LOCUS       NM_001103356            2556 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus similar to human chromosome 6 open reading frame
            120 (C1h6orf120), transcript variant 2, mRNA.
ACCESSION   NM_001103356
VERSION     NM_001103356.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Wang,X., Liu,H., Wang,Y., Wang,P., Yi,Y., Lin,Y. and Li,X.
  TITLE     Novel protein C6ORF120 promotes liver fibrosis by activating
            hepatic stellate cells through the PI3K/Akt/mTOR pathway
  JOURNAL   J Gastroenterol Hepatol 39 (7), 1422-1430 (2024)
   PUBMED   38523410
  REMARK    GeneRIF: Novel protein C6ORF120 promotes liver fibrosis by
            activating hepatic stellate cells through the PI3K/Akt/mTOR
            pathway.
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Wu,Y.N., Zhang,R., Song,X.C., Han,X.X., Zhang,J. and Li,X.
  TITLE     C6orf120 gene knockout in rats mitigates concanavalin A-induced
            autoimmune hepatitis via regulating NKT cells
  JOURNAL   Cell Immunol 371, 104467 (2022)
   PUBMED   34896761
  REMARK    GeneRIF: C6orf120 gene knockout in rats mitigates concanavalin
            Ainduced autoimmune hepatitis via regulating NKT cells.
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Zhang,M.K., Ma,H.M., Zhang,J., Song,X.C., Ye,X.H., Li,Y.F.,
            Zhang,Y.F., He,L.L., Wei,H.S. and Li,X.
  TITLE     Deletion of the C6orf120 gene with unknown function ameliorates
            autoimmune hepatitis induced by concanavalin A
  JOURNAL   Cell Immunol 331, 9-15 (2018)
   PUBMED   29748000
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079175.1, JAXUCZ010000001.1 and BG373545.1.
            
            On Aug 29, 2012 this sequence version replaced NM_001103356.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079175.1, SRR26643298.990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2006              BC079175.1         1-2006
            2007-2540           JAXUCZ010000001.1  64625757-64626290
            2541-2556           BG373545.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2556
                     /gene="C1h6orf120"
                     /gene_synonym="C6orf120"
                     /note="similar to human chromosome 6 open reading frame
                     120"
                     /db_xref="GeneID:100125364"
                     /db_xref="RGD:1642424"
     exon            1..101
                     /gene="C1h6orf120"
                     /gene_synonym="C6orf120"
                     /inference="alignment:Splign:2.1.0"
     exon            102..2541
                     /gene="C1h6orf120"
                     /gene_synonym="C6orf120"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..770
                     /gene="C1h6orf120"
                     /gene_synonym="C6orf120"
                     /note="UPF0669 protein C6orf120 homolog"
                     /codon_start=1
                     /product="UPF0669 protein C6orf120 homolog precursor"
                     /protein_id="NP_001096826.1"
                     /db_xref="GeneID:100125364"
                     /db_xref="RGD:1642424"
                     /translation="MATPWRCALLMILASQVVILVKCLEDDDVPEEWLLLHVVQGQIG
                     AGNYSYLRLNHEGKIILRMQSLRGDADLYVSDSTPHPSFDEYELQSVTCGQDVVSIPA
                     HFQRPVGIGIYGHPSHHESDFEMRVYYDRTVDQYPFGEAAYAADQTGTSQKQAYTPEE
