LOCUS       NP_001386429             430 aa            linear   ROD 11-SEP-2024
DEFINITION  purine nucleoside phosphorylase LACC1 [Rattus norvegicus].
ACCESSION   NP_001386429 XP_233749
VERSION     NP_001386429.1
DBSOURCE    REFSEQ: accession NM_001399500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Mao,X., Li,Z., Gu,S., Song,W., Zhang,M., Tan,X. and Mao,Z.
  TITLE     MicroRNA-211-5p in extracellular vesicles derived from BMSCs
            facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis
  JOURNAL   Tissue Cell 81, 102006 (2023)
   PUBMED   36610229
  REMARK    GeneRIF: MicroRNA-211-5p in extracellular vesicles derived from
            BMSCs facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis.
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Cader,M.Z., Boroviak,K., Zhang,Q., Assadi,G., Kempster,S.L.,
            Sewell,G.W., Saveljeva,S., Ashcroft,J.W., Clare,S.,
            Mukhopadhyay,S., Brown,K.P., Tschurtschenthaler,M., Raine,T.,
            Doe,B., Chilvers,E.R., Griffin,J.L., Kaneider,N.C., Floto,R.A.,
            D'Amato,M., Bradley,A., Wakelam,M.J., Dougan,G. and Kaser,A.
  TITLE     C13orf31 (FAMIN) is a central regulator of immunometabolic function
  JOURNAL   Nat Immunol 17 (9), 1046-1056 (2016)
   PUBMED   27478939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 10, 2022 this sequence version replaced XP_233749.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.46818.1,
                                           SRR26643293.60674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     Protein         1..430
                     /product="purine nucleoside phosphorylase LACC1"
                     /note="laccase domain-containing protein 1; laccase
                     (multicopper oxidoreductase) domain containing 1"
                     /calculated_mol_wt=47117
     Region          195..426
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..430
                     /gene="Lacc1"
                     /gene_synonym="RGD1310185"
                     /coded_by="NM_001399500.1:196..1488"
                     /db_xref="GeneID:313790"
                     /db_xref="RGD:1310185"
ORIGIN      
        1 maeavlidls glqlnsqenc hqmvlktldg ihdhhapkak flciiccsda tngkggeygl
       61 celeagngfs slagkfetvs hpslaaslys vkqkideedl srvkvivpeh rrllmeayvd
      121 qlftavyefe fedlqvaqre sllkpstgvn vttahkledv qseiesylrs lpalkgdlti
      181 vtsplipdif lhgfttrtgg isyiptlssl nlfssskrrd pkvvvqenlr rlanaagfna
      241 ekfyriktdh asevwvmgkk epesydgiit nqrgitital gadcipivfa dpvkkacgaa
      301 hsgwkgtllg vamatvnami aeygcnledi ivvlgpsvgs ccftlpresa tsfhnvhpsc
      361 vrqfdspnpy vdirkatril lerggilpqn iqdqeedldl ctschpekff shvrdglnfg
      421 tqigfislre
//
