LOCUS       NM_001389262            3299 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 75 (Krt75), transcript variant 2, mRNA.
ACCESSION   NM_001389262 XM_006242325
VERSION     NM_001389262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3299)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 3299)
  AUTHORS   Adolphe,C., Hetherington,R., Ellis,T. and Wainwright,B.
  TITLE     Patched1 functions as a gatekeeper by promoting cell cycle
            progression
  JOURNAL   Cancer Res 66 (4), 2081-2088 (2006)
   PUBMED   16489008
REFERENCE   3  (bases 1 to 3299)
  AUTHORS   Winter,H., Schissel,D., Parry,D.A., Smith,T.A., Liovic,M., Birgitte
            Lane,E., Edler,L., Langbein,L., Jave-Suarez,L.F., Rogers,M.A.,
            Wilde,J., Peters,G. and Schweizer,J.
  TITLE     An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of
            the companion layer-specific keratin K6hf: evidence for a risk
            factor in the etiology of the common hair disorder
            pseudofolliculitis barbae
  JOURNAL   J Invest Dermatol 122 (3), 652-657 (2004)
   PUBMED   15086549
REFERENCE   4  (bases 1 to 3299)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   5  (bases 1 to 3299)
  AUTHORS   Winter,H., Langbein,L., Praetzel,S., Jacobs,M., Rogers,M.A.,
            Leigh,I.M., Tidman,N. and Schweizer,J.
  TITLE     A novel human type II cytokeratin, K6hf, specifically expressed in
            the companion layer of the hair follicle
  JOURNAL   J Invest Dermatol 111 (6), 955-962 (1998)
   PUBMED   9856802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 7, 2020 this sequence version replaced XM_006242325.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32041.1,
                                           SRR26643295.30304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680434, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JAXUCZ010000007.1  134575539-134576074 c
            537-751             JAXUCZ010000007.1  134574856-134575070 c
            752-812             JAXUCZ010000007.1  134573960-134574020 c
            813-908             JAXUCZ010000007.1  134573626-134573721 c
            909-1073            JAXUCZ010000007.1  134572792-134572956 c
            1074-1199           JAXUCZ010000007.1  134570996-134571121 c
            1200-1420           JAXUCZ010000007.1  134570645-134570865 c
            1421-1455           JAXUCZ010000007.1  134568753-134568787 c
            1456-3299           JAXUCZ010000007.1  134565826-134567669 c
FEATURES             Location/Qualifiers
     source          1..3299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3299
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /note="keratin 75"
                     /db_xref="GeneID:300247"
                     /db_xref="RGD:1359576"
     exon            1..536
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1694
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     keratin, type II cytoskeletal 75; cytokeratin-75; type II
                     keratin-18; type II keratin-K6hf; keratin-6 hair follicle;
                     type-II keratin Kb18; keratin 75, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 75 isoform 2"
                     /protein_id="NP_001376191.1"
                     /db_xref="GeneID:300247"
                     /db_xref="RGD:1359576"
                     /translation="MSRQSTVTFHSGSRRGFSTASATTPTAGRSRFSSVSVARSSGNS
                     GGLGRISGIGSGFGSRSLYNLGATRPVSVGGCAGSGFRSGFGGRASSSFGYGGGFGGP
                     GFPVCPSGSIQEVTVNQSLLTPLNLQIDPTIQRVRKEEREQIKTLNNKFASFIDKVRF
                     LEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDAYVNDLRRQLDSVTAERGRLDAELRH
                     MQEVVEDFKVRYEDEINKRAAAENEFVGLKKDVDGAYMNKVELEAKVDSLTDQINFYR
                     MVYEAELSQMQNQVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWYQ
                     TKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRSEIDAVKKQCSSLQTAISDTEQR
                     GELALKDARAKLVELEDALQKAKQDMARLLREYQELMNVKLALDVEIATYRKLLEGEE
                     CRLSGEGVSPVNISVVTSTVSSGYGGGTNIGGGSLGLGGNSGYSFTTTGGHSLGTGLG
                     GSGFTTSSSRGPVGSGSSIKFVSSTSSSRKSYKH"
     exon            537..751
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            752..812
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            813..908
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1073
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1199
