LOCUS       NM_001008810            1931 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 86 (Krt86), mRNA.
ACCESSION   NM_001008810 XM_017595034
VERSION     NM_001008810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Nanashima,N., Akita,M., Yamada,T., Shimizu,T., Nakano,H., Fan,Y.
            and Tsuchida,S.
  TITLE     The hairless phenotype of the Hirosaki hairless rat is due to the
            deletion of an 80-kb genomic DNA containing five basic keratin
            genes
  JOURNAL   J Biol Chem 283 (24), 16868-16875 (2008)
   PUBMED   18420582
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Winter,H., Rogers,M.A., Langbein,L., Stevens,H.P., Leigh,I.M.,
            Labreze,C., Roul,S., Taieb,A., Krieg,T. and Schweizer,J.
  TITLE     Mutations in the hair cortex keratin hHb6 cause the inherited hair
            disease monilethrix
  JOURNAL   Nat Genet 16 (4), 372-374 (1997)
   PUBMED   9241275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 8, 2020 this sequence version replaced
            XM_017595034.1, NM_001008810.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK003975.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               JAXUCZ010000007.1  134470224-134470648
            426-634             JAXUCZ010000007.1  134471260-134471468
            635-695             JAXUCZ010000007.1  134472121-134472181
            696-791             JAXUCZ010000007.1  134472917-134473012
            792-956             JAXUCZ010000007.1  134473179-134473343
            957-1082            JAXUCZ010000007.1  134473578-134473703
            1083-1303           JAXUCZ010000007.1  134473979-134474199
            1304-1335           JAXUCZ010000007.1  134476110-134476141
            1336-1931           JAXUCZ010000007.1  134476278-134476873
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1931
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /note="keratin 86"
                     /db_xref="GeneID:407760"
                     /db_xref="RGD:1303215"
     exon            1..425
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1517
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /note="type II keratin Kb26; keratin 86, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb6"
                     /protein_id="NP_001008810.2"
                     /db_xref="GeneID:407760"
                     /db_xref="RGD:1303215"
                     /translation="MTCGSYCGGRAFSCASACGPRPGRCCITAAPYRGISCYRGLSGG
                     FGSHSVCGAFRSGSCGRSFGYRSGGICGPSPPCITTVSVNESLLTPLNLEIDPNAQCV
                     KHEEKEQIKCLNSRFAAFIDKVRFLEQQNKLLETKWQFFQNRKCCESNVEPLFEGYIE
                     TLRREAECVEADSGRLAAELNHAQEAMEGYKKRYEEEVSLRATAENEFVALKKDVDCA
                     YLRKSDLEANTEALTQEIDFLRRLYEEETRILHAHISDTSVIVKMDNSRDLNMDCVIA
                     EIKAQYDDIASRSRAEAESWYRTKCEEIKATVIRHGETLRRTREEINELNRIIQRLTA
                     EIENAKCQNTKLEAAVTQSEQQGEAALTDARCKLAELEAALQKAKQDMACLLKEYQEV
                     MNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCVSGTAPAVN
                     TRVCSAPCSGNVVVGTPNACGPCAGAGACSGGCKKC"
     exon            426..634
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            635..695
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            696..791
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            792..956
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1082
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1303
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1335
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1931
                     /gene="Krt86"
                     /gene_synonym="Kb26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtaccctcc acttggacgt ctccagtctc ccagtcgccc tactccccaa ataaccatga
       61 cttgtggatc ctactgtggt ggccgcgcct tcagctgcgc ctcagcctgt gggccccgtc
      121 ccggccgctg ctgcatcact gcagctccct acaggggcat ctcctgctac cgcggactct
      181 cagggggctt tggcagccac agtgtctgcg gggcctttcg ctctggctcc tgtggacgca
      241 gcttcggtta ccgatccgga ggcatctgtg ggcccagccc cccctgcatc accactgtct
      301 ctgtcaatga gagcctgctc acccccctca acctagagat cgaccccaat gctcagtgcg
      361 tgaagcatga ggagaaggag cagatcaagt gcctgaacag caggttcgcc gccttcatcg
      421 acaaggtgcg cttcctggag cagcagaaca agctgctgga aaccaagtgg cagttcttcc
      481 agaaccgcaa gtgctgtgag agcaacgtgg agcctctgtt cgagggctac atcgagactc
      541 tgaggcggga ggctgagtgt gtggaggccg acagtggcag gctggctgct gagctcaacc
      601 atgctcagga ggccatggag ggctacaaga agaggtacga ggaggaagtt tctctgagag
      661 ctacagctga gaatgagttt gtggctctga agaaggatgt ggactgtgcc tacctgcgca
      721 agtcagacct ggaggccaac acagaggcac tgacccaaga gatcgacttc ctgaggcgac
      781 tgtatgagga ggagacccgc atcctccacg cccacatctc agacacctcc gtcatcgtca
      841 agatggacaa cagccgggac ctgaacatgg actgcgtcat tgctgagatc aaggctcagt
      901 atgatgacat tgccagccgt agccgtgcag aggccgagtc ctggtaccgc accaagtgtg
      961 aggagataaa ggccacagtg atccggcatg gagagaccct gcgtcgcacc agagaggaga
     1021 tcaatgagct gaacagaatc atccagaggc tgacagccga gatcgagaac gccaagtgcc
     1081 agaacaccaa gctggaggct gctgtgaccc agtctgagca gcagggagag gctgccctca
     1141 ccgatgcccg ctgcaagctg gctgagctgg aggctgccct gcagaaggcc aagcaggaca
     1201 tggcctgcct gctcaaggaa taccaggagg tgatgaactc caagctgggt ctggacatcg
     1261 agatcgccac ctacaggcgc ctgctggagg gcgaggaaca gaggttgtgt gagggcgttg
     1321 gctccgtgaa tgtgtgcgtg agcagctccc gcggtggcgt cgtctgtggc gatctctgtg
     1381 tctccggtac tgcccctgct gtcaacacca gagtgtgcag cgcaccttgc agtggcaatg
     1441 tggtggtggg cacccccaat gcctgcggcc cctgcgccgg ggcaggcgcc tgcagcggag
     1501 gctgtaagaa gtgctaggag gccacaaagc tgcaagccac tgccatgggc caccctgccc
     1561 gaaaagacag cacagcggga cagtggcctc ggccccttct tctcattctt tagctttccc
     1621 tagcaacttg tttgcagagt tcttgctttt ctttcccctt ctgccttttt ttctggattc
     1681 attggtctta ggatctcgga ggaaccgctg ccccaggatt ctttgcccaa ctttaccctt
     1741 ttgtctgggc aaggagacag ggaccaatat ggttgctggt tttcctgtca ctcctcgaga
     1801 gaccacgtga cccagagcat cttcttccgg atctccctgg cagcagctcc cccataccag
     1861 agcctctgct gcctgctcgt ttgcctttgt ctcactttac gttcccaata aactaattgc
     1921 agcgaaacaa a
//
