LOCUS       NM_001419616            5153 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus L3MBTL histone methyl-lysine binding protein 1
            (L3mbtl1), mRNA.
ACCESSION   NM_001419616
VERSION     NM_001419616.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5153)
  AUTHORS   Panier,S. and Boulton,S.J.
  TITLE     Double-strand break repair: 53BP1 comes into focus
  JOURNAL   Nat Rev Mol Cell Biol 15 (1), 7-18 (2014)
   PUBMED   24326623
  REMARK    Review article
REFERENCE   2  (bases 1 to 5153)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 5153)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   4  (bases 1 to 5153)
  AUTHORS   Zeng,H., Irwin,M.L., Lu,L., Risch,H., Mayne,S., Mu,L., Deng,Q.,
            Scarampi,L., Mitidieri,M., Katsaros,D. and Yu,H.
  TITLE     Physical activity and breast cancer survival: an epigenetic link
            through reduced methylation of a tumor suppressor gene L3MBTL1
  JOURNAL   Breast Cancer Res Treat 133 (1), 127-135 (2012)
   PUBMED   21837478
REFERENCE   5  (bases 1 to 5153)
  AUTHORS   Acs,K., Luijsterburg,M.S., Ackermann,L., Salomons,F.A., Hoppe,T.
            and Dantuma,N.P.
  TITLE     The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing
            L3MBTL1 from DNA double-strand breaks
  JOURNAL   Nat Struct Mol Biol 18 (12), 1345-1350 (2011)
   PUBMED   22120668
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5153)
  AUTHORS   Kalakonda,N., Fischle,W., Boccuni,P., Gurvich,N., Hoya-Arias,R.,
            Zhao,X., Miyata,Y., Macgrogan,D., Zhang,J., Sims,J.K., Rice,J.C.
            and Nimer,S.D.
  TITLE     Histone H4 lysine 20 monomethylation promotes transcriptional
            repression by L3MBTL1
  JOURNAL   Oncogene 27 (31), 4293-4304 (2008)
   PUBMED   18408754
REFERENCE   7  (bases 1 to 5153)
  AUTHORS   Trojer,P., Li,G., Sims,R.J. 3rd, Vaquero,A., Kalakonda,N.,
            Boccuni,P., Lee,D., Erdjument-Bromage,H., Tempst,P., Nimer,S.D.,
            Wang,Y.H. and Reinberg,D.
  TITLE     L3MBTL1, a histone-methylation-dependent chromatin lock
  JOURNAL   Cell 129 (5), 915-928 (2007)
   PUBMED   17540172
REFERENCE   8  (bases 1 to 5153)
  AUTHORS   MacGrogan,D., Kalakonda,N., Alvarez,S., Scandura,J.M., Boccuni,P.,
            Johansson,B. and Nimer,S.D.
  TITLE     Structural integrity and expression of the L3MBTL gene in normal
            and malignant hematopoietic cells
  JOURNAL   Genes Chromosomes Cancer 41 (3), 203-213 (2004)
   PUBMED   15334543
REFERENCE   9  (bases 1 to 5153)
  AUTHORS   Boccuni,P., MacGrogan,D., Scandura,J.M. and Nimer,S.D.
  TITLE     The human L(3)MBT polycomb group protein is a transcriptional
            repressor and interacts physically and functionally with TEL (ETV6)
  JOURNAL   J Biol Chem 278 (17), 15412-15420 (2003)
   PUBMED   12588862
REFERENCE   10 (bases 1 to 5153)
  AUTHORS   Koga,H., Matsui,S., Hirota,T., Takebayashi,S., Okumura,K. and
            Saya,H.
