LOCUS       NM_001033695            3389 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus L3MBTL histone methyl-lysine binding protein 2
            (L3mbtl2), mRNA.
ACCESSION   NM_001033695 XM_235769
VERSION     NM_001033695.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Qin,J., Whyte,W.A., Anderssen,E., Apostolou,E., Chen,H.H.,
            Akbarian,S., Bronson,R.T., Hochedlinger,K., Ramaswamy,S.,
            Young,R.A. and Hock,H.
  TITLE     The polycomb group protein L3mbtl2 assembles an atypical
            PRC1-family complex that is essential in pluripotent stem cells and
            early development
  JOURNAL   Cell Stem Cell 11 (3), 319-332 (2012)
   PUBMED   22770845
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Guo,Y., Nady,N., Qi,C., Allali-Hassani,A., Zhu,H., Pan,P.,
            Adams-Cioaba,M.A., Amaya,M.F., Dong,A., Vedadi,M., Schapira,M.,
            Read,R.J., Arrowsmith,C.H. and Min,J.
  TITLE     Methylation-state-specific recognition of histones by the MBT
            repeat protein L3MBTL2
  JOURNAL   Nucleic Acids Res 37 (7), 2204-2210 (2009)
   PUBMED   19233876
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Trojer,P., Li,G., Sims,R.J. 3rd, Vaquero,A., Kalakonda,N.,
            Boccuni,P., Lee,D., Erdjument-Bromage,H., Tempst,P., Nimer,S.D.,
            Wang,Y.H. and Reinberg,D.
  TITLE     L3MBTL1, a histone-methylation-dependent chromatin lock
  JOURNAL   Cell 129 (5), 915-928 (2007)
   PUBMED   17540172
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Markus,J., Feikova,S., Sramko,M., Wolff,L. and Bies,J.
  TITLE     Proliferation-linked expression of the novel murine gene m4mbt
            encoding a nuclear zinc finger protein with four mbt domains
  JOURNAL   Gene 319, 117-126 (2003)
   PUBMED   14597177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033695.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101865.1, SRR26643296.20468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000007.1  115066541-115066583
            44-281              JAXUCZ010000007.1  115068970-115069207
            282-415             JAXUCZ010000007.1  115070413-115070546
            416-539             JAXUCZ010000007.1  115071832-115071955
            540-619             JAXUCZ010000007.1  115072505-115072584
            620-737             JAXUCZ010000007.1  115075474-115075591
            738-872             JAXUCZ010000007.1  115076184-115076318
            873-961             JAXUCZ010000007.1  115076802-115076890
            962-1193            JAXUCZ010000007.1  115081038-115081269
            1194-1270           JAXUCZ010000007.1  115081660-115081736
            1271-1375           JAXUCZ010000007.1  115082060-115082164
            1376-1523           JAXUCZ010000007.1  115082947-115083094
            1524-1606           JAXUCZ010000007.1  115083428-115083510
            1607-1841           JAXUCZ010000007.1  115083840-115084074
            1842-1907           JAXUCZ010000007.1  115084456-115084521
            1908-2018           JAXUCZ010000007.1  115085474-115085584
            2019-3389           JAXUCZ010000007.1  115086250-115087620
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3389
                     /gene="L3mbtl2"
                     /note="L3MBTL histone methyl-lysine binding protein 2"
                     /db_xref="GeneID:300320"
                     /db_xref="RGD:1308569"
     exon            1..43
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2131
                     /gene="L3mbtl2"
                     /note="lethal(3)malignant brain tumor-like 2 protein;
                     l(3)mbt-like 2 protein; l(3)mbt-like protein 2; L3MBTL2
                     polycomb repressive complex 1 subunit"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 2"
                     /protein_id="NP_001028867.1"
                     /db_xref="GeneID:300320"
                     /db_xref="RGD:1308569"
                     /translation="MEKPRGTEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSAGSES
                     SSYLEESSEAENEDREAGELPTSPLHLFSSANNRALDGSGSEPAVCEMCGIVGTREAF
                     FSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHAQG
                     TGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVGCFKHVPLYDQWEDVMKGMKVEV
                     LNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAIN
                     SKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFHIKMVESMKYPFRQGMRLEVVDK
                     TQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSE
                     RRCDMSHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATI
                     CKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPF
                     DWESYLEKTKSKAAPARLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLL
                     SIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNTPQKGKDATKKKKK
                     QFGKKRKRIPSAKTRPLRQSSKKPLLEDNLEALGVSEPVPDDIIAVCVKEEHQDLPSP
                     DRSPSPLLPLPTESIKQERDS"
     exon            44..281
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..415
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..539
