LOCUS       NM_001393748           10351 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus laminin subunit alpha 3 (Lama3), transcript
            variant 2, mRNA.
ACCESSION   NM_001393748 XM_039096922
VERSION     NM_001393748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10351)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 10351)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   3  (bases 1 to 10351)
  AUTHORS   Yamashita,H., Shang,M., Tripathi,M., Jourquin,J., Georgescu,W.,
            Liu,S., Weidow,B. and Quaranta,V.
  TITLE     Epitope mapping of function-blocking monoclonal antibody CM6
            suggests a 'weak' integrin binding site on the laminin-332 LG2
            domain
  JOURNAL   J Cell Physiol 223 (3), 541-548 (2010)
   PUBMED   20301201
  REMARK    GeneRIF: Binding sites for alpha3beta1 and alpha6beta4 are closely
            spaced in the Ln-332 LG domains where they regulate alternative
            cell functions, namely adhesion/migration or hemidesmosome
            anchoring.
REFERENCE   4  (bases 1 to 10351)
  AUTHORS   Liu,S., Yamashita,H., Weidow,B., Weaver,A.M. and Quaranta,V.
  TITLE     Laminin-332-beta1 integrin interactions negatively regulate
            invadopodia
  JOURNAL   J Cell Physiol 223 (1), 134-142 (2010)
   PUBMED   20039268
  REMARK    GeneRIF: In bladder carcinoma laminin-332 can suppress the number
            of invadopodia that form by interacting with a3b1 integrin and
            altering the cellular balance of FAK and Src kinase activity.
REFERENCE   5  (bases 1 to 10351)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   6  (bases 1 to 10351)
  AUTHORS   Sathyanarayana,U.G., Toyooka,S., Padar,A., Takahashi,T.,
            Brambilla,E., Minna,J.D. and Gazdar,A.F.
  TITLE     Epigenetic inactivation of laminin-5-encoding genes in lung cancers
  JOURNAL   Clin Cancer Res 9 (7), 2665-2672 (2003)
   PUBMED   12855645
REFERENCE   7  (bases 1 to 10351)
  AUTHORS   Nguyen,N.M., Miner,J.H., Pierce,R.A. and Senior,R.M.
  TITLE     Laminin alpha 5 is required for lobar septation and visceral
            pleural basement membrane formation in the developing mouse lung
  JOURNAL   Dev Biol 246 (2), 231-244 (2002)
   PUBMED   12051813
REFERENCE   8  (bases 1 to 10351)
  AUTHORS   Qin,P., Piechocki,M., Lu,S. and Kurpakus,M.A.
  TITLE     Localization of basement membrane-associated protein isoforms
            during development of the ocular surface of mouse eye
  JOURNAL   Dev Dyn 209 (4), 367-376 (1997)
   PUBMED   9264260
REFERENCE   9  (bases 1 to 10351)
  AUTHORS   Baker,S.E., Hopkinson,S.B., Fitchmun,M., Andreason,G.L.,
            Frasier,F., Plopper,G., Quaranta,V. and Jones,J.C.
  TITLE     Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in
            hemidesmosome stability and assembly
  JOURNAL   J Cell Sci 109 (Pt 10), 2509-2520 (1996)
   PUBMED   8923212
REFERENCE   10 (bases 1 to 10351)
  AUTHORS   Vidal,F., Baudoin,C., Miquel,C., Galliano,M.F., Christiano,A.M.,
            Uitto,J., Ortonne,J.P. and Meneguzzi,G.
