LOCUS       NM_153476               2313 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus keratin 9 (Krt9), mRNA.
ACCESSION   NM_153476
VERSION     NM_153476.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2313)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 2313)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   7  (bases 1 to 2313)
  AUTHORS   Mochida,K., Rivkin,E., Gil,M. and Kierszenbaum,A.L.
  TITLE     Keratin 9 is a component of the perinuclear ring of the manchette
            of rat spermatids
  JOURNAL   Dev Biol 227 (2), 510-519 (2000)
   PUBMED   11071770
REFERENCE   8  (bases 1 to 2313)
  AUTHORS   Kobayashi,S., Kore-eda,S. and Tanaka,T.
  TITLE     Demonstration of the pathogenic effect of point mutated keratin 9
            in vivo
  JOURNAL   FEBS Lett 447 (1), 39-43 (1999)
   PUBMED   10218578
REFERENCE   9  (bases 1 to 2313)
  AUTHORS   Reis,A., Hennies,H.C., Langbein,L., Digweed,M., Mischke,D.,
            Drechsler,M., Schrock,E., Royer-Pokora,B., Franke,W.W., Sperling,K.
            et al.
  TITLE     Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma
            (EPPK)
  JOURNAL   Nat Genet 6 (2), 174-179 (1994)
   PUBMED   7512862
REFERENCE   10 (bases 1 to 2313)
  AUTHORS   Langbein,L., Heid,H.W., Moll,I. and Franke,W.W.
  TITLE     Molecular characterization of the body site-specific human
            epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and
            tissue specificity of gene expression
  JOURNAL   Differentiation 55 (1), 57-71 (1993)
   PUBMED   7507869
  REMARK    Erratum:[Differentiation. 1994 Jan;55(2):164. doi:
            10.1046/j.1432-0436.1994.5520164.x.. PMID: 7511549]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 2, 2020 this sequence version replaced NM_153476.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               JAXUCZ010000010.1  85626988-85627626   c
            640-722             JAXUCZ010000010.1  85625735-85625817   c
            723-879             JAXUCZ010000010.1  85625449-85625605   c
            880-1041            JAXUCZ010000010.1  85625016-85625177   c
            1042-1167           JAXUCZ010000010.1  85624214-85624339   c
            1168-1391           JAXUCZ010000010.1  85623884-85624107   c
            1392-2008           JAXUCZ010000010.1  85622914-85623530   c
            2009-2313           JAXUCZ010000010.1  85621360-85621664   c
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2313
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /note="keratin 9"
                     /db_xref="GeneID:266717"
                     /db_xref="RGD:628785"
     exon            1..639
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2028
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /note="K9; CK-9; cytokeratin-9; spermatid perinuclear ring
                     manchette protein K9; keratin 9 (epidermolytic
                     palmoplantar keratoderma); keratin complex 1, acidic, gene
                     9; keratin 9, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 9"
                     /protein_id="NP_703206.2"
                     /db_xref="GeneID:266717"
                     /db_xref="RGD:628785"
                     /translation="MSFRQISSSFRSSSGSSCGGGGGRGASRGSMRSSFSRSSRAGGG
                     GGRFGSSSGFGGGGFSACGTGGGGSFGSSYGGGYGGGFSAGSSSGMFGGGSRGCFGGG
                     SGGGFGGGSGGGFGGGFGGGFGGGSGGGEGSILNTNEKVVMQNLNSRLASYMDKVQEL
                     EEDNANLEKQIQEWYSRKGNRVFQKDYSHYYNTIEDLKDRIVDLTARNNKALIDMDNT
                     RMTLGDFRVKLEMEQSLRQGVDADINGLQKVLDDINMEKSDLEIQFDSLDDELKALKK
                     NHKEEMNQLTGQNDGDVNVEINVAPSTDLTQVLNDMREEYEHLISKNRQDIEQHYESK
                     MTQIEQQVTNSGQEMETNMKQVSQLQHSVQELNIELQTQLTTKSALEKALEDTKNRYC
