaaa
      541 cttctacaga tgcatagaac tattgtctgc caagaatcag agcttcctga cgagctgctg
      601 ttcggacggg caggatacct gtatgcctta ctgtacctga acacagaaat cggccctggc
      661 actgttggtg agacagctat taaagaggta gtcactgcta ttattgagtc aggaaagagg
      721 ctatctcggg aagagaggaa aagtgagcgc tgccctctgt tgtatcagtg gcacaggaag
      781 caatatgttg gagcagccca tggtatggct ggcatctact acatgttaat gcagccagaa
      841 gcaaaagtgg accaagaaac cttgacagaa atggtgaaac ccagcatcga ttatgtgcgc
      901 cacaaaaaat tcagatctgg aaattatcca tcttcattaa gcaatgaaac agatcgattg
      961 gtccactggt gccacggtgc tccaggagtc atccacatgc tcttacgggc ataccaggtt
     1021 tttaaggagg aaaaatactt gaaagaggcc atggagtgca gtgatgtgat ttggcagcga
     1081 ggtctgctcc ggaaaggcta tggaatctgc catggaactg ctggaaatgg ttattccttt
     1141 ttgtcccttt atcaactgac acaggataag aagtatctct atcgagcttg taagtttgca
     1201 gagtggtgtc tagattatgg agctcacgga tgccgcattc ctgacaggcc ttattccctc
     1261 tttgaaggta tggctggtgc tgttcacttt ctttctgaca tgttggtacc agagacagca
     1321 cggtttccgg catttgaact tggctttgtg cagaaggatt aaaaaggtgc aaaaagacaa
     1381 ctaacatact cgttggacca aaagccacct gactgattag tgcctgacac agaacctact
     1441 gtaaacccta aaagaggaag acagaaggac agaaaccttc acaagcccct ttgttgcaaa
     1501 gacccccaat tagagcatga gcgatagaaa ccttgtcata agcattctgt gacagtgtgt
     1561 ccattaaagg tgtgaaatct gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