  TITLE     Cloning of the laminin alpha 3 chain gene (LAMA3) and
            identification of a homozygous deletion in a patient with Herlitz
            junctional epidermolysis bullosa
  JOURNAL   Genomics 30 (2), 273-280 (1995)
   PUBMED   8586427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 8, 2021 this sequence version replaced XM_039096922.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (B).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN09345238 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JAXUCZ010000018.1  3797939-3798284
            347-499             JAXUCZ010000018.1  3822902-3823054
            500-617             JAXUCZ010000018.1  3850979-3851096
            618-736             JAXUCZ010000018.1  3851776-3851894
            737-907             JAXUCZ010000018.1  3852986-3853156
            908-999             JAXUCZ010000018.1  3853692-3853783
            1000-1115           JAXUCZ010000018.1  3857268-3857383
            1116-1234           JAXUCZ010000018.1  3859542-3859660
            1235-1325           JAXUCZ010000018.1  3864464-3864554
            1326-1457           JAXUCZ010000018.1  3865085-3865216
            1458-1520           JAXUCZ010000018.1  3866370-3866432
            1521-1655           JAXUCZ010000018.1  3879613-3879747
            1656-1793           JAXUCZ010000018.1  3889270-3889407
            1794-1840           JAXUCZ010000018.1  3891111-3891157
            1841-1940           JAXUCZ010000018.1  3894862-3894961
            1941-1993           JAXUCZ010000018.1  3896100-3896152
            1994-2099           JAXUCZ010000018.1  3896376-3896481
            2100-2199           JAXUCZ010000018.1  3897495-3897594
            2200-2356           JAXUCZ010000018.1  3900467-3900623
            2357-2489           JAXUCZ010000018.1  3903288-3903420
            2490-2632           JAXUCZ010000018.1  3903761-3903903
            2633-2730           JAXUCZ010000018.1  3906281-3906378
            2731-2884           JAXUCZ010000018.1  3906823-3906976
            2885-3045           JAXUCZ010000018.1  3912128-3912288
            3046-3154           JAXUCZ010000018.1  3914764-3914872
            3155-3252           JAXUCZ010000018.1  3916398-3916495
            3253-3397           JAXUCZ010000018.1  3918212-3918356
            3398-3524           JAXUCZ010000018.1  3928232-3928358
            3525-3664           JAXUCZ010000018.1  3928437-3928576
            3665-3780           JAXUCZ010000018.1  3930083-3930198
            3781-3992           JAXUCZ010000018.1  3931377-3931588
            3993-4197           JAXUCZ010000018.1  3932418-3932622
            4198-4342           JAXUCZ010000018.1  3940735-3940879
            4343-4483           JAXUCZ010000018.1  3941305-3941445
            4484-4645           JAXUCZ010000018.1  3944567-3944728
            4646-4744           JAXUCZ010000018.1  3947356-3947454
            4745-4828           JAXUCZ010000018.1  3949094-3949177
            4829-5059           JAXUCZ010000018.1  3951566-3951796
            5060-5173           JAXUCZ010000018.1  3955562-3955675
            5174-5283           JAXUCZ010000018.1  3960814-3960923
            5284-5364           JAXUCZ010000018.1  3963872-3963952
            5365-5471           JAXUCZ010000018.1  3966616-3966722
            5472-5522           JAXUCZ010000018.1  3968594-3968644
            5523-5674           JAXUCZ010000018.1  3969659-3969810
            5675-5785           JAXUCZ010000018.1  3974358-3974468
            5786-5897           JAXUCZ010000018.1  3974577-3974688
            5898-6065           JAXUCZ010000018.1  3974859-3975026
            6066-6262           JAXUCZ010000018.1  3975616-3975812
            6263-6379           JAXUCZ010000018.1  3977366-3977482
            6380-6534           JAXUCZ010000018.1  3978225-3978379
            6535-6676           JAXUCZ010000018.1  3978642-3978783
            6677-6779           JAXUCZ010000018.1  3979463-3979565
            6780-6896           JAXUCZ010000018.1  3980201-3980317
            6897-7076           JAXUCZ010000018.1  3980395-3980574
