LOCUS       NM_001100640            5122 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus laminin subunit gamma 2 (Lamc2), mRNA.
ACCESSION   NM_001100640 XM_001071267 XM_213902
VERSION     NM_001100640.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5122)
  AUTHORS   Moon YW, Rao G, Kim JJ, Shim HS, Park KS, An SS, Kim B, Steeg PS,
            Sarfaraz S, Changwoo Lee L, Voeller D, Choi EY, Luo J, Palmieri D,
            Chung HC, Kim JH, Wang Y and Giaccone G.
  TITLE     LAMC2 enhances the metastatic potential of lung adenocarcinoma
  JOURNAL   Cell Death Differ 22 (8), 1341-1352 (2015)
   PUBMED   25591736
REFERENCE   2  (bases 1 to 5122)
  AUTHORS   Korbakis D, Dimitromanolakis A, Prassas I, Davis GJ, Barber E,
            Reckamp KL, Blasutig I and Diamandis EP.
  TITLE     Serum LAMC2 enhances the prognostic value of a multi-parametric
            panel in non-small cell lung cancer
  JOURNAL   Br J Cancer 113 (3), 484-491 (2015)
   PUBMED   26180921
REFERENCE   3  (bases 1 to 5122)
  AUTHORS   Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino
            H, Itesako T, Enokida H, Nakagawa M, Okamoto Y and Seki N.
  TITLE     Tumour-suppressive microRNA-29s inhibit cancer cell migration and
            invasion by targeting laminin-integrin signalling in head and neck
            squamous cell carcinoma
  JOURNAL   Br J Cancer 109 (10), 2636-2645 (2013)
   PUBMED   24091622
REFERENCE   4  (bases 1 to 5122)
  AUTHORS   Uehara T, Kondo C, Morikawa Y, Hanafusa H, Ueda S, Minowa Y,
            Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y
            and Urushidani T.
  TITLE     Toxicogenomic biomarkers for renal papillary injury in rats
  JOURNAL   Toxicology 303, 1-8 (2013)
   PUBMED   23142791
  REMARK    GeneRIF: study aimed to identify genomic biomarkers for early and
            sensitive detection of renal papillary injury in rats; Timp1, Igf1,
            and Lamc2 exhibited the best prediction performance
REFERENCE   5  (bases 1 to 5122)
  AUTHORS   Masuda R, Kijima H, Imamura N, Aruga N, Nakazato K, Oiwa K, Nakano
            T, Watanabe H, Ikoma Y, Tanaka M, Inokuchi S and Iwazaki M.
  TITLE     Laminin-5gamma2 chain expression is associated with tumor cell
            invasiveness and prognosis of lung squamous cell carcinoma
  JOURNAL   Biomed Res 33 (5), 309-317 (2012)
   PUBMED   23124251
REFERENCE   6  (bases 1 to 5122)
  AUTHORS   Sasaki T, Gohring W, Mann K, Brakebusch C, Yamada Y, Fassler R and
            Timpl R.
  TITLE     Short arm region of laminin-5 gamma2 chain: structure, mechanism of
            processing and binding to heparin and proteins
  JOURNAL   J Mol Biol 314 (4), 751-763 (2001)
   PUBMED   11733994
REFERENCE   7  (bases 1 to 5122)
  AUTHORS   Manda R, Kohno T, Niki T, Yamada T, Takenoshita S, Kuwano H and
            Yokota J.
  TITLE     Differential expression of the LAMB3 and LAMC2 genes between small
            cell and non-small cell lung carcinomas
  JOURNAL   Biochem Biophys Res Commun 275 (2), 440-445 (2000)
   PUBMED   10964684
REFERENCE   8  (bases 1 to 5122)
  AUTHORS   Seebacher T, Medina JL and Bade EG.
