LOCUS       NM_001401219            1860 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 85 (Krt85), transcript variant 1, mRNA.
ACCESSION   NM_001401219 XM_006242351
VERSION     NM_001401219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Nanashima,N., Akita,M., Yamada,T., Shimizu,T., Nakano,H., Fan,Y.
            and Tsuchida,S.
  TITLE     The hairless phenotype of the Hirosaki hairless rat is due to the
            deletion of an 80-kb genomic DNA containing five basic keratin
            genes
  JOURNAL   J Biol Chem 283 (24), 16868-16875 (2008)
   PUBMED   18420582
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 13, 2022 this sequence version replaced NM_001401219.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB355640.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16676786
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               JAXUCZ010000007.1  134515294-134515786 c
            494-702             JAXUCZ010000007.1  134512949-134513157 c
            703-763             JAXUCZ010000007.1  134512430-134512490 c
            764-859             JAXUCZ010000007.1  134512201-134512296 c
            860-1024            JAXUCZ010000007.1  134511436-134511600 c
            1025-1150           JAXUCZ010000007.1  134511112-134511237 c
            1151-1371           JAXUCZ010000007.1  134510501-134510721 c
            1372-1403           JAXUCZ010000007.1  134509760-134509791 c
            1404-1860           JAXUCZ010000007.1  134508913-134509369 c
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1860
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /note="keratin 85"
                     /db_xref="GeneID:407762"
                     /db_xref="RGD:1303149"
     exon            1..493
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1597
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type II cuticular Hb5; type II keratin Kb25;
                     keratin 85, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb5 isoform 1"
                     /protein_id="NP_001388148.1"
                     /db_xref="GeneID:407762"
                     /db_xref="RGD:1303149"
                     /translation="MSCRSYRISPGCGVTRNFSSCSAVAPKTGNRCCISAAPFRGVSC
                     YRGLTGFSSRSLCNPSPCGPRMAVGGFRSGSCGRSFGYRAGGVCGPSPPCITTVSVNE
                     SLLTPLNLEIDPNAQCVKHEEKEQIKCLNSKFAAFIDKVRFLEQQNKLLETKWQFYQN
                     QRCCESNLEPLFGGYIETLRREAECVEADGGRLAAELNHVQEAMEGYKKRYEEEVALR
                     ATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLKRLYEEEVRVLQAHISDTSV
                     IVKMDNSRDLNMDCVVAEIKAQYDDVASRSRAEAESWYRTKCEEMKATVIRHGETLRR
                     TREEMNELNRIIQRLTAEIENAKCQRAKLETAVAEAEQQGEAALTDARGKLAELEAAL
                     QKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSSSRG
                     GVTCGGLTYGTTPGRQIASGPSVTGGSITVMAPDSCSPCQPRASSFTCGSSRSVRFA"
     exon            494..702
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            703..763
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            764..859
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1024
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1150
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1371
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1403
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1860
                     /gene="Krt85"
                     /gene_synonym="Kb25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaggattcc aagtctcaca ctctgcaacc tgcaccaaac ccacagccgc gtagacaccg
       61 tccagctccc gccatgtcct gtcgctccta caggatcagc ccaggatgtg gagttaccag
      121 aaacttcagc tcctgctcag ctgtggcccc aaaaactggc aaccgctgct gcatcagcgc
      181 agctcccttc cgaggagtgt cttgctaccg gggattgaca ggcttcagca gtcgaagcct
      241 ctgtaacccg agcccctgcg ggccacgcat ggctgttggg ggcttccgct ctggctcctg
      301 tggacgcagc tttggatacc gagctggagg cgtctgtggt ccaagcccac cctgcatcac
      361 caccgtctct gtcaatgaga gcctgctcac ccccctcaac ctggagatcg accccaatgc
      421 tcagtgcgtg aagcatgagg agaaggagca gatcaagtgt ctgaacagca agttcgcggc
      481 cttcatcgac aaggtgcgct tcctagagca gcagaacaaa ctgctggaga ccaagtggca
      541 gttctaccag aaccagcgct gctgtgagag caatctggag ccactatttg gaggctacat
      601 agagaccctc aggcgggagg ctgagtgtgt ggaggccgac ggcgggaggt tggctgctga
      661 gctcaaccac gtgcaggaag ccatggaggg ctacaagaag aggtatgaag aggaggtggc
      721 tttgagggct acggcagaga acgagtttgt ggttctaaag aaggatgtgg actgcgccta
      781 cttacgtaaa tcggacctgg aggccaacgt ggaggccttg gtggaggagt caagcttcct
      841 gaagcgtctc tatgaagagg aagtccgtgt tctccaagcc cacatctcag acacctccgt
      901 catcgtcaag atggacaaca gccgggacct gaacatggac tgcgtcgtgg ctgagatcaa
      961 ggctcagtat gatgacgtcg cgagtcgcag ccgtgcagag gctgagtcct ggtaccgcac
     1021 caagtgtgag gagatgaagg ccacagtgat ccggcacggg gagaccctcc gccgcaccag
     1081 ggaggagatg aacgagctga accgcatcat ccagaggctg acggctgaga tcgagaacgc
     1141 caagtgccag cgagcaaagc tggagactgc tgtggctgag gcagagcagc agggagaggc
     1201 cgccctcacc gatgcccgcg gcaagctggc tgagctagag gctgccctgc agaaggccaa
     1261 gcaggacatg gcctgcctgc tcaaggagta ccaggaggtg atgaactcca agctggggct
     1321 ggacatcgag atcgccacct acaggcgcct gctggagggc gaggagcaca ggctatgcga
     1381 gggtgtgggc tctgtgaatg tctgtgtcag cagctcccgt ggaggagtca catgtggggg
     1441 cctcacttat ggcactaccc cagggcgcca gattgcctct ggaccctctg tcaccggggg
     1501 cagcatcaca gtgatggccc ctgactcctg ctctccttgc cagccccgtg cctccagctt
     1561 cacctgtggg agcagccgct ctgtgcgctt tgcttagtgc caggacctcc aaatgagcca
     1621 cctgtctgcc ccagagtgga gtggtgtgtg aatggaaaat gtgtgcttgc ttgagaatct
     1681 tctagatgct cctgttagag gaaagagttc agggccactc tcctctgcct tctcctttta
     1741 gggagttgtc tcccagttct cctctggctt tactttagaa ggtcattcat tcccaacccg
     1801 tcccttaacc ctaacatgtc ttcaaatact tgtaaatgat ttgtatcgtt caccaagctc
//
