LOCUS       NM_017068               1747 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus lysosomal-associated membrane protein 2 (Lamp2),
            mRNA.
ACCESSION   NM_017068
VERSION     NM_017068.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Wang,X., Sun,D., Hu,Y., Xu,X., Jiang,W., Shang,H. and Cui,D.
  TITLE     The roles of oxidative stress and Beclin-1 in the autophagosome
            clearance impairment triggered by cardiac arrest
  JOURNAL   Free Radic Biol Med 136, 87-95 (2019)
   PUBMED   30951836
  REMARK    GeneRIF: our data indicate that cardiac arrest and return of
            spontaneous circulation injury impairs autophagosome clearance
            partially through a reactive oxygen species-induced decline in
            LAMP2 and increase in Beclin-1, leading to increased neuronal cell
            death
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Chen,H., Hu,Y., Xie,K., Chen,Y., Wang,H., Bian,Y., Wang,Y., Dong,A.
            and Yu,Y.
  TITLE     Effect of autophagy on allodynia, hyperalgesia and astrocyte
            activation in a rat model of neuropathic pain
  JOURNAL   Int J Mol Med 42 (4), 2009-2019 (2018)
   PUBMED   30015858
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Ma,S., Zhang,M., Zhang,S., Wang,J., Zhou,X., Guo,G., Wang,L.,
            Wang,M., Peng,Z., Guo,C., Zheng,X., Zhou,X., Wang,J. and Han,Y.
  TITLE     Characterisation of Lamp2-deficient rats for potential new animal
            model of Danon disease
  JOURNAL   Sci Rep 8 (1), 6932 (2018)
   PUBMED   29720683
  REMARK    GeneRIF: Lamp2-deficient rats exhibited greater similarity to DD
            patients in terms of onset and multisystem lesions than did mouse
            models, and these rats could be used as a valuable animal model for
            DD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Smirnov,A.V., Mednikov,D.S., Shmidt,M.V., Kurkin,D.V.,
            Bakulin,D.A., Volotova,E.V. and Tyurenkov,I.N.
  TITLE     Expression of Beclin-1 and LAMP-2 in Rat Hippocampus under
            Conditions of Simulated Gravity Overload in the Caudocranial Vector
  JOURNAL   Bull Exp Biol Med 165 (1), 105-109 (2018)
   PUBMED   29797121
  REMARK    GeneRIF: Expression of Beclin-1 and LAMP-2 in Rat Hippocampus under
            Conditions of Simulated Gravity Overload in the Caudocranial Vector
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Hackam,D.J., Rotstein,O.D., Zhang,W., Gruenheid,S., Gros,P. and
            Grinstein,S.
  TITLE     Host resistance to intracellular infection: mutation of natural
            resistance-associated macrophage protein 1 (Nramp1) impairs
            phagosomal acidification
  JOURNAL   J Exp Med 188 (2), 351-364 (1998)
   PUBMED   9670047
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Cuervo,A.M. and Dice,J.F.
  TITLE     A receptor for the selective uptake and degradation of proteins by
            lysosomes
  JOURNAL   Science 273 (5274), 501-503 (1996)
   PUBMED   8662539
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Akasaki,K., Yamaguchi,Y., Furuno,K. and Tsuji,H.
  TITLE     Purification, some properties, and tissue distribution of a major
            lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver
  JOURNAL   J Biochem 110 (6), 922-927 (1991)
   PUBMED   1794981
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Granger,B.L., Green,S.A., Gabel,C.A., Howe,C.L., Mellman,I. and
            Helenius,A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Noguchi,Y., Himeno,M., Sasaki,H., Tanaka,Y., Kono,A., Sakaki,Y. and
            Kato,K.
