LOCUS       XM_008759615            1887 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus cytochrome P450 2C6 (LOC120093077),
            transcript variant X1, mRNA.
ACCESSION   XM_008759615
VERSION     XM_008759615.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008759615.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008759615.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..1887
                     /gene="LOC120093077"
                     /note="cytochrome P450 2C6; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 176
                     ESTs, 117 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 5 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:120093077"
                     /db_xref="RGD:41261854"
     CDS             1..1473
                     /gene="LOC120093077"
                     /codon_start=1
                     /product="cytochrome P450 2C6 isoform X1"
                     /protein_id="XP_008757837.3"
                     /db_xref="GeneID:120093077"
                     /db_xref="RGD:41261854"
                     /translation="MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQ
                     LNVKNITQSLTSFSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPV
                     AEKINKDLGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTN
                     GSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQFCSF
                     FPVLIDYCPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENH
                     NPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKH
                     RSPCMQDRSRMPYTDAMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPKGTTIITSLS
                     SVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSAGKRMCAGEGLARMELFLFLT
                     TILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL"
ORIGIN      
        1 atggatctgg tcatgttgct ggtgctcact ctcacctgtc ttattctcct gtcaatctgg
       61 agacagagtt ctgggagagg aaagctcccc ccaggcccta ttcctctccc aattattggc
      121 aatatctttc agctaaatgt gaagaacatc acccaatcct taaccagttt ctcaaaagtg
      181 tatggtcctg tatttactct ttactttggc acgaagccca ctgtaatatt gcatggatat
      241 gaagcagtaa aagaagcctt gattgatcat ggggaggagt ttgctgaaag aggaagcttc
      301 ccagtagctg aaaaaattaa taaagacctt ggaattgttt ttagccatgg aaatagatgg
      361 aaagaaataa gacgctttac cctcacgact ctgcggaatt tgggcatggg gaaaaggaac
      421 attgaggatc gtgttcaaga ggaagcacgg tgccttgtgg aggaactgag gaaaaccaat
      481 ggctcaccct gtgaccccac gtttatcctg ggctgtgctc cttgcaatgt catctgctcc
      541 attattttcc agaatcgttt tgattataaa gatcaggatt ttcttaactt gatggaaaaa
      601 ctcaatgaga acatgaagat tttgagcagt ccctggacac agttttgcag ttttttccct
      661 gttttaattg attattgtcc gggaagtcat acgacattag ctaaaaatgt gtatcatatt
      721 agaaactacc ttctgaagaa aataaaagag catcaagaat cactggatgt tacaaatccc
      781 cgggacttta ttgattatta cctaattaag tggaagcagg aaaatcacaa tccacattcg
      841 gaatttacac ttgaaaactt atcaatcact gtgactgatt tgtttggtgc tgggacagag
      901 acaacaagca caacactgag atatgctctg ttgctcctgc tgaagtgtcc agaagtcaca
      961 gctaaagtcc aggaagagat tgatcgtgtg gttggcaaac atcgcagccc ttgcatgcag
     1021 gacaggagcc gcatgcccta cacagatgcc atgattcatg aggtccagag gttcattgac
     1081 ctcattccta ccaacctgcc acatgcggtg acctgtgaca ttaagttcag gaactaccta
     1141 atacccaagg gaacaacaat aataacatca ctctcatcag tgctgcatga cagcaaggaa
     1201 ttccccgacc cagagatatt tgaccctggc cactttttag atgggaatgg aaagtttaag
     1261 aaaagtgact atttcatgcc tttctcagca ggaaaacgga tgtgtgcagg agagggccta
     1321 gcccgcatgg agttattttt attcctgacc acgattttac aaaactttaa gctgaaatct
     1381 gtacttcacc caaaggatat cgatacaact ccagttttca atggatttgc ctctctgcca
     1441 ccattttatg agctgtgctt cattcctctc taaagagatc aaattggctg gggatttagc
     1501 tcagtggtag agcgcttacc taggaagcgc aaggccctgg gttcggtccc cagctccgaa
     1561 aaaaagaacc aaaaaaataa ataaataaat aaataaataa ataaataaat aaagagatca
     1621 aattgcctgg ctccggatgt attgtatttt ctcccttaaa ataactccta cactcctcaa
     1681 gattcaagaa atatacacat tgcattttcc agtttctgga gtcactgctc acatatatct
     1741 gcacttccct attctctgta acagtctccc aatctcatgt acctatgtat atctaaattt
     1801 gagttcttac tgtggtttag ctatagcact ggtaattcac agaaatttat cttctttatg
     1861 ttctcaaaaa taagatcttt tgattga
//