  TITLE     A human homolog of Drosophila lethal(3)malignant brain tumor
            (l(3)mbt) protein associates with condensed mitotic chromosomes
  JOURNAL   Oncogene 18 (26), 3799-3809 (1999)
   PUBMED   10445843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMN14984031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000003.1  172021416-172021487
            73-238              JAXUCZ010000003.1  172022535-172022700
            239-384             JAXUCZ010000003.1  172025034-172025179
            385-599             JAXUCZ010000003.1  172025521-172025735
            600-714             JAXUCZ010000003.1  172026032-172026146
            715-862             JAXUCZ010000003.1  172026310-172026457
            863-980             JAXUCZ010000003.1  172026601-172026718
            981-1062            JAXUCZ010000003.1  172027418-172027499
            1063-1151           JAXUCZ010000003.1  172036816-172036904
            1152-1256           JAXUCZ010000003.1  172037392-172037496
            1257-1392           JAXUCZ010000003.1  172038307-172038442
            1393-1484           JAXUCZ010000003.1  172038771-172038862
            1485-1636           JAXUCZ010000003.1  172041207-172041358
            1637-1713           JAXUCZ010000003.1  172041754-172041830
            1714-1799           JAXUCZ010000003.1  172042506-172042591
            1800-1910           JAXUCZ010000003.1  172042757-172042867
            1911-2025           JAXUCZ010000003.1  172043300-172043414
            2026-2125           JAXUCZ010000003.1  172043768-172043867
            2126-2323           JAXUCZ010000003.1  172044022-172044219
            2324-2373           JAXUCZ010000003.1  172044327-172044376
            2374-2531           JAXUCZ010000003.1  172047000-172047157
            2532-2594           JAXUCZ010000003.1  172047594-172047656
            2595-5153           JAXUCZ010000003.1  172050623-172053181
FEATURES             Location/Qualifiers
     source          1..5153
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5153
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /note="L3MBTL histone methyl-lysine binding protein 1"
                     /db_xref="GeneID:311613"
                     /db_xref="RGD:1307316"
     exon            1..72
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            73..238
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            239..384
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..2729
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /note="H-l(3)mbt protein; L(3)mbt protein homolog;
                     L3MBTL1, histone methyl-lysine binding protein"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 1"
                     /protein_id="NP_001406545.1"
                     /db_xref="GeneID:311613"
                     /db_xref="RGD:1307316"
                     /translation="MEGHSDMEIIRAVKGSATGEINVHLVARDSAGSHPHLPTTTFII
                     PTNAATLGLPSTALDVSYPREPVHVGAAERVAGSEPVTATILPQLSTGPGTNSTVRLL
                     DWTGVSAPLAGSGMRFRINEYATQNMIEIERPRSPEQRHEGGTAGREADIQHPDVHKD
                     PQEVIPQEPSVDAGSCKCQTCGPQQSIGLDVGSSGDRCPQPFQKRSVIVENSGCTVAS
                     ELIKPMKKRKHKEYQSPSEESEPEAMKQGKGKDPDREPTPGTSENEEWSRSQLVSSEK
                     KEGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGVDPQHPSMYFVLTV
                     AEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQ
                     YLRSTKAQAAPKHLFVSQSHSPPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVASRFL
                     VHFDDWDDTYDYWCDASSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTS
                     AVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDF
                     WIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSASPGGCPPLSHRSPPHTKTSKYSFH
                     HRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSETTARKKNQSNLS
                     PRKKPRHQGRIGRPPKYRKMPDEDFQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHC
