LOCUS       NM_212513               1817 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus lymphocyte activating 3 (Lag3), mRNA.
ACCESSION   NM_212513 XM_232349
VERSION     NM_212513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Wang,J., Sanmamed,M.F., Datar,I., Su,T.T., Ji,L., Sun,J., Chen,L.,
            Chen,Y., Zhu,G., Yin,W., Zheng,L., Zhou,T., Badri,T., Yao,S.,
            Zhu,S., Boto,A., Sznol,M., Melero,I., Vignali,D.A.A., Schalper,K.
            and Chen,L.
  TITLE     Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of
            LAG-3
  JOURNAL   Cell 176 (1-2), 334-347 (2019)
   PUBMED   30580966
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Workman,C.J., Wang,Y., El Kasmi,K.C., Pardoll,D.M., Murray,P.J.,
            Drake,C.G. and Vignali,D.A.
  TITLE     LAG-3 regulates plasmacytoid dendritic cell homeostasis
  JOURNAL   J Immunol 182 (4), 1885-1891 (2009)
   PUBMED   19201841
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Haudebourg,T., Dugast,A.S., Coulon,F., Usal,C., Triebel,F. and
            Vanhove,B.
  TITLE     Depletion of LAG-3 positive cells in cardiac allograft reveals
            their role in rejection and tolerance
  JOURNAL   Transplantation 84 (11), 1500-1506 (2007)
   PUBMED   18091527
  REMARK    GeneRIF: Targeting LAG-3-positive cells with cytotoxic antibodies
            is immunosuppressive in transplantation by depleting effectors T
            cells
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Brignone,C., Grygar,C., Marcu,M., Schakel,K. and Triebel,F.
  TITLE     A soluble form of lymphocyte activation gene-3 (IMP321) induces
            activation of a large range of human effector cytotoxic cells
  JOURNAL   J Immunol 179 (6), 4202-4211 (2007)
   PUBMED   17785860
  REMARK    GeneRIF: LAG-3 binds to a minority of histocompatibility class
            II-positive cells in peripheral blood mononuclear leukocytes,
            including all myeloid dendritic cells, and a small fraction of
            monocytes.
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Li,N., Wang,Y., Forbes,K., Vignali,K.M., Heale,B.S., Saftig,P.,
            Hartmann,D., Black,R.A., Rossi,J.J., Blobel,C.P., Dempsey,P.J.,
            Workman,C.J. and Vignali,D.A.
  TITLE     Metalloproteases regulate T-cell proliferation and effector
            function via LAG-3
  JOURNAL   EMBO J 26 (2), 494-504 (2007)
   PUBMED   17245433
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Workman,C.J. and Vignali,D.A.
  TITLE     The CD4-related molecule, LAG-3 (CD223), regulates the expansion of
            activated T cells
  JOURNAL   Eur J Immunol 33 (4), 970-979 (2003)
   PUBMED   12672063
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Workman,C.J., Dugger,K.J. and Vignali,D.A.
  TITLE     Cutting edge: molecular analysis of the negative regulatory
            function of lymphocyte activation gene-3
  JOURNAL   J Immunol 169 (10), 5392-5395 (2002)
   PUBMED   12421911
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Workman,C.J., Rice,D.S., Dugger,K.J., Kurschner,C. and Vignali,D.A.
  TITLE     Phenotypic analysis of the murine CD4-related glycoprotein, CD223
            (LAG-3)
  JOURNAL   Eur J Immunol 32 (8), 2255-2263 (2002)
   PUBMED   12209638
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Huard,B., Mastrangeli,R., Prigent,P., Bruniquel,D., Donini,S.,
            El-Tayar,N., Maigret,B., Dreano,M. and Triebel,F.
  TITLE     Characterization of the major histocompatibility complex class II
            binding site on LAG-3 protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (11), 5744-5749 (1997)
   PUBMED   9159144
REFERENCE   10 (bases 1 to 1817)
  AUTHORS   Miyazaki,T., Dierich,A., Benoist,C. and Mathis,D.
  TITLE     Independent modes of natural killing distinguished in mice lacking
            Lag3
  JOURNAL   Science 272 (5260), 405-408 (1996)
   PUBMED   8602528
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091201.1.