  TITLE     Laminin alpha 5, a major transcript of normal and malignant rat
            liver epithelial cells, is differentially expressed in developing
            and adult liver
  JOURNAL   Exp Cell Res 237 (1), 70-76 (1997)
   PUBMED   9417868
REFERENCE   9  (bases 1 to 5122)
  AUTHORS   Qin P, Piechocki M, Lu S and Kurpakus MA.
  TITLE     Localization of basement membrane-associated protein isoforms
            during development of the ocular surface of mouse eye
  JOURNAL   Dev Dyn 209 (4), 367-376 (1997)
   PUBMED   9264260
REFERENCE   10 (bases 1 to 5122)
  AUTHORS   Pulkkinen L, Christiano AM, Airenne T, Haakana H, Tryggvason K and
            Uitto J.
  TITLE     Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in
            the junctional forms of epidermolysis bullosa
  JOURNAL   Nat Genet 6 (3), 293-297 (1994)
   PUBMED   8012393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000243.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001100640.3.
            
            On Mar 5, 2021 this sequence version replaced NM_001100640.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JACYVU010000243.1  200687-200831       c
            146-345             JACYVU010000243.1  200336-200535       c
            346-534             JACYVU010000243.1  182639-182827       c
            535-670             JACYVU010000243.1  177691-177826       c
            671-769             JACYVU010000243.1  173373-173471       c
            770-906             JACYVU010000243.1  170877-171013       c
            907-1029            JACYVU010000243.1  169502-169624       c
            1030-1219           JACYVU010000243.1  167950-168139       c
            1220-1332           JACYVU010000243.1  164663-164775       c
            1333-1551           JACYVU010000243.1  163581-163799       c
            1552-1734           JACYVU010000243.1  162818-163000       c
            1735-1980           JACYVU010000243.1  161036-161281       c
            1981-2129           JACYVU010000243.1  159185-159333       c
            2130-2286           JACYVU010000243.1  156501-156657       c
            2287-2492           JACYVU010000243.1  156004-156209       c
            2493-2572           JACYVU010000243.1  154196-154275       c
            2573-2722           JACYVU010000243.1  152873-153022       c
            2723-2867           JACYVU010000243.1  151067-151211       c
            2868-3017           JACYVU010000243.1  149920-150069       c
            3018-3132           JACYVU010000243.1  149316-149430       c
            3133-3332           JACYVU010000243.1  148152-148351       c
            3333-3491           JACYVU010000243.1  145903-146061       c
            3492-3591           JACYVU010000243.1  145713-145812       c
            3592-5122           JACYVU010000243.1  141331-142861       c
FEATURES             Location/Qualifiers
     source          1..5122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..5122
                     /gene="Lamc2"
                     /note="laminin subunit gamma 2"
                     /db_xref="GeneID:192362"
                     /db_xref="RGD:621053"
     exon            1..145
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..345
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..3845
