LOCUS       NM_012974               5581 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus laminin subunit beta 2 (Lamb2), mRNA.
ACCESSION   NM_012974
VERSION     NM_012974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5581)
  AUTHORS   Wirtz,M.K., Sykes,R., Samples,J., Edmunds,B., Choi,D., Keene,D.R.,
            Tufa,S.F., Sun,Y.Y. and Keller,K.E.
  TITLE     Identification of Missense Extracellular Matrix Gene Variants in a
            Large Glaucoma Pedigree and Investigation of the N700S
            Thrombospondin-1 Variant in Normal and Glaucomatous Trabecular
            Meshwork Cells
  JOURNAL   Curr Eye Res 47 (1), 79-90 (2022)
   PUBMED   34143713
REFERENCE   2  (bases 1 to 5581)
  AUTHORS   Pulido,D., Briggs,D.C., Hua,J. and Hohenester,E.
  TITLE     Crystallographic analysis of the laminin beta2 short arm reveals
            how the LF domain is inserted into a regular array of LE domains
  JOURNAL   Matrix Biol 57-58, 204-212 (2017)
   PUBMED   27425256
  REMARK    GeneRIF: Crystallographic analysis of the LAMB2 short arm reveals
            how the LF domain is inserted into a regular array of LE domains.
REFERENCE   3  (bases 1 to 5581)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 5581)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 5581)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 5581)
  AUTHORS   Noakes,P.G., Miner,J.H., Gautam,M., Cunningham,J.M., Sanes,J.R. and
            Merlie,J.P.
  TITLE     The renal glomerulus of mice lacking s-laminin/laminin beta 2:
            nephrosis despite molecular compensation by laminin beta 1
  JOURNAL   Nat Genet 10 (4), 400-406 (1995)
   PUBMED   7670489
REFERENCE   7  (bases 1 to 5581)
  AUTHORS   Noakes,P.G., Gautam,M., Mudd,J., Sanes,J.R. and Merlie,J.P.
  TITLE     Aberrant differentiation of neuromuscular junctions in mice lacking
            s-laminin/laminin beta 2
  JOURNAL   Nature 374 (6519), 258-262 (1995)
   PUBMED   7885444
REFERENCE   8  (bases 1 to 5581)
  AUTHORS   Utani,A., Nomizu,M., Timpl,R., Roller,P.P. and Yamada,Y.
  TITLE     Laminin chain assembly. Specific sequences at the C terminus of the
            long arm are required for the formation of specific double- and
            triple-stranded coiled-coil structures
  JOURNAL   J Biol Chem 269 (29), 19167-19175 (1994)
   PUBMED   8034675
REFERENCE   9  (bases 1 to 5581)
  AUTHORS   Engvall,E., Earwicker,D., Haaparanta,T., Ruoslahti,E. and
            Sanes,J.R.
  TITLE     Distribution and isolation of four laminin variants; tissue
            restricted distribution of heterotrimers assembled from five
            different subunits
  JOURNAL   Cell Regul 1 (10), 731-740 (1990)
   PUBMED   2099832
REFERENCE   10 (bases 1 to 5581)
  AUTHORS   Hunter,D.D., Shah,V., Merlie,J.P. and Sanes,J.R.
  TITLE     A laminin-like adhesive protein concentrated in the synaptic cleft
            of the neuromuscular junction
  JOURNAL   Nature 338 (6212), 229-234 (1989)
   PUBMED   2922051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X16563.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5581
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5581
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /note="laminin subunit beta 2"
                     /db_xref="GeneID:25473"
                     /db_xref="RGD:2988"
     exon            1..67
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            68..153
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..5474
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /note="laminin chain beta 2; laminin, beta 2; laminin
                     chain B3; S-LAM beta; S-laminin subunit beta; laminin-3
                     subunit beta; laminin-4 subunit beta; laminin-7 subunit
                     beta; laminin-9 subunit beta; laminin-11 subunit beta;
                     laminin-14 subunit beta; laminin-15 subunit beta"
                     /codon_start=1
                     /product="laminin subunit beta-2 precursor"
