LOCUS       NM_001008814            1854 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus keratin 81 (Krt81), mRNA.
ACCESSION   NM_001008814 XM_008765774
VERSION     NM_001008814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Sha,Z., Lai,R., Zhang,X., Zhao,Y., Wu,J., Geng,C. and Guo,Z.
  TITLE     A Polymorphism at the microRNA Binding Site in the 3' Untranslated
            Region of KRT81 Is Associated with Breast Cancer
  JOURNAL   DNA Cell Biol 39 (10), 1886-1894 (2020)
   PUBMED   32678982
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Nanashima,N., Akita,M., Yamada,T., Shimizu,T., Nakano,H., Fan,Y.
            and Tsuchida,S.
  TITLE     The hairless phenotype of the Hirosaki hairless rat is due to the
            deletion of an 80-kb genomic DNA containing five basic keratin
            genes
  JOURNAL   J Biol Chem 283 (24), 16868-16875 (2008)
   PUBMED   18420582
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Winter,H., Rogers,M.A., Gebhardt,M., Wollina,U., Boxall,L.,
            Chitayat,D., Babul-Hirji,R., Stevens,H.P., Zlotogorski,A. and
            Schweizer,J.
  TITLE     A new mutation in the type II hair cortex keratin hHb1 involved in
            the inherited hair disorder monilethrix
  JOURNAL   Hum Genet 101 (2), 165-169 (1997)
   PUBMED   9402962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 8, 2020 this sequence version replaced
            XM_008765774.1, NM_001008814.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB355638.1, BK003974.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               JAXUCZ010000007.1  134460531-134460967 c
            438-646             JAXUCZ010000007.1  134459712-134459920 c
            647-707             JAXUCZ010000007.1  134458992-134459052 c
            708-803             JAXUCZ010000007.1  134458262-134458357 c
            804-968             JAXUCZ010000007.1  134457931-134458095 c
            969-1094            JAXUCZ010000007.1  134457571-134457696 c
            1095-1315           JAXUCZ010000007.1  134457075-134457295 c
            1316-1347           JAXUCZ010000007.1  134456662-134456693 c
            1348-1854           JAXUCZ010000007.1  134455842-134456348 c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1854
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /note="keratin 81"
                     /db_xref="GeneID:407761"
                     /db_xref="RGD:1303316"
     exon            1..437
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1514
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /note="type II keratin Kb21; keratin 81, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb1"
                     /protein_id="NP_001008814.2"
                     /db_xref="GeneID:407761"
                     /db_xref="RGD:1303316"
                     /translation="MTCGSGFCGRAFSCASACGPRPGRCCITAAPYRGISCYRGLSGG
                     FGSRSVCGAFRSGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCV
                     KHEEKEQIKCLNSRFAAFIDKVRFLEQQNKLLETKWQFFQNRKCCESNVEPLFEGYIE
                     TLRREAECVEADSGRLAAELNHAQEAMEGYKKRYEEEVSLRATAENEFVALKKDVDCA
                     YLRKSDLEANTEALTQEIDFLRRLYEEETRILHAHISDTSVIVKMDNSRDLNMDCVIA
                     EIKAQYDDIASRSRAEAESWYRTKCEEIKATVIRHGETLRRTREEINELNRIIQRLTA
                     EIENAKCQNTKLEAAVTQSEQQGEAALTDARCKLAELEAALQKAKQDMACLLKEYQEV
                     MNSKLGLDIEIATYRHLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCVSGSRPVTG
                     SACSAPCSGNLAVNTGLCAPCGSAVSCGRKC"
     exon            438..646
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            647..707
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            804..968
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1094
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1315
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1347
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1854
                     /gene="Krt81"
                     /gene_synonym="Kb21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattggagc ttccatcagg actccggagc tcccatccag aactttgcag cccatcttca
       61 gaagcacaat gacctgtgga tcaggattct gtggccgcgc cttcagctgc gcctcagcct
      121 gtgggccccg tcccggccgc tgctgcatca ctgcagctcc ctacaggggc atctcctgct
      181 accgcggact ctcagggggt ttcggcagcc gcagtgtctg cggggccttc cgctctggct
      241 cctgtggacg cagcttcgga taccgatccg gaggcgtctg tgggcccagc ccgccctgca
      301 tcaccaccgt ctctgtcaac gagagcctgc tcacccccct caacctggag atcgacccca
      361 atgctcagtg cgtgaagcat gaggagaagg agcagatcaa gtgcctgaac agcaggttcg
      421 cggccttcat cgacaaggtg cgcttcctgg agcagcagaa caagctgctg gagaccaagt
      481 ggcagttctt ccagaaccgc aagtgctgtg agagcaacgt ggagcctctg ttcgagggct
      541 acatcgagac tctgaggcgg gaggctgagt gtgtggaggc cgacagtggc aggctggctg
      601 ctgagctcaa ccatgctcag gaggccatgg agggctacaa gaagaggtac gaggaggaag
      661 tttctctgag agccacagct gagaatgagt ttgtggctct gaagaaggat gtggactgtg
      721 cctacctgcg caagtcagac ctggaggcca acacagaggc gctgacccag gagatcgact
      781 tcctgaggcg actgtatgag gaggagaccc gcatcctcca cgcccacatc tcagacacct
      841 ccgtcatcgt caagatggac aacagccggg acctgaacat ggactgcgtc attgctgaga
      901 tcaaggctca gtacgatgac attgccagcc gcagccgcgc agaggccgag tcctggtacc
      961 gcaccaagtg tgaggagata aaggccacag tgatccggca tggagagacc ctgcgtcgca
     1021 ccagagagga gatcaatgag ctgaacagaa tcatccagag gctgacagcc gagatcgaga
     1081 acgccaagtg ccagaacacc aagctggagg ctgctgtgac ccagtctgag cagcagggag
     1141 aggctgccct caccgatgcc cgctgcaagc tggctgagct ggaggctgcc ctgcagaagg
     1201 ccaagcagga catggcctgc ctgctcaagg aataccagga ggtgatgaac tccaagctgg
     1261 gtctggacat cgagatcgcc acctacaggc acctgctgga gggcgaggaa cagagactgt
     1321 gtgaaggtgt cggagctgtg aatgtctgtg tcagcagctc ccgcggagga gttgtgtgtg
     1381 gggacctgtg cgtgtcaggt tccaggccgg tgaccggcag cgcctgcagc gccccctgca
     1441 gcgggaactt ggcagtgaac acaggcctgt gtgcaccctg tggctcagct gtgtcctgtg
     1501 gccgtaaatg ttaaaaactg ccttcacatc ccggcccctt catagcattt catcctgagt
     1561 catccctggc tgaccaatat tgggacctag aagaagggac tcagccactc gctcactttg
     1621 aaatgaccct cactcttggc ccctctggtc tccctggagg accccctttg ctctcagaag
     1681 tgaatactgg cttctagaag tccctttgga gcttcagggt ggggagtctg ggggcggggc
     1741 tagaatacca cctaccctgc cttaactgtg agccagcagt tagaaccaca gtccccctcc
     1801 cctctctaat ctctgtcttg atctgtttcc aataaattaa tgtagtcaac tctg
//
