LOCUS       NM_001399500            2275 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus laccase domain containing 1 (Lacc1), mRNA.
ACCESSION   NM_001399500 XM_233749
VERSION     NM_001399500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Mao,X., Li,Z., Gu,S., Song,W., Zhang,M., Tan,X. and Mao,Z.
  TITLE     MicroRNA-211-5p in extracellular vesicles derived from BMSCs
            facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis
  JOURNAL   Tissue Cell 81, 102006 (2023)
   PUBMED   36610229
  REMARK    GeneRIF: MicroRNA-211-5p in extracellular vesicles derived from
            BMSCs facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis.
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Cader,M.Z., Boroviak,K., Zhang,Q., Assadi,G., Kempster,S.L.,
            Sewell,G.W., Saveljeva,S., Ashcroft,J.W., Clare,S.,
            Mukhopadhyay,S., Brown,K.P., Tschurtschenthaler,M., Raine,T.,
            Doe,B., Chilvers,E.R., Griffin,J.L., Kaneider,N.C., Floto,R.A.,
            D'Amato,M., Bradley,A., Wakelam,M.J., Dougan,G. and Kaser,A.
  TITLE     C13orf31 (FAMIN) is a central regulator of immunometabolic function
  JOURNAL   Nat Immunol 17 (9), 1046-1056 (2016)
   PUBMED   27478939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 10, 2022 this sequence version replaced XM_233749.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.46818.1,
                                           SRR26643293.60674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000015.1  58816694-58816840   c
            148-757             JAXUCZ010000015.1  58815132-58815741   c
            758-936             JAXUCZ010000015.1  58814375-58814553   c
            937-1102            JAXUCZ010000015.1  58813527-58813692   c
            1103-1328           JAXUCZ010000015.1  58810981-58811206   c
            1329-1489           JAXUCZ010000015.1  58809768-58809928   c
            1490-2275           JAXUCZ010000015.1  58804393-58805178   c
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..2275
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /note="laccase domain containing 1"
                     /db_xref="GeneID:313790"
                     /db_xref="RGD:1310185"
     exon            1..147
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     exon            148..757
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1488
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /note="laccase domain-containing protein 1; laccase
                     (multicopper oxidoreductase) domain containing 1"
                     /codon_start=1
                     /product="purine nucleoside phosphorylase LACC1"
                     /protein_id="NP_001386429.1"
                     /db_xref="GeneID:313790"
                     /db_xref="RGD:1310185"
                     /translation="MAEAVLIDLSGLQLNSQENCHQMVLKTLDGIHDHHAPKAKFLCI
                     ICCSDATNGKGGEYGLCELEAGNGFSSLAGKFETVSHPSLAASLYSVKQKIDEEDLSR
                     VKVIVPEHRRLLMEAYVDQLFTAVYEFEFEDLQVAQRESLLKPSTGVNVTTAHKLEDV
                     QSEIESYLRSLPALKGDLTIVTSPLIPDIFLHGFTTRTGGISYIPTLSSLNLFSSSKR
                     RDPKVVVQENLRRLANAAGFNAEKFYRIKTDHASEVWVMGKKEPESYDGIITNQRGIT
                     ITALGADCIPIVFADPVKKACGAAHSGWKGTLLGVAMATVNAMIAEYGCNLEDIIVVL