                     /protein_id="NP_037106.1"
                     /db_xref="GeneID:25473"
                     /db_xref="RGD:2988"
                     /translation="MEWASGKPGRGRQGQPVPWELRLGLLLSVLAATLAQVPSLDVPG
                     CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSA
                     RDNPNSHRIQNVVTSFAPQRRTAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRP
                     AAMLVERSADFGRTWRVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEG
                     EVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYA
                     LYELVIRGNCFCYGHASQCAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYQDL
                     PWHPAEDGHTHACRKCECNGHSHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELC
                     RPFFYRDPTKDMRDPAACRPCDCDPMGSQDGGRCDSHDDPVLGLVSGQCRCKEHVVGT
                     RCQQCRDGFFGLSASNPRGCQRCQCNSRGTVPGGTPCDSSSGTCFCKRLVTGDGCDRC
                     LPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCPCRPHMIGRRCEQVQPGYFRPF
                     LDHLTWEAEGAHGQVLEVVERLVTNRETPSWTGVGFVRLREGQEVEFLVTSLPRAMDY
                     DLLLRWEPQVPEQWAELELVVQRPGPVSAHSPCGHVLPRDDRIQGMLHPNTRVLVFPR
                     PVCLEPGLSYKLKLKLTGTGGRAHPETPYSGSGILIDSLVLQPHVLMLEMFSGGDAAA
                     LERRTTFERYRCHEEGLMPSKTPLSEACVPLLISASSLVYNGALPCQCDPQGSLSSEC
                     NPHGGQCRCKPGVVGRRCDACATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCLCR
                     TGAFGLRCDHCQRGQWGFPNCRPCVCNGRADECDAHTGACLGCRDYTGGEHCERCIAG
                     FHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHRDGYSQQIVCHCRAGYTGLRCEACA
                     PGHFGDPSKPGGRCQLCECSGNIDPTDPGACDPHTGQCLRCLHHTEGPHCGHCKPGFH
                     GQAARQSCHRCTCNLLGTDPQRCPSTDLCHCDPSTGQCPCLPHVQGLSCDRCAPNFWN
                     FTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSECQELHWGDPGLQCRAC
                     DCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHACFGDWDRVV
                     QDLAARTRRLEQWAQELQQTGVLGAFESSFLNLQGKLGMVQAIVAARNTSAASTAKLV
                     EATEGLRHEIGKTTERLTQLEAELTDVQDENFNANHALSGLERDGLALNLTLRQLDQH
                     LDILKHSNFLGAYDSIRHAHSQSTEAERRANASTFAIPSPVSNSADTRRRAEVLMGAQ
                     RENFNRQHLANQQALGRLSTHTHTLSLTGVNELVCGAPGDAPCATSPCGGAGCRDEDG
                     QPRCGGLGCSGAAATADLALGRARHTQAELQRALVEGGGILSRVSETRRQAEEAQQRA
                     QAALDKANASRGQVEQANQELRELIQNVKDFLSQEGADPDSIEMVATRVLDISIPASP
                     EQIQRLASEIAERVRSLADVDTILAHTMGDVRRAEQLLQDAQRARSRAEGERQKAETV
                     QAALEEAQRAQGAAQGAIRGAVVDTKNTEQTLQQVQERMAGTEQSLNSASERARQLHA
                     LLEALKLKRAGNSLAASTAEETAGSAQSRAREAEKQLREQVGDQYQTVRALAERKAEG
                     VLAAQARAEQLRDEARGLLQAAQDKLQRLQELEGTYEENERELEVKAAQLDGLEARMR
                     SVLQAINLQVQIYNTCQ"
     exon            154..326
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            327..462
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            463..536
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            537..725
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            726..789
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            790..992
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1113
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1302
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1482
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1595
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1675
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1808
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1967
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2095
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2228
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2421
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2565
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2797
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2961
