LOCUS       NM_001106441             574 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 2 (Lamtor2), mRNA.
ACCESSION   NM_001106441 XM_001070050 XM_215630
VERSION     NM_001106441.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Bar-Peled L and Sabatini DM.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T,
            Ebner HL, Offterdinger M, Munck S, Hess MW, Wickstrom SA, Lange A,
            Wunderlich W, Fassler R, Teis D and Huber LA.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Bar-Peled L, Schweitzer LD, Zoncu R and Sabatini DM.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   4  (bases 1 to 574)
  AUTHORS   Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S and Sabatini
            DM.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   5  (bases 1 to 574)
  AUTHORS   Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y and Okada M.
  TITLE     The novel lipid raft adaptor p18 controls endosome dynamics by
            anchoring the MEK-ERK pathway to late endosomes
  JOURNAL   EMBO J 28 (5), 477-489 (2009)
   PUBMED   19177150
REFERENCE   6  (bases 1 to 574)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 574)
  AUTHORS   Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F,
            Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA and Clausen
            T.
  TITLE     Crystal structure of the p14/MP1 scaffolding complex: how a twin
            couple attaches mitogen-activated protein kinase signaling to late
            endosomes
  JOURNAL   Proc Natl Acad Sci U S A 101 (30), 10984-10989 (2004)
   PUBMED   15263099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473976.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215630.4, XM_001070050.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG667142.1, FM124363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..574
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 2"
                     /db_xref="GeneID:295234"
                     /db_xref="RGD:1562501"
     exon            1..144
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..454
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /note="mitogen-activated protein binding protein
                     interacting protein; roadblock domain containing 3"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR2"
                     /protein_id="NP_001099911.1"
                     /db_xref="GeneID:295234"
                     /db_xref="RGD:1562501"
                     /translation="MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARV
                     TAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFG
                     MLKAKAQALVQYLEEPLTQVAAS"
     exon            145..307
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /inference="alignment:Splign:2.1.0"
     exon            308..397
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..574
                     /gene="Lamtor2"
                     /gene_synonym="Mapbpip; RGD1562501; Robld3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaagcga tgagggaggg caagaggctg cgactgtagt gtttgtggga gcaggtcagg
       61 gttaagagac gcaggcatgc tgcgtcctaa ggctttgacg caggtgctaa gccaagccaa
      121 cactggagga gtccaaagta ccctgctgct gaataatgag ggatcgttgc tggcctactc
      181 cggttatggg gacacagatg cccgggtcac cgcggccatc gccagtaaca tctgggccgc
      241 atacgatagg aacgggaacc aagcgtttaa tgaagacagt ctcaaattta tcctcatgga
      301 ctgcatggag ggccgtgtag ccattaccag ggtggccaac cttctgctat gtatgtatgc
      361 caaggagact gtaggcttcg ggatgctcaa ggccaaggcc caggccttgg tgcagtacct
      421 ggaggaaccc ctcacccaag tagcagcctc ataatagtgt gatggaagct ggagtggaaa
      481 agggatcgtg attgggaaga gcagggcccc ggaaatgcct cactgggctg ggtgaggggt
      541 tgcttttttc taaataaatt ttcaactctt gcct
//