            7077-7219           JAXUCZ010000018.1  3982078-3982220
            7220-7390           JAXUCZ010000018.1  3984980-3985150
            7391-7542           JAXUCZ010000018.1  3986976-3987127
            7543-7705           JAXUCZ010000018.1  3987261-3987423
            7706-7839           JAXUCZ010000018.1  3987850-3987983
            7840-7984           JAXUCZ010000018.1  3989780-3989924
            7985-8104           JAXUCZ010000018.1  3993575-3993694
            8105-8238           JAXUCZ010000018.1  3994442-3994575
            8239-8356           JAXUCZ010000018.1  3997423-3997540
            8357-8497           JAXUCZ010000018.1  3997828-3997968
            8498-8637           JAXUCZ010000018.1  4000481-4000620
            8638-8769           JAXUCZ010000018.1  4001548-4001679
            8770-8923           JAXUCZ010000018.1  4004054-4004207
            8924-9090           JAXUCZ010000018.1  4009783-4009949
            9091-9274           JAXUCZ010000018.1  4013832-4014015
            9275-9415           JAXUCZ010000018.1  4016387-4016527
            9416-9575           JAXUCZ010000018.1  4019413-4019572
            9576-9706           JAXUCZ010000018.1  4019679-4019809
            9707-9800           JAXUCZ010000018.1  4022877-4022970
            9801-9920           JAXUCZ010000018.1  4025089-4025208
            9921-10351          JAXUCZ010000018.1  4025913-4026343
FEATURES             Location/Qualifiers
     source          1..10351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..10351
                     /gene="Lama3"
                     /note="laminin subunit alpha 3"
                     /db_xref="GeneID:307582"
                     /db_xref="RGD:628776"
     exon            1..346
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..10066
                     /gene="Lama3"
                     /note="isoform B precursor is encoded by transcript
                     variant 2; laminin 5 alpha 3; laminin, alpha 3"
                     /codon_start=1
                     /product="laminin subunit alpha-3 isoform B precursor"
                     /protein_id="NP_001380677.1"
                     /db_xref="GeneID:307582"
                     /db_xref="RGD:628776"
                     /translation="MAVALGWAPRSSPPLLVLLLLLLRMSPCWSVVAQDPPAARLSLH
                     PPYFNLAQAAKIWATATCGERGLDVSRPRPELFCKLVGGPTAPGSGHTIQGQFCDYCN
                     SEDSRKAHPAIHAIDGSERWWQSPPLSSGTQYNKVNLTLDLGQLFHVAYILIKFANSP
                     RPDLWVLERSVDFGNTYSPWQYFAHSRGDCLQQFGQEANMAVTRDDQVLCVTEYSRIV
                     PLENGEIVVSLINGRPGAKHFAFSDTLREFTKATNIRLRFLRTNTLLGHLISKAERDP
                     TVTRRYYYSIKDISVGGRCVCNGHAEACSADNPEKQFRCKCQHHTCGDTCNRCCAGYN
                     QRPWRPAAQDQHNECEACNCHGHAVDCYYDEAVSRQQASLNSKGVYTGGGVCIDCQHN
                     TAGVNCEKCAKGYFRPHGVPVEALHGCIPCSCDPDRADECDQGSGRCHCKPNFSGDFC
                     ETCADGYYNFPFCLRIPVFPDYTLNPEDPMAGNIKGCDCNLEGVLPEICDDRGRCLCR
                     PGVEGPRCDSCRSGSYSFPICQACQCSTSGSYPVPCDPETGQCECLPGVTGRRCDRCL
                     SGAYDFPYCQGSSSVCDPAGTMDSSLGYCQCKLHVTSPTCSVCKPLYWDLAKENPRGC
                     SECQCHEAGTVSGIGECGQEDGDCSCKAHVTGDACDTCADGYFSLEKSNYFGCQGCQC
                     DIGGALTTMCSGPSGECQCREHIEGKQCQRPESNCYFPDLHHMKYEVEGGTGPNGRDL
                     RFGFDPLEFPEFSWRGYVPMTSVQNEVKVRLTVRKSSLSLFRIILRYINPGMEEVSGR
                     ITVYSSRGKSDASQSKEITFPPSKEPAFVTVPGNGFADPFSITPGTWIACIQVEGVLL
                     DYLVLLPRDYYEAFALQVPVTEPCAHTGSPQDNCLLYQHLPLTRFSCTLACEATHFLI
                     DGERRPLAVRQPMPTHPAMVDLSGTEVELHLRLRVPQIGHYVVMLEYATEVDQLFVVD
                     VNLKSPESALAGQVNIYSCKYSILCRSVVIDSLSRTAVYELLADADVQLKVHAARFLL
                     HHICVIPAEEFSTEYLRPQVHCIASYGQSANPSASCVSVTHETPPTALILDATSGGHF
                     SPLPHEPSSPADVTNGVTLKAPQNQVTLRGLIPHLGRHVFVVHFYQAEHPGFPTEVVV
                     DGGRRWSGSFRASFCPHLLGCQDQVISEGQVEFDISEADVAVTVKIPDGKSLTLVRVL
                     VVPAEDYDYHILHRTSVDKSSEFISSCGGDSFYIDPQAASGFCKNSARSLVAFYHNGA
                     VPCECHPAGAAVHHCSPEGGQCPCRPNVIGRQCTRCATGYYGFPHCKPCNCGRRLCEE
