LOCUS       NM_001395622            2547 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus leucine rich repeat transmembrane neuronal 1
            (LRRTM1), transcript variant 1, mRNA.
ACCESSION   NM_001395622 XM_017592881
VERSION     NM_001395622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Ban,D., Xiang,Z., Yu,P. and Liu,Y.
  TITLE     Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal
            Cord Injury via miR-3551-3p/LRRTM1 Axis
  JOURNAL   Appl Biochem Biotechnol 194 (11), 5151-5166 (2022)
   PUBMED   35699802
  REMARK    GeneRIF: Circular RNA Hecw1 Regulates the Inflammatory Imbalance in
            Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Schroeder,A., Vanderlinden,J., Vints,K., Ribeiro,L.F.,
            Vennekens,K.M., Gounko,N.V., Wierda,K.D. and de Wit,J.
  TITLE     A Modular Organization of LRR Protein-Mediated Synaptic Adhesion
            Defines Synapse Identity
  JOURNAL   Neuron 99 (2), 329-344 (2018)
   PUBMED   29983322
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Soler-Llavina,G.J., Arstikaitis,P., Morishita,W., Ahmad,M.,
            Sudhof,T.C. and Malenka,R.C.
  TITLE     Leucine-rich repeat transmembrane proteins are essential for
            maintenance of long-term potentiation
  JOURNAL   Neuron 79 (3), 439-446 (2013)
   PUBMED   23931994
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Voikar,V., Kulesskaya,N., Laakso,T., Lauren,J., Strittmatter,S.M.
            and Airaksinen,M.S.
  TITLE     LRRTM1-deficient mice show a rare phenotype of avoiding small
            enclosures--a tentative mouse model for claustrophobia-like
            behaviour
  JOURNAL   Behav Brain Res 238, 69-78 (2013)
   PUBMED   23089646
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Ko,J., Soler-Llavina,G.J., Fuccillo,M.V., Malenka,R.C. and
            Sudhof,T.C.
  TITLE     Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent
            synapse elimination in cultured neurons
  JOURNAL   J Cell Biol 194 (2), 323-334 (2011)
   PUBMED   21788371
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Takashima,N., Odaka,Y.S., Sakoori,K., Akagi,T., Hashikawa,T.,
            Morimura,N., Yamada,K. and Aruga,J.
  TITLE     Impaired cognitive function and altered hippocampal synapse
            morphology in mice lacking Lrrtm1, a gene associated with
            schizophrenia
  JOURNAL   PLoS One 6 (7), e22716 (2011)
   PUBMED   21818371
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Linhoff,M.W., Lauren,J., Cassidy,R.M., Dobie,F.A., Takahashi,H.,
            Nygaard,H.B., Airaksinen,M.S., Strittmatter,S.M. and Craig,A.M.
  TITLE     An unbiased expression screen for synaptogenic proteins identifies
            the LRRTM protein family as synaptic organizers
  JOURNAL   Neuron 61 (5), 734-749 (2009)
   PUBMED   19285470
REFERENCE   10 (bases 1 to 2547)
  AUTHORS   Francks,C., Maegawa,S., Lauren,J., Abrahams,B.S., Velayos-Baeza,A.,
            Medland,S.E., Colella,S., Groszer,M., McAuley,E.Z., Caffrey,T.M.,
            Timmusk,T., Pruunsild,P., Koppel,I., Lind,P.A., Matsumoto-Itaba,N.,
            Nicod,J., Xiong,L., Joober,R., Enard,W., Krinsky,B., Nanba,E.,
            Richardson,A.J., Riley,B.P., Martin,N.G., Strittmatter,S.M.,
            Moller,H.J., Rujescu,D., St Clair,D., Muglia,P., Roos,J.L.,
            Fisher,S.E., Wade-Martins,R., Rouleau,G.A., Stein,J.F.,
            Karayiorgou,M., Geschwind,D.H., Ragoussis,J., Kendler,K.S.,
            Airaksinen,M.S., Oshimura,M., DeLisi,L.E. and Monaco,A.P.