                     AAQEEESVLWTILISILKLVLEILF"
ORIGIN      
        1 gactacacta cttccgggcg cggcttctct tccgccagct ggggcgagtt ccaggctgag
       61 cccggatgct gatggtgctg cgtggcctgc ggggcgtggc ggtgcacgca tcttggtctg
      121 cgtggacgag cacctccggt caagtctgtc acccgtgcct tcccagcaca gcgactgcag
      181 atgagggagt ccccgagttg agtgtcccag cgatggctac tccctggagg tgcgccctgt
      241 tgatgatcct ggcatcccag gtggtgatcc tggtaaaatg tttggaagac gacgacgtcc
      301 ctgaggagtg gctccttctg catgtggtcc agggccaaat aggagccggg aattacagct
      361 acttgcggtt gaaccacgag ggtaaaatta ttctcaggat gcagagcctg agaggggatg
      421 cggacctgta tgtgtccgac agcactccgc acccaagctt cgacgagtat gagctgcagt
      481 ctgtcacttg cggccaggac gtagtctcta taccagcaca cttccagcga ccggtcggga
      541 taggaattta tggacaccct tctcaccatg agagcgactt tgagatgagg gtatactatg
      601 acagaactgt ggatcagtac ccattcggag aggctgccta tgccgctgac caaacaggaa
      661 ccagtcagaa gcaagcttac actccagagg aggcagccca agaagaggag tcagtcctct
      721 ggacgatatt gattagcatt ttgaaattgg tgcttgaaat tctcttctga tcccttgaat
      781 atgcgctgga gcacaaaccc ttatttgcac ggatcgatta cagtttgctg tgaaccttgc
      841 tacttgacct ggtgaaattc tggttacttt tttctagact aggatggaaa aataaagcca
      901 tacagttttg ttacctcagt ttactcccca agcaggaaaa gcagcaagca caatatttta
      961 gaaattaaaa ttcctataaa aaggaatctg ctcaatttaa acattttttt aaatacattt
     1021 tggttagtca ggtgagtaaa aagattacag taacaggctg tataaatcag attaaacttt
     1081 cctgctagtg caaaagttaa aaggctgatg actgtagaat ttattctata gacattctaa
     1141 gtgaagtaca gcacttcaag ttttaaagag gtactaaagc caggtcggaa acgcagtgag
     1201 accttcgctc ttcccagagc ctctgcacag tagggatatg gcacctgata tctaagcaag
     1261 atttcctggc agcaagtatt tacagactgt ttgtagctgt gcggtaatga cgattccaaa
     1321 tccagttgta ctagatcttg ggccatttgc cctttcctat gcttagccag attggagccc
     1381 tctagttatt aggtaactat gatcctacct aatcaggtca agacagagtc ataacaagtg
     1441 gtaactttgt tatattcaag aagaaatatt tcaaattaag ttgctacctc tttctgctga
     1501 tctctggaaa aagacaacac taagaaatta atgtctgggg aaatgagcta tttctctgac
     1561 tttctttcaa gggtagaagt tgctaataaa gaaataaatc aactggatgt ttaaggtctt
     1621 agttaatttc aaaaaaagtt ctttattggc ataaaaatga aagtgttgta aataaattgg
     1681 caccaaatat cccaaacacg agggtcaaag cctatttacc cctctttgct gtttttcccc
     1741 cttctgccca ctttcctggg tgttggggga gctcgctgac aacagtcaca aatccagcga
     1801 cctaggagaa aaattgttag ttaatataga gtggactttt atttttatag gactgagtac
     1861 aaaccatcta aactcattcc tgagctacct gtagtgataa ctccctggga gttttcagtg
     1921 ggagggagta gtgactggtt ccttaagtca aagaagaaaa tgtaaacaac ccttaatcag
     1981 tgtgaacttt agtgcatggc caaaaagaaa aaagaaaaaa gactgttatc cttcctaaaa
     2041 ttcaagtacc atcatacttt tgaaacctca acacaattcc taatgtagag actgttaaag
     2101 aagctggctt tctatggcct ctttcttcac tattctaaca gcacttgtgc ttgctctgtc
     2161 tctgtctgtc tctctctctg cgcctgcccc ccccctccat gtctccatgc actttaaaac
     2221 tagcacctag accacatact tgatctgaat tactacagaa acctaagtaa ctattcaagt
     2281 tgcgtatttc taaaggaatt ccaggaacca ttttttaaag agcactatac agtgttagct
     2341 atgcaactaa attcttcata ttgacctgta taatgtttta atagaattac tgtgatttac
     2401 tatttgaatc tgtggccatc ctaaagttat ctggaactgt catgctgcct cactttataa
     2461 aaatgtctta gcatatgtaa agacatagca gtcactttgt taataaataa tctttaaaaa
     2521 taaaatcaaa ccattgagac aaaaaaaaaa aaaaaa
//
