LOCUS       NM_001276440            2154 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus keratin 71 (Krt71), mRNA.
ACCESSION   NM_001276440 XM_003750409
VERSION     NM_001276440.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Fujimoto,A., Farooq,M., Fujikawa,H., Inoue,A., Ohyama,M., Ehama,R.,
            Nakanishi,J., Hagihara,M., Iwabuchi,T., Aoki,J., Ito,M. and
            Shimomura,Y.
  TITLE     A missense mutation within the helix initiation motif of the
            keratin K71 gene underlies autosomal dominant woolly
            hair/hypotrichosis
  JOURNAL   J Invest Dermatol 132 (10), 2342-2349 (2012)
   PUBMED   22592156
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Kuramoto,T., Hirano,R., Kuwamura,M. and Serikawa,T.
  TITLE     Identification of the rat Rex mutation as a 7-bp deletion at
            splicing acceptor site of the Krt71 gene
  JOURNAL   J Vet Med Sci 72 (7), 909-912 (2010)
   PUBMED   20179389
  REMARK    GeneRIF: a 7-bp deletion at the splicing acceptor site of intron 1
            of the keratin 71 (Krt71) gene plays an important role in hair
            formation.
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Kikkawa,Y., Oyama,A., Ishii,R., Miura,I., Amano,T., Ishii,Y.,
            Yoshikawa,Y., Masuya,H., Wakana,S., Shiroishi,T., Taya,C. and
            Yonekawa,H.
  TITLE     A small deletion hotspot in the type II keratin gene
            mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the
            wavy hair of the caracul (Ca) mutation
  JOURNAL   Genetics 165 (2), 721-733 (2003)
   PUBMED   14573483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 12, 2013 this sequence version replaced XM_003750409.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KF303589.1, KF303588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               JAXUCZ010000007.1  134760529-134761033 c
            506-720             JAXUCZ010000007.1  134758217-134758431 c
            721-781             JAXUCZ010000007.1  134757220-134757280 c
            782-877             JAXUCZ010000007.1  134756733-134756828 c
            878-1042            JAXUCZ010000007.1  134756257-134756421 c
            1043-1168           JAXUCZ010000007.1  134755936-134756061 c
            1169-1389           JAXUCZ010000007.1  134754493-134754713 c
            1390-1424           JAXUCZ010000007.1  134753708-134753742 c
            1425-2154           JAXUCZ010000007.1  134752248-134752977 c
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2154
                     /gene="Krt71"
                     /note="keratin 71"
                     /db_xref="GeneID:683613"
                     /db_xref="RGD:1584538"
     exon            1..505
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1636
                     /gene="Krt71"
                     /note="keratin 71, type II"
                     /codon_start=1
                     /product="keratin 71"
                     /protein_id="NP_001263369.1"
                     /db_xref="GeneID:683613"
                     /db_xref="RGD:1584538"
                     /translation="MSRQFTCKSGAGNRGFSGCSAVLSGGSSSSYRAGGKGLSGGFGS
                     RSLYSLGGPRSITLNMASGSGKNGGFGFGRNRASGFAGSIFGSVALGPVCPTVCPPGG
                     IHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLE
                     TKWELLQQLDLNNCKNNLEPILEGYISNMRKQLETLSGDRVRLDSELRNVRDVVEDYK
                     KKYEEEINRRTAAENEFVLLKKDVDAAYANKVELQAKVDTMDQDIKFFKCLFEAEMAQ
                     IQSHISDMSVILSMDNNRNLDLDSIIDEVRAQYEEIALKSKAEAEALYQTKFQELQLA
