LOCUS       NM_001100841            4078 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus laminin subunit beta 3 (Lamb3), mRNA.
ACCESSION   NM_001100841 XM_001069930 XM_223087
VERSION     NM_001100841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4078)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   2  (bases 1 to 4078)
  AUTHORS   Yamashita,H., Shang,M., Tripathi,M., Jourquin,J., Georgescu,W.,
            Liu,S., Weidow,B. and Quaranta,V.
  TITLE     Epitope mapping of function-blocking monoclonal antibody CM6
            suggests a 'weak' integrin binding site on the laminin-332 LG2
            domain
  JOURNAL   J Cell Physiol 223 (3), 541-548 (2010)
   PUBMED   20301201
  REMARK    GeneRIF: Binding sites for alpha3beta1 and alpha6beta4 are closely
            spaced in the Ln-332 LG domains where they regulate alternative
            cell functions, namely adhesion/migration or hemidesmosome
            anchoring.
REFERENCE   3  (bases 1 to 4078)
  AUTHORS   Liu,S., Yamashita,H., Weidow,B., Weaver,A.M. and Quaranta,V.
  TITLE     Laminin-332-beta1 integrin interactions negatively regulate
            invadopodia
  JOURNAL   J Cell Physiol 223 (1), 134-142 (2010)
   PUBMED   20039268
  REMARK    GeneRIF: In bladder carcinoma laminin-332 can suppress the number
            of invadopodia that form by interacting with a3b1 integrin and
            altering the cellular balance of FAK and Src kinase activity.
REFERENCE   4  (bases 1 to 4078)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (bases 1 to 4078)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   6  (bases 1 to 4078)
  AUTHORS   Manda,R., Kohno,T., Niki,T., Yamada,T., Takenoshita,S., Kuwano,H.
            and Yokota,J.
  TITLE     Differential expression of the LAMB3 and LAMC2 genes between small
            cell and non-small cell lung carcinomas
  JOURNAL   Biochem Biophys Res Commun 275 (2), 440-445 (2000)
   PUBMED   10964684
REFERENCE   7  (bases 1 to 4078)
  AUTHORS   Seebacher,T., Medina,J.L. and Bade,E.G.
  TITLE     Laminin alpha 5, a major transcript of normal and malignant rat
            liver epithelial cells, is differentially expressed in developing
            and adult liver
  JOURNAL   Exp Cell Res 237 (1), 70-76 (1997)
   PUBMED   9417868
REFERENCE   8  (bases 1 to 4078)
  AUTHORS   Qin,P., Piechocki,M., Lu,S. and Kurpakus,M.A.
  TITLE     Localization of basement membrane-associated protein isoforms
            during development of the ocular surface of mouse eye
  JOURNAL   Dev Dyn 209 (4), 367-376 (1997)
   PUBMED   9264260
REFERENCE   9  (bases 1 to 4078)
  AUTHORS   Pulkkinen,L., Christiano,A.M., Gerecke,D., Wagman,D.W.,
            Burgeson,R.E., Pittelkow,M.R. and Uitto,J.
  TITLE     A homozygous nonsense mutation in the beta 3 chain gene of laminin
            5 (LAMB3) in Herlitz junctional epidermolysis bullosa
  JOURNAL   Genomics 24 (2), 357-360 (1994)
   PUBMED   7698759
REFERENCE   10 (bases 1 to 4078)
  AUTHORS   Aberdam,D., Galliano,M.F., Mattei,M.G., Pisani-Spadafora,A.,
            Ortonne,J.P. and Meneguzzi,G.
