LOCUS       NM_001013164            1417 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus kynurenine aminotransferase 1 (Kyat1), mRNA.
ACCESSION   NM_001013164 XM_231118
VERSION     NM_001013164.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Structure, expression, and function of kynurenine aminotransferases
            in human and rodent brains
  JOURNAL   Cell Mol Life Sci 67 (3), 353-368 (2010)
   PUBMED   19826765
  REMARK    Review article
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Han,Q., Robinson,H., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Structural insight into the inhibition of human kynurenine
            aminotransferase I/glutamine transaminase K
  JOURNAL   J Med Chem 52 (9), 2786-2793 (2009)
   PUBMED   19338303
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Adriaansen,J., Kuhlman,R.R., van Holten,J., Kaynor,C.,
            Vervoordeldonk,M.J. and Tak,P.P.
  TITLE     Intraarticular interferon-beta gene therapy ameliorates adjuvant
            arthritis in rats
  JOURNAL   Hum Gene Ther 17 (10), 985-996 (2006)
   PUBMED   16984225
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Malherbe,P., Alberati-Giani,D., Kohler,C. and Cesura,A.M.
  TITLE     Identification of a mitochondrial form of kynurenine
            aminotransferase/glutamine transaminase K from rat brain
  JOURNAL   FEBS Lett 367 (2), 141-144 (1995)
   PUBMED   7796908
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Perry,S., Harries,H., Scholfield,C., Lock,T., King,L., Gibson,G.
            and Goldfarb,P.
  TITLE     Molecular cloning and expression of a cDNA for human kidney
            cysteine conjugate beta-lyase
  JOURNAL   FEBS Lett 360 (3), 277-280 (1995)
   PUBMED   7883047
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Mosca,M., Cozzi,L., Breton,J., Speciale,C., Okuno,E., Schwarcz,R.
            and Benatti,L.
  TITLE     Molecular cloning of rat kynurenine aminotransferase: identity with
            glutamine transaminase K
  JOURNAL   FEBS Lett 353 (1), 21-24 (1994)
   PUBMED   7926014
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Baran,H., Okuno,E., Kido,R. and Schwarcz,R.
  TITLE     Purification and characterization of kynurenine aminotransferase I
            from human brain
  JOURNAL   J Neurochem 62 (2), 730-738 (1994)
   PUBMED   8294935
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Abraham,D.G. and Cooper,A.J.
  TITLE     Glutamine transaminase K and cysteine S-conjugate beta-lyase
            activity stains
  JOURNAL   Anal Biochem 197 (2), 421-427 (1991)
   PUBMED   1723851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF100154.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001013164.4.
            
            On May 26, 2007 this sequence version replaced NM_001013164.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1417
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /note="kynurenine aminotransferase 1"
                     /db_xref="GeneID:311844"
                     /db_xref="RGD:1306912"
     CDS             1..1374
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /EC_number="2.6.1.64"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /note="kynurenine--oxoglutarate transaminase 1,
                     mitochondrial; glutamine transaminase K; kynurenine
                     aminotransferase/glutamine transaminase K; kynurenine
                     aminotransferase I; cysteine-S-conjugate beta-lyase;
                     glutamine--phenylpyruvate transaminase;
                     kynurenine--oxoglutarate transaminase I; cysteine
                     conjugate-beta lyase 1; cysteine conjugate-beta lyase,
                     cytoplasmic"
                     /codon_start=1
                     /product="kynurenine--oxoglutarate transaminase 1"
                     /protein_id="NP_001013182.3"
                     /db_xref="GeneID:311844"
                     /db_xref="RGD:1306912"
                     /translation="MFRSAAALSVHLMWPLWGRKAGASLTRCLHQSLTMTKRLQARRL
                     DGIDQNLWVEFGKLTKEYDVVNLGQGFPDFSPPDFATQAFQQATSGNFMLNQYTRAFG
                     YPPLTNVLASFFGKLLGQEMDPLTNVLVTVGAYGALFTAFQALVDEGDEVIIMEPAFD
                     CYEPMTMMAGGCPVFVTLKPSPAPKGKLGASNDWQLDPAELASKFTPRTKILVLNTPN
                     NPLGKVFSRMELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTI
                     GSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFG
                     QPSSYFLQLPQAMELNRDHMIRSLQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAE
                     DEPYDRRFAKWMIKNMGLVGIPVSTFFSRPHQKDFDHYIRFCFVKDKATLQAMDERLR
                     KWKELQP"
     exon            1..96
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            97..155
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            156..303
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            304..453
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            454..540
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            541..669
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            670..790
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            791..867
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            868..957
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1144
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1224
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1311
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1417
                     /gene="Kyat1"
                     /gene_synonym="Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcagga gtgcagcagc cctctcggtg cacctgatgt ggccactctg gggaaggaaa
       61 gctggagcct cactcacccg gtgcttgcac cagtctctca ccatgaccaa acggctgcag
      121 gctcggaggc tggacgggat tgatcaaaac ctctgggtgg agtttggcaa actgaccaag
      181 gagtatgacg tcgtgaactt gggtcagggc ttccctgact tctcgcctcc ggactttgca
      241 acgcaagctt ttcagcaggc taccagtggg aacttcatgc tcaaccagta caccagggca
      301 tttggttacc caccactgac aaacgtcctg gcaagtttct ttggcaagct gctgggacag
      361 gagatggacc cactcacgaa tgtgctggtg acagtgggtg cctatggggc cttgttcaca
      421 gcctttcagg ccctggtgga tgaaggagat gaggtcatca tcatggaacc tgcttttgac
      481 tgttatgaac ccatgacaat gatggctgga ggttgccctg tgttcgtgac tctgaagccg
      541 agccctgctc ctaaggggaa actgggagcc agcaatgatt ggcaactgga tcctgcagaa
      601 ctggccagca agttcacacc tcgcaccaag atcctggtcc tcaacacacc caacaaccct
      661 ttaggaaagg tattctctag gatggagctg gagctggtgg ctaatctgtg ccagcagcac
      721 gatgtcgtgt gcatctctga tgaggtctac cagtggctgg tctatgacgg gcaccagcac
      781 gtcagcatcg ccagcctccc tggcatgtgg gatcggaccc tgaccatcgg cagtgcaggc
      841 aaaagcttca gtgccactgg ctggaaggtg ggctgggtca tgggtccaga taacatcatg
      901 aagcacctga ggacagtgca ccagaattct atcttccact gccccaccca ggcccaggct
      961 gcagtagccc agtgctttga gcgggagcag caacactttg gacaacccag cagctacttt
     1021 ttgcagctgc cacaggccat ggagctgaac cgagaccaca tgatccgtag cctgcagtca
     1081 gtgggcctca agctctggat ctcccagggg agctacttcc tcattgcaga catctcagac
     1141 ttcaagagca agatgcctga cctgcccgga gctgaggatg agccttatga cagacgcttt
     1201 gccaagtgga tgatcaaaaa catgggcttg gtgggcatcc ctgtctccac attcttcagt
     1261 cggccccatc agaaggactt tgaccactac atccgattct gttttgtcaa ggacaaggcc
     1321 acactccagg ccatggatga gagactgcgc aagtggaaag agctccaacc ctgaggaggc
     1381 tgccctcagc cccacctcga acacaggcct cagctat
//
