LOCUS       NM_017345               5079 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus L1 cell adhesion molecule (L1cam), mRNA.
ACCESSION   NM_017345 XM_346879
VERSION     NM_017345.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5079)
  AUTHORS   Gallo,P.N., Mihelc,E., Eisert,R., Bradshaw,G.A., Dimek,F.,
            Leffler,A., Kalocsay,M. and Moiseenkova-Bell,V.
  TITLE     The dynamic TRPV2 ion channel proximity proteome reveals functional
            links of calcium flux with cellular adhesion factors NCAM and L1CAM
            in neurite outgrowth
  JOURNAL   Cell Calcium 121, 102894 (2024)
   PUBMED   38728789
  REMARK    GeneRIF: The dynamic TRPV2 ion channel proximity proteome reveals
            functional links of calcium flux with cellular adhesion factors
            NCAM and L1CAM in neurite outgrowth.
REFERENCE   2  (bases 1 to 5079)
  AUTHORS   Platek,R., Grycz,K., Wieckowska,A., Czarkowska-Bauch,J. and Skup,M.
  TITLE     L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan
            and Up Regulates Structural Plasticity-Related Genes Rostral and
            Caudal to the Complete Spinal Cord Transection
  JOURNAL   J Neurotrauma 37 (3), 534-554 (2020)
   PUBMED   31426714
  REMARK    GeneRIF: L1 Cell Adhesion Molecule Overexpression Down Regulates
            Phosphacan and Up Regulates Structural Plasticity-Related Genes
            Rostral and Caudal to the Complete Spinal Cord Transection.
REFERENCE   3  (bases 1 to 5079)
  AUTHORS   Emmert,A.S., Vuong,S.M., Shula,C., Lindquist,D., Yuan,W., Hu,Y.C.,
            Mangano,F.T. and Goto,J.
  TITLE     Characterization of a novel rat model of X-linked hydrocephalus by
            CRISPR-mediated mutation in L1cam
  JOURNAL   J Neurosurg 132 (3), 945-958 (2019)
   PUBMED   30738385
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5079)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 5079)
  AUTHORS   White,K.M., Sabatino,J.A., He,M., Davis,N., Tang,N. and Bearer,C.F.
  TITLE     Toluene disruption of the functions of L1 cell adhesion molecule at
            concentrations associated with occupational exposures
  JOURNAL   Pediatr Res 80 (1), 145-150 (2016)
   PUBMED   27027721
  REMARK    GeneRIF: toluene inhibits L1-lipid raft interactions at
            occupationally relevant concentrations and may lead to a fetal
            solvent spectrum disorder similar to fetal alcohol spectrum
            disorder
REFERENCE   6  (bases 1 to 5079)
  AUTHORS   Shults,C.W., Alberti,L., Kimber,T.A. and Stallcup,W.B.
  TITLE     Mesostriatal dopaminergic axons transiently express high levels of
            NILE during development
  JOURNAL   Exp Neurol 116 (3), 275-285 (1992)
   PUBMED   1350253
REFERENCE   7  (bases 1 to 5079)
  AUTHORS   Tocco,M.D., Fujita,K. and Guroff,G.
  TITLE     Effect of dexamethasone on the nerve growth factor-induced increase
            in the NILE glycoprotein in PC12 cells
  JOURNAL   J Neurosci Res 31 (1), 28-32 (1992)
   PUBMED   1377284
REFERENCE   8  (bases 1 to 5079)
  AUTHORS   Miura,M., Kobayashi,M., Asou,H. and Uyemura,K.
  TITLE     Molecular cloning of cDNA encoding the rat neural cell adhesion
            molecule L1. Two L1 isoforms in the cytoplasmic region are produced
            by differential splicing
  JOURNAL   FEBS Lett 289 (1), 91-95 (1991)
   PUBMED   1894011
REFERENCE   9  (bases 1 to 5079)
  AUTHORS   Prince,J.T., Milona,N. and Stallcup,W.B.
