LOCUS       NM_053902               1764 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kynureninase (Kynu), mRNA.
ACCESSION   NM_053902
VERSION     NM_053902.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Shi,H., Enriquez,A., Rapadas,M., Martin,E.M.M.A., Wang,R.,
            Moreau,J., Lim,C.K., Szot,J.O., Ip,E., Hughes,J.N., Sugimoto,K.,
            Humphreys,D.T., McInerney-Leo,A.M., Leo,P.J., Maghzal,G.J.,
            Halliday,J., Smith,J., Colley,A., Mark,P.R., Collins,F.,
            Sillence,D.O., Winlaw,D.S., Ho,J.W.K., Guillemin,G.J., Brown,M.A.,
            Kikuchi,K., Thomas,P.Q., Stocker,R., Giannoulatou,E., Chapman,G.,
            Duncan,E.L., Sparrow,D.B. and Dunwoodie,S.L.
  TITLE     NAD Deficiency, Congenital Malformations, and Niacin
            Supplementation
  JOURNAL   N Engl J Med 377 (6), 544-552 (2017)
   PUBMED   28792876
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Maddison,D.C. and Giorgini,F.
  TITLE     The kynurenine pathway and neurodegenerative disease
  JOURNAL   Semin Cell Dev Biol 40, 134-141 (2015)
   PUBMED   25773161
  REMARK    Review article
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Christensen,M., Duno,M., Lund,A.M., Skovby,F. and Christensen,E.
  TITLE     Xanthurenic aciduria due to a mutation in KYNU encoding
            kynureninase
  JOURNAL   J Inherit Metab Dis 30 (2), 248-255 (2007)
   PUBMED   17334708
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Comai,S., Costa,C.V., Ragazzi,E., Bertazzo,A. and Allegri,G.
  TITLE     The effect of age on the enzyme activities of tryptophan metabolism
            along the kynurenine pathway in rats
  JOURNAL   Clin Chim Acta 360 (1-2), 67-80 (2005)
   PUBMED   15970278
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Csillik,A.E., Okuno,E., Csillik,B., Knyihar,E. and Vecsei,L.
  TITLE     Expression of kynurenine aminotransferase in the subplate of the
            rat and its possible role in the regulation of programmed cell
            death
  JOURNAL   Cereb Cortex 12 (11), 1193-1201 (2002)
   PUBMED   12379607
  REMARK    GeneRIF: Kynurenine aminotransferase is expressed in the neurons of
            the transient subplate zone during prenatal development of the
            cerebral cortex and may play a role in regulating programmed
            neuronal cell death.
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Ubbink,J.B., Vermaak,W.J. and Bissbort,S.H.
  TITLE     High-performance liquid chromatographic assay of human lymphocyte
            kynureninase activity levels
  JOURNAL   J Chromatogr 566 (2), 369-375 (1991)
   PUBMED   1939450
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Okayama,A., Ogawa,Y., Goto,S., Yamatodani,A., Wada,H., Okuno,E.,
            Takikawa,O. and Kido,R.
  TITLE     Enzymatic studies on tryptophan metabolism disorder in rats
            chronically exposed to carbon disulfide
  JOURNAL   Toxicol Appl Pharmacol 94 (3), 356-361 (1988)
   PUBMED   3400092
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Takeuchi,F. and Shibata,Y.
  TITLE     Kynurenine metabolism in vitamin-B-6-deficient rat liver after
            tryptophan injection
  JOURNAL   Biochem J 220 (3), 693-699 (1984)
   PUBMED   6466295
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Inada,J., Okuno,E., Kimura,M. and Kido,R.
  TITLE     Intracellular localization and characterization of
            3-hydroxykynureninase in human liver
  JOURNAL   Int J Biochem 16 (6), 623-628 (1984)
   PUBMED   6468727
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   Smith,S.A., Carr,F.P. and Pogson,C.I.
  TITLE     The metabolism of L-tryptophan by isolated rat liver cells.
            Quantification of the relative importance of, and the effect of
            nutritional status on, the individual pathways of tryptophan
            metabolism
  JOURNAL   Biochem J 192 (2), 673-686 (1980)
   PUBMED   7236232
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U68168.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053902.3.