  TITLE     Assignment of mouse nicein genes to chromosomes 1 and 18
  JOURNAL   Mamm Genome 5 (4), 229-233 (1994)
   PUBMED   8012114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_223087.4, XM_001069930.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.53612.1,
                                           SRR26643297.42573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000013.1  107362553-107362700
            149-208             JAXUCZ010000013.1  107364237-107364296
            209-363             JAXUCZ010000013.1  107365173-107365327
            364-478             JAXUCZ010000013.1  107381625-107381739
            479-552             JAXUCZ010000013.1  107382222-107382295
            553-744             JAXUCZ010000013.1  107384105-107384296
            745-808             JAXUCZ010000013.1  107385940-107386003
            809-1002            JAXUCZ010000013.1  107386277-107386470
            1003-1123           JAXUCZ010000013.1  107388645-107388765
            1124-1312           JAXUCZ010000013.1  107389381-107389569
            1313-1468           JAXUCZ010000013.1  107390793-107390948
            1469-1665           JAXUCZ010000013.1  107391517-107391713
            1666-1777           JAXUCZ010000013.1  107392061-107392172
            1778-2156           JAXUCZ010000013.1  107392881-107393259
            2157-2317           JAXUCZ010000013.1  107395012-107395172
            2318-2535           JAXUCZ010000013.1  107395248-107395465
            2536-2733           JAXUCZ010000013.1  107395680-107395877
            2734-2878           JAXUCZ010000013.1  107396175-107396319
            2879-3086           JAXUCZ010000013.1  107399078-107399285
            3087-3228           JAXUCZ010000013.1  107399661-107399802
            3229-3405           JAXUCZ010000013.1  107400122-107400298
            3406-3559           JAXUCZ010000013.1  107400950-107401103
            3560-4078           JAXUCZ010000013.1  107403563-107404081
FEATURES             Location/Qualifiers
     source          1..4078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..4078
                     /gene="Lamb3"
                     /note="laminin subunit beta 3"
                     /db_xref="GeneID:305078"
                     /db_xref="RGD:1562668"
     exon            1..148
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            149..208
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..3696
                     /gene="Lamb3"
                     /note="laminin chain; laminin, beta 3"
                     /codon_start=1
                     /product="laminin subunit beta-3 precursor"
                     /protein_id="NP_001094311.1"
                     /db_xref="GeneID:305078"
                     /db_xref="RGD:1562668"
                     /translation="MMTALFLLWLALPGLLCAQQPCSRGACYPPVGDLLIGRTQLLRA
                     SSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRNYNSHRVENVVSSSGPMRWWQSQNDV
                     SPVSLQLDLDKRMQLQDIMMDFKGLMPAGMLIERSSDFGKTWRVYQYLATDCASTFPQ
                     VHQGQPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMDLASAIPASQSKKIQELGDITNL
                     RVNFTKLAPVPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGPTGSTTAVQV
                     NDVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDIHECQRCDCNGHSETCHFDPAVFA
                     ASQGTSGGVCDNCQDHTEGKNCERCQLHYFRNRRPGAPIHETCIPCECDPDGAVPGAP
                     CDRLTGQCVCKDHVQGERCDLCKPGFTGLTFANPQGCHPCDCSILGTRQDMPCEEETG
                     RCLCLPNVVGPKCDQCAPSHWKLASGRGCEPCACDPRNSLSSQCNQFTGQCPCREGFG
                     GLTCSSAAIRQCPDRTHGDVATGCRACDCDFRGTEGPGCDKTSGRCLCRPGLTGPRCD