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3186
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3404
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3501
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3874
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4059
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4301
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4650
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4858
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..5000
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5177
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            5178..5337
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            5338..5581
                     /gene="Lamb2"
                     /gene_synonym="SLAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgactgct ggtcggaccc tgggacagac tgagggcctg gagggaaacc agcccagtac
       61 ccacacggat ggagtgggcc tcaggaaaac cagggagggg caggcaggga cagcctgtgc
      121 catgggaact tcgcttgggc ctacttctaa gtgtgctggc tgccacattg gcccaagtcc
      181 catccttgga tgtacctggc tgttctcgag gaagctgcta tccagccacc ggtgacctgt
      241 tggtgggccg tgcagacaga ctgacagcct cctccacgtg tggcttgcat agccctcaac
      301 cctactgtat tgtcagtcac ctgcaggatg aaaagaagtg cttcctgtgt gactcccgac
      361 gtcccttctc tgctcgagac aacccaaata gtcaccggat ccagaatgta gtcactagct
      421 ttgcgccaca acgccggacg gcctggtggc agtcggagaa cggtgttccg atggtcacca
      481 tccaactgga cctggaagct gagtttcatt tcacccacct catcatgacc ttcaagacat
      541 ttcgtcctgc ggccatgctg gtggagcgct ctgcagactt cggccgcacg tggcgtgtct
      601 accgatattt ttcctacgac tgcggggctg acttcccagg aatcccgctg gccccgccgc
      661 gtcgctggga tgatgtagtg tgtgagtccc gctactcaga aattgagcca tctactgaag
      721 gcgaggtcat ctatcgtgtg ctggatcctg ctattcctat tccagacccc tacagctcac
      781 ggattcagaa cctgttgaag atcaccaacc tccgtgtgaa cctcacccgg cttcacacac
      841 tgggagacaa cttgcttgac ccacggcggg agatccggga aaaatattat tatgctctct
      901 atgaacttgt catccgcggg aactgcttct gctatggaca tgcctcacag tgtgcgcctg
      961 caccaggggc accggcccat gctgagggca tggtacatgg ggcctgtatt tgcaagcaca
     1021 atactcgtgg gctcaactgt gagcagtgtc aggatttcta tcaggacctt ccctggcatc
     1081 ctgctgagga tggccatact cacgcctgtc ggaagtgtga gtgcaacggg catagtcata
     1141 gctgccactt tgacatggct gtgtacctgg catctggaaa cgtaagtgga ggtgtctgcg
     1201 atggctgtca gcacaacacg gctgggcgcc actgcgagct ctgccggccc ttcttctacc
     1261 gtgacccaac caaggacatg cgggatccag ctgcgtgccg tccttgtgac tgtgacccaa
     1321 tgggttctca agacggtggc cgctgtgatt cccatgatga ccctgtgcta ggtctggtct
     1381 caggccagtg tcgctgcaaa gaacacgtgg ttggcactcg ctgccagcaa tgccgggacg
     1441 gcttctttgg acttagtgcc agcaaccctc gaggatgtca gcgttgtcag tgtaactcaa
     1501 ggggcacagt gcctgggggc accccttgtg actccagtag tggaacctgt ttctgcaagc
     1561 gtctggtgac tggagacggc tgtgaccgct gtctgcctgg ccactggggc ctgagccatg
     1621 acctgctagg ctgccgcccc tgtgactgtg atgtgggcgg tgccttggat cctcagtgtg
     1681 atgaagccac gggtcagtgc ccgtgccgcc cacacatgat tgggcggcgc tgtgaacaag
     1741 tacagcctgg ctacttccgg ccttttctag accatctaac ctgggaggct gagggtgccc
     1801 atgggcaggt gcttgaggtg gtagaacgtc tggtgaccaa ccgagagact ccgtcctgga
     1861 ctggtgtagg ctttgtgcga ctgcgggaag gtcaggaagt ggagttcctg gtgacctctt
     1921 tgcctagggc catggactat gacctgctac tgcgctggga gccccaggtt cctgagcagt
     1981 gggcagagct ggaattggtg gtgcagcgcc cagggcctgt gtctgcacac agtccgtgtg
     2041 ggcacgtgct gccgagggat gaccgcattc aggggatgct tcacccaaac accagggttt
     2101 tggtgtttcc cagacctgtc tgccttgagc ctggtctctc ctacaagctg aagttgaaat
     2161 tgactggaac agggggacgt gcccatcctg aaaccccata ctctggatct ggaatactca
     2221 ttgactcgct ggtgctgcag ccccatgtct tgatgctaga gatgtttagt gggggggatg
     2281 ctgctgccct ggaacgccgt accacctttg aacgctaccg ctgccatgag gaaggtctga
     2341 tgcccagcaa gaccccccta tctgaggcct gcgttcccct cctcatcagt gcgtcctccc
     2401 tggtctacaa tggcgccttg ccctgccagt gtgaccctca aggctcactg agttccgaat
