LOCUS       NM_001382488            5673 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus kinase suppressor of ras 1 (Ksr1), mRNA.
ACCESSION   NM_001382488 XM_006246927
VERSION     NM_001382488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5673)
  AUTHORS   Bai Y, Han G, Guo K, Yu L, Du X and Xu Y.
  TITLE     Effect of lentiviral vector-mediated KSR1 gene silencing on the
            proliferation of renal tubular epithelial cells and expression of
            inflammatory factors in a rat model of ischemia/reperfusion injury
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (8), 807-816 (2018)
   PUBMED   30020400
  REMARK    GeneRIF: Findings indicate that kinase suppressor of ras 1 (KSR1)
            gene silencing might inhibit the expression of inflammatory factors
            in renal tubular epithelial cells (RTECs) and promote their
            proliferation renal ischemia/reperfusion (I/R) injury.
REFERENCE   2  (bases 1 to 5673)
  AUTHORS   Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin
            T, Kurinov I, Sicheri F and Therrien M.
  TITLE     MEK drives BRAF activation through allosteric control of KSR
            proteins
  JOURNAL   Nature 554 (7693), 549-553 (2018)
   PUBMED   29433126
REFERENCE   3  (bases 1 to 5673)
  AUTHORS   Stebbing J, Zhang H, Xu Y, Lit LC, Green AR, Grothey A, Lombardo Y,
            Periyasamy M, Blighe K, Zhang W, Shaw JA, Ellis IO, Lenz HJ and
            Giamas G.
  TITLE     KSR1 regulates BRCA1 degradation and inhibits breast cancer growth
  JOURNAL   Oncogene 34 (16), 2103-2114 (2015)
   PUBMED   24909178
  REMARK    Erratum:[Oncogene. 2021 May;40(19):3473. PMID: 33888869]
REFERENCE   4  (bases 1 to 5673)
  AUTHORS   Nemoto S, Taguchi K, Matsumoto T, Kamata K and Kobayashi T.
  TITLE     Pravastatin normalizes ET-1-induced contraction in the aorta of
            type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex
  JOURNAL   Am J Physiol Heart Circ Physiol 303 (7), H893-H902 (2012)
   PUBMED   22886408
  REMARK    GeneRIF: In type 2 diabetic rats, pravastatin normalizes
            ET-1-induced contraction in aortic smooth muscle via a suppression
            of PP2A/KSR1/ERK1/ERK2 activities after an enhancement of Src
            kinase activity.
REFERENCE   5  (bases 1 to 5673)
  AUTHORS   Quiel A, Jurgen B, Greinacher A, Lassen S, Worl R, Witt S and
            Schweder T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   6  (bases 1 to 5673)
  AUTHORS   Zhang Y and Dong C.
  TITLE     Regulatory mechanisms of mitogen-activated kinase signaling
  JOURNAL   Cell Mol Life Sci 64 (21), 2771-2789 (2007)
   PUBMED   17726577
  REMARK    Review article
REFERENCE   7  (bases 1 to 5673)
  AUTHORS   Xu J, Keeton AB, Franklin JL, Li X, Venable DY, Frank SJ and
            Messina JL.
  TITLE     Insulin enhances growth hormone induction of the MEK/ERK signaling
            pathway
  JOURNAL   J Biol Chem 281 (2), 982-992 (2006)
   PUBMED   16272159
REFERENCE   8  (bases 1 to 5673)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 5673)
  AUTHORS   Lozano J, Xing R, Cai Z, Jensen HL, Trempus C, Mark W, Cannon R and
            Kolesnick R.
  TITLE     Deficiency of kinase suppressor of Ras1 prevents oncogenic ras
            signaling in mice
  JOURNAL   Cancer Res 63 (14), 4232-4238 (2003)
   PUBMED   12874031
REFERENCE   10 (bases 1 to 5673)
  AUTHORS   Stewart S, Sundaram M, Zhang Y, Lee J, Han M and Guan KL.
