LOCUS       NM_001106345             743 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus L antigen family, member 3 (Lage3), mRNA.
ACCESSION   NM_001106345 XM_001056585 XM_215227
VERSION     NM_001106345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 743)
  AUTHORS   Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W,
            Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson
            JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N,
            Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC,
            Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult
            S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY,
            Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T,
            Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A,
            Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM,
            Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre
            E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F,
            Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE,
            Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH,
            Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N,
            Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G,
            Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P,
            Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M,
            Antignac C and Hildebrandt F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   2  (bases 1 to 743)
  AUTHORS   Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N,
            Huang H, Laister R, Caudy AA, Gingras AC, Durocher D and Sicheri F.
  TITLE     Proteomic analysis of the human KEOPS complex identifies C14ORF142
            as a core subunit homologous to yeast Gon7
  JOURNAL   Nucleic Acids Res 45 (2), 805-817 (2017)
   PUBMED   27903914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474099.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056585.1, XM_215227.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM107254.1, CB315596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..743
                     /gene="Lage3"
                     /gene_synonym="RGD1562476"
                     /note="L antigen family, member 3"
                     /db_xref="GeneID:293863"
                     /db_xref="RGD:1562476"
     exon            1..295
                     /gene="Lage3"
                     /gene_synonym="RGD1562476"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..539
                     /gene="Lage3"
                     /gene_synonym="RGD1562476"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit LAGE3"
                     /protein_id="NP_001099815.1"
                     /db_xref="GeneID:293863"
                     /db_xref="RGD:1562476"
                     /translation="MQTAHAGLSHTAGGADSPTGRFCPGNAGTMAVLPSGAHPVARAL
                     EAPRNSSKSSVPLTQRPGIRHHKFALFVPFPTSLEAEIACGSLAPDVEPHQGLVEKEL
                     KVSGSVLEVHWIAEDSRLLRISIMNFLDQLSLVVNTIQLFGPPISC"
     exon            296..424
                     /gene="Lage3"
                     /gene_synonym="RGD1562476"
                     /inference="alignment:Splign:2.1.0"
     exon            425..743
                     /gene="Lage3"
                     /gene_synonym="RGD1562476"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaggata aggcgggttc tgagccgcag caatggcgga ggaggcgggc tggtgacagg
       61 aggataggtt tgaaggagga gcaacagcag ccatgcagac ggcacacgca gggttaagcc
      121 atactgcagg tggcgccgac agtccgactg gccgcttctg tcctggtaat gcaggcacaa
      181 tggcagttct tcctagtgga gctcaccctg ttgcaagagc actggaagcc ccccgaaatt
      241 ccagcaaaag ctccgtgcct ttaacccaaa ggcctggaat ccgacatcat aaattcgccc
      301 tcttcgtgcc tttccctacc tctttggagg cggaaatcgc ctgtgggtcc ctagctcctg
      361 atgtcgaacc acaccaagga ctggtagaga aggagcttaa agtgagcggc agcgtgctgg
      421 aggtacactg gatcgcagaa gattctcgcc tcctccgaat ttccatcatg aactttcttg
      481 accagctttc tctagtggtg aacaccattc agctctttgg gcccccgatt tcctgttaag
      541 cctggctggg gacccaggtc tgaccttatc cccatcgact aagcagtaca agtttcctta
      601 gtgaaaagat tccagaaata gtagctgcta cataaatgtg ggggcctaat tttttttcac
      661 gcacgtaggg gccatttgtt ctggtgcttc aatgtttgtt gctagagaaa ataaagctat
      721 actgctaatc tacatttgtg ttt
//