  TITLE     LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is
            associated paternally with handedness and schizophrenia
  JOURNAL   Mol Psychiatry 12 (12), 1129-1139 (2007)
   PUBMED   17667961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 22, 2021 this sequence version replaced XM_017592881.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.23575.1,
                                           SRR26360194.709025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               JAXUCZ010000004.1  111259859-111260401
            544-2547            JAXUCZ010000004.1  111260677-111262680
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     gene            1..2547
                     /gene="LRRTM1"
                     /note="leucine rich repeat transmembrane neuronal 1"
                     /db_xref="GeneID:679668"
                     /db_xref="RGD:1585921"
     exon            1..543
                     /gene="LRRTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..2547
                     /gene="LRRTM1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacacactc ctcagaggag ggaaggagcc gggcgctgct ctgcgctccg caaagcaaag
       61 catgagccgg ccaggtttcc gcagctgccc gggacacgaa tggcaggcgt tttccaactg
      121 ggactccaag gtggctgcga ttcgcggtgg tcattgccga tgacattctc cagactgtca
      181 aatcctgggg agtctcgagc cccgagtttg gagttgattt tttccctcaa ccccccaacc
      241 acgtcacagt ctcaactgca gaggaaaaaa aaagggggga ccgaggcagg aaggcgagaa
      301 gcccgggctc ccggcacgta gttgggaaac ttgcgggtcc tagaagtcgc ctcctcgcct
      361 cgccgaccgc ccctgcagcc ccggagcgca gcagcaaagt gagacattgt gcgtctgcca
      421 gatcctcggg ccgcggagca gggctgcctc gggaaacaca gaggggtctt ctctcgccct
      481 gcatataatt agcctacaca caaagggagc agctgaatgg aggttgtcac tcgctggaaa
      541 aggatttctg acccagcgct tccaatggac attctccagt ctctctggaa agattctcgc
      601 taatggattt cctgctactc ggcctctgtc tacactggct gctgaggagg ccctcggggg
      661 tggtcttgtg tctgctgggg gcctgctttc agatgctgcc cgccgccccc agcggatgcc
      721 cggggcagtg tcggtgcgag gggcggctgc tgtactgcga ggcgctcaac ctgaccgagg
      781 cgccccacaa cctgtccggc ctgctgggct tgtctttgcg ctacaacagc ctctcggagc
      841 tgcgcgctgg ccagttcaca gggttaatgc agctcacgtg gctgtatttg gatcacaatc
      901 acatctgctc ggtgcagggg gacgcctttc agaaactgcg ccgagttaag gaactcacac
      961 tgagttccaa ccagatcacc gaactggcca acaccacctt tcggcccatg cccaacctgc
     1021 gcagcgtgga cctgtcctac aacaagctgc aggcgctagc tccggatctc ttccacgggc
     1081 tgcggaagct caccaccctg cacatgcggg ccaatgccat tcaattcgtg ccggtgcgca
     1141 tctttcagga ctgccgcagc ctcaagtttc tcgacattgg atacaatcag ctcaagagtc
     1201 tggcgcgcaa ctctttcgcc ggcttgttca agctcacaga gctacacctg gagcataacg
     1261 acttgatcaa ggtgaacttc gcccatttcc cgcgcctcat ctccctgaac tcgctctgcc
     1321 tgaggcggaa taaggttgcc attgtggtca gctctcttga ctgggtttgg aatttggaga
     1381 aaatggactt gtctgggaac gagatcgaat acatggagcc ccatgtgttc gagaccgtgc
     1441 cgtacctgca gtccctacag ctggactcca accgcctcac ctacattgag ccccgtatcc
     1501 tcaactcctg gaagtccctt acgagcatca ctctagccgg gaacctgtgg gactgcgggc
     1561 gcaacgtgtg tgccctggct tcctggctca gcaacttcca gggacgttac gatgctaact
     1621 tgcagtgcgc cagcccggag tacgcacagg gcgaggacgt cttggatgca gtttatgctt
     1681 tccacttgtg tgaggatggg gccgagccca ccagcggcca cctcctgtcg gcggccgtca
     1741 ctaaccgcag tgacctagcg ccccctgaga gctcagccac gactctggtg gacggtgggg
     1801 aggggctgca cgatagcacg cttgaaccca tcaccgtggc tatccccggc ggtgagcacg
     1861 cagagaacgc agtgcaaatc cacaaggtgg tcacgggcac gatggccctc atcttctcct
     1921 tcctcatcgt ggtcctcgta ctttatgtat cctggaagtg tttcccagcc agcctcaggc
     1981 agctcagaca gtgctttgtc acgcagcgca ggaagcagaa gcagaaacag accatgcatc
     2041 agatggctgc tatgtctgcc caggaatatt atgttgatta caaacccaac cacatcgagg
     2101 gggccctggt tatcatcaac gagtacggct cgtgtacctg tcaccagcag cctgcgaggg
     2161 aatgtgaggt gtgattgtcc aagaggctcc ctacccatgc actaccaaat acgcctgggc
     2221 agccaggcgg gccagcgggc accaggactg gtttcctctg cgctctgatt tgttgactga
     2281 aactgtaagg ggatctctcc cagagacttg acattttagc tttatgtgtc ttaaaaacaa
     2341 acaaacaaac aaaatcccga aataaaacac aacaaaaaac cccaccccat aatcttcagg
     2401 acagtctgtc ttaaatttca tatgagaact tcttcctccc tttgaagata tgtccatatt
     2461 caggaatctg agagtgttaa aaaaggtacc aatcattgat ttttttttgt aaactaaaac
     2521 gtttaaaata aaatagcatt tacagtt
//
