LOCUS       NM_012594                713 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus lactalbumin, alpha (Lalba), mRNA.
ACCESSION   NM_012594 XM_001061979
VERSION     NM_012594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Yamaguchi,M., Takai,S., Hosono,A. and Seki,T.
  TITLE     Bovine milk-derived alpha-lactalbumin inhibits colon inflammation
            and carcinogenesis in azoxymethane and dextran sodium
            sulfate-treated mice
  JOURNAL   Biosci Biotechnol Biochem 78 (4), 672-679 (2014)
   PUBMED   25036966
REFERENCE   2  (bases 1 to 713)
  AUTHORS   O'Dowd,R., Wlodek,M.E. and Nicholas,K.R.
  TITLE     Uteroplacental insufficiency alters the mammary gland response to
            lactogenic hormones in vitro
  JOURNAL   Reprod Fertil Dev 20 (4), 460-465 (2008)
   PUBMED   18462607
  REMARK    GeneRIF: Mammary tissue from late pregnant Restricted rats had
            elevated alpha-lactalbumin, but not beta-casein mRNA.
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Holm,S., Andersson,Y., Gothefors,L. and Lindberg,T.
  TITLE     Increased protein absorption after acute gastroenteritis in
            children
  JOURNAL   Acta Paediatr 81 (8), 585-588 (1992)
   PUBMED   1327323
REFERENCE   4  (bases 1 to 713)
  AUTHORS   Qasba,P.K. and Safaya,S.K.
  TITLE     Similarity of the nucleotide sequences of rat alpha-lactalbumin and
            chicken lysozyme genes
  JOURNAL   Nature 308 (5957), 377-380 (1984)
   PUBMED   6709045
REFERENCE   5  (bases 1 to 713)
  AUTHORS   Prasad,R.V., Butkowski,R.J., Hamilton,J.W. and Ebner,K.E.
  TITLE     Amino acid sequence of rat alpha-lactalbumin: a unique
            alpha-lactalbumin
  JOURNAL   Biochemistry 21 (7), 1479-1482 (1982)
   PUBMED   7044414
REFERENCE   6  (bases 1 to 713)
  AUTHORS   Dandekar,A.M. and Qasba,P.K.
  TITLE     Rat alpha-lactalbumin has a 17-residue-long COOH-terminal
            hydrophobic extension as judged by sequence analysis of the cDNA
            clones
  JOURNAL   Proc Natl Acad Sci U S A 78 (8), 4853-4857 (1981)
   PUBMED   6272279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and V01251.1.
            
            On Oct 11, 2022 this sequence version replaced NM_012594.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V01251.1, SRR26643295.30040.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000007.1  131506928-131507072 c
            146-304             V01251.1           10-168
            305-380             JAXUCZ010000007.1  131505907-131505982 c
            381-713             JAXUCZ010000007.1  131504572-131504904 c
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..713
                     /gene="Lalba"
                     /note="lactalbumin, alpha"
                     /db_xref="GeneID:24528"
                     /db_xref="RGD:2987"
     exon            1..145
                     /gene="Lalba"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..492
                     /gene="Lalba"
                     /EC_number="2.4.1.22"
                     /note="alpha-lactalbumin; lactose synthase B protein"
                     /codon_start=1
                     /product="alpha-lactalbumin precursor"
                     /protein_id="NP_036726.1"
                     /db_xref="GeneID:24528"
                     /db_xref="RGD:2987"
                     /translation="MMRFVPLFLACISLPAFQATEFTKCEVSHAIEDMDGYQGISLLE
                     WTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCDKFLDD
                     ELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQWRCEKPGAPALVVPALNSETPVP"
     exon            146..304
                     /gene="Lalba"
                     /inference="alignment:Splign:2.1.0"
     exon            305..380
                     /gene="Lalba"
                     /inference="alignment:Splign:2.1.0"
     exon            381..713
                     /gene="Lalba"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcaggca aaatgatgcg ttttgttcct ctgttcctgg cgtgtatttc gctgcctgcc
       61 tttcaagcca cagagtttac aaaatgtgag gtgtcccacg ccattgaaga catggatggc
      121 tatcaaggca tcagcttgct tgaatggacc tgtgttttat tccacaccag tggctatgac
      181 tcacaagcta tcgtcaagaa caatggcagc acagagtatg gactcttcca gatcagtaac
      241 agaaattggt gcaagagtag cgagttcccc gagtcagaga acatctgtga catctcctgt
      301 gacaagttcc tggatgatga gcttgcggat gacatagtat gtgccaagaa gatcgtggct
      361 atcaaaggga tcgactactg gaaggctcac aagcccatgt gctctgagaa gctggaacag
      421 tggcgctgtg agaagccggg agctcctgcc cttgttgtcc ctgccctgaa ttcagaaaca
      481 cctgttccct aaggctacct cagtttggct ctttctatcg tgaagatgat ctgtctctga
      541 gccttgtatc ctgtagtgac accatcggac tctagaggac ttttattcaa caggcgtgtg
      601 actggcacac tggactgcaa acccttgctt agtgacggca agggtcttga tggtggtttt
      661 actaatgcaa gagaaccctc ccctgtccca aataaagggc ccaatttgat gtc
//
