LOCUS       NM_053723               1470 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus LanC like glutathione S-transferase 1 (Lancl1),
            mRNA.
ACCESSION   NM_053723 XM_343584
VERSION     NM_053723.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Huang,C., Chen,M., Pang,D., Bi,D., Zou,Y., Xia,X., Yang,W., Luo,L.,
            Deng,R., Tan,H., Zhou,L., Yu,S., Guo,L., Du,X., Cui,Y., Hu,J.,
            Mao,Q., Worley,P.F. and Xiao,B.
  TITLE     Developmental and activity-dependent expression of LanCL1 confers
            antioxidant activity required for neuronal survival
  JOURNAL   Dev Cell 30 (4), 479-487 (2014)
   PUBMED   25158856
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Zhong,W.X., Wang,Y.B., Peng,L., Ge,X.Z., Zhang,J., Liu,S.S.,
            Zhang,X.N., Xu,Z.H., Chen,Z. and Luo,J.H.
  TITLE     Lanthionine synthetase C-like protein 1 interacts with and inhibits
            cystathionine beta-synthase: a target for neuronal antioxidant
            defense
  JOURNAL   J Biol Chem 287 (41), 34189-34201 (2012)
   PUBMED   22891245
  REMARK    GeneRIF: Lanthionine synthetase C-like protein 1 interacts with and
            inhibits cystathionine beta-synthase: a target for neuronal
            antioxidant defense.
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Zhang,W., Wang,L., Liu,Y., Xu,J., Zhu,G., Cang,H., Li,X.,
            Bartlam,M., Hensley,K., Li,G., Rao,Z. and Zhang,X.C.
  TITLE     Structure of human lanthionine synthetase C-like protein 1 and its
            interaction with Eps8 and glutathione
  JOURNAL   Genes Dev 23 (12), 1387-1392 (2009)
   PUBMED   19528316
  REMARK    GeneRIF: expression of LanCL1 mutants defective in Eps8 interaction
            inhibits nerve growth factor (NGF)-induced neurite outgrowth
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Nielsen,J.E., Hansen,M.A., Jorgensen,M., Tanaka,M., Almstrup,K.,
            Skakkebaek,N.E. and Leffers,H.
  TITLE     Germ cell differentiation-dependent and stage-specific expression
            of LANCL1 in rodent testis
  JOURNAL   Eur J Histochem 47 (3), 215-222 (2003)
   PUBMED   14514412
  REMARK    GeneRIF: LanC-like protein 1 expression in rat testes was initiated
            already in pachytene spermatocytes in stage IX, but otherwise
            similar to mouse.
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Mayer,H., Bauer,H., Breuss,J., Ziegler,S. and Prohaska,R.
  TITLE     Characterization of rat LANCL1, a novel member of the lanthionine
            synthetase C-like protein family, highly expressed in testis and
            brain
  JOURNAL   Gene 269 (1-2), 73-80 (2001)
   PUBMED   11376939
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Bauer,H., Mayer,H., Marchler-Bauer,A., Salzer,U. and Prohaska,R.
  TITLE     Characterization of p40/GPR69A as a peripheral membrane protein
            related to the lantibiotic synthetase component C
  JOURNAL   Biochem Biophys Res Commun 275 (1), 69-74 (2000)
   PUBMED   10944443
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ131111.1.