                     QCQRGYCDRYPVCVACHSCFQAYDTDLQEQAWRLGSLRNTTEGLGTGTGLEDRGLASR
                     LLDAKSKIEQIRQILGGTSVTERDVAQVANAILSIRRTLQGLPLDLPLEEEMESFSGD
                     LGNLDRSFNRLLLMYRSKKEQFEKLSSVDPSGAFRMLTMAYEQSSRAAQQVSDSSSLL
                     SQLRDSRREVEGLERQTGEGGAGGAQLMALRLEMASLPDLTPTINKLCGGSRQTACTP
                     GDCPGLLCPQDNGTACGSHCRGALPRARGALHMAGQVAEQLRSFNTQLQQTRQMIRAA
                     EEAASKVQSDAQRLETQVSTSRLQMEEDVRRTRLLIQQVRGFLTDPHTDAATIQQVSE
                     AVLALWLPTDSATVLRKMKEIQDIAARLPNVDLVLSQTKQDIARARRLQAEAEKARSR
                     AHVVEGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVTEVQQVLVPAERLVK
                     GMKEQMSGFWARVKELRHQAQEEQAQAMKAQQLAEGASNQAMNAQEGFERLKQRYTEL
                     KDRLGQSSMLGEQGNRILSIKAEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSAD
                     LSGLEKRVEQIRSYINGRVLYYATCK"
     exon            209..363
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..478
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..552
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..744
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..808
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1002
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1123
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1312
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1468
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1665
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1777
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2156
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2317
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2535
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2733
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2878
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3086
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3228
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3405
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3559
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..4078
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggtgggg ctacacccag ccagggagtc tccagaggtg aggctgttgt ttaaaactgt
       61 ggagccaaga gaggagaccc ccacattccc agggagctct ccgagaggga tctggagaaa
      121 ggcaggggag cataggagct ggggtgaggt gacctctctg gggacctgca ctggcccatg
      181 atgacggcac ttttcctctt gtggcttgcc ttgcctggcc tcctgtgtgc ccagcaaccc
      241 tgctcccgag gggcctgtta tccacctgtt ggggacttgc tcattggaag gactcagctt
      301 cttcgagcct cgtctacctg tggattgacc aagcctgaga cctattgcac ccaatatgga
      361 cagtggcaga tgaaatgctg caagtgtgac tccaggctgc ctcgcaacta caacagtcac
      421 cgagtggaga acgttgtatc gtcttcaggc cccatgcgct ggtggcagtc ccagaacgat
      481 gtgagccctg tctctcttca actggaccta gacaagagga tgcagcttca ggacataatg
      541 atggatttta agggtctcat gccagctggc atgttgattg agcgctcttc tgactttggc
      601 aagacatgga gggtgtacca gtacctggcg acagactgtg ccagcacctt tccccaggtc
      661 caccagggcc agcccaagaa ctggcaggac gtccggtgcc ggcccttgtc ccagaggcct
      721 aatgggcatc tgactggggg aaaggtccaa cttaacctta tggatttggc atcagctatc
      781 cctgcatctc aaagtaaaaa gattcaagaa ctaggagaca tcacgaactt gagagtcaac
      841 ttcaccaagc tggccccagt gccccagagg ggctcctatc cacccagcgc ctactttgca
      901 gtatcacagc tacgtctaca ggggagttgc ttctgtcatg gacatgccga ccgctgtgcc
      961 cctaatcctg gaggccctac aggttccacc accgctgtgc aggtcaacga tgtctgtgtc
     1021 tgccagcaca acacagctgg ccccaactgt gaccgctgcg cccccttcta caacaaccgg
     1081 ccatggagac ctgcagaggg acaggacatc catgagtgcc aaaggtgtga ctgcaatggg
     1141 cactcagaga cctgccactt cgacccagct gtgtttgctg ctagccaagg gacaagtgga