  TITLE     Kinase suppressor of Ras forms a multiprotein signaling complex and
            modulates MEK localization
  JOURNAL   Mol Cell Biol 19 (8), 5523-5534 (1999)
   PUBMED   10409742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001382488.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001382488.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               JACYVU010000220.1  20922385-20922934   c
            551-691             JACYVU010000220.1  20847450-20847590   c
            692-839             JACYVU010000220.1  20819970-20820117   c
            840-1263            JACYVU010000220.1  20818184-20818607   c
            1264-1268           JACYVU010000220.1  20816654-20816658   c
            1269-1329           JACYVU010000220.1  20814320-20814380   c
            1330-1413           JACYVU010000220.1  20812084-20812167   c
            1414-1475           JACYVU010000220.1  20810469-20810530   c
            1476-1582           JACYVU010000220.1  20810278-20810384   c
            1583-1748           JACYVU010000220.1  20806485-20806650   c
            1749-1803           JACYVU010000220.1  20802385-20802439   c
            1804-1852           JACYVU010000220.1  20801788-20801836   c
            1853-2232           JACYVU010000220.1  20800636-20801015   c
            2233-2329           JACYVU010000220.1  20798491-20798587   c
            2330-2463           JACYVU010000220.1  20794812-20794945   c
            2464-2595           JACYVU010000220.1  20794065-20794196   c
            2596-2731           JACYVU010000220.1  20793751-20793886   c
            2732-2865           JACYVU010000220.1  20793004-20793137   c
            2866-5673           JACYVU010000220.1  20786629-20789436   c
FEATURES             Location/Qualifiers
     source          1..5673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..5673
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /note="kinase suppressor of ras 1"
                     /db_xref="GeneID:108348076"
                     /db_xref="RGD:1308105"
     exon            1..550
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2944
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="kinase suppressor of Ras 1"
                     /protein_id="NP_001369417.1"
                     /db_xref="GeneID:108348076"
                     /db_xref="RGD:1308105"
                     /translation="MDRAALRAAAMGEKKEGGGGGASAAADGGAGAAASRALQQCGQL
                     QKLIDISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQSKLSVTPSDRTAE
                     LNSYPRFSDWLYIFNVRPEVVQEIPQELTLDALLEMDEAKAKEMLRRWGASAEECSRL
                     QQALTCLRKVTGLGGEHKEDSGWSSAEARESSSGPSVDMLSSLGRAGASTQGPRSISV
                     SALPASDSPVPGLSEGLSDTCIPLHTSGRLTPRALHSFITPPTTPQLRRHAKLKPPRT
                     PPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVAPMRFELPHGSPQLVRRDIGLPV
                     THRFSTKSWLSQVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPLARLRRT
                     ESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNLDSSSNPSSTTSSTPSSPAPFL
                     TSSNPSSATTPPNPSPGQRDSRFNFPDISACPQAAPLSSTADSTRLDDQPKTDVLGVP
                     EAEAEEPEAGKSEAEDDEDEIDDLPSSRRHWRGPISRKASQTSVYLQEWDIPFEQVEL
                     GEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFM
                     GACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVH
                     KDLKSKNVFYDNGKVVITDFGLFGISGVVREERRENQLKLSHDWLCYLAPEIVREMIP
                     GRDEDQLPFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVKRVLASVS
                     LGKEVGEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADANSSKVM
                     PRFERFGLGTLESSNPKM"
     exon            551..691
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            692..839
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1263
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1268
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1329
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1413