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1420
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1455
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..3299
                     /gene="Krt75"
                     /gene_synonym="CK-75; K75; Kb18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggtttc tctaccccct tcacgcatct acctcggagc gcccgtgctg ccttcctcac
       61 ccatcatgtc ccggcaatct actgtcacct tccactccgg cagccgcagg ggcttcagca
      121 cagcctcagc caccacccct accgctggac gctcccgctt cagctcggtg tccgtagccc
      181 gctcctcagg aaacagtggg gggctgggca ggatcagtgg gattggttct ggctttggga
      241 gccgcagcct ctacaacctg ggggctacca ggccggtctc tgttggtggt tgtgctggca
      301 gtggcttcag gagtggcttt ggtggcaggg ctagcagtag ctttggttat ggagggggtt
      361 ttggtggtcc tggcttccct gtctgtccct ctggaagcat tcaagaagtt actgtcaacc
      421 agagcctcct gactcccctc aacctgcaaa tcgaccccac catccagcgg gtgcggaaag
      481 aagagcggga acagatcaag accctgaaca acaagttcgc ctccttcatc gacaaggtac
      541 gcttcctgga gcagcagaac aaggtccttg agaccaagtg gaacctccta caggagcagg
      601 gctccaggac agtcagacag aacctggagc ctttcttcga tgcctacgtc aatgacctcc
      661 gccggcagct ggacagcgtc acagctgaaa ggggcagact ggatgctgaa ctgaggcaca
      721 tgcaggaggt cgtagaagac ttcaaagtca ggtatgaaga cgaaattaac aagcgtgcag
      781 ctgccgagaa cgagttcgtg ggcctgaaaa aggacgtaga tggggcctac atgaacaagg
      841 tggagctgga agcgaaggtt gactctctga ctgaccagat caacttctac cggatggtct
      901 atgaggcaga gctgtctcag atgcagaacc aggtcagcga cacctctgtg gtcctctcca
      961 tggacaacaa ccgcagcctg gatctggaca gcatcatcgc tgaggtcaag gcccagtatg
     1021 aggacattgc caaccgcagc cgggcagagg ctgagtcctg gtaccagacc aagtatgagg
     1081 agctgcaggt gacagcaggc cggcacgggg atgacctccg caacaccaaa caggagatct
     1141 cggagatgaa ccggatgatc cagaggctga gatctgagat tgatgccgtc aagaagcagt
     1201 gctccagcct gcaaactgct atctctgaca cggagcagcg tggggagctg gccctcaagg
     1261 atgctcgggc caaactggtg gagcttgaag acgccctgca gaaggccaag caggacatgg
     1321 cccggctgct gcgcgagtac caggagctca tgaacgtcaa actggccctg gatgtggaga
     1381 tcgccaccta caggaagctg ctggagggcg aggagtgcag gctgagcgga gagggagttt
     1441 ccccagtgaa catctctgtg gtcacttcta cagtttccag tggctacggc ggtggcacca
     1501 acatcggagg tggaagcctg ggtcttggcg ggaacagtgg ctactccttc acgaccactg
     1561 gtgggcacag cctgggtaca ggtctgggag gctctggctt taccaccagt agcagccggg
     1621 gcccagtggg cagtggctcc agcatcaagt ttgtctccag cacgtcatcc agcaggaaga
     1681 gttacaagca ctgaggtggt cagccggcag tcccccttgc cactgctccg aagcctctca
     1741 tacatttata actggatgtc tgggcccttg tcctgtatcc tcttcatagt agccacctcc
     1801 ccagctgcca gggatcctgg catcccggct gaacccattc cctggcctat ggcagcctcc
     1861 cgacagccct aggctgctcc tggtacttct ttgtgttaga cacatagacc caaagctcgc
     1921 acccctccaa agttcacaat cagtggatct gccagagccg gacatctgca aacgcctctt
     1981 cagtgccacc ggcccctttc ctccaggtgc agcagcactg gaggagtccg tgtctcccag
     2041 tccacctcaa caccaggctg tcttgtccct ctctggctgc ttacacactg ccagctggag
     2101 tcaaagctcc tctgtttcct cctggaatgc gcctattaaa tccatgtgtc atgtgtttgg
     2161 ctcagccctc tgtgtgcagc atcgatgagc cccaagtaac tctgactctc agaaggcccc
     2221 agccagtgtt attccacaca agcagtactc agggcacaat agctgctgcc cattgcagag
     2281 gggctggagg gaggggcatg gagagggaga agcacgggga tggcggcagg ccaatagtct
     2341 tcctccttta gcggctccta ctccccttgc tattctttgg aatgcttgtt tgggaagtcc
     2401 caacccctgg gcagagccct gcccagccag cctcctgccc agtatgtcat gcagggtggg
     2461 gaggtaccct ccccaaatga gcctgacata ggacaggtgg ccaaggccct ggccagcaaa
     2521 ggagctgatt gttccctgac agcttcaaac ttgcaggact gaacagagaa ataacagggc
     2581 gggagaggag ttaaaagtca gccccgaggc caaggagcaa aagaaccata attgttaaga
     2641 cacagagaca cccaggaagc tcctcattcc tgagtttaca gtctcctgga cccctcccct
     2701 caagaccaag ggggatgatg ggactaatcg tgagcagggt ccaggtgttt gaacagggtg
     2761 ggcttgtcac ttaagattac tgacaggagc tgccgagcag aactgtgaaa accactcatg
     2821 ctcagaaagg agaagttctg ttataggagt cagaggagag gaaggtgaaa taggagactg
     2881 aagtctagaa tggttaagag gggaatgatt tcagagtaga caggaaaaac cctgggaata
     2941 atcgtcaaat tcactagcta agaccgggga ggaaagagaa gagggcagag atttggggta
     3001 acctcatact acttaggaaa gaccagagac ctcattatcc cctgctatgt gaagtacaga
     3061 gattctgggc acacagccca atcagccact gggttctagt attgtctcca gcattccctg
     3121 gccatgtgac atggttgcca atgattgcag gtaaaaacca agggcaaaag cagccaagat
     3181 tggaaggcaa acagttgggg ttcatccccc atgatactgc tcataaaaag gttggcaatg
     3241 ccccatcatc tgttttcata aagttaaaaa aaataaaatg taatgtttgt ggtagatct
//