                     GQLQQIQEQISEMEAQLAQVRAETECQNQEYGLLLSIKTRLEKEIETYRKLLEGGQQD
                     FESSGAGQIGFGSGKGRQRGSGGSYGGGSGDSYEGGSGRSYGGGHRGSHGGKSGGSHG
                     GGSRGSYGGESGGSYGGGSGGSHGGKSGGSYGGGSSSGGGSGGSYGGGSGGSHGGKSG
                     GSHGGGSGGSYGGGSGSGGESGGSYGGGSGGSHGGQKGGSGGSYEGGSGGSYGGGSGS
                     GGGSGGSYGGGNRRPSQSQSSKSADCDDDDSKGHKMRY"
     exon            640..722
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            723..879
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1041
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1167
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1391
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..2008
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2313
                     /gene="Krt9"
                     /gene_synonym="Krt1-9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccgctt cctgcctaca gactccggca ggcagcacca tgagtttcag acagatctcc
       61 tcatctttcc ggagcagcag cggcagcagc tgtggaggag gaggaggcag aggggccagc
      121 agaggcagca tgcggtcttc tttcagtcgc tcctccaggg ctggtggagg aggaggccgc
      181 tttggctctt ccagtggttt tggtggaggt ggcttttcag cctgtggcac tggaggtggt
      241 ggcagttttg gctctagcta tggtggagga tatggagggg gttttagcgc aggtagttcc
      301 agcggtatgt ttggtggagg ttctagaggt tgctttggtg gaggttctgg aggtggcttt
      361 ggtggaggtt ctggaggtgg ctttggtggg ggttttggag gtggctttgg tggtggctct
      421 ggaggtggcg aaggtagtat tctgaacacc aatgagaaag tcgtcatgca gaacctcaat
      481 tcccgtctgg cctcttacat ggataaagtg caggaactgg aggaggacaa cgccaacctg
      541 gagaagcaga tccaggaatg gtattcaagg aaggggaaca gagtcttcca gaaggactac
      601 tctcattatt ataacactat cgaagacctg aaggacagaa ttgtggatct cacagcgagg
      661 aacaacaaag cactcataga catggacaat actcgcatga ctctgggtga cttcagggtt
      721 aagcttgaga tggagcagag cctacgccaa ggggtggatg ctgatattaa tggcctgcag
      781 aaggttttgg atgacataaa tatggagaaa tctgatctgg agatacagtt tgatagtctg
      841 gacgatgagc tgaaggccct taagaagaac cacaaggagg agatgaacca gctgacgggc
      901 cagaatgatg gagatgttaa tgtggagata aatgttgctc ctagcacaga cctcacccag
      961 gtcctcaatg acatgcgtga ggaatatgaa cacctcattt ctaagaaccg ccaggacatt
     1021 gagcaacact atgagtccaa gatgacccag attgagcagc aagtgacaaa tagtggccaa
     1081 gagatggaga ccaacatgaa gcaagtgtcc cagctccagc acagtgtcca ggagttgaac
     1141 attgagctgc agactcagct taccacgaaa tcagccctgg agaaggcttt ggaagacaca
     1201 aagaaccgct actgtggcca gctgcagcag attcaggaac agatcagtga gatggaggcc
     1261 cagcttgctc aggtccgggc agaaactgag tgccagaacc aggaatatgg ccttctgctc
     1321 agcatcaaga cacggctgga gaaagaaatt gagacttacc gaaagctcct tgaaggcggc
     1381 cagcaagact ttgaatcttc tggagctgga caaattggct ttggaagtgg caaaggaaga
     1441 caaagaggaa gtggcggcag ctatggagga ggaagtgggg acagctatga aggaggaagt
     1501 ggaaggagct atggaggagg acataggggc agtcatggtg gaaaaagtgg aggcagtcat
     1561 ggaggaggaa gtaggggcag ctatggagga gaaagtgggg gcagctatgg aggaggaagt
     1621 gggggcagcc acggtggaaa aagtggaggt agttatggag gaggaagcag ctctggggga
     1681 ggaagtggag gcagctatgg aggaggaagt gggggcagcc atggtggaaa aagtgggggt
     1741 agccatggag gaggaagtgg gggcagctat ggtggaggaa gtggttctgg aggagaaagt
     1801 ggaggcagct atggaggagg aagtggaggc agccacggtg gacaaaaagg aggaagtggg
     1861 ggcagctatg aaggaggaag tggagggagc tatggaggag gaagtggttc tggaggagga
     1921 agtgggggta gctacggtgg aggaaataga aggccatctc agtcccagtc ctcaaaatct
     1981 gccgactgcg atgacgatga ttcgaaaggc cacaagatgc gatactagaa ccctgattaa
     2041 ctttctccac cggaccccag ctgagagtgt ctcaggaggg caggagctac atgaggcata
     2101 cttacagcat cctgacagca agtctacctg gcaacaagcc gggggaaccg tttggaactg
     2161 gacggagttg gcgttgtgcc tctggacatc tattggctcc gttccttgct ggggaggctt
     2221 cagggctggg gagaacttga ttttcccatg tgtcctgggg gtggcccccc tcccttcctt
     2281 atcctgactt cctaataaag ctttcctatt gca
//