            
            On Aug 30, 2012 this sequence version replaced NM_053902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68168.1, BC078762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1764              U68168.1           2-1765
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..1764
                     /gene="Kynu"
                     /note="kynureninase"
                     /db_xref="GeneID:116682"
                     /db_xref="RGD:71061"
     exon            1..44
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            45..219
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1445
                     /gene="Kynu"
                     /EC_number="3.7.1.3"
                     /note="L-kynurenine hydrolase"
                     /codon_start=1
                     /product="kynureninase"
                     /protein_id="NP_446354.1"
                     /db_xref="GeneID:116682"
                     /db_xref="RGD:71061"
                     /translation="MEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLKRFKD
                     CFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGH
                     EVGKRPWIIGDESIVTLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILL
                     EAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVV
                     LFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYK
                     YLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNP
                     PILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIIT
                     PSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKF
                     IRLLTAILDSTERN"
     exon            220..340
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            341..423
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            424..485
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            486..557
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            558..632
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            633..779
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            780..878
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            879..952
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1005
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1091
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1322
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1760
                     /gene="Kynu"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaaaggta ctggaaactg aggaccctat ctggatcaaa gcagtttctg atggagccct
       61 cgcctcttga gctaccagtt gatgcagtgc ggcgcatcgc ggctgaactc aattgtgacc
      121 caaccgatga gagggtggct ctccgcttgg atgaggaaga taaactgaag cgttttaagg
      181 actgttttta tatccccaaa atgcgggacc tgccttcaat tgatctatct ttagtgaatg
      241 aggatgataa tgccatctat ttcctgggaa attcccttgg tcttcaaccg aagatggtta
      301 aaacatacct ggaggaagag ctagataagt gggccaaaat aggagcctat ggccatgagg
      361 tagggaaacg tccttggatt ataggagatg agagcattgt aacccttatg aaggacattg
      421 taggagccca tgagaaagaa atagctctaa tgaatgcttt gactgttaat ttacatctcc
      481 tgctgttatc attctttaag cctacaccaa agcggcacaa aattcttcta gaagccaaag
      541 ccttcccttc tgatcattat gcgatcgagt cacagattca acttcatgga cttgatgttg
      601 agaaaagtat gcggatgata aagccacgag agggggaaga gaccttaaga atggaggaca
      661 tactggaagt aattgagaag gaaggagact caattgctgt ggtcctgttc agtggcctgc
      721 acttttatac tggacagctg ttcaacattc ctgccattac acaagccgga catgcaaagg
      781 gctgttttgt tggctttgac ctagcgcatg cggttggaaa tgttgaactc cacttacatg
      841 actgggatgt tgactttgcc tgctggtgct cctacaagta tttaaattca ggagctggag
      901 gtctggctgg tgccttcatc catgagaaac acgctcacac gatcaagcca gcgttagtgg
      961 gatggttcgg ccatgaactc agtacaagat ttaacatgga taacaaacta caattaatcc
     1021 ccggggtcaa tggattccga atttccaacc ctcccattct gttggtctgc tccttgcatg
     1081 ccagtttaga gatctttcag caagcaacta tgactgcgct gaggagaaaa tccattctgc
     1141 tgacaggtta tctggaatac ttgctcaaac attaccatgg cggaaatgac acagaaaaca
     1201 agaggccagt tgtgaacata atcaccccat ccagagcaga ggaacgaggc tgccagctga
     1261 cactgacctt ttccatttcc aagaaaggcg tttttaagga actagaaaaa agaggagtcg
     1321 tctgtgacaa gcgagaacca gaaggcatcc gggtggcccc ggttcctctc tataattctt
     1381 tccatgatgt ttataagttc atcagactgc ttactgccat actcgactct acagaaagaa
     1441 actagccatg ctttctaaat aactcaagta aatctcacac actgggggtt ccacttctac
     1501 tgcattttag tcattcaaaa gtctccagaa attgatggca tagaaatgat gatgatttta
     1561 taaacttaca taaaacctgg tacatgtttt aatatctgtg tcgctgatgt gctgtggact
     1621 aagaagtcac attttacatg actccaacct acagatgact gtcttgatca gctgtcacct
     1681 tccatggtca ctgaaaggtt gtgtgtttaa tttgtgactg aaatgacaac attaaaatgt
     1741 atctggactt cttgtataaa aaaa
//
