LOCUS       NM_001047870            2085 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus keratin 7 (Krt7), transcript variant 1, mRNA.
ACCESSION   NM_001047870 XM_001064467 XM_003750407 XM_217035
VERSION     NM_001047870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Xu,Y., Wang,W., Li,L., Liu,J., Wu,X., Yu,J., Wang,H., Cui,W. and
            Zhang,R.
  TITLE     FOXA1 and CK7 expression in esophageal squamous cell carcinoma and
            its prognostic significance
  JOURNAL   Neoplasma 65 (3), 469-476 (2018)
   PUBMED   29788741
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Moreira,A.J., Rodrigues,G.R., Bona,S., Fratta,L.X., Weber,G.R.,
            Picada,J.N., Dos Santos,J.L., Cerski,C.T., Marroni,C.A. and
            Marroni,N.P.
  TITLE     Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl
            transferase in multistage hepatocarcinogenesis in rats
  JOURNAL   Protoplasma 254 (2), 911-920 (2017)
   PUBMED   27525410
  REMARK    GeneRIF: an extensive ductular reaction in advanced Hepatocellular
            carcinoma (HCC) and a strong correlation between PCK7 and levels of
            gammaGT and the poor prognosis and aggressiveness of HCC, is
            reported.
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Gralinski,L.E., Bankhead,A. 3rd, Jeng,S., Menachery,V.D., Proll,S.,
            Belisle,S.E., Matzke,M., Webb-Robertson,B.J., Luna,M.L.,
            Shukla,A.K., Ferris,M.T., Bolles,M., Chang,J., Aicher,L.,
            Waters,K.M., Smith,R.D., Metz,T.O., Law,G.L., Katze,M.G.,
            McWeeney,S. and Baric,R.S.
  TITLE     Mechanisms of severe acute respiratory syndrome coronavirus-induced
            acute lung injury
  JOURNAL   mBio 4 (4), e00271-13 (2013)
   PUBMED   23919993
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2085)
  AUTHORS   Badea,L., Herlea,V., Dima,S.O., Dumitrascu,T. and Popescu,I.
  TITLE     Combined gene expression analysis of whole-tissue and
            microdissected pancreatic ductal adenocarcinoma identifies genes
            specifically overexpressed in tumor epithelia
  JOURNAL   Hepatogastroenterology 55 (88), 2016-2027 (2008)
   PUBMED   19260470
REFERENCE   6  (bases 1 to 2085)
  AUTHORS   Komuta,M., Spee,B., Vander Borght,S., De Vos,R., Verslype,C.,
            Aerts,R., Yano,H., Suzuki,T., Matsuda,M., Fujii,H., Desmet,V.J.,
            Kojiro,M. and Roskams,T.
  TITLE     Clinicopathological study on cholangiolocellular carcinoma
            suggesting hepatic progenitor cell origin
  JOURNAL   Hepatology 47 (5), 1544-1556 (2008)
   PUBMED   18393293
REFERENCE   7  (bases 1 to 2085)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   8  (bases 1 to 2085)
  AUTHORS   Stoesz,S.P. and Gould,M.N.
  TITLE     Overexpression of neu-related lipocalin (NRL) in neu-initiated but
            not ras or chemically initiated rat mammary carcinomas
  JOURNAL   Oncogene 11 (11), 2233-2241 (1995)
   PUBMED   8570173
REFERENCE   9  (bases 1 to 2085)
  AUTHORS   Glass,C. and Fuchs,E.
  TITLE     Isolation, sequence, and differential expression of a human K7 gene
            in simple epithelial cells
  JOURNAL   J Cell Biol 107 (4), 1337-1350 (1988)
   PUBMED   2459129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jan 13, 2022 this sequence version replaced
            XM_003750407.5, NM_001047870.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR22582419.2979636.1, SRR22582416.481892.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN16676784, SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000007.1  134407626-134407705
            81-124              JAXUCZ010000007.1  134407966-134408009
            125-857             JAXUCZ010000007.1  134408478-134409210
            858-1069            JAXUCZ010000007.1  134410452-134410663
            1070-1130           JAXUCZ010000007.1  134412540-134412600
            1131-1226           JAXUCZ010000007.1  134414805-134414900
            1227-1391           JAXUCZ010000007.1  134415954-134416118
            1392-1517           JAXUCZ010000007.1  134416855-134416980
            1518-1738           JAXUCZ010000007.1  134419653-134419873
            1739-1773           JAXUCZ010000007.1  134423046-134423080
            1774-2085           JAXUCZ010000007.1  134423476-134423787
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2085
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /note="keratin 7"
                     /db_xref="GeneID:300242"
                     /db_xref="RGD:1310865"