                     /gene="Lamc2"
                     /note="lamimin, gamma 2; laminin, gamma 2"
                     /codon_start=1
                     /product="laminin subunit gamma-2 precursor"
                     /protein_id="NP_001094110.1"
                     /db_xref="GeneID:192362"
                     /db_xref="RGD:621053"
                     /translation="MPALWLSCCLGVALLLPAAQATSRREVCDCNGKSRQCVFDQELH
                     RQTGNGFRCLNCNDNTAGVHCERCREGFYRQRDRDRCLPCNCHSKGSLGAGCDNSGQC
                     RCKPGVVGQRCDRCQPGFHMLTDAGCTRDQRQLDSKCDCDPAGISGPCDSGRCVCKPA
                     VTGERCDRCRAGYYHLDRANPEGCTQCFCYGHSDSCHTSADFSVHKITSTFNQDEDGW
                     KAVQRNWAPAKLHWSPRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVD
                     RGGRHPSAYDVILEGAGLQIRAPLMPPGKTLPCGITKTYTFRLNEHPSSHWSPQLSYF
                     EYRRLLRNLTALLIRATYGEYSTGYIDNVTLISARPVSGAPAPWVERCVCPAGYKGQF
                     CQECASGYKRDSARLGPFGTCVPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFY
                     NDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGER
                     GPVRPCQRCQCNNNVDPSASGNCDQLTGRCLKCIYNTAGIYCDQCKAGYFGDPLAPNP
                     ADKCRACNCNPVGSEPGECRSDGSCVCKPGFGGLNCAHAAALTSCPACYNQVKTQMDQ
                     FAQQLQNLEALVSKAQGGNGAVPSEELEGRMQQAEQALRDILREAQISEGAMRALSLQ
                     LAKARSQENNYKNRLDDLKMTVERIRALGSQYQNRVQDTSRLISQMRLSLAESEASLQ
                     NTNIHSSEHYVGPNGFKSLAQEAARLADSHVESANTMKQLTRETEDYSKQALSLARKA
                     LSGGGGSGVLDSSVVQGLMGKLEKTKSLTQQLSREGTQADIEADRSYQHSLRLLDSAS
                     QLQGIRDSSFQAEAKRIRQKADSLSNLVTKQMDAFTSVRNNLGNWEKETRQLLQTGKD
                     RRQTSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAM
                     KRLSYISQKVADASDKTQQAETALGSATADTQRAKNAATEALEITSEIEQEIGSLNLE
                     ANVTADGALAMEKGLATLKSEMREVEGELARKELEFHTDKDSLQLVITEAQQADARAK
                     STGVTIQDTLNTLEGILRLIDQPDAVDEEGLMLLEQELFQAKTQINSRLRPLMSELED
                     RARRQSNHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ"
     exon            346..534
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..670
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..769
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..906
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1029
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1219
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1332
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1551
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1734
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1980
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2129
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2286
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2492
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2572
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2722
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2867
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3017
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3132
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3332
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3491
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3591