                     VTGKCLCPPNTVRPQCEVCEMNSFNFHPVAGCEVCNCSRKGTVEAAVSECDRDSGQCR
                     CKPRVTGQQCDKCAPGFYHFPECVPCSCNRDGTEPGVCDPGTGACMCKENVEGPQCQF
                     CREGSFYLDSANPEGCTRCFCFGVNTDCRSSHKRRAKFVDMMGWRLETADGVDVPVSF
                     NPSSNSVVADLQELPSSVHSASWVAPPSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLE
                     KQPDVQLIGQHMSIIHAEPSDPRPDRPHHGRVQVVEGNFRHAGNSAPVSREELMAVLS
                     SLEGLHIRGLHFTETQRLTLGEVGLEEASDTGSGPRAHLVEMCTCPPDYTGDSCQGCR
                     PGYYRDIKSFPAGRCVPCNCNGHSNRCQDGSGVCINCQHNTAGEHCERCQEGYYGSAI
                     HGSCRVCPCPHTNSFATGCAVDGGAVRCACKPGYTGAQCERCAPGYFGNPQKFGGSCQ
                     PCNCNSNGQFGTCDPLTGDCVSQEPKDGSPAEECDDCDSCVMTLLNDLVSMGEELRLV
                     KSRLQGLSVSTGALEQIRHVEMQAKDLRNQLLGFRSAISSHGSKMDGLEKELSHLNQE
                     FETLQEKAQVNSRKAQTLYNNIDQTIQNAKELDMKIKNIIQNVHILLKQIARPGGEGM
                     DLPVGDWSRELAEAQRMLRELRGRDFKKHLQEAEAQKMEAQLLLNRIRTWLESHQVEN
                     NGLLKNIRDSLNDYEAKLQDLRSVLQEAAAQGKQATGLNHENEGVLGAIQRQMKEMDS
                     LKNDLTEHLATADASLLQTNSLLQRMDTSQKEYESLAAALNGARQELNDQVRELSRSG
                     GKAPLVAEAEKHAQSLQELAKQLEEIKRNTSGDELVRCAVDAATAYESILNAIRAAED
                     AAGKAASASESAFQTVIKEDLPRRAKTLSSDSEELLNEAKMTRKRLQQEINPALNSLQ
                     QTLKTVSVQKDLLDANVTAVRNDLRGIQRGDIDSVVSGAKSMVRKANGITSEVLDGLS
                     PIQTDLGRIKDSYGSTRHEDFNKALIDANNSVKKLTKKLPDLFVKIESINQQLLPLGN
                     ISDNVDRIRELIQQARDAANKVAIPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRP
                     DLRENGGTEDMFVMYLGNKDASKDYIGMAVVDGQLTCVYNLGDREAEVQIDQVLTESE
                     SQEAVMDRVKFQRIYQFAKLNYTKEATSNKPKAPAVYDLEGGSSNTLLNLDPEDAVFY
                     VGGYPPDFELPSRLRFPPYKGCIELDDLNENVLSLYNFKTTFNLNTTEVEPCRRRKEE
                     SDKNYFEGTGYARIPTQPNAPFPNFIQTIQTTVDRGLLFFAENQDNFISLNIEDGNLM
                     VRYKLNSEPPKEKGIRDTINDGKDHSILITIGKLQKRMWINVNERSVRIEGEIFDFST
                     YYLGGIPIAIRERFNISTPAFQGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRTAS
                     FSRGGQMSFTNLDVPSTDRFQLSFGFQTFQPSGTLLNHQTRTSSLLVTLEDGHIELST
                     RDSNIPIFKSPGTYMDGLLHHVSVISDTSGLRLLIDDQVLRRNQRLPSFSNAQQSLRL
                     GGGHFEGCISNVLVQRFSQSPEVLDLASKSTKKDASLGGCSLNKPPFLMLFKSPKRFN
                     KGRIFNVNQLMQDAPQATRSTEAWQDGRSCLPPLNTKASHRALQFGDSPTSHLLFKLP
                     QELLKPRSQFSLDIQTTSPKGLVFYTGTKDSFLALYVADGRVVFALGAGGKKLRLRSK
                     ERYHDGKWHTVVFGLNGGKARLVVDGLRAQEGSLPGNSTISPREQVYLGLPLSRKPKS
                     LPQHSFVGCLRDFQLNSKPLDSPSARFGVSPCLGGSLEKGIYFSQGGGHVILANSVSL
                     GPELKLTFSIRPRSLTGVLIHVGSQSGQRLSVYMEAGKVTTSVSSDAGGSVTSITPKQ
                     SLCDGQWHSVAVSIKQRILHLELDTDSSYTVAPLSFSPNSTRGSLHVGGVPDKLKMLT
                     LPVWNSFFGCLKNIQVNHVPVPITEATEVQGSVSLNGCPDH"
     exon            347..499
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..617
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..736
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..907
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..999
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1115
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1234
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1325
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1457
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1520
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1655
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1793
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1840
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1940
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..1993
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2099
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2199
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2356
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2489
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2632
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2730
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2884
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3045
