LOCUS       NM_012857               2005 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus lysosomal-associated membrane protein 1 (Lamp1),
            mRNA.
ACCESSION   NM_012857
VERSION     NM_012857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Scheefhals,N., Catsburg,L.A.E., Westerveld,M.L., Blanpied,T.A.,
            Hoogenraad,C.C. and MacGillavry,H.D.
  TITLE     Shank Proteins Couple the Endocytic Zone to the Postsynaptic
            Density to Control Trafficking and Signaling of Metabotropic
            Glutamate Receptor 5
  JOURNAL   Cell Rep 29 (2), 258-269 (2019)
   PUBMED   31597090
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Deng,L., Liu,G., Zheng,C., Zhang,L., Kang,Y. and Yang,F.
  TITLE     Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via
            acting as a ceRNA for miR-615-5p to regulate DDR2 expression
  JOURNAL   Gene 701, 146-151 (2019)
   PUBMED   30922709
  REMARK    GeneRIF: these findings documented that circ-LAMP1 might be an
            oncogene in T-cell lymphoblastic lymphoma (T-LBL), which might be
            useful in developing promising therapies for T-LBL.
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Chino,H., Hatta,T., Natsume,T. and Mizushima,N.
  TITLE     Intrinsically Disordered Protein TEX264 Mediates ER-phagy
  JOURNAL   Mol Cell 74 (5), 909-921 (2019)
   PUBMED   31006538
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Zhou,K., Enkhjargal,B., Xie,Z., Sun,C., Wu,L., Malaguit,J.,
            Chen,S., Tang,J., Zhang,J. and Zhang,J.H.
  TITLE     Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through
            Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent
            Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in
            Rat
  JOURNAL   Stroke 49 (1), 175-183 (2018)
   PUBMED   29273596
  REMARK    GeneRIF: dihydrolipoic acid (DHLA) treatment improved neurofunction
            and alleviated inflammation through the lysosome-associated
            membrane protein-1/CaMKII/TAK1 pathway in early brain injury after
            subarachnoid hemorrhage (SAH). DHLA may provide a promising
            treatment to alleviate early brain injury after SAH.
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Goo,M.S., Sancho,L., Slepak,N., Boassa,D., Deerinck,T.J.,
            Ellisman,M.H., Bloodgood,B.L. and Patrick,G.N.
  TITLE     Activity-dependent trafficking of lysosomes in dendrites and
            dendritic spines
  JOURNAL   J Cell Biol 216 (8), 2499-2513 (2017)
   PUBMED   28630145
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Garver,W.S., Heidenreich,R.A., Erickson,R.P., Thomas,M.A. and
            Wilson,J.M.
  TITLE     Localization of the murine Niemann-Pick C1 protein to two distinct
            intracellular compartments
  JOURNAL   J Lipid Res 41 (5), 673-687 (2000)
   PUBMED   10787428
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Wasano,K. and Hirakawa,Y.
  TITLE     Lamellar bodies of rat alveolar type 2 cells have late endosomal
            marker proteins on their limiting membranes
  JOURNAL   Histochemistry 102 (5), 329-335 (1994)
   PUBMED   7868367
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Himeno,M., Noguchi,Y., Sasaki,H., Tanaka,Y., Furuno,K., Kono,A.,
            Sakaki,Y. and Kato,K.
  TITLE     Isolation and sequencing of a cDNA clone encoding 107 kDa
            sialoglycoprotein in rat liver lysosomal membranes
  JOURNAL   FEBS Lett 244 (2), 351-356 (1989)
   PUBMED   2920835
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   Howe,C.L., Granger,B.L., Hull,M., Green,S.A., Gabel,C.A.,
            Helenius,A. and Mellman,I.
  TITLE     Derived protein sequence, oligosaccharides, and membrane insertion
            of the 120-kDa lysosomal membrane glycoprotein (lgp120):
            identification of a highly conserved family of lysosomal membrane
            glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7577-7581 (1988)
   PUBMED   3174652
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M34959.1.