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..619
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..737
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..872
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..961
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1193
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1270
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1375
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1523
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1606
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1841
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1907
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2018
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..3389
                     /gene="L3mbtl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaattgaa tttggtatca tggagaagcc gcggggcact gaggagacgc catcttcaga
       61 gccaatggaa gaggaggaag atgatgactt ggaactcttc ggaggctacg atagcttccg
      121 gagttacaac agcagtgcgg gcagtgagag cagctcctac ttggaggagt caagtgaagc
      181 agaaaatgag gatcgggaag caggggagct gcccacctca cctctgcatc tgttcagctc
      241 tgcgaataac cgcgccttgg atggcagtgg ttctgagcca gctgtctgtg agatgtgtgg
      301 tattgtgggc accagagaag ctttcttttc aaagaccaag aggttctgca gtgtctcatg
      361 ttccaggagc tactcttcca actccaagaa agccagtatc ttggctagac ttcagggaaa
      421 gccccccacc aagaaagcca aagtcctgca caaagcagcc tggtccgcca aaattggagc
      481 cttcctccac gcccagggaa caggacagct agcagatggg acacccacag gacaagacgc
      541 tctagtcttg gggttcgact gggggaagtt cctgaaggat cacagttaca aggctgctcc
      601 tgtcggctgc tttaaacacg tacccctcta tgaccagtgg gaggacgtca tgaaggggat
      661 gaaggtagaa gtcctcaaca gcgacgccgt gctccccagc cgggtgtact ggatcgccac
      721 tgtcatccag gcagctgggt accgggtact gctccgatat gaaggctttg agaatgacgc
      781 cagtcatgac ttctggtgca acctggggac tgtggacgtc caccccattg ggtggtgtgc
      841 catcaacagc aagatcctgg tgcctccacg gaccatccat gccaagttta ctgactggaa
      901 gagctacctc atgaagcggt tggtgggatc caggacactt cctgcagatt tccatatcaa
      961 gatggtagaa agcatgaagt acccttttcg gcagggcatg cgcttagagg ttgtagacaa
     1021 gactcaggtg tcacggaccc gcatggctgt ggtggacaca gtaattgggg gtcgcctgcg
     1081 gctcctctat gaggatggtg acagtgatga tgacttctgg tgccatatgt ggagtcccct
     1141 gatccatcca gtgggttggt cacggcgtgt tggccacggc atcaagatgt cagagagacg
     1201 atgtgacatg tctcatcacc ctaccttccg gaaaatctac tgtgatgctg ttccttacct
     1261 cttcaagaag gtccgagctg tctacacaga aggtggttgg tttgaggaag gaatgaaact
     1321 agaggccatt gaccctctga atctgggcaa tatctgtgta gcaaccatct gcaaggtgct
     1381 cctggatggt tacctgatga tctgtgtgga tggggggccg tccacggatg gctcagattg
     1441 gttctgctac cacgcctcct cccacgccat cttcccagcc accttctgcc aaaagaatga
     1501 catcgagctc acacccccaa aagggtatga gacacagcct tttgactggg agagctactt
     1561 agaaaagacc aagtcaaaag cagctccagc gagactcttt aacatggact gccccaacca
     1621 tggcttcaag gtgggcatga agctggaggc tgtggacttg atggagccac ggctcatctg
     1681 tgtggccacc gtgaagcgag tggtgcatcg tctcctgagc atccacttcg atggctggga
     1741 caacgagtat gatcagtggg tggactgcga gtcccccgac atctaccctg ttggctggtg
     1801 tgaactcacc ggctaccagc tccagccgcc cgtgtccgca gaaccaaaca cacctcagaa
     1861 aggcaaggat gccacgaaga agaagaagaa gcagtttggg aagaaaagga aaagaatccc
     1921 gtcagccaag actcggcccc tcagacagag ctccaagaaa cccttactgg aggacaacct
     1981 tgaggctttg ggggtctcgg aaccagttcc tgatgacatc atcgctgtgt gtgtgaaaga
     2041 ggagcaccag gacctgccct cgcctgacag gtcacccagt ccactgctgc ctctccccac
     2101 cgagagtatc aagcaagaaa gggacagctg agacttccct ggcatcagcc tggaggctgc
     2161 ctgaagccaa gcctggtcac gagcaaagag ggggccggct ttactgttct gcagcaagtg
     2221 tccagggcct ccctccgccc tctgcacagg cctgctgaca ggtcagcttg agttctaagc
     2281 tggcacactc attgcacctc agcacactgg aaaacgagac tgatccccat gtgtctaccc
     2341 aggcgagtgg tggaagtaag gctatggagc agctgtaggt gggcagccca tgctgacgct
     2401 gggtgtggac atagccacct ctgcccaaaa taaattgagc atcctatacc tcctgggggc
     2461 accctgcctg atgtcccagg agccccactg tggcaggtga ttgaccaagg tagtgggttt
     2521 gaactttgac ctcagggatg gcaagaacac tgacgtcttt cttagaggga atggttggga
     2581 agacatatag ggacctgtgg ccctaaggga aacatgggcc aggctgcctg ctgttgggca
     2641 caggaccaga cagtagttga cccatgcagt ctggggtgct gactgagacc atcctctaga
     2701 gctgagcttg ggttggacct aaggtttcca ttcccctgcc tggtcagcag ggccactgct
     2761 cagcataccg tcgctacagt gttggctttt gatttcccac ttagacactt tagttgtttt
     2821 tttttgtttt gttttgtttt gttttctgga gctggggacc gaacccaggg ccttgtgctt
     2881 gctaggcaag cactctacca ctgagctaaa tccccagccc ctagttgttt atttttgaga
     2941 cagggtctat gtagtacttg ctgttctgga gcttgagatg tagcccatgc agataaactg
     3001 atagggatcc ccctgtctcc gcctcctcgt gctgggataa agctgtgcgt ccagccccca
     3061 gctagacact ttggaactgg tggtgtagcc ctcagtatca tcttgaacac cagttggggc
     3121 tcctgcagtg ccctttgtgc ttcactgggt tttggacgaa gcagtgaggc ccctgcttcc
     3181 tgtcatgtag tgactgtagt gtgctgcgtg actatctcgg tcaagtcccg tcaagaagat
     3241 gaaagtccac agcaaaaggc aggttcgatt cccagtgcct gctcacagct gcctgtatct
     3301 tgatctgcag gggaccctgt gcctctggtt tctgtggata caaatgtgta tgcccttaaa
     3361 aatcattaaa aaaaaaaaaa aactttgaa
//