  TITLE     Characterization of a partial cDNA clone for the NILE glycoprotein
            and identification of the encoded polypeptide domain
  JOURNAL   J Neurosci 9 (5), 1825-1834 (1989)
   PUBMED   2723751
REFERENCE   10 (bases 1 to 5079)
  AUTHORS   Prince,J.T., Milona,N. and Stallcup,W.B.
  TITLE     Characterization of a partial cDNA clone for the NILE glycoprotein
            and identification of the encoded polypeptide domain
  JOURNAL   J Neurosci 9 (3), 876-883 (1989)
   PUBMED   2466966
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_017345.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000021.1  156764808-156764983 c
            177-191             JAXUCZ010000021.1  156761773-156761787 c
            192-297             JAXUCZ010000021.1  156760770-156760875 c
            298-497             JAXUCZ010000021.1  156760328-156760527 c
            498-620             JAXUCZ010000021.1  156758935-156759057 c
            621-791             JAXUCZ010000021.1  156758670-156758840 c
            792-903             JAXUCZ010000021.1  156757951-156758062 c
            904-1088            JAXUCZ010000021.1  156757643-156757827 c
            1089-1220           JAXUCZ010000021.1  156757354-156757485 c
            1221-1364           JAXUCZ010000021.1  156757075-156757218 c
            1365-1476           JAXUCZ010000021.1  156756372-156756483 c
            1477-1643           JAXUCZ010000021.1  156756098-156756264 c
            1644-1800           JAXUCZ010000021.1  156755841-156755997 c
            1801-1925           JAXUCZ010000021.1  156755517-156755641 c
            1926-2036           JAXUCZ010000021.1  156755247-156755357 c
            2037-2234           JAXUCZ010000021.1  156754827-156755024 c
            2235-2305           JAXUCZ010000021.1  156754509-156754579 c
            2306-2528           JAXUCZ010000021.1  156754111-156754333 c
            2529-2644           JAXUCZ010000021.1  156752810-156752925 c
            2645-2846           JAXUCZ010000021.1  156752402-156752603 c
            2847-2969           JAXUCZ010000021.1  156752185-156752307 c
            2970-3143           JAXUCZ010000021.1  156751922-156752095 c
            3144-3263           JAXUCZ010000021.1  156751657-156751776 c
            3264-3425           JAXUCZ010000021.1  156751386-156751547 c
            3426-3563           JAXUCZ010000021.1  156750919-156751056 c
            3564-3636           JAXUCZ010000021.1  156750532-156750604 c
            3637-5079           JAXUCZ010000021.1  156748597-156750039 c
FEATURES             Location/Qualifiers
     source          1..5079
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..5079
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /note="L1 cell adhesion molecule"
                     /db_xref="GeneID:50687"
                     /db_xref="RGD:619777"
     exon            1..176
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3868
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /note="NILE; nerve-growth factor-inducible large external
                     glycoprotein; NCAM-L1; N-CAM-L1; neuron-glia cell adhesion
                     molecule; neural cell adhesion molecule L1"
                     /codon_start=1
                     /product="neural cell adhesion molecule L1 precursor"
                     /protein_id="NP_059041.2"