                     KLLPGVAGISASAVSKWTIEEVFGFVQTLTGSEDQARLFKEEMIDGEAFLLLTQADIV
                     KIMSVKLGPALKIYNAILMFKNNDDVFK"
     exon            385..599
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            600..714
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            715..862
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            863..980
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1062
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1151
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1256
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1392
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1484
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1636
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1713
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1799
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1910
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2025
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2125
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2323
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2373
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2531
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2594
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..5153
                     /gene="L3mbtl1"
                     /gene_synonym="L3mbtl; RGD1307316"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtgcgca ggcgcgcgcc gcaccaggct cccacggtcg ctcggtgcgg gcggcaaccg
       61 ccagccttgc aggtaggatt ccctggaatc acagactagg tttatgagag tagccttgtg
      121 aaaccagcaa gattgggcag agatggtgaa atgctgacct agtcccggca gaggcctcag
      181 cctggggagc aggaagccct gaacctgata tggccctgca gagacccctc aaatgaagac
      241 gcaaccagat ggaggggcac agtgacatgg aaataataag ggcagtgaaa gggtctgcca
      301 cgggggagat caacgtacac ctggtggcca gagacagcgc gggttcccac cctcacctgc
      361 ctacaaccac cttcatcatt cctaccaatg cagctaccct tggtctgcct agcactgccc
      421 tggatgtgtc ctacccccgg gagccagtcc acgtgggcgc agcggagcga gtggctggca
      481 gcgaacccgt cacagccacc attctgccac agctgagcac cggaccaggg accaatagca
      541 cagtcaggct tctggactgg acaggggttt ctgcaccttt agctgggagc ggcatgaggt
      601 tccggataaa cgagtacgcg acacagaaca tgatcgaaat agagcggcca cgaagcccag
      661 agcagcgaca tgagggtggc acggctggaa gagaagcaga catccagcac cctgatgttc
      721 acaaggaccc tcaagaagtc attcctcagg aaccttcagt agacgcaggt tcttgcaagt
      781 gccagacttg tgggccccaa caaagtattg gtctagacgt tggttcatcc ggagaccggt
      841 gtcctcagcc tttccagaag cggtcagtca tagttgagaa ctcaggctgt accgtcgctt
      901 ctgagctgat aaaacccatg aaaaagagga aacataagga gtatcagagc ccgtcagagg
      961 agtccgagcc ggaggccatg aagcaaggaa aaggaaaaga cccagacaga gagcccaccc
     1021 cgggcacctc agagaatgag gagtggagca gaagccagct ggtgtccagt gagaagaagg
     1081 aaggctggtc ctgggagtcc tacctggagg agcagaaggc agtcacggcc ccagttagcc
     1141 tcttccagga ctcccaggca gtcacccata acaagaatgg cttcaaactg ggcatgaagc
     1201 tagagggcgt tgacccccaa cacccgtcca tgtacttcgt cctcactgtg gctgaggtgt
     1261 gtggctaccg cctgcgtctg cactttgatg gctactctga gtgccatgac ttctgggtca
     1321 atgccaactc cccggacatt catcctgccg gctggtttga gaagactgga cacaagctgc
     1381 agcctcccaa aggttacaag gaggaggagt tcagctggag ccagtacctg cgcagcacga
     1441 aagctcaggc agcccccaag catctgtttg tgagccagag ccacagtcct ccgccggtgg
     1501 gcttccaggt gggcatgaag ctagaagctg tggaccgcat gaacccatcc ctcgtgtgtg
     1561 tggccagcgt gaccgatgtg gtggccagcc gcttcctggt gcactttgat gactgggacg
     1621 atacttatga ctactggtgt gatgccagca gcccctacat ccacccagta ggctggtgcc
     1681 agaagcaagg aaagcccctt acccctccac aagactaccc agaccctgac agcttctgct
     1741 gggagaaata tctagaagaa actgggacct cagctgtgcc cacttgggcc ttcaaagtgc
     1801 gaccccctca cagcttcctg gtcaacatga agctggaggc tgtagaccgc cggaacccag
     1861 cactgattcg ggtagccagt gtggaggatg tggaggatca ccggataaag ctccactttg
     1921 atggctggag tcacaactat gatttctgga ttgatgctga tcacccggac atccatcctg
     1981 caggctggtg ctccaagaca ggacatcccc tggagcctcc tctccggccc agagagtcca