            
            On Jan 1, 2004 this sequence version replaced XM_343584.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131111.1, BC085811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1470
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /note="LanC like glutathione S-transferase 1"
                     /db_xref="GeneID:114515"
                     /db_xref="RGD:69416"
     exon            1..228
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1347
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /EC_number="2.5.1.18"
                     /function="putative role in peptide modification"
                     /note="lanC (bacterial lantibiotic synthetase component
                     C)-like 1; lanC-like protein 1; LanC like 1; 40 kDa
                     erythrocyte membrane protein; LanC-like 1(bacterial); LanC
                     lantibiotic synthetase component C-like 1"
                     /codon_start=1
                     /product="glutathione S-transferase LANCL1"
                     /protein_id="NP_446175.1"
                     /db_xref="GeneID:114515"
                     /db_xref="RGD:69416"
                     /translation="MAQRAFPNPYADYNKSLAENYFDSTGRLTPEFSHRLTNKIRELL
                     QQMERGLKSADPQDGTGYTGWAGIAVLYLHLHNVFGDPAYLQMAHSYVKHSLNCLSRR
                     SITFLCGDAGPLAVAAVLYHKMNSGKQAEDCITRLIHLNKIDPHVPNEMLYGRIGYIF
                     ALLFVNKNFGEEKIPQSHIQQICETILTSGEKLSRKRNFTTKSPLMYEWYQEYYVGAA
                     HGLAGIYYYLMQPSLHVSQGKLHSLVKPSVDFVCQLKFPSGNYPSCLDDTRDLLVHWC
                     HGAPGVIYMLIQAYKVFKEEHYLCDAQQCADVIWQYGLLKKGYGLCHGAAGNAYAFLA
                     LYNLTQDAKYLYRACKFAEWCLDYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKA
                     KFPAFEL"
     exon            229..346
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            347..554
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            555..690
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            691..837
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1020
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1197
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1270
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1453
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1451
                     /gene="Lancl1"
                     /gene_synonym="GPR69A; p40"
ORIGIN      
        1 gtctcgcgca cctgccgagc ggctgccagc cgggggccgc ttggagggaa ggggctgtca
       61 aagcgcctgc agtcgcgtcc cagccccgag ccccgacccc tcttgagatc tctctttccc
      121 ctgttctgca ggttcgcttg cggcgtcatg gctcagaggg cctttccgaa tccttatgcc
      181 gattataaca agtcgctggc cgaaaactat tttgattcta ctgggaggct gactcctgag
      241 ttttcacatc gcttgaccaa taagatccgg gagctccttc agcaaatgga gagaggccta
      301 aagtctgcag accctcagga cggcactgga tacaccggct gggcaggcat tgctgtgctt
      361 taccttcatc tccacaatgt gtttggggac ccggcctatc tgcagatggc gcacagctat
      421 gtaaagcaca gcctcaactg tttgagcagg cggtccatca ccttcctgtg tggggacgcg
      481 ggccccctgg ctgtggctgc tgtgctgtac cacaagatga acagcgggaa gcaggcagag
      541 gattgcatca cacggctcat tcacctaaat aagattgatc cccacgtacc aaatgaaatg
      601 ctctacggcc gcataggcta catcttcgct ctgctttttg tcaataagaa ctttggagag
      661 gagaagattc ctcagagcca cattcagcag atttgtgaaa ccatcttaac ctctggggag
      721 aagctgtcta gaaagagaaa cttcacaacg aaatccccac tgatgtacga gtggtaccag
      781 gagtattacg tgggggctgc ccacggcttg gcgggcattt attactacct gatgcagccc
      841 agccttcatg taagccaagg gaagttacat agtttggtga aacccagtgt agactttgtc
      901 tgccagctga agttcccttc tggcaactac ccttcatgtt tggatgacac cagagacctg
      961 cttgtccact ggtgccatgg cgcccctggg gtcatctata tgctcatcca agcatacaag
     1021 gtgttcaaag aggagcatta cctgtgtgac gcccagcagt gtgctgacgt gatctggcag
     1081 tacgggctac tgaagaaggg ctatgggctg tgccacggtg ctgcagggaa tgcctatgct
     1141 ttcctggcac tctataacct cacacaagat gcgaaatacc tgtacagggc ctgtaagttt
     1201 gctgagtggt gcttagacta tggagagcac gggtgcagga caccggacac gcccttctct
     1261 ctctttgaag ggatggctgg aacgatatat ttcttggctg acctgttagt ccccacaaag
     1321 gccaagttcc ctgcatttga actctgagaa gaaagcatgt cccctgccgc tcacagcatg
     1381 gttctgtgta tccctctgag ctctgtgtgt ccattgcttt tgaaggaagc agaatgaaac
     1441 tgtatacttt gaaaaaaaaa aaaaaaaaaa
//
