LOCUS       NM_001015037            1660 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus kynurenine aminotransferase 3 (Kyat3), mRNA.
ACCESSION   NM_001015037 XM_001062489
VERSION     NM_001015037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Maddison,D.C. and Giorgini,F.
  TITLE     The kynurenine pathway and neurodegenerative disease
  JOURNAL   Semin Cell Dev Biol 40, 134-141 (2015)
   PUBMED   25773161
  REMARK    Review article
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Structure, expression, and function of kynurenine aminotransferases
            in human and rodent brains
  JOURNAL   Cell Mol Life Sci 67 (3), 353-368 (2010)
   PUBMED   19826765
  REMARK    Review article
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Han,Q., Robinson,H., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Biochemical and structural properties of mouse kynurenine
            aminotransferase III
  JOURNAL   Mol Cell Biol 29 (3), 784-793 (2009)
   PUBMED   19029248
  REMARK    Erratum:[Mol Cell Biol. 2018 Apr 30;38(10):e00099-18. doi:
            10.1128/MCB.00099-18.. PMID: 29712768]
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Yu,P., Li,Z., Zhang,L., Tagle,D.A. and Cai,T.
  TITLE     Characterization of kynurenine aminotransferase III, a novel member
            of a phylogenetically conserved KAT family
  JOURNAL   Gene 365, 111-118 (2006)
   PUBMED   16376499
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY955395.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001062489.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY955395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1660
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /note="kynurenine aminotransferase 3"
                     /db_xref="GeneID:541589"
                     /db_xref="RGD:1359262"
     exon            1..83
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            84..183
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1449
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /EC_number="2.6.1.63"
                     /note="KATIII; cysteine-S-conjugate beta-lyase 2;
                     kynurenine--oxoglutarate transaminase III;
                     kynurenine--glyoxylate transaminase; kynurenine
                     aminotransferase III; kynurenine aminotransferase
                     III-like; cysteine conjugate-beta lyase 2"
                     /codon_start=1
                     /product="kynurenine--oxoglutarate transaminase 3"
                     /protein_id="NP_001015037.1"
                     /db_xref="GeneID:541589"
                     /db_xref="RGD:1359262"
                     /translation="MLLAQRRLFSLGCRAKPIKTIYSSKVLGLSTSAKMALRFKNAKR
                     IEGLDQNVWVEFTKLAADPSVVNLGQGFPDITLPSYVQEELSKAAFIDNLNQYTRGFG
                     HPSLVKALSCLYGKIYQKQIDPNEEILVTVGGYGSLFNAIQGLVDPGDEVIIMVPFYD
                     CYEPMVKMAGAVPVFIPLRSKRTDGMKWTSSDWTFNPQELESKFSSKTKAIILNTPHN
                     PIGKVYTREELQVIADLCIKHDTLCISDEVYEWLVYTGHKHIKVASLPGMWDRTLTIG
                     SAGKTFSVTGWKLGWSIGPGHLIKHLRTVQQTSVYTCATPLQAALAEAFWIDIKRMDD
                     PECYFNSLPKELEVKRDRMACLLNSVGLKPIIPDGGYFIIADVSSLGVDLSDVKSDEP
                     YDYKFVKWMTKNKKLSAIPVSAFCDSESKPHFEKLVRFCFIKKDSTLDAAEEIFRTWN
                     SRKS"
     exon            184..242
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..387
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..537
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..624
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..750
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..871
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..948
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1038
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1225
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1299
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1386
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1649
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggtctcgt gtgtttcatc aggaccctgc gacactagcg atctccggac taaagccagg
       61 ctgattcaaa ccaggagaac gaccatgctt ttggcccaga ggagactctt ctcccttggc
      121 tgcagagcaa agcccataaa gacaatttac tcttcgaaag ttctcggact ctccacttct
      181 gccaaaatgg ctttgagatt caaaaatgcc aaacgaatcg aaggcctgga ccaaaacgtg
      241 tgggttgaat ttaccaagtt ggccgcggat ccttctgtgg tgaatcttgg acaaggtttt
      301 cctgatataa cccttccttc atatgtacaa gaagaattgt caaaggcggc atttattgat
      361 aacctgaatc aatacacaag gggctttggt catccatcac ttgtgaaagc gctatcctgc
      421 ttatacggaa agatttatca aaagcaaatt gatccaaatg aagaaattct tgtgacggtg
      481 gggggatatg gatcgctctt taatgccatc caaggcttgg tggacccagg agatgaagtg
      541 ataattatgg tgccttttta cgactgttat gagcccatgg tgaaaatggc tggagcagtg
      601 cctgtgttta ttcccctgag atctaaacgt actgacggga tgaagtggac tagctctgat
      661 tggacattca atcctcaaga actggaaagt aaattcagtt ccaaaacgaa agccattata
      721 ttaaatactc cacataaccc catcggcaag gtgtatacca gagaggagct gcaagtcatt
      781 gctgaccttt gcatcaaaca tgacactttg tgcatcagcg atgaggttta tgaatggctt
      841 gtctatactg gacataagca cataaaagta gccagcctcc ctggcatgtg ggatcggacc
      901 ctgaccatcg gcagtgcagg caagacattc agtgtgaccg gctggaagct cggctggagc
      961 attggccctg gtcacctgat aaaacatttg cggactgttc agcaaaccag tgtatacacg
     1021 tgtgcaactc ctttacaggc agccttggcc gaggcttttt ggatcgatat caagcgcatg
     1081 gatgacccag agtgttactt caattctctg ccaaaggaat tagaagttaa gagagatcgg
     1141 atggcctgtt tacttaacag cgttggcctg aaacccatca tccctgacgg gggctacttc
     1201 atcattgccg atgtgtcttc attaggtgtt gacctctcgg atgtgaagag cgatgagcct
     1261 tatgactata agtttgtgaa gtggatgacg aaaaataaga aattgtcagc cattcctgta
     1321 tccgcgttct gcgactccga gtctaaacct cactttgaga agttggtgcg gttttgcttt
     1381 atcaaaaaag acagcactct ggatgctgcg gaagaaatct tcaggacgtg gaacagccgg
     1441 aagtcttgac ttgtgcgggt gtgagggttc catcttcttg caaggacttt gctactcggt
     1501 gctgccacct cgtgggcact aaaaggaaaa gccgtttcag gacaaacatt taaataaaca
     1561 tttccactgt ctccgaagtt aaccccattc ctaacagtgt tcagtacatt atggtttgac
     1621 tcgttcggaa tatattaagg caccttccga aaaaaaaaaa
//