  TITLE     Isolation and sequencing of a cDNA clone encoding 96 kDa
            sialoglycoprotein in rat liver lysosomal membranes
  JOURNAL   Biochem Biophys Res Commun 164 (3), 1113-1120 (1989)
   PUBMED   2590192
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017068.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061990.1, FQ211284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000021.1  122087508-122087673 c
            167-279             JAXUCZ010000021.1  122073578-122073690 c
            280-493             JAXUCZ010000021.1  122071769-122071982 c
            494-652             JAXUCZ010000021.1  122066655-122066813 c
            653-852             JAXUCZ010000021.1  122065166-122065365 c
            853-975             JAXUCZ010000021.1  122064243-122064365 c
            976-1039            JAXUCZ010000021.1  122057630-122057693 c
            1040-1204           JAXUCZ010000021.1  122056599-122056763 c
            1205-1747           JAXUCZ010000021.1  122044130-122044672 c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..1747
                     /gene="Lamp2"
                     /note="lysosomal-associated membrane protein 2"
                     /db_xref="GeneID:24944"
                     /db_xref="RGD:2990"
     exon            1..166
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1344
                     /gene="Lamp2"
                     /note="lysosome-associated membrane glycoprotein 2; LGP-B;
                     LAMP-2; LGP-96; LGP-110; CD107 antigen-like family member
                     B; lysosomal membrane glycoprotein type B;
                     lysosome-associated membrane protein 2; lysosomal membrane
                     glycoprotein 2"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 2
                     precursor"
                     /protein_id="NP_058764.3"
                     /db_xref="GeneID:24944"
                     /db_xref="RGD:2990"
                     /translation="MRLLSPVTGSKLVLLFLFLGAVRSDALKLNLTDSKGTCLYAEWE
                     MNFTITYEALKVNETVTITVPDKVTYNGSSCGDDKNGAKIMIQYGSTLSWAVNFTKEA
                     SQYFINNITLSYNTNDTKTFPGAVPKGILTVIIPVGSQLPLGVIFKCSSVLTFNLSPV
                     VQHYWGIHLQAFVQNGTVSKHEQVCKEDKTATTVAPIIHTTVPSPTTTLTPTSIPVPT
                     PTVGNYTISNGNATCLLATMGLQLNITEEKVPFIFNINPAITNFTGSCQPQTAQLRLN
                     NSQIKYLDFIFAVKNEKRFYLKEVNVNMYLANGSAFHVSNNNLSFWDAPLGSSYMCNK
                     EQVVSVSRTFQINTFNLKVQPFNVTKGEYSTAQDCSADEDNFLVPIAVGAALGGVLIL
                     VLLAYFIGLKRHHTGYEQF"
     exon            167..279
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..493
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..652
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..852
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..975
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1039
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1204
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1747
                     /gene="Lamp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgcggtg cctctggtcg gtggtcgccc gtgctttcgc tttctcaggg ctgtgagggt
       61 gttcgttgga attgtcggtc cagtcgtcac ttgtcctgag ggatcacgat gcgcctcctc
      121 tctccggtta cgggctcgaa gctcgtcctg ctctttctgt tcctgggagc agttcggtcc
      181 gatgcattga aacttaattt gacagattca aagggtactt gcctttatgc agaatgggag
      241 atgaatttca caataacata tgaagctcta aaagtcaatg aaactgtaac cattacagtg
      301 cctgacaagg tgacatacaa tggaagcagt tgtggcgatg ataagaatgg tgccaaaata
      361 atgatacaat atggatccac tctctcttgg gctgtgaatt tcaccaagga agcatctcag
      421 tattttatta acaacatcac gctttcttac aacactaatg ataccaaaac atttcctggt
      481 gctgtaccta aaggaatcct tactgttatc attcctgtgg gatcccagct tccattgggt
      541 gtcatcttta agtgcagtag tgttttaact ttcaacctga gtcctgttgt tcagcactat
      601 tggggcattc acctgcaagc ttttgtccaa aatggtacag tgagtaaaca tgaacaagtg
      661 tgtaaggagg acaaaactgc taccactgta gcacccatca ttcacaccac cgtgccatcg
      721 cctactacga cactcactcc aacttcaata cccgttccaa ctccaacggt tggaaactac
      781 accatttcta atggcaatgc tacctgtctg ctggctacca tggggctgca gctgaacatc
      841 accgaggaga aggtgccttt catttttaac atcaaccctg ccataaccaa cttcaccggc
      901 agctgtcagc cccaaacagc tcaacttagg ctgaacaaca gccaaattaa gtatctcgac
      961 tttatctttg ctgtgaaaaa tgaaaaacgg ttctatctga aggaagtgaa tgtcaacatg
     1021 tatttggcta atggctcagc tttccatgtt tcaaataaca accttagctt ctgggatgct
     1081 cctctgggaa gttcttatat gtgcaacaaa gagcaggtgg tttccgtgtc tcgaacattt
     1141 cagataaata cctttaacct gaaggtgcaa ccttttaatg tgacgaaagg agagtattct
     1201 acagctcaag actgcagtgc agatgaagac aacttccttg tgcccatagc ggtgggagca
     1261 gccctgggag gagtacttat tctagtgttg ctggcttatt ttattggtct caagcgccat
     1321 catactggat atgagcaatt ttagcaccta caatctgatt gaatatatta caaaatacat
     1381 acaaataaca aagttgtctt acctgtcagt ttatgaaaca ctttgctact taagacagac
     1441 tccttggaac ttttatttgg aaatcagtcc ccacaatttg agataaggct ttttttgaaa
     1501 aaaaaaacaa aaaacaacaa aaaaacaaaa aacaaaaaaa tcattctctg atctgcttaa
     1561 aatgcagact ggctttaaaa aaaggagaaa atgaatacac gtgtgtgatg ttttaaggtc
     1621 tgtcttaaga agctttggcc aaattgggat cctaacctaa atgccttaaa cttattaaca
     1681 tgaccgttat aagaaaagat atatggagtt gtatcttact ggaattaata aacactgctt
     1741 caccacc
//