     2461 gcaatcctca tggtggccag tgccggtgca agcctggagt ggttggacga cgctgtgatg
     2521 cctgtgctac tggctactat ggctttgggc ccgcaggctg tcaagcctgc cagtgtagtc
     2581 ccgacggagc actcagtgcc ctgtgtgaag ggactagtgg acagtgtctc tgccgaaccg
     2641 gtgcctttgg tcttcgctgt gaccactgtc aacgtggcca gtggggtttc cctaactgcc
     2701 ggccgtgtgt ctgcaacggg cgtgcagatg agtgtgacgc ccacacaggc gcttgcctgg
     2761 gctgccgtga ttacacaggg ggcgagcact gtgagaggtg cattgctggt tttcatgggg
     2821 acccacggct gccatatggg ggccagtgcc ggccttgtcc ctgccctgaa ggccccggga
     2881 gccagcgaca ctttgctact tcatgtcacc gggatggata ttcccagcaa attgtgtgcc
     2941 actgtcgagc aggctacaca gggcttcggt gtgaggcttg tgcccccggg cactttgggg
     3001 acccatccaa gccaggtggc aggtgccaac tgtgtgagtg cagtgggaac attgacccca
     3061 cggatcccgg tgcctgtgat ccccacacgg ggcaatgctt gcgctgttta caccacacgg
     3121 aggggcccca ctgtggccat tgcaagcctg gcttccatgg gcaagctgcc cgacagagct
     3181 gtcaccgctg tacctgcaac cttctgggca cagatcccca gcggtgccca tctacagacc
     3241 tgtgccattg tgacccaagc actgggcagt gcccatgcct cccccatgtc caaggcctca
     3301 gttgcgaccg ttgtgccccc aacttttgga actttaccag tggacgtggc tgccagcctt
     3361 gtgcttgtca cccaagccgg gccagaggcc ctacctgcaa tgagttcaca gggcagtgcc
     3421 actgtcatgc tggctttggt gggaggacct gttctgagtg ccaagagctc cactggggag
     3481 accctggact gcagtgccgc gcctgtgact gtgatcccag aggaatagac aaaccccaat
     3541 gtcatcgttc tactggtcac tgtagctgcc gcccaggcgt gtctggcgtg cgctgcgacc
     3601 agtgtgctcg tggcttctcg ggtgtttttc ctgcttgtca cccctgccat gcatgctttg
     3661 gagactggga tcgtgtggta caggaccttg ctgctcgtac gcggcgcctg gagcagtggg
     3721 ctcaggaatt gcagcaaacg ggtgtgctgg gtgcctttga gagcagcttt ttaaacctgc
     3781 aggggaagct gggaatggtg caggccatcg tggctgcccg caacacctca gctgcgtcta
     3841 ctgcaaagct tgtagaggcc acagagggac tgcgtcatga aattgggaag accactgaac
     3901 gcctgactca gttagaagca gagctcacag atgtacagga tgagaacttc aatgccaacc
     3961 atgcactcag tggtctggag agagacgggc tcgcacttaa tctcacactg aggcagcttg
     4021 accagcatct ggatatcctc aaacactcaa atttcttagg tgcctatgac agcatccgac
     4081 atgcccacag tcagtctaca gaagcagagc gccgggccaa tgcctccacc tttgcaatac
     4141 ccagccctgt gagcaactca gcagataccc ggcgtcgggc agaagtgcta atgggtgccc
     4201 aaagagagaa cttcaaccgc cagcacttgg ccaaccagca ggcacttgga cggctgtcca
     4261 cacacaccca taccctgagc ctgacgggag taaatgagct ggtgtgtggg gccccagggg
     4321 acgcaccctg tgctaccagc ccttgtgggg gtgctggatg tcgggatgag gatgggcaac
     4381 cccgctgtgg tggcctcggt tgcagtggag cagcagccac agcagatcta gcactgggcc
     4441 gggctcggca cacacaggca gagctgcaga gagcgctggt agaaggtggt ggcatcctca
     4501 gccgagtgtc tgagactcgt cggcaggcag aggaggccca gcaacgagca caggcagccc
     4561 tggacaaggc taatgcttct aggggccaag tggagcaggc caatcaggag cttcgagaac
     4621 ttatccagaa tgtgaaggac ttcctcagcc aggagggagc tgatcccgac agtattgaaa
     4681 tggtagcaac acgggtgcta gacatctcca tcccagcctc gcctgagcag atccagcgcc
     4741 tagcaagtga gattgcagaa cgtgtccgaa gcctggcgga tgtggacaca atcctggcac
     4801 ataccatggg ggatgtgcgt cgggctgaac agctactgca agatgcacag cgggcacgga
     4861 gccgggctga gggtgagaga cagaaggcag agacagtcca agcggcactg gaggaggccc
     4921 agagggcaca gggagctgct cagggcgcca tccggggagc agtggttgac acaaaaaaca
     4981 cagagcagac cctgcagcag gtccaggaga ggatggcagg tacagagcag tctctgaact
     5041 ctgctagtga gcgggctcgg cagttacatg cccttctgga agccctgaaa ctgaaaaggg
     5101 caggaaacag cctggcagca tctacagctg aagagacagc aggcagtgcc cagagccgtg
     5161 ccagggaggc tgagaaacag ctacgggaac aagtaggtga ccagtaccaa actgtgaggg
     5221 cgttggctga acggaaggct gaaggtgttc tggccgcaca agccagagca gaacaactgc
     5281 gggatgaggc tcggggtctg ttgcaggctg ctcaggacaa gttgcagcgg ctacaggaac
     5341 tggagggcac atatgaagag aatgaacgcg aactggaggt caaagcggct cagctggatg
     5401 ggctggaggc caggatgcgc agtgtgcttc aggcaatcaa cctgcaggtc cagatctaca
     5461 acacctgcca gtgaccactc cctagggttt agccttgtct ccaagcacag ttccacatgc
     5521 gtttgtccgc acattaaaga gctcttggct agcaagtgct ttcaataaac cagtgtgaac
     5581 c
//