     2041 gctctgcctc ccctggggga tgcccccctc tcagccacag gagcccaccc cacacaaaga
     2101 cctccaagta tagctttcac caccggaagt gccccactcc tggctgtgac ggctccggcc
     2161 atgtcactgg taagttcaca gctcatcact gcctctctgg ctgcccactg gctgagagga
     2221 accagagccg gctgaaagcg gagctgtccg actcagagac cacagccagg aagaagaacc
     2281 agtctaattt gtccccaagg aaaaagcctc gccatcaagg ccggattgga cgccctccaa
     2341 agtatcgcaa gatgccagat gaagatttcc aagccctccc tcccagtgtg gtacaccagt
     2401 ccctcttcat gtccaccttg ccgacccacg ctgatcgccc actgtctgtg tgctgggagc
     2461 aacactgcaa gctgttgcca ggagtggcag gcatctcagc ctccgcagtc tccaagtgga
     2521 ccatcgaaga ggtctttggc ttcgttcaga ccttgacggg ctctgaggac caagcgcgcc
     2581 tcttcaaaga ggagatgatt gacggcgagg ccttcctttt gctgacacag gcggatattg
     2641 tgaagatcat gagtgtcaag ctgggcccag ctttgaagat ctataatgcc attctcatgt
     2701 tcaaaaacaa tgacgatgtc tttaagtgac tgactggggg gggggggcag tgtggaatgc
     2761 tcctcccacc ctcgctgggc tccctctgca gatggtgctt ctctcccaac ttgagttctg
     2821 cacccctgcc ctcactgtct gactaggtgt acgggagcag aggcgcccag ggaagagggt
     2881 ctaagtcctc agtcctggag ttcatttgtc tccagttgcc ccagggaggg tgtgactaaa
     2941 ctgaggcctg actgacagaa agggctgcac gtatcctgac tagggcagcc accttggtta
     3001 tcgtcttagg aagtagaaag acatggtagg cagtctctat tcagacctat gtccttcttg
     3061 gcatctcgat gccctttctc ctcctcggac cctctcttcc tattaagaag tgaccatgac
     3121 cttggcatac atatttacac atgaaaggtg cctcctccct ttctgctggt agctatgtac
     3181 ccttgctccc cattcatggt ccagccaggc cccatggctc ttcccctgta gatgcttaag
     3241 tctcagaaat atgggaactt cctactagga gcctctggct gtctaggcag agattcagaa
     3301 ccaaggcacc ttcctgaaca cattcagttc aggatcactg agcactgaag tgggcatacg
     3361 gagtgagcag atggttaaag cccctgtcat aacaagcagg gtctaagtcc cctgatgctt
     3421 tctctgttgg gtgtggggag aagcctggcc tgactagcag tccaggctag gatatcgtca
     3481 gacacatcgg cgtctttgac ctgaagagta gctccagaaa gcacgacagc agcatccttc
     3541 tctctgtgtc tgtggatctc agccaagata tcacacatga gggagagtcc cctgccagcc
     3601 cagcctgcca gtagagtgta gccgtccagc atacaacccc tgtgacatca cgtccactct
     3661 gtcccttaaa cgtttttcat tttgctctta agactaacaa aggccactta cagtagaaag
     3721 ttggaaaggt cccctctcct ggcctttcct gccagtctcc aacagtctct cactgccagc
     3781 taggttcctg ctggggctct aggacttgga cctttccgtc cgagtagaga ttcagcctct
     3841 gctcaattac tgccaaaccc gcctcccagc ctaagcgggg agtgccagag cccaataggt
     3901 gggaaccagt gccaagcatc atctggtgct gaggtgggcc cgcaggctga agagcagggt
     3961 cgtcccccag tctggtatac ttctaagtcg tggtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4021 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtacaggt gttggtcatt ccgcagtgtc
     4081 tgtcaggtgc agtgttggga ctattaaggg cgactgttaa actgtgaggc tttattattt
     4141 cctcagaaat gggaagccaa aagtcctttc tccagtgctt tggggacctc cccgccctaa
     4201 gccagacagc ttctggggaa cagcccagtg gcacccagct agtctggcag aggctcagat
     4261 ttcctttccc tctcagccct cgggggtaac tgagctctga gcataatcct tctaggaggg
     4321 caccggacaa ggctggccaa gtggggtggg tgacagatgt gacaccactg cccctttgcc
     4381 actctctctc caatctcagt tgtctgggct gcggtggaac ctaccacccc ctggccttta
     4441 gtctgcccgc cacactctga cgggtctgag gcagcaagcg ttctgtgttc tttggctggt
     4501 gctgtgacac tacacagctc ccgaggaagg gactgttcag ctctgccagt gatgaccgcc
     4561 tgtgggaaag accagacgga ctgacggccg tggagaagac gactcacccc ttccacaata
     4621 ataccagaaa ccaaatctta aaaagtcaaa cctgccgtcc gaccatcccc cacccatcca
     4681 cgacactggg tccccagacg agaccattgc accttaacct gggcgcgcag gcagtgggtg
     4741 gctgtttctg gcccttgtac cctgaccact agcaacagga actactcacc ctttgtcctc
     4801 aacaggcttg tcccgcctcg gcccagccct ggcctaggac agagatgaac tctgtttaat
     4861 ttccaaggca gagagaatgg ttccagagtc tgacaatgaa acctgtttgc aaattcattc
     4921 acacgcaccg tgacacgggg ttacattttt tttttactta cactgtgcgc gtatgtctct
     4981 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gctctcaagt gtacattctt aaagaaaatc
     5041 ctctggtttg aactaaagta actcttgaga gaggaaacag tacaaagaaa atatagtgag
     5101 atttgtctgt gtattgaaac aacacaaaaa aataaatggt tgaccagtct gta
//