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3154
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3252
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3397
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3524
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3664
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3780
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3992
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4197
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4342
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4483
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4645
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4646..4744
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4828
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..5059
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5060..5173
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5174..5283
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5284..5364
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5365..5471
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5522
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5674
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5675..5785
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5786..5897
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            5898..6065
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6066..6262
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6263..6379
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6380..6534
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6535..6676
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6677..6779
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6780..6896
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            6897..7076
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7077..7219
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7220..7390
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7391..7542
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7543..7705
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7706..7839
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7840..7984
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            7985..8104
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8105..8238
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8239..8356
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8357..8497
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8498..8637
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8638..8769
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8770..8923
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            8924..9090
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9091..9274
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9275..9415
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9416..9575
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9576..9706
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9707..9800
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9801..9920
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
     exon            9921..10351
                     /gene="Lama3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtggcag cctcctgctc cgtggtgcca tccggagcac aagcaggaga accagcgccc
       61 cgggatggcg gtggctctgg gctgggcacc gcgatcttca ccaccgctgc tcgtgctatt
      121 gctgctgctg ctgaggatgt cgccctgctg gagcgtggtg gctcaggacc ctccggccgc
      181 ccggctcagt ctgcacccac cctacttcaa cctggcccag gcagcgaaga tctgggccac
      241 cgccacctgc ggggagcggg gcctggatgt ctcaaggccc cggcctgagc ttttctgcaa
      301 attggtgggc ggccccactg caccgggcag cggccacacc atccagggcc agttctgcga
      361 ctactgtaat tctgaggatt ccaggaaggc acatccggcc atccacgcga ttgatgggtc
      421 tgaacggtgg tggcagagcc cgcctctctc ctccggcaca cagtacaaca aagtcaacct
      481 caccttggat ctgggtcagc tcttccatgt ggcttatatc ttaatcaagt ttgcgaactc
      541 tccccgccct gatctttggg tcctggaacg atccgtagac tttggaaaca cctactcgcc