                     AGRHGDDLKNTKNEITELTRFIQRLRSEIENAKKQASNLETAIADAEQRGDSALKDAR
                     AKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEYSS
                     PVSISIISSTSGSGGYGFRPSTVSGGYVANSTSCISGVCSVRGGENRSRGSASDYKDS
                     LTKGSSLSTPSKKGGR"
     exon            506..720
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            721..781
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            782..877
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1042
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1168
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1389
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1424
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..2154
                     /gene="Krt71"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacaaccttc gtgggatctg ccttcctcct gcattcgtcc tccatctcta ccaacaacag
       61 catgagtcgc cagttcacct gcaagtctgg agccggcaac aggggcttca gcggttgctc
      121 tgcagtgctg tccgggggaa gctcatcctc ctaccgggca ggaggcaaag ggctcagcgg
      181 gggctttggc agtcggagtc tctacagcct gggaggcccc aggagcatca ctctcaacat
      241 ggctagtggc agcgggaaga acggaggttt tggatttggc cggaaccgag ccagcggctt
      301 tgccggaagt atctttggca gtgtggccct gggacccgtg tgccccactg tgtgcccgcc
      361 tggcggcatc caccaggtca cagtcaatga gagcctcctg gccccactca atgtggagct
      421 ggaccctgag atccagaagg tgcgcgccca ggagagggag cagatcaagg cactgaacaa
      481 caagttcgcc tccttcatcg acaaggtgcg cttcctggag cagcagaacc aggtgctgga
      541 gaccaagtgg gagctgctgc agcagctgga cctcaacaac tgcaagaaca acctggagcc
      601 catcctcgag ggctacatca gcaacatgcg gaagcagctg gagacactgt ctggggacag
      661 agtgaggctg gactccgagc tgaggaacgt gcgtgacgtg gtggaggact acaagaagaa
      721 gtacgaggag gagatcaacc ggcggacagc tgcagagaac gagtttgtgc tgctgaagaa
      781 ggatgtggat gcagcatatg ccaacaaggt ggaactgcag gctaaggtgg acaccatgga
      841 ccaggacatc aaattcttca agtgtctgtt cgaagccgag atggctcaga tccagtccca
      901 catcagcgac atgtccgtca tcctgtccat ggacaacaat aggaacctgg acctggacag
      961 catcattgat gaggtccggg cccagtatga ggagatcgcc ctgaagagca aggctgaggc
     1021 tgaggccctg taccagacca agttccagga gctgcagctg gccgccggcc gccatggaga
     1081 cgacctcaaa aacaccaaaa atgaaatcac cgagctgacc cggttcatcc agagactccg
     1141 ctccgagatt gagaatgcaa agaaacaggc ttctaacctg gagacggcca tcgctgacgc
     1201 tgagcagcga ggagacagtg ctctcaagga tgcccgggcc aagctggatg agctggaagg
     1261 tgcccttcat caggccaagg aggagctggc caggatgctg cgtgaatacc aggagctcat
     1321 gagcctaaag ctggccctgg acatggagat cgccacctac cgcaagctgc tggagagcga
     1381 ggagtgcagg atgtctggag aatactcttc ccctgtcagc atctccatta tcagcagcac
     1441 cagtggcagt gggggctatg gcttccggcc cagcacagtc agcggtggct acgtggccaa
     1501 tagcactagc tgcatctctg gagtgtgcag cgtccgtggt ggggagaaca ggagcagagg
     1561 cagtgccagc gactacaagg attccctaac aaagggctcc agtctgagca ccccctccaa
     1621 gaaaggtggc cggtgagagg gcttcctgtg gcctccctca ctcagcaccc tctgtgccct
     1681 agcctattgt cccccttcct accccatgta ccactcctgg gccaatctcc ttctctctcc
     1741 aagtgttttg ggactggata gctctgggct accatgtggt gcacttctga tagacaccag
     1801 gagcttctca gcttcagctc aggtccagcc tgtcccttcc accagccgtt ggctctgtcc
     1861 ttaccgtact acctggcttc ttgggtctcc atctgggctt cttcatctgc tgagcttttg
     1921 tcgcagctcc tgcctatgac aggagctggc tatacccaag aagaagacta acagaaaacc
     1981 aattcagagt ggccacccca ccccacccca gcacagtctc attttgagca gaaccactca
     2041 gaataaaggg actctgcctt cactttcctg aacccagaac cagagaaaag gggacagcct
     2101 tggcttctct tgtattcctt aaagccctcc ctgttgcatt ctcaataaac agca
//