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..5122
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtctatcac cctgagttcc ctccaggacc accccgggag agaacggctg tgtgtaaagg
       61 ggtgcggggg ggggggggag gatgtggtac attccagaag gatctctaga ccgcagcctc
      121 tgcaccacgc cctcggcggg gccaggactg agtcaggtag aagagtcgat aaaacacctg
      181 atcgaggtaa aaggaaggca cagcggggcg aagactccgg cgcccggcag gcacccgcag
      241 cggcagcgac cgagcgcggc ccggccatgc ctgcgctctg gctcagctgc tgcctcgggg
      301 tcgcgctcct gctgccagca gcccaggcca cctccaggag agaagtctgt gattgcaatg
      361 ggaagtccag gcagtgcgtc tttgaccagg agctccatcg acagacaggc aatgggttcc
      421 gttgcctcaa ctgcaatgac aatacggccg gggttcactg cgagaggtgc agggaggggt
      481 tttaccggca gcgagacaga gatcgctgcc tgccctgcaa ctgccactca aaaggttccc
      541 tcggtgctgg atgtgacaac tctggacaat gcaggtgtaa gccaggtgtg gtaggacaga
      601 ggtgtgaccg atgtcagcca ggcttccata tgctcaccga tgctggatgt acccgagacc
      661 agaggcaact agattccaag tgtgactgtg acccagccgg catctctgga ccctgtgatt
      721 ctggccgatg tgtgtgcaaa ccagccgtca ctggagaacg ctgtgacagg tgccgagcag
      781 gctactatca tctggacagg gcaaaccctg agggctgcac ccagtgtttc tgctatgggc
      841 attcagacag ctgccacacc tctgctgact tcagtgtcca caaaatcacc tcaactttca
      901 atcaggatga agatggttgg aaagcagttc agagaaattg ggcgcctgca aaactccact
      961 ggtcaccgcg ccatcaggat gtatttagtt ctgcccgaag atcagaccca gtctatttcg
     1021 tggcacccgc caaatttctc ggtaatcagc aagtgagtta cgggcagagc ctgtcttttg
     1081 actaccgcgt ggacagagga ggtcgacacc catctgccta tgatgtgatc ctggaaggtg
     1141 ctggtctaca gatcagagct cctctgatgc caccaggcaa gacacttccc tgtgggatca
     1201 caaagactta cacgttcaga ttaaacgaac atccaagcag tcactggagc ccccagctga
     1261 gttatttcga gtatcgaagg ttactgcgga acctcacagc cctcctcatc cgagctacgt
     1321 acggagaata cagtacaggg tacattgaca atgtgaccct gatttcagcc cgccctgtct
     1381 ctggagcccc agcaccctgg gttgaacgtt gtgtatgccc tgctgggtac aagggacaat
     1441 tctgccagga atgtgcttct ggttacaaaa gagattcagc aagactgggg ccttttggca
     1501 cctgtgttcc ctgtaactgc caagggggag gggcctgtga cccagacaca ggggattgct
     1561 actcagggga cgagaatcct gacattgagt gtgccgactg ccccattggt ttctataacg
     1621 acccgcacga cccccgcagc tgcaagccgt gtccctgcca caatggcttc agctgttccg
     1681 tgatgcctga gacagaggag gtggtgtgca acaactgccc ccctggggtc acaggtgccc
     1741 gctgtgagct ctgtgcagat ggcttctttg gggacccctt tggggaacgt ggcccagtga
     1801 ggccttgtca gcggtgccaa tgcaacaaca atgtggaccc cagtgcttct gggaactgtg
     1861 accagttgac aggcagatgt ttgaaatgca tctacaacac agcgggaatc tactgtgacc
     1921 agtgcaaagc aggttacttc ggagacccat tggctcccaa cccagcagac aagtgtcgag
     1981 cttgcaactg caaccctgtg ggctcggagc ctggagagtg tcgaagtgat ggcagctgtg
     2041 tttgcaagcc aggctttgga ggcctcaact gtgcgcacgc cgccgcccta accagttgcc
     2101 ctgcttgcta caatcaagtg aagactcaga tggaccagtt tgcccagcag ctccagaact
     2161 tggaggccct ggtttcaaag gctcagggtg gtaatggtgc agtccccagc gaggagctgg
     2221 aaggcaggat gcagcaggct gagcaggccc ttcgagacat tctgagagaa gctcagattt
     2281 cagaaggtgc tatgagagcc ctcagcctcc agctggccaa ggcaaggagc caagagaaca
     2341 actacaagaa ccgcctggat gacctcaaga tgactgtgga aaggattcgg gccctgggca
     2401 gtcagtatca gaaccgagtt caggatacaa gcagactcat ctctcagatg cgcctgagcc
     2461 tggcagaaag tgaagcttcc ctgcaaaaca ctaacatcca ttcctctgag cactacgtgg
