LOCUS       NM_001008825            1599 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus keratin 90 (Krt90), mRNA.
ACCESSION   NM_001008825 XM_001066509 XM_345877
VERSION     NM_001008825.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Kubo,A., Oura,Y., Hirano,T., Aoyama,Y., Sato,S., Nakamura,K.,
            Takae,Y. and Amagai,M.
  TITLE     Collapse of the keratin filament network through the expression of
            mutant keratin 6c observed in a case of focal plantar keratoderma
  JOURNAL   J Dermatol 40 (7), 553-557 (2013)
   PUBMED   23662636
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Tam,C., Mun,J.J., Evans,D.J. and Fleiszig,S.M.
  TITLE     Cytokeratins mediate epithelial innate defense through their
            antimicrobial properties
  JOURNAL   J Clin Invest 122 (10), 3665-3677 (2012)
   PUBMED   23006328
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Miranda-Carboni,G.A., Krum,S.A., Yee,K., Nava,M., Deng,Q.E.,
            Pervin,S., Collado-Hidalgo,A., Galic,Z., Zack,J.A., Nakayama,K.,
            Nakayama,K.I. and Lane,T.F.
  TITLE     A functional link between Wnt signaling and SKP2-independent p27
            turnover in mammary tumors
  JOURNAL   Genes Dev 22 (22), 3121-3134 (2008)
   PUBMED   19056892
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Wong,P., Domergue,R. and Coulombe,P.A.
  TITLE     Overcoming functional redundancy to elicit pachyonychia
            congenita-like nail lesions in transgenic mice
  JOURNAL   Mol Cell Biol 25 (1), 197-205 (2005)
   PUBMED   15601842
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Wojcik,S.M., Bundman,D.S. and Roop,D.R.
  TITLE     Delayed wound healing in keratin 6a knockout mice
  JOURNAL   Mol Cell Biol 20 (14), 5248-5255 (2000)
   PUBMED   10866680
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK003995.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            XM_345877.2, XM_001066509.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK003995.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760389
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1599
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /note="keratin 90"
                     /db_xref="GeneID:366992"
                     /db_xref="RGD:1565564"
     CDS             1..1599
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /note="type II keratin Kb15"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal cochleal"
                     /protein_id="NP_001008825.1"
                     /db_xref="GeneID:366992"
                     /db_xref="RGD:1565564"
                     /translation="MTQRSSVTIKSGGTRNFSASSASLLPGCRPGFSSVSVSQSGKSF
                     GGGIGGGFGTRSLHSFGGNKRISIGGGYRSSRASFGGAACGLGVSGIGYRVGGSYGGY
                     GFGGGMAPGAGGIHEVTVNQSLLTPLHLEIDPSLQRVRKEEREQIKTLNNKFASFIDK
                     VRFLEQQNKVLETKWSLLQEHKTTRTNLEPMFEAYITNLKRQLECLGGERGRLEMELK
                     NMQDVVEDFKNKYEEEIHRRTAAENEFVVLKKDVDAAYMNKVELEAKVDALMDEINFL
                     RAFYEAELAQLQAQISETSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWY
                     QTKYEELQRSAGQRGDDLRTTKMEISELNRAMQRLRSEIDNLKKQASIADAEQRGELA
                     LKDAKNKLAELEDALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEECRLT
                     GEGVGAVNISVVSSSGGTGYSGGGGLCVSGGGYGGAGYSGSGLCYGGGSSGGFSSTSG
                     RSVSGSSSSMRIVSKTSSTKSYRS"
     exon            1..480
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            481..689
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            690..750
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            751..846
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1011
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1137
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1343
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1378
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1599
                     /gene="Krt90"
                     /gene_synonym="Kb15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacccagc gatcctcggt gaccatcaag tctgggggca cacggaactt cagcgcctcc
       61 tcagctagcc tccttcctgg ctgtcggccc ggattcagct ctgtctccgt gtcccagagc
      121 gggaagagtt tcggaggcgg catagggggt ggttttggga caagaagcct acacagtttt
      181 gggggtaaca agagaatctc cattggcggg ggctaccgct ccagccgagc cagctttgga
      241 ggtgctgcct gtggtctggg tgtcagtggc ataggataca gagttggggg atcttatggc
      301 gggtatggat tcggaggtgg gatggcccct ggagctggag gcatccatga agtcactgtc
      361 aaccagagtc tccttacgcc cctgcacctg gagatcgatc catctctcca gcgtgttcga
      421 aaggaagaga gggagcagat caagaccctc aacaacaagt tcgcctcctt catagacaag
      481 gtgcggttcc tggagcagca gaacaaagtc ttagagacca aatggagcct cctccaggag
      541 cacaaaacaa ccaggaccaa cctagagccc atgttcgaag cctacatcac caacctgaaa
      601 cgccagctgg agtgtctggg aggggagcgg ggcaggctgg agatggagct gaagaacatg
      661 caggacgtgg tggaggactt caagaacaaa tacgaagagg aaatccacag acgcacagcg
      721 gcagagaatg agtttgtggt gctcaaaaaa gatgtggacg ccgcctacat gaacaaggtg
      781 gagctagagg ccaaggtgga tgctctgatg gacgagatca acttcctgag agctttctat
      841 gaggcggagc tggctcagct tcaggctcaa atctctgaga cctctgtggt gctgtcaatg
      901 gacaacaacc gcagcctgga tctggacagc atcatcgctg aggtcaaggc ccagtacgag
      961 gacattgcca accgcagccg ggcagaggct gagtcctggt accagaccaa gtatgaggag
     1021 ctgcagcggt ctgctggcca acgtggggat gacctccgta ctaccaagat ggagatctct
     1081 gagctgaacc gggccatgca gaggctgcgt tctgagatcg ataacctgaa gaagcaggct
     1141 tccattgctg atgcagagca gcgtggggag ctggctctca aagacgccaa gaacaagctg
     1201 gccgagctgg aggacgccct gcagaaggcc aagcaggaca tggcccgtca gcttcgcgag
     1261 taccaggagc tcatgaacgt caagctggcg ctggacatag agatcgccac ctaccgcaag
     1321 ctgttggagg gcgaggagtg caggctcact ggagaaggcg ttggtgccgt gaacatctct
     1381 gtagtctctt cctccggggg cacaggctac agcggaggtg gcggcctgtg cgtgagcggc
     1441 ggtggctacg gcggagccgg ctacagtggg agtggcctct gctacggtgg aggcagcagc
     1501 ggaggcttta gctccactag cggccgcagt gtgagcggca gcagctcaag catgcgcatt
     1561 gtctccaaga catcgtccac caagagctac aggagctaa
//