            
            On Feb 21, 2013 this sequence version replaced NM_012857.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34959.1, LC222322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2005              M34959.1           1-2005
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2005
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /note="lysosomal-associated membrane protein 1"
                     /db_xref="GeneID:25328"
                     /db_xref="RGD:2989"
     exon            1..149
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1327
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /note="lysosome-associated membrane glycoprotein 1;
                     LAMP-1; LGP-120; CD107 antigen-like family member A; 120
                     kDa lysosomal membrane glycoprotein; lysosome-associated
                     membrane protein 1; Lysosomal associated membrane protein
                     1 (120 kDa); lysosomal membrane glycoprotein 1"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 1
                     precursor"
                     /protein_id="NP_036989.1"
                     /db_xref="GeneID:25328"
                     /db_xref="RGD:2989"
                     /translation="MAAPGARRPLLLLLLAGLAHSAPALFEVKDNNGTACIMASFSAS
                     FLTTYDAGHVSKVSNMTLPASAEVLKNSSSCGEKNASEPTLAITFGEGYLLKLTFTKN
                     TTRYSVQHMYFTYNLSDTQFFPNASSKGPDTVDSTTDIKADINKTYRCVSDIRVYMKN
                     VTIVLWDATIQAYLPSSNFSKEETRCPQDQPSPTTGPPSPSPPLVPTNPSVSKYNVTG
                     DNGTCLLASMALQLNITYMKKDNTTVTRAFNINPSDKYSGTCGAQLVTLKVGNKSRVL
                     ELQFGMNATSSLFFLQGVQLNMTLPDAIEPTFSTSNYSLKALQASVGNSYKCNSEEHI
                     FVSKALALNVFSVQVQAFRVESDRFGSVEECVQDGNNMLIPIAVGGALAGLVLIVLIA
                     YLIGRKRSHAGYQTI"
     exon            150..271
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            272..491
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            492..650
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            651..829
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            830..949
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1016
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1187
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2005
                     /gene="Lamp1"
                     /gene_synonym="LGP120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcgccg cagctgccgg gcctctcgag tcggtggacg cgccctcccg ccggcctcgc
       61 cgcccgcgca accgccgtcc ttcggcctcg gctgcgtcgc gccatggcgg ccccgggcgc
      121 ccggcggccg ctgctcctgt tgctgctggc aggccttgca cacagcgccc cagcactgtt
      181 cgaggtgaaa gacaacaacg gcacagcgtg tataatggcc agcttctctg cctcctttct
      241 gaccacctat gatgctggac atgtttctaa ggtctcgaat atgaccctgc cagcctctgc
      301 agaagtcctg aagaatagca gctcttgtgg tgaaaagaat gcttctgagc ccaccctcgc
      361 aatcaccttt ggagaaggat atttactgaa actcaccttc acaaaaaaca caacacgtta
      421 cagtgtccag cacatgtatt tcacatataa cctgtcagac acacaattct ttcccaatgc
      481 cagctccaaa gggcccgaca ctgtggattc cacaactgac atcaaggcag acatcaacaa
      541 aacataccga tgtgtcagcg acatcagggt ctacatgaag aatgtgacca ttgtgctctg
      601 ggacgctact atccaggcct acctgccgag tagcaacttc agcaaggaag agacacgctg
      661 cccacaggat caaccttccc caactactgg gccacccagc ccctcaccac cacttgtgcc
      721 cacaaacccc agtgtgtcca agtacaatgt gactggtgac aatggaacct gcctgctggc
      781 ctctatggca ctgcaactca acatcaccta catgaagaag gacaacacga ctgtgaccag
      841 agcattcaac atcaacccaa gtgacaaata tagtgggact tgcggtgccc agttggtgac
      901 cctgaaggtg gggaacaaga gcagagtcct ggagctgcag tttgggatga atgccacttc
      961 tagcctgttt ttcctgcaag gagttcagtt gaacatgact cttcctgatg ccatagagcc
     1021 cacgttcagc acctccaact attccctgaa agctcttcag gccagtgtcg gcaactcata
     1081 caagtgcaac agtgaggagc acatctttgt cagcaaggcg ctcgccctca atgtcttcag
     1141 cgtgcaagtc caggctttca gggtagaaag tgacaggttt gggtctgtgg aagagtgtgt
     1201 acaggacggt aacaacatgc tgatccccat tgctgtgggc ggggccctgg cagggctggt
     1261 cctcatcgtc ctcatcgcct acctcatcgg caggaagagg agtcacgcgg gctatcagac
     1321 catctagcct ggtgggcagg tgcgccacag acgcacacgg gcctgttctc acatccccaa
     1381 gcttagatag gtgtggaagg gagggaggca cacttgtggc aaactgtttt caaatctgct
     1441 ttatcaaatg tgaagctcat cttgcaacat ttactatgca caaaggaata actattgaaa
     1501 tgacggtgtt aattttgcta actgggttaa atattttgct aactggttaa atgttaatat
     1561 gttaccaaag tagagctcta aagaggacaa gaaggctcca cgcatttgac ttttaagact
     1621 tggtgtttgg ttcttcattc ttttactcag atttacgcct tacaaaggga atctctggtc
     1681 cagacacttg ggcctggcaa gggtggctga tggtggttag gctgcacact tgagaagcaa
     1741 acaggagcag ggacgtcctg ccacacaggc acgcacaggg tcagcctctg gacacttggc
     1801 ttgggctgcc tggcctgggg ggctagactc tggcatctgg ctgggcacac ccaccagtgt
     1861 ttctgtgctc tgccgcctgt gagctaccac tttcctaaat agaaaatggc attatggggt
     1921 tggggattta gctcagtggt agagcccttg cctaggaagc gcaaggccct gggttcggtc
     1981 cccagctccg gaaaaaaaaa aaaga
//