     exon            1..80
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            81..124
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            125..857
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..1925
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type II cytoskeletal 7; K7; CK-7; cytokeratin-7;
                     type-II keratin Kb7; keratin complex 2, basic, gene 7;
                     keratin 7, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 7 isoform 1"
                     /protein_id="NP_001041335.2"
                     /db_xref="GeneID:300242"
                     /db_xref="RGD:1310865"
                     /translation="MSIHFSSRSTAYPGRGAQVRLSSGRAGFGSRSLYGLGTSRPRVA
                     VRSAYGGPVGAGIREITINQNLLAPLSVDIDPTIQQVRQEEREQIKTLNNKFASFIDK
                     VRFLEQQNKMLETKWALLQDQKSAKSSQLPRIFEAQIAGLRQQLEALQLDGGRLEVEL
                     RSMQDVVEDFKNKYEEEINRRTAAENEFVLLKKDVDAAYTNKVELEAKADSLQDKINF
                     LKTLHETELAELQSQISDTCVVLSMDNSRSLDLDGIIADVKAQYEEMANHSQAEAEAW
                     YQTKFETLQAQAGKHGDDLRNTRNEIAEMNRSIQKLQAEIDTVKNQRAKLESSIAEAE
                     EQGELALKDARAKLAEVEEALQKAKQDLARLLREYQELMNVKLGLDIEIATYRKLLEG
                     EESRLSGDGMEPVNISVVNSTGANGSRLTIGGTMGSNALSFSGGPGVLRTYSIKTTST
                     ARRGTHH"
     exon            858..1069
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1130
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1226
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1391
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1517
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1738
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1773
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2085
                     /gene="Krt7"
                     /gene_synonym="Krt2-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttcccag tactctgctt cccagctctc actagacacg ctgaaggagc tgtggctgag
       61 ggggccagtg actcgttcag ggtgccccta aaggaccagt gaggctcatt gcatggggcc
      121 agagcacttg gctttcctgc tggccccagg aatctctgtg ttcactcccc aagcctgctc
      181 cagaaagcct tgctctgcca attgtaaggt ggtctctttg agatctagag atttctgagc
      241 tgtgggtatc ttgggcaact tgcctcaggt gtgggtgtct cacgatggcg tctgggtctc
      301 ctgcagacac ttcctgagtg gacggggaga ctgggcggtg gctgggggcg gtgcgagggc
      361 agaaggcagg cggacaggag ggccctggcg gcagagaaag gtggccagcg gccagcggcc
      421 agccccgccc tgtccccacc tgtgtgcgct cagcctccgc ccctcatgga gggataaaag
      481 gtctcagact gcctgaggtc agggagttcg cgctgcttct ctcctggtcc agccagccct
      541 gtccagccgc tatgtccatc cacttcagct ctcgctccac tgcctatccc ggccgcgggg
      601 ctcaggtgcg gctgagctcg ggccgcgcgg gcttcggcag caggagcctc tatggcctgg
      661 gcacttccag gcctcgtgtg gccgtgcgct ccgcttatgg gggcccggtg ggcgccggca
      721 tccgtgagat caccatcaat cagaacttgc tggcacctct gagtgtggac atcgacccca
      781 ccatccagca ggtgcgccag gaagagcgtg agcagatcaa gaccctcaac aacaaattcg
      841 cctccttcat cgacaaggtg cgcttcctgg aacagcagaa caagatgctg gagaccaagt
      901 gggcgctgct gcaggatcag aagtcagcca agagcagcca gcttccccgc atcttcgagg
      961 cccagattgc tggtctgcgg cagcagcttg aggcactgca gctggatggg ggccgcctgg
     1021 aggtggagct gcggagcatg caggatgtgg tggaagattt caagaacaag tatgaggagg
     1081 agatcaaccg acgcacagct gccgagaacg agtttgtgct gctgaagaag gacgtggatg
     1141 ctgcctacac aaacaaggtg gagctggagg ccaaggcaga cagtctgcag gacaagatca
     1201 actttctcaa gacccttcat gagacagagt tagcagagct gcagtcacag atctcagaca
     1261 catgcgtggt gctgtccatg gataacagcc gctccctgga cttggatggc atcatcgctg
     1321 acgtcaaagc ccagtacgag gagatggcca accatagcca ggcagaggct gaagcctggt
     1381 accagaccaa gttcgagaca ctccaggccc aggctgggaa gcacggggat gacctccgca
     1441 acacccggaa tgagattgcg gagatgaacc gctccatcca gaagctgcag gcagagattg
     1501 acaccgtgaa gaaccagcgt gccaagctgg aatccagcat cgccgaggct gaggaacaag
     1561 gggagctggc actcaaggat gctcgggcca agctggctga ggtggaggag gctctgcaga
     1621 aggccaagca ggacctggcc cggctgctgc gcgaatacca ggagctcatg aacgtcaagc
     1681 tggggctgga catcgagatc gccacctaca ggaagctgct ggagggcgag gagagcaggt
     1741 tgtctggaga cggaatggaa cctgtgaaca tctctgttgt gaattccact ggggccaatg
     1801 gcagtaggct taccatcggg ggaaccatgg gaagcaacgc tctgagcttt agtgggggac
     1861 ccggagtcct cagaacttat tccatcaaga ctacatctac cgcccgcagg ggcacccacc
     1921 attgagcaca tgcgactgag ctgtgggctt ggagagaccc catacccttt tgtccacata
     1981 cagaaagacc cctcctgcct catgtccctg tcccaagcct ggaagacggt ttgaaactgt
     2041 cattggtttt aataaagggc ctctcggaga gagcttcatc agcta
//