                     /db_xref="GeneID:50687"
                     /db_xref="RGD:619777"
                     /translation="MVMMLWYVLPLLLCSPCLLIQIPDEYKGHHVLEPPVITEQSPRR
                     LVVFPTDDISLKCEARGRPQVEFRWTKDGIHFKPKEELGVVVHEAPYSGSFTIEGNNS
                     FAQRFQGIYRCYASNNLGTAMSHEIQLVAEGAPKWPKETVKPVEVEEGESVVLPCNPP
                     PSAAPLRIYWMNSKILHIKQDERVSMGQNGDLYFANVLTSDNHSDYICNAHFPGTRTI
                     IQKEPIDLRVKPTNSMIDRKPRLLFPTNSSSHLVALQGQSLILECIAEGFPTPTIKWL
                     HPSDPMPTDRVIYQNHNKTLQLLNVGEEDDGEYTCLAENSLGSARHAYYVTVEAAPYW
                     LQKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGMSIEKVNKDQKYRIEQGSLILSN
                     VQPSDTMVTQCEARNQHGLLLANAYIYVVQLPARILTKDNQTYMAVEGSTAYLLCKAF
                     GAPVPSVQWLDEEGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCQAANDQNNVTIL
                     ANLQVKEATQITQGPRSTIEKKGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSD
                     KYFIEDGQLVIQSLDYSDQGNYSCVASTELDEVESRAQLLVVGSPGPVPHLELSDRHL
                     LKQSQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEKWFSLGKVPGNQTSTTLKLSPYV
                     HYTFRVTAINKYGSGEPSPVSETVVTPEAAPEKNPVDVRGEGNETNNMVITWKPLRWM
                     DWNAPQIQYRVQWRPLGKQETWKEQTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPE
                     PQVTIGYSGEDYPQVSPELEDITIFNSSTVLVRWRPVDLAQVKGHLRGYNVTYWWKGS
                     QRKHSKRHVHKSHMVVPANTTSAILSGLRPYSSYHVEVQAFNGRGLGPASEWTFSTPE
                     GVPGHPEALHLECQSDTSLLLHWQPPLSHNGVLTGYLLSYHPLDGESKEQLFFNLSDP
                     ELRTHNLTNLNPDLQYRFQLQATTQQGPGEAIVREGGTMALFGKPDFGNISVTAGENY
                     SVVSWVPREGQCNFRFHILFKALPEGKVSPDHQPQPQYVSYNQSSYTQWDLQPDTKYE
                     IHLMREKVLLHHLAVKTNGTGPVRVSTTGSFASEGWFIAFVSAIILLLLILLILCFIK
                     RSKGGKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSSQPSLNGDIKPLGSDD
                     SLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE"
     exon            177..191
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            192..297
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            298..497
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            498..620
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            621..791
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            792..903
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1088
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1220
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1364
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1476
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1643
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1800
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1925
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2036
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2234
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2305
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2528
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2644
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2846
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2969
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3143
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3263
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3425
