LOCUS       NM_001106833            1987 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus lactamase, beta (Lactb), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001106833 XM_001056675 XM_217181
VERSION     NM_001106833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S,
            Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt
            F, Thiru P, Golub TR, Vance JE and Weinberg RA.
  TITLE     LACTB is a tumour suppressor that modulates lipid metabolism and
            cell state
  JOURNAL   Nature 543 (7647), 681-686 (2017)
   PUBMED   28329758
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Zhao X, Leon IR, Bak S, Mogensen M, Wrzesinski K, Hojlund K and
            Jensen ON.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Polianskyte Z, Peitsaro N, Dapkunas A, Liobikas J, Soliymani R,
            Lalowski M, Speer O, Seitsonen J, Butcher S, Cereghetti GM, Linder
            MD, Merckel M, Thompson J and Eriksson O.
  TITLE     LACTB is a filament-forming protein localized in mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 106 (45), 18960-18965 (2009)
   PUBMED   19858488
  REMARK    GeneRIF: LACTB resides in the mitochondrial intermembrane space and
            forms a soluble high molecular weight homopolymer.
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474041.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217181.4, XM_001056675.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1987
                     /gene="Lactb"
                     /note="lactamase, beta"
                     /db_xref="GeneID:300803"
                     /db_xref="RGD:1304788"
     exon            1..440
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1742
                     /gene="Lactb"
                     /codon_start=1
                     /product="serine beta-lactamase-like protein LACTB,
                     mitochondrial"
                     /protein_id="NP_001100303.1"
                     /db_xref="GeneID:300803"
                     /db_xref="RGD:1304788"
                     /translation="MYRFLSSVTSRATATAGPALGGGRRGAHGRPGLPMLSLGWAGGL
                     GLGLGLALGAKLAIGLRGAVPIQSPADPEASGATELPHEQAPGPGSPHTPASPAARGF
                     SRAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRI
                     ASISKSLTMVALAKLWEAGKLDLDLPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGI
                     RHYEKDMKKVKEEKAYKALKMMKGTPPPDQEKELKEKGGKDNDKSDSPKAKAEQDSEA
                     KCRSAKPGKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLL
                     AAIVERTSGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYV
                     DNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPV
                     PNTEMSWDKEGKYAMAWGVVEKKQTHGACRKQRHYASHTGGAVGASSVLLVLPEELDP
                     EAVNNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRAD"
     exon            441..507
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
     exon            508..698
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1050
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1216
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1987
                     /gene="Lactb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtaaggccc cgccccaggc ccgcccctcg tcccgcgggc cgctggctaa gctaggaagc
       61 taggaagcag ctggctctgc ggaggcgaca tgtaccggtt cctgtcaagc gtgacatctc
      121 gggctacggc caccgcaggc ccagccttgg gcggagggcg gcgtggggcg cacgggcgac
      181 ccggcctgcc tatgctgagc cttggatggg ccggcggcct ggggctcggg ctggggctgg
      241 ctcttggggc gaaactggcg attgggctga ggggcgccgt ccccattcag tcccccgcgg
      301 accccgaggc gtccggcgct actgagctgc cgcatgagca ggccccgggc ccagggagcc
      361 cgcacacgcc tgcgtcgccc gctgccaggg gcttctccag agccatagag agcagccgcg
      421 atctgctgca ccggatcaag gatgaggttg gtgcccctgg catagtggtt ggagtttctg
      481 tagatggaaa agaagtctgg tcagaaggtt taggctatgc agatgtggag aaccgagtac
      541 cctgcaaacc agaaacggtc atgagaattg caagcatcag caaaagcctt accatggtgg
      601 ctctggctaa actgtgggaa gcagggaagc tggatctgga cctccccgtg cagcactatg
      661 tccctgagtt cccagaaaaa gaatacgagg gtgaaaaggt ctctgtcaca acgagattac
      721 taatttccca cttaagtgga attcgtcatt atgaaaagga catgaagaaa gtgaaagaag
      781 agaaggctta taaagccttg aagatgatga aagggacacc accccctgac caagagaaag
      841 aactgaaaga aaagggaggc aaggataacg acaagagcga ctcaccgaaa gccaaagctg
      901 agcaggacag tgaagccaaa tgccgcagcg caaagccggg caagaagaag aatgactttg
      961 aacaaggcga attatatttg aaagaaaagt tcgaaaattc gatcgaatca ctaagattat
     1021 ttaaaaatga tcctttattc tttaaacctg gtagtcagtt tttgtattca acgtttggct
     1081 atactctgct ggcagccata gtagaaagaa cttcaggata taaatatttg gactatatgc
     1141 agaaaatttt ccatgatttg gacatgctga caactgtcca ggaagaaaac gagccagtga
     1201 tttacaacag agcaagattt tatgtgtaca ataaaaagaa acgtcttgtc aacacacctt
     1261 acgtggataa ctcctataaa tgggctggtg gtggatttct gtccacggtg ggggacctcc
     1321 tgaagtttgg gaatgcaatg ctgtatggct accaagttgg gctgtttaag aactcaaatg
     1381 aaaatctctt gcctggatat ctcaagccag aaacgatggt gatgatgtgg accccagtcc
     1441 ctaacacaga gatgtcctgg gataaagagg gcaaatatgc catggcgtgg ggtgttgtag
     1501 agaagaagca aacgcacggc gcctgcagga agcagcggca ctacgcctca cacactggag
     1561 gtgccgtggg tgccagcagt gtgctgctgg tcctccctga agaactggac ccagaggccg
     1621 taaacaacaa ggttcccccg aggggaataa ttgtctcaat catatgcaac atgcagtctg
     1681 tgggcctcaa cagcactgct ttaaagatcg ccctggagtt tgataaagac agagccgact
     1741 aatcctaacc gcggcacagg tccacagtga gccttccgtt ctgtgaaatg ttgacgttcc
     1801 aaaatacaaa aacactttaa gaatacattt gtaatagaat acagttaaat gtggaaaatt
     1861 atgtacctct aattgcttaa ttttgtaatt gcctttttat tggacaatta gttctttaca
     1921 ctcagggaaa tagcagttgt ttctactttt ttttaaagtg ttaactcttg aaataaaata
     1981 ttctgat
//
