LOCUS       NM_001008375            1240 bp    mRNA    linear   ROD 11-APR-2024
DEFINITION  Rattus norvegicus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 3 (Lamtor3), transcript variant 1, mRNA.
ACCESSION   NM_001008375 XM_342347
VERSION     NM_001008375.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1240)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   2  (bases 1 to 1240)
  AUTHORS   Schiefermeier,N., Scheffler,J.M., de Araujo,M.E., Stasyk,T.,
            Yordanov,T., Ebner,H.L., Offterdinger,M., Munck,S., Hess,M.W.,
            Wickstrom,S.A., Lange,A., Wunderlich,W., Fassler,R., Teis,D. and
            Huber,L.A.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
REFERENCE   3  (bases 1 to 1240)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   4  (bases 1 to 1240)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1240)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   6  (bases 1 to 1240)
  AUTHORS   Nada,S., Hondo,A., Kasai,A., Koike,M., Saito,K., Uchiyama,Y. and
            Okada,M.
  TITLE     The novel lipid raft adaptor p18 controls endosome dynamics by
            anchoring the MEK-ERK pathway to late endosomes
  JOURNAL   EMBO J 28 (5), 477-489 (2009)
   PUBMED   19177150
REFERENCE   7  (bases 1 to 1240)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1240)
  AUTHORS   Pullikuth,A., McKinnon,E., Schaeffer,H.J. and Catling,A.D.
  TITLE     The MEK1 scaffolding protein MP1 regulates cell spreading by
            integrating PAK1 and Rho signals
  JOURNAL   Mol Cell Biol 25 (12), 5119-5133 (2005)
   PUBMED   15923628
  REMARK    GeneRIF: The MP1/p14 complex regulates PAK1-dependent ERK
            activation during adhesion and cell spreading but is not required
            for ERK activation by platelet-derived growth factor.
REFERENCE   9  (bases 1 to 1240)
  AUTHORS   Kurzbauer,R., Teis,D., de Araujo,M.E., Maurer-Stroh,S.,
            Eisenhaber,F., Bourenkov,G.P., Bartunik,H.D., Hekman,M., Rapp,U.R.,
            Huber,L.A. and Clausen,T.
  TITLE     Crystal structure of the p14/MP1 scaffolding complex: how a twin
            couple attaches mitogen-activated protein kinase signaling to late
            endosomes
  JOURNAL   Proc Natl Acad Sci U S A 101 (30), 10984-10989 (2004)
   PUBMED   15263099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086353.1.
            
            On Dec 16, 2004 this sequence version replaced XM_342347.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086353.1, EV764509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1240
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 3"
                     /db_xref="GeneID:362045"
                     /db_xref="RGD:1307133"
     exon            1..81
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..127
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..493
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /note="MEK partner 1; mitogen-activated protein kinase
                     scaffold protein 1; mitogen-activated protein kinase
                     kinase 1-interacting protein 1; late endosomal/lysosomal
                     adaptor and MAPK and MTOR activator 3"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR3"
                     /protein_id="NP_001008376.1"
                     /db_xref="GeneID:362045"
                     /db_xref="RGD:1307133"
                     /translation="MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHA
                     LRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGL
                     IVSLEKELAPLFEELIKVVEVS"
     exon            128..162
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..221
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..355
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..419
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1218
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapksp1; MP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacttgac aggcagcttc agagaagcga ctgaactgcg ggaacaccgg ggcaggtgga
       61 gcgcgcgttg cgtctgcaga ggagtggaga ctgattctgc gagagaaagg ggttcatcat
      121 ggcggatgat ctaaagcgat tcctatacaa aaagttgcca agcgttgaag ggctccatgc
      181 aatcgttgtg tcagatagag atggggtgcc tgttattaaa gtggctaacg acagtgctcc
      241 agaacatgcc ctgaggcctg gcttcttgtc cactttcgcc ctcgcaacag accaaggcag
      301 caagctcgga ctttcaaaaa ataaaagcat catctgctac tataatacct accaggtggt
      361 tcaattcaat cgtttgcctc tggtggtgag ttttatagcc agcagcaatg ccaacacagg
      421 actaattgtc agcctagaaa aggagctcgc tcccttattt gaagaactga taaaagttgt
      481 ggaagtgtct taatccagca gtggttctgg tgcgtgcctc ggcctccctg cagcaaccct
      541 ggaccaggcc agcaaccttc agaccacact cgtacttgta tccatgtatt caaagggccg
      601 cctttccacc gtacactaaa gaagagccta ccactataat ttatagacag atcaattgtt
      661 atatttatgt gtatgaagtc ttttcttcct cagtgagacc tgggaacgcc acagaaatgg
      721 ttcattctat tgcagctccc atggagttag tgcgggcgcc tgagagagcg gcctctgtcc
      781 agcacatcag ggtgggatgg tacggtgagg ccggagcccg caagcacacc tgaactctgc
      841 tccactccat aagccgtaga cctttaccga gattgtaatg aggtcgtttt cttattaagg
      901 ttatattgta tttcttctca ctgtgaggaa gatgaaatgg ctcagtaaaa ataatcaagt
      961 acaatcgcta acgcccctct gctctcagtg cggtgagtgt tactaatgga ctcgattctt
     1021 cagggtgccg ctcctcagtg agaatgaaat cactactcag actcttctgc ttcccctgta
     1081 accgtgcttc catgattatg ttctttgtac ggttgaaatg catgacactg aattgtttcc
     1141 attatcagta tgtatataaa aatgacagga tagccatttt tatacatgag tataaataaa
     1201 atagtatttt taaaagtaaa aaaaaaaaaa aaaaaaaaaa
//
