LOCUS       NM_001399842            3117 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus LINE-1 type transposase domain containing 1
            (L1td1), mRNA.
ACCESSION   NM_001399842 XM_001063462
VERSION     NM_001399842.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Moszczynska,A., Flack,A., Qiu,P., Muotri,A.R. and Killinger,B.A.
  TITLE     Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the
            Neurogenic Zones of the Adult Rat Brain
  JOURNAL   Sci Rep 5, 14356 (2015)
   PUBMED   26463126
  REMARK    GeneRIF: The present study demonstrates that systemic
            administration of neurotoxic METH doses increases the activity of
            Long INterspersed Element (LINE-1) in two neurogenic niches in the
            adult rat brain in a promoter hypomethylation-independent manner.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 18, 2022 this sequence version replaced XM_001063462.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2760863.1,
                                           SRR26360172.2407631.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000005.1  118488688-118488770
            84-166              JAXUCZ010000005.1  118489344-118489426
            167-1145            JAXUCZ010000005.1  118495309-118496287
            1146-3117           JAXUCZ010000005.1  118499620-118501591
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3117
                     /gene="L1td1"
                     /note="LINE-1 type transposase domain containing 1"
                     /db_xref="GeneID:685355"
                     /db_xref="RGD:1595093"
     exon            1..83
                     /gene="L1td1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..166
                     /gene="L1td1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..1145
                     /gene="L1td1"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2759
                     /gene="L1td1"
                     /codon_start=1
                     /product="LINE-1 type transposase domain-containing
                     protein 1"
                     /protein_id="NP_001386771.1"
                     /db_xref="GeneID:685355"
                     /db_xref="RGD:1595093"
                     /translation="MSGVQSKAARLQKEQKEKPSADGERKMATSPCLKHNDVPAAMMK
                     QFNALMEMQDAMFAEMRETYKNDIKEVLLQRAAPWVKLLEERIEQQRDAVSERPKPGE
                     KVEEERSGTDEDTENITVRSKEKRKPERKQDKAKQLNSSPVVKPSLERAGDALHRERG
                     RCGESSSLVDTLERESVKSADERPAEEPGCQREENRLKAPEESTPEGAGATLRLAADF
                     SAATLDIGRRWGQVFRLLRERELEPELQCTVKLAFKCDGEAKVFSDLHSLRQFANRKP
                     FLKELLKDVFPQNETRSEGGRRNELQERLGKTLGDTKHEARRMASDSLSFLFIKEVKV
                     ESPEVKTYEEETLDQKDKETLKKQEASRLEGEEEISGKQGEETSEGEASELGEEEGSE
                     EEEEEEGSESEEEEDSGEEEEEEENSEMGKKEETLVLHDARGSTFQGLTVTEEHCDEK
                     ITRSAEEIGLVSLVVDSESEEEGNRKTSSQTKKKETFHGLKELAFSYLVWDSKGKKLV
                     KCQDGGAAAESGQRFGIPCLTLYLASPSESLGAGSDGPKGCSRTKSSVPSQATPLLMN
                     TEKGRCKTPQIEELMGKEADLIHETEENFRRGVIGVIRQMQREVENIKNLYFSDILNM
                     KSSMDDLNSLACMIEARVNEQEDALEGLAKETLQLAKEIVDKERLREREDRLRSSNIR
                     VIGIPEKENRENGAEDIIKEVIEENFAELEDQSLEIVSAHRIPNSVDEHRLTPRHILV
                     KFWNTGDKQRILKASRAKKEITYRGTKIRLTADLSPSTIDARSQWSSIIKILQEEGFQ
                     PKILYPAKLAFDFKGKTKVFLDIEEFKKFISDIPYLKELFNNMP"
     exon            1146..3117
                     /gene="L1td1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgagtc tctcctgcgc tcagacgccg gccctgcttt tgttggcgcg tgtgacctcc
       61 tggctggacc tcgtggctcc caggtgctgt gggacgccag tgtaggtgga cagatcaatc
      121 ctgacctgag gagagctggt tccttcctgg ggaaggcaca gatttgaatt tttgaccttc