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1475
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1582
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1748
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1803
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1852
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2232
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2329
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2463
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2595
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2731
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2865
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..5673
                     /gene="Ksr1"
                     /gene_synonym="Ksr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccccgag ggcgcgggcc agaaggcaga tgcaagatgc gcactacaag tcccaggata
       61 cgccgcggcc ccgatccggc ccccgcggtc gcttaaaggc tccggcaacc acagccgtcg
      121 ggtcgcggag gctttcgctt tgccgccgcg tctgagtggt aggaggagcg gactgagcag
      181 caggctctcg ggactgcagg cttcggaggc accgaggggg cgcttcctag tgcagccttc
      241 ccggctccgg acttctctgc ggaggcgccc gtgtccccgg gcacctcgcc tcggccccca
      301 gcggccccga tgccgaggca tggatagagc ggcgttgcgc gcagcagcga tgggcgagaa
      361 aaaggagggc ggcggcgggg gcgcctcggc ggccgcggac gggggtgcag gggccgccgc
      421 cagccgggcg ctgcagcagt gcggccagct gcagaagctc attgatatct ccatcggcag
      481 tctgcgcggg ctgcgcacca agtgctcagt gtccaacgac ctcacgcagc aggagatccg
      541 gaccctagag gcaaagctgg tgcggtacat ctgtaagcag cggcagagca agctgagcgt
      601 gaccccgagc gacaggaccg ccgagctcaa cagctacccg cgcttcagtg actggctgta
      661 catcttcaat gtgaggcctg aggtggtaca ggagatcccc caagagctca cactggatgc
      721 cctgctggag atggacgagg ccaaagccaa ggagatgctg cggcgatggg gggccagcgc
      781 tgaggagtgc agccgtctac agcaagccct cacctgcctt cggaaggtga ctggtctggg
      841 aggggagcac aaagaggact ctggttggag ttcagcagaa gcacgagaaa gtagctctgg
      901 gccttcagtg gacatgctct cctcgctggg cagagcgggt gccagcactc agggaccccg
      961 ttccatctct gtgtctgccc tgcctgcctc agactctcca gtccccggcc tcagcgaggg
     1021 cctctcggac acctgtatcc ccttgcacac cagtggccgg ctgacccccc gggccctgca
     1081 cagcttcatc acacccccta ccacacccca gctacgacgg cacgccaagc tgaagccacc
     1141 aaggacaccc ccgccaccaa gccgcaaggt cttccagctg ctccccagct tccccacact
     1201 cacacggagc aagtcccacg agtcccagct gggaaaccga atcgatgaag ttgccccgat
     1261 gaggtttgaa cttcctcatg gatccccaca gctggtacga agggacatcg ggctcccagt
     1321 aacacatagg ttctccacaa agtcatggtt gtcgcaggtc tgcaatgtgt gccagaagag
     1381 catgatgttc ggcgtgaagt gcaagcattg caggttaaaa tgtcataata agtgtacaaa
     1441 ggaagctccc gcctgcagaa tatccttcct cccactagcc aggcttcgga ggacagagtc
     1501 tgtcccctca gatatcaaca acccagtgga ccgagcagca gagccccatt ttggaaccct
     1561 tcccaaggcc ctaaccaaga aggagcaccc tccagccatg aacctggact ccagcagcaa
     1621 cccatcctcc accacgtcct ccacaccgtc atcgccggcg cctttcctga cctcatctaa
     1681 cccctccagt gccaccacgc cccccaaccc atcacctggc cagcgggaca gcaggttcaa
     1741 cttcccagac atttcagcct gtcctcaggc agccccgctg tccagcacag ccgacagtac
     1801 acggcttgat gaccagccca aaacagatgt gctgggtgtt cccgaagcag aggccgagga
     1861 gcctgaggct ggcaagtcag aggcagaaga tgatgaggac gagattgatg acctccccag
     1921 ctcccgtcgg cactggcggg gccccatctc tcggaaagcc agccagacca gcgtctacct
     1981 gcaagagtgg gatatcccct ttgaacaagt ggaactgggc gagcccattg ggcagggccg
     2041 ttggggccgt gtgcaccgag gccgttggca tggcgaggtg gccattcggc ttctggaaat
     2101 ggatggccac aaccaggacc acctgaagct gttcaagaaa gaggtgatga actaccggca
     2161 gacccggcat gagaacgtgg tgctcttcat gggggcctgc atgaacccac ctcacctggc
     2221 cattattacc agcttctgca aggggcggac actgcattca tttgtgaggg accccaagac
     2281 gtctctggat atcaacaaga ccaggcagat cgcccaggag atcatcaagg gcatggggta
     2341 tcttcatgca aaaggcatcg tgcacaagga cctcaagtcc aagaatgtct tctatgacaa
     2401 tggcaaagtg gtcatcacag acttcgggct gtttgggatt tcgggcgtgg tccgagagga
     2461 acggcgagag aaccaactga aactgtcaca cgactggctg tgctacctgg cccccgagat