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3563
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3636
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..5079
                     /gene="L1cam"
                     /gene_synonym="Hsas; Hyd; N-CAM L1; NCAML1; NgCAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacccccg tcagcaggta ccgctggaac caaccaccag tgagagggtg agtggaatct
       61 ggccagttgt gctgcactga tctgctgagc tgacaggaag atggtcatga tgctgtggta
      121 cgtgttgcct cttctcctct gcagcccctg cctgctcata cagattcctg atgaatataa
      181 aggacaccat gtactggagc cacctgtcat cacagaacag tctccacggc gcctggttgt
      241 cttcccaaca gatgacataa gcctcaaatg tgaagccaga ggcagacccc aagtggagtt
      301 ccgctggacg aaagatggca tccacttcaa acctaaggaa gaattgggtg tagtggtaca
      361 cgaggcaccc tattctggct ccttcaccat cgaaggcaac aacagctttg cccagaggtt
      421 tcagggcatc tatcgctgct atgccagcaa taatctagga actgccatgt cgcatgagat
      481 ccagctcgtg gctgagggtg cccccaaatg gccgaaggag actgtaaaac ccgtggaagt
      541 ggaggaagga gaatcagtag ttctaccttg caatcctcca cccagtgcag ccccacttag
      601 gatctactgg atgaacagca agattttgca catcaaacaa gatgagcggg tgtccatggg
      661 ccagaacgga gacctatatt ttgccaatgt gcttacctca gacaatcatt cagactacat
      721 ctgcaatgcc cacttccctg gcacccggac catcattcaa aaggaaccta ttgacctccg
      781 ggtcaagccc accaacagca tgattgaccg gaagccacgc ctgctcttcc ccacaaactc
      841 cagcagtcac ctcgtggcct tgcagggcca gtcattaatc ctggagtgca ttgctgaggg
      901 attccctaca cccaccatca agtggctgca ccccagtgac cctatgccaa cagaccgtgt
      961 tatctaccag aaccataaca agacactgca gctcctcaat gtgggcgagg aagatgatgg
     1021 cgagtatacc tgccttgctg agaactcact gggcagtgct cggcatgcct actatgtcac
     1081 tgtggaagct gccccatact ggctgcagaa gccccagagt catttgtatg ggccaggaga
     1141 gactgcccgc ctagactgcc aagtccaggg caggccccaa ccagaggtca cctggagaat
     1201 caacggaatg tctatagaga aggtgaacaa ggaccagaag taccggattg agcaggggtc
     1261 tttgatcctg agtaatgtgc aaccaagtga cacaatggtg acccagtgtg aagctcgcaa
     1321 ccagcatggg ctcctactag ccaatgccta tatctatgtt gtccagctgc cagccaggat
     1381 cctaacaaaa gacaatcaga catacatggc agtagagggc agtactgctt acttgctgtg
     1441 caaagccttt ggagctcctg ttcccagtgt ccagtggctg gatgaggaag gaaccacagt
     1501 gcttcaggat gaaagatttt tcccctatgc caatggaacg ctgggcatca gagatctcca
     1561 ggccaatgac actggacgct atttctgcca ggctgccaat gaccagaaca atgtgaccat
     1621 tttggctaac ctacaggtta aagaagcaac ccagatcaca caaggacccc ggagcacaat
     1681 tgagaagaaa ggtgcaaggg tgacattcac gtgccaggcc tcctttgacc cctctttaca
     1741 agccagcatc acttggcgtg gagatgggag agacctccag gaacgtggag acagtgacaa
     1801 gtatttcata gaagatgggc aacttgtcat ccagagcctg gactacagtg accagggcaa
     1861 ctacagttgt gtggccagca ctgaactgga tgaggtggag agcagggcac aactcttagt
     1921 ggtgggaagc cctgggccag tgcctcacct ggagctgtcc gaccgccact tgctgaagca
     1981 gagccaggtg cacttgtctt ggagccctgc tgaagaccac aactctccca ttgagaaata
     2041 tgacattgaa tttgaggaca aggaaatggc tcctgagaaa tggttcagtc taggcaaggt
     2101 gccaggaaat cagacctcta ctaccctcaa gctgtccccc tatgtccact atacctttcg
     2161 ggtcactgcc attaacaaat atggttccgg agaacccagc cctgtctctg agactgtagt
     2221 cacacctgag gcagccccag agaagaaccc tgtggatgtg agaggggaag gaaatgagac
     2281 caacaatatg gtcatcacat ggaagcccct tcggtggatg gattggaatg ccccccagat
     2341 tcagtaccgt gtacagtggc gaccactggg caaacaagag acctggaagg aacagaccgt
