LOCUS       NM_001029928             854 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus leukocyte-associated immunoglobulin-like receptor
            1 (Lair1), mRNA.
ACCESSION   NM_001029928 XM_001070337 XM_001078788
VERSION     NM_001029928.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 854)
  AUTHORS   Peng,D.H., Rodriguez,B.L., Diao,L., Chen,L., Wang,J., Byers,L.A.,
            Wei,Y., Chapman,H.A., Yamauchi,M., Behrens,C., Raso,G.,
            Soto,L.M.S., Cuentes,E.R.P., Wistuba,I.I., Kurie,J.M. and
            Gibbons,D.L.
  TITLE     Collagen promotes anti-PD-1/PD-L1 resistance in cancer through
            LAIR1-dependent CD8+ T cell exhaustion
  JOURNAL   Nat Commun 11 (1), 4520 (2020)
   PUBMED   32908154
  REMARK    GeneRIF: Collagen promotes anti-PD-1/PD-L1 resistance in cancer
            through LAIR1-dependent CD8(+) T cell exhaustion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 854)
  AUTHORS   Hoelsbrekken,S.E., Fossum,S. and Dissen,E.
  TITLE     Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat,
            two novel immunoglobulin-like receptors encoded by the leukocyte
            receptor gene complex
  JOURNAL   Immunogenetics 57 (7), 479-486 (2005)
   PUBMED   16041585
REFERENCE   3  (bases 1 to 854)
  AUTHORS   Lebbink,R.J., de Ruiter,T., Kaptijn,G.J. and Meyaard,L.
  TITLE     Identification and characterization of the rat homologue of LAIR-1
  JOURNAL   Immunogenetics 57 (5), 344-351 (2005)
   PUBMED   15902436
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY863023.1.
            
            On or before Jul 27, 2007 this sequence version replaced
            XM_001078788.1, XM_001070337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY863023.1, DQ025756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345329, SAMN13663593
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..854
                     /gene="Lair1"
                     /note="leukocyte-associated immunoglobulin-like receptor
                     1"
                     /db_xref="GeneID:574531"
                     /db_xref="RGD:1560048"
     exon            1..65
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..823
                     /gene="Lair1"
                     /note="leukocyte-associated Ig-like receptor 1; LAIR-1;
                     rLAIR1"
                     /codon_start=1
                     /product="leukocyte-associated immunoglobulin-like
                     receptor 1 precursor"
                     /protein_id="NP_001025099.1"
                     /db_xref="GeneID:574531"
                     /db_xref="RGD:1560048"
                     /translation="MPLHSVIVLVLVLCLGWKSNTQEESLSDFTICAEPGPVIPQGNF
                     ITIVCSTSGEYDTVRLEKEGSTFMEKKTEPHGKQHRFRIGPVNETITGYYNCIFEKNY
                     VWSQRSNDLQLKVIKENVTQGLAPGPSMTSDTSWLKTYSIHILTVVSVIFLLCLSLFL
                     FCFLSHRQKKQGLPNNKSQHQRSQERLNLATNGLEKTSDIVMDDSLSEDRQTETWTPV
                     AGDLQEVTYAQLDHDSLTQRTVKDVTPQNRVIMAESSTYAAIMRC"
     exon            66..101
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..428
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..545
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..588
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..626
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..676
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..854
                     /gene="Lair1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacctggt aaggttgctg gagcctgagt catgccactt cattctgtca tcgtgctggt
       61 gcttgtactg tgcctgggat ggaaaagtaa cacacaggag gaatctctgt ccgatttcac
      121 tatctgcgct gagccaggtc ctgtgattcc tcaagggaat ttcataacca ttgtgtgctc
      181 aacctctggt gaatatgaca cggtccgcct ggagaaggaa ggcagcacct ttatggaaaa
      241 gaaaacagag cctcatggaa aacagcatag attccgtatt gggccagtga atgaaaccat
      301 tactggatat tataactgta tctttgaaaa aaattatgta tggtctcaac gaagtaatga
      361 tctgcagcta aaagtgatca aagaaaatgt cacccagggt cttgccccag gtccatcaat
      421 gacctcagat acatcttggc tgaagacgta cagcattcac attcttactg tggtctctgt
      481 gattttcctc ctttgtcttt ccctctttct attctgcttt cttagccacc gtcagaaaaa
      541 gcagggactt ccaaacaata agagccagca tcagaggtca caggagaggc tcaacctagc
      601 tactaatggc ctggagaaga catcagacat agtcatggat gacagccttt ctgaggacag
      661 acagacagaa acttggaccc cagttgcagg agatcttcag gaggtgacat atgcccagct
      721 ggaccatgac tccctcacac aaaggactgt taaagatgtg accccacaga acagagttat
      781 catggctgag tccagtacat atgcagccat catgagatgc tgagcctggg catcctggag
      841 acacaaatgg tcac
//