     1201 ggcgtgtgtg acaactgcca ggaccacaca gagggcaaga actgtgagcg atgtcagcta
     1261 cactatttcc ggaatagacg accaggcgct cccattcatg agacctgtat tccctgcgag
     1321 tgtgatccag acggggcagt cccaggagct ccctgtgacc gactgacggg ccagtgcgtg
     1381 tgcaaagacc acgtgcaagg ggagcgctgt gatctttgca agcctggttt cacagggctc
     1441 accttcgcca acccacaggg ctgccatccc tgtgactgca gcatcttagg tacccggcaa
     1501 gatatgcctt gtgaggagga aactggacgc tgcttgtgtc ttcccaatgt agtgggcccc
     1561 aaatgtgacc agtgcgcccc ttcccactgg aagctggcca gcggccgggg ctgtgagccc
     1621 tgtgcctgtg acccacgcaa ctccctcagc tcccagtgca accagtttac agggcagtgt
     1681 ccttgtcggg aagggtttgg tggcctcaca tgtagttctg cagccattcg tcagtgtccc
     1741 gaccggaccc atggagacgt ggccacaggg tgccgagcct gtgactgtga cttcagagga
     1801 accgagggtc ctggctgtga caaaacctca ggccgttgcc tctgccgccc cggcttgaca
     1861 gggccccgct gcgaccagtg ccaacgaggc tactgcgacc gctacccagt gtgtgtggcc
     1921 tgccactctt gcttccaggc ctatgacaca gacctccagg agcaggcttg gcgccttggc
     1981 agtctccgta ataccactga aggcctgggc acagggacag gtctggagga ccgtggcctg
     2041 gcttctcggt tgctagatgc caagagcaaa atcgagcaga tcagacagat tctgggtggc
     2101 acctctgtca cagagcggga tgtggctcaa gtggccaatg ccatcctgtc tatcaggagg
     2161 actcttcagg gcctgcccct ggacctaccc ttagaggagg agatggaatc cttctctgga
     2221 gacctgggga atctagacag aagcttcaat cgcctcctcc ttatgtaccg gagcaagaag
     2281 gagcagtttg agaagctaag cagtgtggac ccttcaggag ccttccgcat gctgactatg
     2341 gcttatgagc agtcctcccg ggctgcacag caagtatccg acagttccag cctgctgagc
     2401 cagctgaggg acagtcgcag agaggtagaa ggtctggaga gacagactgg agagggagga
     2461 gctggaggag ctcagctcat ggccctgcgc ctagagatgg cttcactgcc tgacttgaca
     2521 cccaccatca acaagctctg tggtggctct aggcagacag cctgcacccc aggagactgc
     2581 cctggattgc tgtgtcccca ggacaatggt acagcctgtg gctctcactg caggggagcc
     2641 ctgcccagag ccagaggggc cttacacatg gcagggcagg tagctgagca gctacgaagc
     2701 ttcaataccc agctccagca gaccaggcaa atgatcaggg cagctgagga ggcagcatca
     2761 aaggtccaat cagatgccca gcgccttgag actcaggtga gtaccagccg cttacagatg
     2821 gaggaagatg tccggcgcac acggcttctc atccagcagg tccggggctt cctcacagac
     2881 cctcacacag atgcagccac catccaacag gtgagcgagg cagtgctggc tctctggctg
     2941 cccacagact cagctacagt gctacgcaag atgaaagaga tccaggacat tgctgccagg
     3001 ctccctaacg tggacttagt gctatcccag actaagcagg acattgcacg ggcccgcagg
     3061 ctccaggctg aggccgagaa ggccagaagc cgagcccacg ttgtggaagg gcaggtggat
     3121 gacgtggtcg ggaacctcag gcagggcacc gtggctctgc aggaggctca ggacactatg
     3181 cagggcactg gccgctctct tcggctcatc caggaaaggg ttactgaggt tcagcaggtc
     3241 ctggtaccag ctgaaaggct ggtgaaaggc atgaaggaac agatgagtgg attctgggca
     3301 cgggtgaagg agctccgcca tcaggcccag gaagagcagg cacaggcaat gaaggcccag
     3361 cagcttgcag agggtgccag caatcaggcc atgaatgctc aggagggctt tgagagactt
     3421 aagcaaaggt atacagagtt gaaagaccgg ctgggtcaga gttctatgct gggtgagcaa
     3481 ggcaatcgga tcttgagcat caaggcggag gcagaggagc tctttgggga aaccatggaa
     3541 atgatggata aaatgaaaga catggagtca gagctgcttc gagggagtca ggccatcatg
     3601 cttcgttcag cagacctgtc ggggctggag aagcgcgtgg agcagatccg cagttacatc
     3661 aacgggcgtg tgctgtacta tgccacctgc aagtgatctt aagtcccagc ctcagacaat
     3721 tcccctccct gccttggaag ggacacaggg gaggggaggt gtttcctgga cctagggcac
     3781 ttggatacca ttgatagcat agtctggtca ccatggacat gcttcaaggt acctgactgc
     3841 cactgagcct gtgcttgcct gaccacacta aggagagaga tggtgcaggg ggtggggctg
     3901 tcacaactga aaatcctccc aaaaagggag ctggatggac agagtgcccc caacaccaac
     3961 tcctgccctc cactgtggta aagtctggga ccaactcaaa aactgaacaa agtgtgatgt
     4021 acgaccacaa agtccaataa aaatctttgg acaggagcct ggaagctcaa taagaaaa
//