                     GPSVGSCCFTLPRESATSFHNVHPSCVRQFDSPNPYVDIRKATRILLERGGILPQNIQ
                     DQEEDLDLCTSCHPEKFFSHVRDGLNFGTQIGFISLRE"
     exon            758..936
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1102
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1328
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1489
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2275
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaactcc ggtgcccgga ggcccgggac gctgtgaggc gggcgagcgg gcggaccgct
       61 tcgggcgact ctggggttcg ttccccgagg ctgcagctca caccccagct cgcggccgcc
      121 gaggagagcg cgggaagcgg ccccgcgctg atttggcata aaagtctttg ggggaaaaag
      181 gtgcctgact gaagaatggc agaagcagtc ttgatagatc tctctggttt acaattgaac
      241 tctcaggaaa actgtcatca gatggtactg aagacgctgg atggtattca cgaccaccat
      301 gcccccaagg ccaagttcct ttgtataata tgttgcagcg atgccaccaa tggaaagggt
      361 ggggaatatg gcctctgtga actggaagca ggaaatggct tttcaagtct cgcgggaaaa
      421 ttcgagactg ttagccatcc cagcctggct gcctctttgt attcagttaa acaaaaaata
      481 gatgaggagg atctgagccg cgttaaggtg attgtgcccg agcacaggag actgttgatg
      541 gaggcttatg ttgaccaact cttcaccgcg gtgtatgagt ttgagtttga agatttacag
      601 gtagctcaga gggaaagcct tttgaaaccg tccactggcg taaatgtgac cacagctcat
      661 aaactggaag acgtccagag tgaaatagaa tcgtacttga gaagcctgcc agcgttgaaa
      721 ggggacctaa ctattgtcac atctcctttg atcccagaca tcttcctgca cggatttaca
      781 actcggacag gtggcatttc ttacataccc actctcagct cactcaatct tttcagtagt
      841 tccaaacgga gagatcccaa agtagttgtt caagaaaacc tccgcaggct ggcaaatgct
      901 gcagggttta atgcagagaa attttaccga ataaagactg atcacgccag tgaagtatgg
      961 gtaatgggga agaaggagcc tgaatcttac gatggaataa ttacaaatca gagaggaatc
     1021 acaatcacag ctcttggcgc agactgtata cctatagtct ttgcagatcc tgtgaaaaaa
     1081 gcatgtgggg ctgctcactc gggctggaag ggcactttgt tgggcgtcgc tatggctact
     1141 gtgaatgcta tgatagcaga atatggctgt aatctggagg acatcattgt tgttctgggc
     1201 ccttcagtgg gatcttgctg ctttactctt cccagagaat cagcaacctc atttcacaat
     1261 gttcatcctt cgtgtgtgag acagtttgac tcaccaaatc cctacgttga catccgaaaa
     1321 gccaccagga ttcttctaga acgaggagga attcttccac agaatattca agaccaggag
     1381 gaagatcttg acctctgcac atcttgccat cctgagaagt ttttctccca tgtccgtgat
     1441 ggccttaact tcggtacaca gataggcttc atatccctta gagaatgagg ttcttgtctg
     1501 gaattttgca taaatgcttc ccgtatcctt ctacaatggc tgcaaaagaa aatatttagc
     1561 tttttgattt atataaaacc atgaggatta caaaagataa ttcatcttta gggtattctc
     1621 tcactgttac cggatgcaca atgaccttgg tctaattctt atgacaactg atgaaaaaac
     1681 tcagtgagat gtcattgcta acgttgttct ctgtatctat aaatcaaggc cggatctgtt
     1741 tagttcagta ttcactagat gccgactttt gttcaggaat gggactcagc acagtgaatt
     1801 gaaatgaaga cacctttctc atttgaatca aatgcagtag gggagataaa cgtttccttt
     1861 taaatgtata tttttaactg ccttataaaa taccaggttt ccttatgctg ttctcaagca
     1921 ccatgttttt ctggccctcc gctctccctt tccctggccc cttgtgtacc ctttcactgc
     1981 agaagcccct ctttcctgtc tcatgtgttt tgttctccct tgcacaatcc ccttttatgt
     2041 tccctttcta gtttcaacac ctatccacac ttatacccac agatttacat agccatatac
     2101 atgtatgttt acataaacat taaaggttag aatttatata taagaaagaa catgtggtgt
     2161 ttcttattct gagtctggat tattttgctc ataataaata attccagatc catcaatttt
     2221 tcctataagt ttgataattt cattatggct aaataaaata ctgtgtgtat gtact
//