            
            On Mar 27, 2005 this sequence version replaced NM_212513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091201.1, AY230414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1817
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /note="lymphocyte activating 3"
                     /db_xref="GeneID:297596"
                     /db_xref="RGD:1302990"
     exon            1..180
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1700
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /note="LAG-3; lymphocyte activation gene 3 protein;
                     lymphocyte-activation gene 3"
                     /codon_start=1
                     /product="lymphocyte activation gene 3 protein precursor"
                     /protein_id="NP_997678.2"
                     /db_xref="GeneID:297596"
                     /db_xref="RGD:1302990"
                     /translation="MRQDLFLDLLLLQLLWEAPVVSSGPGKELSVVWAQEGAPVHLPC
                     SLEFPHLDPNFLRRGWVTWQHRPDSDQPASIPALDLLQGMPSTRRHPPHRYTVLSVAP
                     GGLRSGRQPLLSHVQLEKRGPQRGDFSLWLRPATRKDAGEYHAFVRLPDRDFSCSLRL
                     RVGQASMIASPPGTLKPSDWVILNCSFSRPDRPVSVHWFQGQSRVPVHNSPRHYLAES
                     FLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVQGLEPVAPLTVYAAEGSRVELPC
                     HLPPVVGTPSLLIAKWTPPGGGPELPVTGKSGNFTLQLENVGRAQAGTYTCSIHLQGR
                     QLSAAVTLAVITVTPKSFGLPGSPQKLLCEVVPASGEGRFVWRPLSDLSRSSLGPVLE
                     LQEAKLLAEQWQCQLYEGQKLLGATVYTAESSSGAWSAKRISGDLKGGHLFLSLILGA
                     LALFLLVTGAFGFHLWRRQLLRRRFSALEHGIRPPPVQSKIEELEREPETEMEPETEP
                     DPEPQPEPELEPESRQL"
     exon            181..328
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            329..621
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            622..885
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1161
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1398
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1529
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1792
                     /gene="Lag3"
                     /gene_synonym="CD223"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattctttg cctcacctcc ctccttgtgg aatttctctc tctctctctc tttttttttt
       61 ctcccaggac ctttttctga actcccttgc agggcctgtg aagcccgggg gccacagagg
      121 agatgaggca ggatctgttc cttgaccttt tgcttctgca gctgctttgg gaagctccag
      181 ttgtgtcttc agggcctggg aaagagctct ccgtggtgtg ggcccaggag ggagctcctg
      241 tccatcttcc ctgcagcctc gaatttcccc acctggatcc caactttctg cgaagaggat
      301 gggtcacctg gcaacatcga ccagacagtg accaacccgc ttccatcccg gcccttgacc
      361 ttctccaggg aatgccctcg actaggagac acccacccca tcgctacacg gtgctgagtg
      421 tggctccagg aggcctgcgc agcgggaggc agcccctgct atcccacgtg cagctggaga
      481 agcgtggccc ccagcgcggg gacttctctc tgtggttgcg cccagctacg cgcaaagatg
      541 cgggcgagta ccacgccttc gtgcgcctcc cggaccgcga cttctcctgc agcctccgcc
      601 tgcgcgtcgg ccaggcctcg atgattgcca gtcccccagg aaccctcaag ccgtctgatt
      661 gggtcatttt gaactgctcc ttcagtcgtc ctgaccgccc agtctctgtg cactggttcc
      721 agggccaaag ccgagtgccc gtccacaatt caccccgtca ttatctagct gaaagtttcc
      781 tcttactgcc ccaagtcagc ccactggatt ccgggacctg gggctgtgtc ctcacctaca
      841 gagatggctt caatgtctcc atcacgtaca acctcaaggt tcagggtctg gaacctgtag
      901 cccctttgac agtgtacgct gctgaaggtt ctagggtgga gctgccctgt cacttgcctc
      961 ccgttgtggg gaccccttct ttgctcattg ccaagtggac tcctcctggg ggaggtcctg
     1021 agctcccggt gactggaaag agtggcaatt ttacccttca acttgagaat gtgggtcggg
     1081 cacaggctgg gacctacacc tgcagcatcc atctgcaggg gcggcagctc agtgcggctg
     1141 tgacgttggc agtcatcaca gtgactccta aatccttcgg gttacctggc tccccgcaga
     1201 agctgttatg tgaggtagtc ccggcatctg gagaaggaag atttgtgtgg cgccccctca
     1261 gcgatctgtc caggagttcc ctgggccctg tgctggagtt gcaggaggcc aagcttctgg
     1321 ctgagcaatg gcagtgtcag ctgtatgagg gccagaaact tcttggagca acagtgtaca
     1381 ccgcagagtc tagctcaggc gcctggagtg ctaagagaat ctcaggtgac cttaaaggag
     1441 gccatctctt cctctctctc atccttggtg cccttgcctt gttcctcttg gtgaccgggg
     1501 cctttggctt tcacctgtgg agaagacagt tgctacggag aagattttct gccttagagc
     1561 atgggattcg cccacctccg gttcagagta agatagagga gctggagcga gaaccggaga
     1621 ccgagatgga accagagaca gagcccgatc cggagcctca gccggagccc gagctggaac
     1681 cagagtccag gcagctctga ccaggagctg agacagccag cagcaggtct cagcagctct
     1741 gcccgcccgc ccgcctgccc gcccgccgga ataaactccc tgtcagcagc aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaa
//