      181 tgaagctctc gccaggagaa gaaggtgcac tccgtgttag tgtatccacc atgtcaggcg
      241 tgcaatccaa agcggctagg cttcaaaagg agcagaaaga aaagccatca gcagatgggg
      301 aaaggaaaat ggccacatct ccgtgtttaa agcacaacga cgtaccggca gccatgatga
      361 agcagtttaa tgctttgatg gaaatgcaag atgcaatgtt tgcagagatg agagaaacct
      421 ataaaaatga tataaaggaa gtgctgttgc aacgcgcagc accctgggtg aagcttctgg
      481 aagagcggat agaacagcaa agagatgcag tctcagaaag gccaaagcca ggagagaaag
      541 tggaagagga gcgttctgga acagacgagg acactgaaaa cataactgtg agaagcaagg
      601 agaagaggaa gccggagagg aagcaggaca aagctaaaca actcaacagc agccctgttg
      661 tgaaaccgtc actagagaga gcaggagacg ccctgcatcg tgaacgcggg aggtgtggag
      721 agagcagcag ccttgtagac actctagaga gggagtccgt gaagagtgcg gatgagagac
      781 cggccgaaga gcccggctgt cagagagaag agaaccgtct aaaggccccc gaagagagca
      841 cgccggaagg agccggagca accctgaggc tggccgctga cttctccgca gccactctgg
      901 atatcggcag gcggtggggc caagtcttcc gccttctgag agaacgggaa ttggagcccg
      961 agttgcagtg cacggtgaag ttggcattta agtgtgacgg tgaagcaaag gttttctcag
     1021 acctccacag cctccgacaa tttgccaaca gaaagccttt tctgaaggag ttgctgaaag
     1081 atgtgttccc gcaaaacgag acgagaagtg aaggaggcag aagaaacgag cttcaagaaa
     1141 gattgggtaa aactctagga gacacgaagc acgaagctag aagaatggca agtgacagtt
     1201 tgagtttcct gttcatcaaa gaggtaaaag tggaaagtcc agaggtgaag acttacgaag
     1261 aagaaacact ggatcagaaa gataaagaaa ctctcaagaa gcaagaggcc tcaaggctag
     1321 agggggaaga agaaatctca gggaaacagg gagaagaaac ttcagaggga gaggcctcag
     1381 agttggggga ggaggagggt tcagaggagg aagaagagga ggagggttca gagtcagaag
     1441 aggaggagga ctcaggggag gaggaagagg aggaagagaa ctcagaaatg gggaaaaagg
     1501 aagaaacctt ggtactacat gacgctcgag gctcaacctt tcagggcctt actgtgacag
     1561 aagagcattg cgatgagaaa atcaccagga gtgctgagga gattggttta gttagtttgg
     1621 tggtagactc tgaatcagag gaagaaggaa acagaaagac gtcttctcag actaagaaaa
     1681 aggagacctt ccatggactt aaagaacttg cctttagtta cctggtttgg gactctaagg
     1741 gaaaaaagct ggtgaaatgc caggatggtg gagcagctgc cgagtctggt caaaggtttg
     1801 ggataccgtg tctgacctta tatttggctt ctccatctga atctctaggg gcaggtagtg
     1861 atggtcctaa aggctgttca cgtacaaagt cgagtgttcc gtctcaagcc actccacttc
     1921 taatgaacac agaaaaaggg aggtgcaaga caccgcaaat agaagagcta atgggcaaag
     1981 aggcagactt gatccatgaa accgaagaaa actttagaag aggcgtgatc ggtgttatca
     2041 gacagatgca gagggaggtg gaaaatatca aaaaccttta cttttcagat atcctaaaca
     2101 tgaaaagctc aatggatgat ctgaattcct tagcgtgcat gattgaagca agggtgaacg
     2161 aacaggaaga tgccttggag gggttggcca aggagacact gcagttggcc aaggagattg
     2221 ttgataaaga aaggctgaga gagagagagg acagattgcg gagctccaac atccgagtga
     2281 tagggattcc agagaaggaa aaccgggaga acggagcaga ggacataatc aaggaagtaa
     2341 ttgaagaaaa ctttgctgag ctggaagacc agagtctcga gattgtcagt gcccatcgaa
     2401 tccccaactc agtggatgag cacaggctca cgccgagaca catcttggtg aagttttgga
     2461 atactggcga taagcagaga attctaaaag cttccagagc caaaaaagaa ataacctaca
     2521 gaggaaccaa gatcaggctg acagccgact tatcacctag tactatagat gcaaggagtc
     2581 agtggtccag catcataaaa attctgcaag aagaaggctt tcaaccgaaa atcctttatc
     2641 ctgccaaact ggcatttgat tttaaaggta aaaccaaggt atttttggat attgaagaat
     2701 tcaagaagtt tatctcagat attccctatt tgaaagaact gtttaacaat atgccttagc
     2761 aatctggagt gctttctgtc taccaaaaca catccaaaag gtagagtcag acagtgcacc
     2821 atggcgtctc tgtcctgaaa agctgacttt ttgcccccag ggaaaggggc tgggggagca
     2881 atgtcactcc ctgcaggttg gttgacttag acagcgcgtg tagcttttca ataggtatct
     2941 accttggtaa agaggcaact tgtcagtgta accacacaca gggaatacta ctagaggcca
     3001 cagtgggatg ggaaaggaca cagtaagtta gaagagactg gctacccagg ctgactgaac
     3061 caacagatta cattacttta tttttctgcc attgtatatt aaagcttgaa gtttgaa
//