      601 ctggcagtat tttgctcatt ctagaggaga ttgtctacaa cagtttgggc aagaagcaaa
      661 tatggctgtc acccgggatg accaggtgct atgcgtcaca gagtattcta gaatcgtacc
      721 tctggaaaat ggcgagattg ttgtatcctt gataaatggt cgtccaggtg caaaacattt
      781 tgctttctct gacaccctga gggagtttac gaaggcaaca aacatccgct tgcggtttct
      841 gcgaaccaac accctcctcg ggcatcttat atccaaggca gagcgagacc ccaccgtcac
      901 gcgtcggtat tactacagca taaaggacat cagtgtcggt gggcggtgtg tttgcaacgg
      961 ccatgcggag gcctgcagcg ctgacaaccc tgaaaagcag ttccgatgca aatgccagca
     1021 ccatacctgt ggggacacgt gtaatcgctg ctgtgcaggc tacaatcaga ggccctggcg
     1081 gcccgctgct caggaccagc acaatgagtg tgaagcctgc aactgccatg ggcacgccgt
     1141 ggactgttac tatgacgagg ctgtgtcgcg tcagcaggcg agcttaaaca gcaaaggtgt
     1201 ctacacaggc ggaggggtct gcattgactg ccagcacaac actgcgggtg tgaactgtga
     1261 aaagtgtgcg aagggttact tccggcccca tggagttccg gtggaagcac tgcacggatg
     1321 catcccttgc agctgtgacc ctgaccgtgc agatgaatgt gaccagggct caggccgctg
     1381 tcattgtaag ccaaacttct ctggagactt ctgcgagacg tgtgcagacg gatactataa
     1441 tttcccattt tgcctgagaa ttccagtctt tcctgactac actctgaatc cagaagatcc
     1501 catggctggc aatataaaag ggtgtgactg taacttggaa ggtgttctcc ccgagatatg
     1561 tgacgatcgt ggcaggtgcc tgtgccgtcc tggggttgag ggtccccggt gtgactcctg
     1621 ccgttcgggg tcctattcat tcccaatatg ccaagcttgc cagtgttcaa ctagtggatc
     1681 ctatccagtg ccctgtgacc cagagactgg ccagtgtgaa tgcctgcctg gagtaacggg
     1741 gaggcggtgt gacagatgtc tctcaggagc ctacgatttt ccctactgcc aagggtccag
     1801 cagtgtttgc gatccagctg ggaccatgga ctccagcttg ggttactgcc agtgcaagct
     1861 tcatgttaca agccctacat gtagtgtctg caaaccacta tattgggatc tggccaaaga
     1921 aaacccccgt ggatgctcag agtgccaatg ccatgaggca gggacagtga gcgggattgg
     1981 agagtgtgga caggaagatg gtgactgcag ctgcaaagct catgtaactg gtgatgcttg
     2041 tgacacctgc gcagatggat atttctcctt ggagaagagc aattactttg gctgtcaagg
     2101 gtgtcagtgt gacattggcg gagcgctcac taccatgtgt agtgggccct cgggagaatg
     2161 ccagtgcaga gagcacattg aggggaaaca gtgccagagg cctgaaagta actgctactt
     2221 cccggacttg caccacatga agtatgaggt tgaaggtggc actggaccta acggaagaga
     2281 cctacggttt ggatttgatc ccctggaatt ccctgagttt agctggagag gatatgtccc
     2341 aatgacctct gtgcagaatg aagtaaaggt aagactgacc gtgaggaagt caagcctctc
     2401 cttattccgg attattctga ggtacatcaa tcctggaatg gaagaagtat ccggccgtat
     2461 cactgtttac tcatccaggg ggaagtcaga tgcctctcaa agcaaagaga tcacctttcc
     2521 cccgagtaaa gagccagcct tcgtcacggt cccgggaaat ggctttgcag atccattctc
     2581 catcacacca ggaacatgga ttgcttgtat ccaggtggaa ggagtccttc tggattacct
     2641 ggtgctgctt cccagggact actatgaagc attcgccctg caagtgccag tcacagagcc
     2701 gtgtgcccac acaggatctc cccaggacaa ttgtttgctt taccagcatt taccactgac
     2761 ccgattctcc tgtaccctgg cttgtgaggc cacacacttc ctgattgatg gagagcggag
     2821 acccttggca gtgaggcagc ccatgcccac acacccagcc atggtggacc tcagtgggac
     2881 agaggtggaa ttgcacctac gtctgcgggt cccacagatt ggccactatg tggtcatgtt
     2941 ggagtatgcc acggaggtgg accagctttt tgtggtggac gtgaatctga agagcccaga
     3001 gtctgccttg gcaggccagg tgaacatata cagctgcaag tacagcattc tgtgcaggag
     3061 tgtggtgatt gacagcctga gtcgtacagc tgtgtatgag ctgttggcag atgcagacgt
     3121 tcagctcaag gtgcacgcgg cccgtttcct tctgcatcac atctgcgtca tacccgctga
     3181 agaattctca actgaatatt tgagacctca agtccactgc attgccagct atgggcagag
     3241 tgccaatcca agtgcttcct gtgtctctgt gacccatgaa actcctccaa cagccctaat
     3301 tttggatgct acgagtgggg gccatttctc tcccctgcct catgagcctt cctctcctgc
     3361 agatgttact aatggagtta ctctgaaggc accacagaat caagtaaccc tgagaggact
     3421 cataccacac ctgggccgac acgtctttgt cgtccatttt tatcaagccg agcacccggg
     3481 gtttcccact gaggtggttg tggatggagg aagacggtgg tcaggttcct tccgtgcctc
     3541 cttttgtccc cacttacttg gctgccagga ccaagtgatc tctgagggcc aggtggagtt
     3601 tgacatctca gaagcagatg tagctgtgac tgtgaagatt ccagatggaa agtccttgac
     3661 attggtccgg gttctggtgg tacctgcaga ggattacgac taccacatac ttcacagaac
     3721 atcagtggac aagtcctccg agttcatcag cagttgtgga ggggacagtt tttatattga
     3781 tccccaggca gcctctggat tctgtaagaa ttctgcaagg tccttggtag ccttttacca