     2521 tgtacgggaa atgatacccg ggagggacga ggaccagctg cccttctcca aagccgccga
     2581 tgtctatgcg tttgggacgg tgtggtatga actgcaggca agagactggc cctttaagca
     2641 ccaacctgcc gaggccttga tctggcagat tggaagtggg gaaggagtaa agcgtgtcct
     2701 ggcatccgtc agtctgggga aggaagtcgg agagatcctg tctgcctgct gggcttttga
     2761 cctgcaggaa agacccagct tcagcctgct gatggacatg ctggagaagc tacccaagct
     2821 gaaccggcgg ctctcccacc ctgggcactt ttggaagtcg gctgatgcta acagcagcaa
     2881 agtcatgccc cgctttgaaa ggtttggcct ggggaccctg gagtccagta atccaaagat
     2941 gtagccagcc atgcacgttc atgcagacag cgtcttcctt tctgaaacat gatgacgaga
     3001 catgcaaact accacaagga atcagaaaca ttgcatccca ggctgcggac taggagcatg
     3061 actcctccat gaagaacgcg catcaccgtg tgtggagctc gggattgcag ccgtccactc
     3121 gaccccagat gataccacca cagccagtgt ttacacagag gtttctgccc agcaagcttg
     3181 gtgttttaca gtttgtaagg ataattctgc agaagggtgc tggcactgtg gagcagcagc
     3241 aatgcctccc ctcccccttc cggaggggcc cagggctgag ccagaaggaa gaggaaaagc
     3301 aaaaggcagc atgaatgtgg ctgttttggg aaaagggcat gtggcaggct tgccttggcc
     3361 tgtgcttggg ccccgaacca cactaaggag caacagcctt ggttgggaat ctgtctggat
     3421 tacagggtca gagttcctgg agagctggag tccatttctg ctctgaccca ggtttgctgt
     3481 gcttttttaa aaaaacaaaa gtacagacag aatctctgtg gcttctagac cgagctgatg
     3541 gatcttagcc tggctcctac tgcaggggga gggaaatagc cacacatctg tggagatacc
     3601 cacatcttat ctgaggcctc cgggtaggga tgaaggctgt ggaactcagc ctctgtcatc
     3661 agacaccttc cggtgcctga tttacacctc ttcccggagc tgagggctag tccatctggt
     3721 gtgtgttcag tcagttcttg gttaaggaga gcagggaagt tggcagacgc agcctgcagt
     3781 ggccctagca ccttaaaacc cattgtctgt caccccagaa tgttctagac ctactgccac
     3841 ttccccttcc ccatctcatg gaaacctttt agcccattct gtcccctgtg catgctctga
     3901 actcagattg ggttatcaga ctgtccaggt acatcagtta ggtaagctct gatctgagcc
     3961 ttagacctct ccgttcattc ccatgagcag taggggccag actggagtaa atcagctgtg
     4021 ctccccagaa actgtcagct gccaagcacg ttggtccttg agcagagggt aggcagcatc
     4081 agactccaca atcagaggag ggaagaaatg ggggtgtagt ggaaatgtgg ttggattcag
     4141 acccacaggc ttaaagtccc actttggaat ggccatgtgg ctccctctca gttaaactcc
     4201 cagtaaagtg tcaattttca gagctctcca cagcacccaa gtctggtccg ggtgcctctt
     4261 aaaacaggcc actctcgggg ttggggattt agctcagtgg tagagcgctt gcctagcgag
     4321 tgcaaggccc tgggtttggt ccccagctcc ggaaaaaaaa aaaaaaaaaa agaaaaaaaa
     4381 aaaaaaaaaa aaaacaggcc actctctgag aagttgtgga aactccccgc tcccctagcg
     4441 catttgttcc tgctacagga cagttgggat agtagcatct tgaccctgcc tcagggtagg
     4501 aaggaagagc ctctcttcag ctcgtgggct gtccagtcat ttctccaccc ctcagatttc
     4561 cacagtagcc cttgatgtga cctccctact tcaaaacaca tagtgtgtgc ccattgcctc
     4621 gggcagtctc aggcctgcac cttcccagag gccacagtgc ataaggctct ggccagtccc
     4681 ctcaccagga catgagccat caggctacca gctgagtcaa ccctttcagc tatcccctga
     4741 caccaaatca cagcagacag cacataccca ctgacagcga gcctaggtct tgctgtatac
     4801 tgtgagcatc ccggatcaga ccgttttgag ccctgcattg aatgcggtct tatgcgtgtg
     4861 ctgagaacca gataggaata gtcgtggtcc ctggcttgag gagctggcca tcttctgggg
     4921 gccaattctc ttggggccga catctgccaa gggtggacct gtatgtagtg ctggaaccct
     4981 cctcctcatt ctccaggtcc tgcttctgtt ctgcccttca tgtaagagag ttccccaccc
     5041 tggttcccac tttctagtaa gtgactgtga attgatgtta ggaaagctca cctcctgtgt
     5101 accctcctta tctcctggga aacacatgaa ggatgacaga tactgtgaat tcagccccca
     5161 tggccactat gaaggcaatg aaaaaggccc aagctgcaga gaacctgccc acctaaagtg
     5221 tgaggcactt ttcccatcag agtggcaaga agtgagtcct agctagcgct gggccgctcc
     5281 tctcctaatg catccaatca aagccctggg ccattgtctt cttgtgctcc aggcagggag
     5341 tggcaagcct gtgtttctct gtagtgacag ggtggggtgg aacagccata ctgtgctcag
     5401 cgctagccag gagtgatcag tgtgtacacc tagcgtcttc tgtggccacg aggcagacat
     5461 ttcttttgaa tgtgatgtaa aatttgtaca gtaaaagttt ttatattttc tatcaattgc
     5521 atttgtcttc cagaaatgct ttaatttaaa ttaaaatggt tagtcttgat gaatgtgtta
     5581 tattggggtt tttgccactg ctaagaatga atgtaccctg tggctaagcc aggcctaggg
     5641 gtctggagtt tgtgaataaa gtttacaaag gtg
//