     2521 ggccaaatgg atttaaaagt ctggctcagg aggccgcaag attggcagat agccatgttg
     2581 agtcagctaa cacaatgaag cagctaacga gggaaaccga ggactattcc aaacaagcac
     2641 tttcattggc ccgcaaggct ctgagtggag gaggtggaag cggtgtcctg gacagctccg
     2701 tggtacaagg tcttatggga aaattagaga aaaccaagtc cctgacccag cagttgtcaa
     2761 gggagggcac ccaagccgac atcgaagctg ataggtccta tcaacatagt ctccgcctcc
     2821 tggattcagc gtctcagctt cagggaatcc gtgattcctc ttttcaggca gaggcaaaga
     2881 ggatcaggca gaaggctgat tccctctcca acttggtgac caaacaaatg gatgcattca
     2941 cgagtgtgcg aaacaatctg gggaactggg aaaaagaaac acggcagctc ttgcagactg
     3001 ggaaggacag aagacagact tcggatcagc tgctttcccg tgccaacctt gctaaaagca
     3061 gagcccaaga agcgctaagt atgggcaatg ccacttttta tgaagttgag aacatcctaa
     3121 agaacctcag agagtttgat ctgcaggttg aagacagaaa agcagaggct gaggaggcca
     3181 tgaagagact ctcctatatt agccagaagg ttgcagatgc cagtgacaag acccagcaag
     3241 cagaaacggc cctggggagc gccactgctg acacccaacg ggcaaagaac gcagctacgg
     3301 aggccctaga gatcaccagc gagatagagc aggagatagg gagtctgaac ttggaagcca
     3361 atgtgacagc agatggggcc ttggccatgg aaaagggact ggccactctg aagagcgaga
     3421 tgagagaggt ggaaggggag ttggccagga aggagcttga gttccacacg gataaagact
     3481 ccttgcagct ggtgattact gaagcccagc aagctgatgc cagagccaag agcacgggag
     3541 ttacgatcca agacacgctc aacacattgg aaggcatcct gcgcctaata gaccagcctg
     3601 atgctgtgga tgaagagggg ctgatgctgt tagaacaaga gcttttccaa gccaagaccc
     3661 agatcaacag tcgacttcgg cccttgatgt ctgaactgga ggacagggcg cgtcgacaga
     3721 gcaaccacct ccacctgctg gagaccagca tagatgggat tctagccgat gtgaagaacc
     3781 tggagaacat tcgagacaac ctgcccccag gctgctacaa cacccaagct cttgagcagc
     3841 agtgaagtcg ccatagagat ttgtccattg tggtgaggga cacagccctc aggggtcggg
     3901 agccatctca ggtggatggg ctgggctcag gatatttgaa cgtgtttaat gggtttgttc
     3961 aggtctatgg gacctgactc cacccctgag accatgatgg atgtcctcct gtactgatat
     4021 aatcctgttt gccccctgac gcttggctgt gaggcagata gcgttgagta tgagaatgat
     4081 cagagaccaa caaatgctga gctcagaaca gtcgtaaact gaattctggg atatagaaag
     4141 tcctgctgct atgtcagggc aagaaatcta atcccactgt ggccagtatt cttgcttccc
     4201 ccactatatg tttttgttga ccagatttct tccaccgccc acccaataca tgagtatgtc
     4261 ctttactgca tagtgagaca gtagtaatgg gtgtagacct ggaaatctgg cccactcgga
     4321 gcaatggtgc ccactgccac ccctcacctt catgctctcc acctgagagt gacagccttt
     4381 ctcctaatgg tgccagaaca acttggagac tgtgtcctta tgaaagcatt tttttttttt
     4441 tttaccagcc aaggaatccc tgggaaagta tttcctttga gtttcaaagc aataaaagaa
     4501 aatatgtctt gggcactaca ggaagtagaa ttatatcaat cttaatccag tcttcctttg
     4561 ggaatgctga aactcatata cgtctgtgta ttgtgtctta ttttctccct ctctccctaa
     4621 atcatggata atccatcctt ctaacatata tttattgagt cactactagg tgccaggggc
     4681 gagtggaaca gtatggacat tctctaccct catggagttg agtgtctagt gagaagggca
     4741 aatgttagaa taaataaatg gaaactccca agccttgttc atctcatgtc atatttattg
     4801 cagtcaccca ccctttggtt tgaaacctct tttctcaata gaacatgtgt tgcaagacag
     4861 tcccatgagg gtacttgagt tagggcaaag ttgaaaattg ctctgaattg gacacatttc
     4921 tctgcgttcc tgccctgcct ccaccccttc ctacggtaga ctgttgccac agacggttgc
     4981 atcatgggaa taccagtggg aattgctgga ggaacggagg catttgtacc tcagtttgga
     5041 agacctgtac tagctcactt ttgaatttcc ttgtcttttc atggatgtgt attaaataaa
     5101 gaaggagtgt tagatgcttg gg
//