     3841 caatggtgct gtaccctgtg agtgccaccc tgccggggct gccgtccacc actgtagtcc
     3901 tgagggtggg cagtgcccct gccggcccaa cgtcatcgga aggcagtgca cacgctgtgc
     3961 aacaggctac tatggattcc cacactgcaa gccttgtaat tgtggcagac gcctttgcga
     4021 ggaggtgaca gggaagtgtc tctgcccacc caacacagtc aggccccagt gtgaggtctg
     4081 cgagatgaat tccttcaact tccaccctgt ggctggctgt gaagtctgca actgctccag
     4141 gaagggcacc gttgaggcag ccgtctctga gtgtgacagg gacagcgggc agtgcaggtg
     4201 caagcctaga gtcacggggc agcagtgtga caagtgtgct cctggcttct accacttccc
     4261 tgagtgtgtc ccctgcagct gtaacagaga tgggactgag cccggagtat gcgacccagg
     4321 gactggggct tgcatgtgca aggaaaatgt ggagggcccc cagtgtcaat tttgtcgaga
     4381 aggatcattc tacctggact ccgccaaccc agagggttgt accaggtgct tctgtttcgg
     4441 agtgaatact gactgtcgga gttcacacaa gcgaagagcc aagtttgtag acatgatggg
     4501 ctggcgtctg gagacagcag atggagttga tgtccccgtg tccttcaacc ccagcagcaa
     4561 cagcgtggtt gctgatctgc aggaactgcc gtcctcagtc cacagtgcat cctgggtggc
     4621 acctccatcc tacctaggtg ataaggtgtc ctcctatggc ggctacctca cctaccaagc
     4681 caagtccttt ggcttacctg gagacatggt tcttctggaa aagcagccgg acgtgcagct
     4741 cattgggcaa cacatgtcca tcatccatgc ggagcccagc gacccacggc cagacaggcc
     4801 acatcacgga agagtgcaag tggttgaggg aaacttcagg cacgcaggca acagtgcccc
     4861 agtgtcccgg gaagagctga tggctgtgct gtccagcctg gaaggcctcc acatccgggg
     4921 cctccacttc acggagacac agcggctcac cctgggtgag gtagggctgg aggaggcctc
     4981 tgacacggga agcggcccca gggcccatct tgtggagatg tgtacctgtc cccctgacta
     5041 caccggtgac tcatgtcagg gctgtcgccc aggatactat cgagacatca aaagcttccc
     5101 tgcgggaagg tgtgttccct gcaattgcaa cggacattca aatagatgcc aagacggctc
     5161 gggagtgtgc attaactgtc agcacaacac agctggggag cactgtgagc gttgccaaga
     5221 gggttactat ggaagcgcca tccatggatc ctgcagggtt tgcccctgtc ctcacaccaa
     5281 cagctttgcc actggctgtg ctgtggatgg aggagctgtg aggtgtgcct gcaaacccgg
     5341 atacacagga gcacagtgtg agaggtgtgc accaggatat tttgggaacc cccagaaatt
     5401 tggaggtagc tgccaaccat gcaattgcaa cagtaatggc cagtttggca cttgtgatcc
     5461 cctaactgga gactgtgtaa gccaagaacc caaagatggc agccctgcag aagaatgtga
     5521 tgactgtgac agctgtgtga tgactctctt aaatgacttg gtctccatgg gtgaggaact
     5581 ccgcctggtg aagtcaagac tgcaggggct gagtgtgagc actggtgctc tggaacagat
     5641 ccggcatgtg gagatgcagg ccaaggacct gaggaaccag ctgcttggct tccgttccgc
     5701 catctccagt cacgggtcca aaatggacgg cctggaaaaa gaactcagtc atttgaacca
     5761 ggaattcgaa actttgcaag aaaaggcgca ggtcaattcc agaaaagcac aaacattata
     5821 taacaacatc gatcagacaa tccaaaacgc caaagagttg gacatgaaga ttaaaaacat
     5881 cattcagaat gtgcacattc tcctgaagca gatcgctcgg ccaggtggag aaggaatgga
     5941 cttgccggtg ggcgactggt ccagggagct ggcggaagct cagcgcatgt tgcgggagct
     6001 gcgaggccga gactttaaaa agcacctcca agaagcagag gcccagaaaa tggaagccca
     6061 gctcttactg aaccgaatca ggacctggct ggaatcccac caggtggaga acaatggact
     6121 gctaaagaat attcgggatt cattaaatga ttatgaagcc aaacttcagg acctgcgttc
     6181 cgtgcttcag gaggcggcag cccagggaaa gcaggctaca ggcctcaacc acgaaaatga
     6241 gggggtccta ggagccatcc agagacaaat gaaggaaatg gattccctga agaatgacct
     6301 caccgagcac ctggccacag cagacgcttc cctgctgcaa accaacagtc tactgcagcg
     6361 gatggacacg agccagaagg agtatgaaag cttagctgct gctttaaacg gagcaagaca
     6421 ggaactgaat gaccaagtgc gggaactctc cagatccgga ggcaaagcac ccctggtggc
     6481 tgaggccgag aagcacgctc agtctttaca ggagctggca aagcagctgg aagagataaa
     6541 gagaaacacc agcggggatg agctggtgcg ctgtgctgtg gacgctgcca ctgcctatga
     6601 gagcatcctc aacgccatcc gagcagcaga ggatgcagcc ggcaaggccg ccagtgcctc
     6661 agagtccgcc ttccagacag tgataaagga agatcttccg agaagagcca aaaccctgag
     6721 ttctgacagc gaggaactgt taaacgaggc caagatgaca cggaaaaggc tacagcaaga
     6781 aatcaatcca gctctcaaca gcctacagca aaccctgaag actgtatcag ttcagaagga
     6841 cctgctagat gccaatgtca ctgctgtccg taatgacctt cgtgggatcc agagaggtga
     6901 tattgacagt gtggtgagtg gagcgaagag catggtcagg aaagccaatg ggataacgag
     6961 cgaggtcctg gacgggctca gccccatcca gacggatttg ggaaggatta aggacagcta
     7021 cgggagcaca cggcatgagg acttcaacaa agctctgatt gacgccaata actcagtaaa
     7081 gaaattaacc aagaagttgc ctgatctttt tgtcaagatt gaaagcatca atcaacagtt