     2401 gagcgacccc ttcctggtgg tgtctaacac ttccacattt gtgccttatg agatcaaagt
     2461 ccaggcagtg aacaaccagg ggaagggccc tgagccccag gtcaccattg gctattcagg
     2521 ggaagactac ccccaggtga gccctgagct tgaagacatc acaatcttca actcaagcac
     2581 tgtgctggtc aggtggaggc ctgtggactt ggcccaggtt aagggccacc tcaggggata
     2641 caatgtaacg tactggtgga agggcagtca gagaaagcac agcaagaggc atgtccacaa
     2701 aagtcacatg gtggtacctg cgaacaccac cagtgccatc ctcagtggtt tgcgtcctta
     2761 cagctcttat catgtggagg tacaggcctt taatgggcgg ggcttagggc ctgcaagtga
     2821 atggaccttc agcaccccag agggagtgcc tggccaccct gaggcattac atctggagtg
     2881 ccagtcggac actagcctgc tactgcactg gcagccacca ctcagccaca atggagtgct
     2941 cactggctac ctgctctctt accatccctt ggatggggaa agcaaagagc agttgttctt
     3001 caacctttcg gacccagagc tccggactca taatctcacc aacctcaacc ctgatctaca
     3061 gtaccgcttc cagcttcagg ccaccaccca gcagggtcct ggtgaggcca ttgtgcgtga
     3121 aggaggcact atggccctat ttggcaagcc agattttggc aacatttcag tcacagcagg
     3181 tgaaaactac agtgtggtct cctgggtccc tcgggagggc cagtgcaatt tcaggttcca
     3241 catcctgttc aaagccttgc cagaagggaa agtgagccct gatcaccagc ctcagcctca
     3301 atatgtgagc tacaatcaga gctcctacac acagtgggac ctacagcctg acaccaaata
     3361 tgagatccac ctgatgaggg agaaggtcct cttgcaccat ctggctgtga agactaatgg
     3421 cactggcccc gtgcgagttt ctactacagg tagctttgcc tccgagggct ggttcatcgc
     3481 ctttgtcagt gctatcattc tcttgctcct catcctgctc atcctctgct tcatcaaacg
     3541 cagcaagggc ggcaaatatt cagtgaagga caaggaggac actcaggtag attccgaggc
     3601 ccggcccatg aaagacgaga ccttcggcga gtacagtgac aatgaagaga aggccttcgg
     3661 cagcagccag ccatctctca atggagacat caaaccccta ggcagtgatg acagtctggc
     3721 tgattatggg ggcagtgtgg atgtccagtt caatgaggat ggctctttca tcggccaata
     3781 cagtggcaaa aaagagaagg aggcagcggg aggcaatgac agctcagggg ctacctctcc
     3841 tatcaatcct gcagtagccc tagaatagca aggtccagtc atgtgaggca ggaccaagct
     3901 gggcccaggg ccagaggtgc agaagagcca ggggccaaga cacctggcca atgcaccatg
     3961 ccattggcct gctgactttg ggatcgaggt ccttccttct ttccacagag catggaagac
     4021 ttgactggag cagagaggaa ctgtgacttc gagtctcttt cttaccacct gctaccctct
     4081 ttattgccaa aacccagctg caccctttcc tgggcatacg ctgctttgcc ccgctcaggg
     4141 cagttcactc ccatatcagg gatcttcagg tgctgccttg ccgacccatt tagacagaga
     4201 ggccatagtt tgtgggagaa gacaaaggag agtcctctga gccatctctg agaagctgtc
     4261 ctcactttct gactggaaac aggcatggtg gggtctgttc aggactagct tggcacctct
     4321 tctttctccc tggctagcct gactggagac agaactctgt ccccaccatc tgctcccttt
     4381 gccatttttg atccaatcag gatggggacc tgagcaagct ggccgcctgt gtagaagagg
     4441 ccatctggaa agcccagagt cgtcccccac ccccttagca cactaggttt acaccctcct
     4501 cccattgcta ttccaccttt caggacacac acacacacac acacacacac acacacactt
     4561 actcatattg ccttcgatac ccaccagaga acatcgaagt ggcttctctc actgctggag
     4621 ataggcagac ctcttcctac tggaattggc tagacttttc cctgctgcca ccatacccca
     4681 ggacccctta gcagccctgc ctgcccccag ttcttgtcct cagccccttc ccctgttcct
     4741 cacgttggga atgtaaatac accgtgactt tgaaagtttg tgctgttgcc ctttccccat
     4801 atgccactag cttgtaggca gatgtctgag tctctaggtg gtttccccat tttatagcag
     4861 ttagctttga tgatctcact ccaagaaaaa taaaagcaga cacacacaca aaaaagcaaa
     4921 gattggctgt cccagcactg ctgtggttct gctcagcagc tgtgctcttc ctgtatgcct
     4981 ttgcttggtc tgttgatgag ccctctacaa aaaacaaata tatatatatg tacataatat
     5041 cagaattata acaggcaaat aaaaacctgg aaatgaaaa
//
