LOCUS       NM_199102               1118 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 1 (Lamtor1), mRNA.
ACCESSION   NM_199102 XM_218971
VERSION     NM_199102.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1118)
  AUTHORS   Chichger,H., Braza,J., Duong,H., Stark,M. and Harrington,E.O.
  TITLE     Neovascularization in the pulmonary endothelium is regulated by the
            endosome: Rab4-mediated trafficking and p18-dependent signaling
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 309 (7), L700-L709 (2015)
   PUBMED   26254426
  REMARK    GeneRIF: This study shows for the first time that
            neovascularization within the pulmonary vasculature is dependent on
            the prorecycling endocytic proteins Rab4 and p18.
REFERENCE   2  (bases 1 to 1118)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   3  (bases 1 to 1118)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   4  (bases 1 to 1118)
  AUTHORS   Han,J.M., Jeong,S.J., Park,M.C., Kim,G., Kwon,N.H., Kim,H.K.,
            Ha,S.H., Ryu,S.H. and Kim,S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   5  (bases 1 to 1118)
  AUTHORS   Guillaumot,P., Luquain,C., Malek,M., Huber,A.L., Brugiere,S.,
            Garin,J., Grunwald,D., Regnier,D., Petrilli,V., Lefai,E. and
            Manie,S.N.
  TITLE     Pdro, a protein associated with late endosomes and lysosomes and
            implicated in cellular cholesterol homeostasis
  JOURNAL   PLoS One 5 (6), e10977 (2010)
   PUBMED   20544018
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1118)
  AUTHORS   Hahm,J.R., Ahn,J.S., Noh,H.S., Baek,S.M., Ha,J.H., Jung,T.S.,
            An,Y.J., Kim,D.K. and Kim,D.R.
  TITLE     Comparative analysis of fat and muscle proteins in fenofibrate-fed
            type II diabetic OLETF rats: the fenofibrate-dependent expression
            of PEBP or C11orf59 protein
  JOURNAL   BMB Rep 43 (5), 337-343 (2010)
   PUBMED   20510017
  REMARK    GeneRIF: Study suggest that PEBP and C11orf59 might be involved in
            controlling lipid or carbohydrate metabolism in diabetes via
            PPARalpha activation.
REFERENCE   7  (bases 1 to 1118)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   8  (bases 1 to 1118)
  AUTHORS   Nada,S., Hondo,A., Kasai,A., Koike,M., Saito,K., Uchiyama,Y. and
            Okada,M.
  TITLE     The novel lipid raft adaptor p18 controls endosome dynamics by
            anchoring the MEK-ERK pathway to late endosomes
  JOURNAL   EMBO J 28 (5), 477-489 (2009)
   PUBMED   19177150
  REMARK    GeneRIF: p18 is an endosomal membrane-anchored protein that
            interacts with the p14/MP1 ERK scaffold protein.
REFERENCE   9  (bases 1 to 1118)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061783.1.
            
            On Jan 1, 2004 this sequence version replaced XM_218971.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061783.1, FQ219988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1118
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 1"
                     /db_xref="GeneID:308869"
                     /db_xref="RGD:735078"
     exon            1..101
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..545
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /note="p27Kip1-releasing factor from RhoA; p27RF-Rho;
                     lipid raft adaptor protein p18; late endosomal/lysosomal
                     adaptor and MAPK and MTOR activator 1; RhoA activator
                     C11orf59 homolog"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR1"
                     /protein_id="NP_954533.1"
                     /db_xref="GeneID:308869"
                     /db_xref="RGD:735078"
                     /translation="MGCCYSSENEDSDQDQEERKLLLDPSNTPTKALNGAEPSYHSLP
                     SARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHW
                     KKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGI
                     P"
     exon            102..247
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     exon            248..325
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     exon            326..452
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     exon            453..1072
                     /gene="Lamtor1"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcctgac ggacgccgtc cctcctcggc gccgcctgag cgcccggccc gaccccgcca
       61 tggggtgctg ctatagcagc gaaaacgagg actcggacca ggaccaggag gagaggaagc
      121 tgttgttgga ccccagtaac acccctacca aagccctcaa tggagccgag cccagctacc
      181 atagcctgcc ttcagctcgc acagatgagc aggccctgct ttcctccatc cttgccaaga
      241 cagctagcaa catcattgat gtgtctgccg cagactccca gggcatggag cagcatgagt
      301 acatggaccg ggcaaggcag tacagtaccc gcttggctgt gcttagcagc agtctgaccc
      361 attggaagaa gctgccaccg ctgccatctc tcaccagcca gccccaccaa gtgctggcca
      421 gcgagcctat ccctttctct gacttgcagc aggtctccag gatagctgct tatgcctata
      481 gtgcactttc tcagatccgc gtggatgcga aagaagagct ggttgtacag tttgggatcc
      541 catgaagaaa ggggtcctgg gacagctctt ccctcgtctt catcccgtct ccaccccacc
      601 tcttctggcc cccagcctca ctgtggcttt ctacagaacc caacctgcta ctaatcacgg
      661 agaagaatgt ggaggacaag aataaggcta gaagccagag caagtgagga ctgagcaagg
      721 gaagggagaa ccgattgcca tcggccttca tgctctggtt agggtgaggt tggggccaag
      781 aggactgggc ctggcagatc ttcaagtcat tgggaagatg gagataccac tgtaggggtg
      841 aacaccggga gacctaggag atcccctccc caccctttct cttggcctcc gattcactcc
      901 tgtcccgttc cctgacttgg tgctcatagg cacctcactg ggaattatga ccagggtcta
      961 gacaagcttg aatctgaatt gagtttgtat ttctagcacc ctggattttt acatgtttgc
     1021 tctttttgtt ttttgtttgt cacccctcga taaagaaagt atattcattg tgaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