     7141 gctgcccctg ggaaacatct ctgacaatgt agaccgaatc cgagagctca ttcagcaggc
     7201 cagagatgct gcgaacaagg ttgcaattcc catgaggttc aatggtaaat ctggtgttga
     7261 agtccgtctg ccaaatgacc tagaagactt gaagggatac acgtctctgt ctttgttcct
     7321 ccaaagacca gacttaagag agaatggagg cactgaggac atgtttgtaa tgtaccttgg
     7381 aaacaaggat gcctccaagg actacatcgg catggcggtt gtagatggcc agctgacgtg
     7441 tgtctacaac ctgggggacc gagaagctga agttcagatc gatcaggtcc tgacggagag
     7501 tgagtctcag gaggcagtta tggaccgggt gaagttccag agaatatatc aatttgccaa
     7561 gcttaattac accaaagaag ccacgtccaa taaacccaaa gctcccgcgg tctacgacct
     7621 ggagggtggc agtagcaaca cgctccttaa tttggatccc gaggacgctg tgttttatgt
     7681 cggaggttac ccaccggatt ttgaacttcc tagcagactg cggttccctc catacaaagg
     7741 ctgtatcgaa ctagatgacc tcaatgaaaa cgttctaagc ttgtacaatt tcaagacaac
     7801 tttcaatctc aacaccacgg aggtggagcc ttgtaggagg agaaaggaag agtcagacaa
     7861 aaattacttt gaaggtacag gctatgctcg catccctact caaccaaatg ctcccttccc
     7921 aaacttcata cagaccatcc agactactgt ggacagaggt ttactgttct tcgcagaaaa
     7981 ccaggataac ttcatatctc tgaacataga agatggcaat ctcatggtga gatacaaact
     8041 aaattcagag ccacccaaag agaagggaat tcgagacacc atcaacgatg ggaaagatca
     8101 ttcgatctta atcacaattg gaaaactaca aaaacgcatg tggataaatg tgaacgaacg
     8161 cagtgtacga atcgaagggg aaatatttga tttcagcaca tattatttgg gtggaattcc
     8221 aattgcaatc agagaaaggt ttaacatctc aacgcctgct ttccaaggct gcatgaagaa
     8281 tctgaagaaa accagtgggg ttgtcaggtt gaatgatact gtgggtgtaa ccaagaagtg
     8341 ctcagaagac tggaagcttg tgcgaaccgc ctcgttctcc agaggagggc agatgagctt
     8401 tacaaacttg gacgtgccct cgactgaccg cttccagctc tcctttgggt ttcagacctt
     8461 tcaacccagt ggcacactac tcaatcatca gacgcggaca agcagcctgc tggtcaccct
     8521 ggaagatggg cacattgagt tgagcactag ggacagcaac atcccaattt tcaagtctcc
     8581 agggacctac atggacggtt tactgcatca tgtatctgta ataagtgaca cctcaggtct
     8641 ccgccttctc atcgatgacc aggtcctgag aaggaaccag aggcttccta gcttctctaa
     8701 cgcccagcag tcgctccgcc tcggaggcgg tcatttcgag ggttgtatca gcaatgtttt
     8761 agtccaaagg ttttcacaga gtccagaagt cctggatctg gccagtaaat ctaccaagaa
     8821 ggatgcatcc ctaggaggct gcagtttaaa caagccacct tttcttatgt tgtttaaaag
     8881 tcccaagaga tttaacaagg gccggatttt caatgttaat cagctgatgc aagatgcacc
     8941 tcaggccaca aggagcacag aggcttggca agatgggagg tcctgcctac cacctctgaa
     9001 caccaaggcc tctcacagag ccctgcagtt tggagacagc cccaccagcc acttgctatt
     9061 caagcttccc caggaactgc tgaaacctag gtcacagttt tctttagaca tacagacaac
     9121 ttcccccaaa ggactggtgt tttacacagg caccaaggac tccttcctgg ctctttatgt
     9181 cgcagatggc cgtgttgtct ttgctttggg ggcaggaggg aagaaactga gactcaggag
     9241 caaggagaga taccatgacg ggaagtggca cacggtggtg ttcggactaa atggaggaaa
     9301 ggcacgcctg gttgtggatg ggctaagggc ccaggaaggc agtttgcctg gaaattctac
     9361 catcagcccc agagaacagg tttacctggg gttgccgcta tcaagaaagc caaagagcct
     9421 accccagcac agttttgtgg ggtgcctgag agatttccag ttgaactcga aacccctgga
     9481 ttctccttct gcgaggtttg gggtatctcc ctgcttgggt ggctctttag agaaaggcat
     9541 ttatttctcc caaggaggag gccatgtgat cctagccaat tctgtgtcct tggggccaga
     9601 gcttaagctc actttcagca ttcgcccacg gagtctcact ggggtcttaa tacacgtcgg
     9661 aagtcaatct ggacagcgct taagtgtgta catggaggca ggaaaggtca caacctctgt
     9721 gagcagtgat gcaggaggaa gtgtgacatc aattacaccg aagcagtctc tgtgtgatgg
     9781 acagtggcac tcggtggcag tctccattaa acagcgcatc ctgcatctag aactggatac
     9841 agacagtagc tacacagtcg caccactttc cttctcacca aacagcaccc gagggtcact
     9901 gcacgtcgga ggtgtcccag acaaattgaa aatgcttaca ctccctgtgt ggaactcatt
     9961 ttttggctgt ctgaagaata ttcaagtcaa ccatgtccct gtccccatca cagaagccac
    10021 agaagtccaa ggttctgtca gcctgaatgg ctgccctgac cactaaccct acacagcaag
    10081 attcaccttt ggaagtacca ccagccaagt gtacccctcc cccatcaaag ccatcaagcc
    10141 ggcacagcac acactgacag agcaatgtca ttttgagttc caaccacaca gacccatcac
    10201 tctgtctttc agtgacacat atgcattttc tatcaaaccc caattcatga agaaaatgag
    10261 caaattgtca ttcaaacatt cgcacaaggc ttttgttaat attatttttc cactaagaat
    10321 taaatgcctt ttagagaacc tttttcccca a
//
