LOCUS       NM_001014183            1841 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus lysosomal-associated membrane protein family,
            member 5 (Lamp5), mRNA.
ACCESSION   NM_001014183 XM_342525
VERSION     NM_001014183.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Defays,A., David,A., de Gassart,A., De Angelis Rigotti,F.,
            Wenger,T., Camossetto,V., Brousset,P., Petrella,T., Dalod,M.,
            Gatti,E. and Pierre,P.
  TITLE     BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid
            dendritic cells
  JOURNAL   Blood 118 (3), 609-617 (2011)
   PUBMED   21642595
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   David,A., Tiveron,M.C., Defays,A., Beclin,C., Camosseto,V.,
            Gatti,E., Cremer,H. and Pierre,P.
  TITLE     BAD-LAMP defines a subset of early endocytic organelles in
            subpopulations of cortical projection neurons
  JOURNAL   J Cell Sci 120 (Pt 2), 353-365 (2007)
   PUBMED   17215451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On May 18, 2021 this sequence version replaced NM_001014183.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087680.1, SRR22399492.415172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000003.1  143825197-143825558
            363-535             JAXUCZ010000003.1  143826148-143826320
            536-667             JAXUCZ010000003.1  143826693-143826824
            668-773             JAXUCZ010000003.1  143826945-143827050
            774-962             JAXUCZ010000003.1  143827999-143828187
            963-1841            JAXUCZ010000003.1  143836821-143837699
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1841
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /note="lysosomal-associated membrane protein family,
                     member 5"
                     /db_xref="GeneID:362220"
                     /db_xref="RGD:1306991"
     exon            1..362
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1141
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /note="LAMP family protein C20orf103 homolog;
                     brain-associated LAMP-like protein; lysosome-associated
                     membrane protein 5; brain and dendritic cell-associated
                     LAMP; lysosome-associated membrane glycoprotein 5"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 5
                     precursor"
                     /protein_id="NP_001014205.1"
                     /db_xref="GeneID:362220"
                     /db_xref="RGD:1306991"
                     /translation="MDLRGRALLGGDRLRILLMFFHAMAQTVAEQEVENLSGLSTNPE
                     KDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQAEISLTRGAEVKGRCGHN
                     ESELQVFWVDRAYTLKMLFVKESHNTSKGLEATWKLSKVQFVYDSSEKTHFKDAVSAG
                     KHTANSHHLSALVTPAGMSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFV
                     FSEEHKCPVDEREQLEETLPLILGLILGLVIVITLVIYHIHHKMTANQVQIPRDRSQY
                     KHMG"
     exon            363..535
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
     exon            536..667
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
     exon            668..773
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
     exon            774..962
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1841
                     /gene="Lamp5"
                     /gene_synonym="BAD-LAMP; LAMP-5; RGD1306991"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctccccc acaccacccc aatcctattg gccttctcca caagccaaat tacaaatcct
       61 gcaacacaac ctcgttgttt ccagaactct cagcgtggac agctcccgca tcctgggtgc
      121 ctcctctgca gtgtgcggca agggagctgt agcgcctggt gaagcacgag acaatcccgc
      181 gcgctcgctc ctccctgtcc gccccctccc ttagctcact ctaccggcca ctttgaggga
      241 tttcctcccg gggcggcctt tgcagcagaa acacatctgc ctggttcccg gcaacagcat
      301 ggatctacga ggaagagccc ttctcggtgg agacagactt cggattctcc taatgttctt
      361 ccatgcaatg gcccaaaccg tggcagaaca agaagtggaa aatctttcgg gcctttccac
      421 gaacccggag aaagacatat ttgtggtgcg ggaaaatggg acgacgtgtc tcatggcaga
      481 gtttgcagcc aaatttattg taccttatga tgtgtgggcc agcaattatg tggatctgat
      541 cacagagcag gctgagatct ccttgacccg gggagctgag gtgaagggcc gctgtggtca
      601 caacgagtcg gagctgcagg tgttctgggt agatcgcgcc tacacactca aaatgctctt
      661 tgtaaaggaa agtcacaaca cttccaaagg actagaggcg acttggaagc tgagcaaggt
      721 gcagtttgtc tatgattcct cagagaagac ccactttaaa gatgctgtga gtgctgggaa
      781 gcataccgcc aactctcacc acctctctgc cttggtgacc ccagctggga tgtcctatga
      841 gtgccaggct cagcagacca tttctctggc ctccagtgat cctcagaaga ctgtcaccat
      901 gatcctgtct gcagtgcaca ttcagccctt tgatatcatc tctgactttg tcttcagtga
      961 agagcataaa tgtccagtgg atgagcgaga acagttggaa gagaccctgc ccctgatcct
     1021 gggcctcatc ttaggcctgg tcattgtcat aacacttgtg atttaccaca ttcatcacaa
     1081 aatgactgcc aaccaagtgc agatccccag agaccgttcc cagtacaagc acatgggcta
     1141 gagccatcag gcagacagcc tccacgtcct gcccccaaac cggatgacgt agagtggcaa
     1201 tgacactttt tcacctgtat acaggatcca ccaacatagc tacactccaa caggcccagg
     1261 cacctgaggt ctgactggcc tgtgtccatg cttaaaccca gggatgaaag acaggccttg
     1321 gggtttgggg gattaatggt gactgttgtg tccatgctgg gcagtaaggg tgggtgagta
     1381 gggtaacagc tttcgtgctc atgatggctt aactttggct ctctgacttt gtaagtctac
     1441 agcatgtaga agggacgata tggtccttat atttagaaag tggaccactt cctttgggag
     1501 acctctttag atctaaagac accgggtgct tcagtccctt ggcctcagct ggcatattac
     1561 acagttttca atgcacacaa aatacaacct catgctcctt gcaagcagca agacccctga
     1621 aagtgaccca tgcttctggc tggcactctg catgtctagt gattgttttg ggaatgtttc
     1681 actgctacct gcacccagtg actctgcagc acaagaaccc gtctaatgtc actatgcacg
     1741 gttgtttgga attcataatg tgtcggttcc aagtgagggg acctcaagaa tttatgtgag
     1801 tttgcttttg aaaatgaatt aaaaagaaaa aaacagcact a
//
