LOCUS       NM_183333               2185 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus keratin 5 (Krt5), mRNA.
ACCESSION   NM_183333
VERSION     NM_183333.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Mantel,A., Carpenter-Mendini,A.B., Vanbuskirk,J.B., De
            Benedetto,A., Beck,L.A. and Pentland,A.P.
  TITLE     Aldo-keto reductase 1C3 is expressed in differentiated human
            epidermis, affects keratinocyte differentiation, and is upregulated
            in atopic dermatitis
  JOURNAL   J Invest Dermatol 132 (4), 1103-1110 (2012)
   PUBMED   22170488
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Acroplaxome, an F-actin-keratin-containing plate, anchors the
            acrosome to the nucleus during shaping of the spermatid head
  JOURNAL   Mol Biol Cell 14 (11), 4628-4640 (2003)
   PUBMED   14551252
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Hofmann,I., Mertens,C., Brettel,M., Nimmrich,V., Schnolzer,M. and
            Herrmann,H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Nan,L., Kawamata,H., Tan,X., Kameyama,S. and Oyasu,R.
  TITLE     Differential expression of keratin 5 gene in non-tumorigenic and
            tumorigenic rat bladder cell lines
  JOURNAL   Cancer Lett 75 (2), 87-93 (1993)
   PUBMED   7507402
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Kartasova,T., Roop,D.R., Holbrook,K.A. and Yuspa,S.H.
  TITLE     Mouse differentiation-specific keratins 1 and 10 require a
            preexisting keratin scaffold to form a filament network
  JOURNAL   J Cell Biol 120 (5), 1251-1261 (1993)
   PUBMED   7679677
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Paine,M.L., Gibbins,J.R., Chew,K.E., Demetriou,A. and Kefford,R.F.
  TITLE     Loss of keratin expression in anaplastic carcinoma cells due to
            posttranscriptional down-regulation acting in trans
  JOURNAL   Cancer Res 52 (23), 6603-6611 (1992)
   PUBMED   1384967
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Lane,E.B., Rugg,E.L., Navsaria,H., Leigh,I.M., Heagerty,A.H.,
            Ishida-Yamamoto,A. and Eady,R.A.
  TITLE     A mutation in the conserved helix termination peptide of keratin 5
            in hereditary skin blistering
  JOURNAL   Nature 356 (6366), 244-246 (1992)
   PUBMED   1372711
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 3, 2021 this sequence version replaced NM_183333.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062086.1, SRR22582424.681173.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               JAXUCZ010000007.1  134729940-134730569 c
            631-845             JAXUCZ010000007.1  134729200-134729414 c
            846-906             JAXUCZ010000007.1  134728423-134728483 c
            907-1002            JAXUCZ010000007.1  134728217-134728312 c
            1003-1167           JAXUCZ010000007.1  134727937-134728101 c
            1168-1293           JAXUCZ010000007.1  134727437-134727562 c
            1294-1514           JAXUCZ010000007.1  134726622-134726842 c
            1515-1549           JAXUCZ010000007.1  134725861-134725895 c
            1550-2185           JAXUCZ010000007.1  134724840-134725475 c
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2185
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /note="keratin 5"
                     /db_xref="GeneID:369017"
                     /db_xref="RGD:727894"
     exon            1..630
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1818
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /note="keratin complex 2, basic, gene 5; keratin 5
                     (epidermolysis bullosa simplex,
                     Dowling-Meara/Kobner/Weber-Cockayne types); cytokeratin-5;
                     type-II keratin Kb5; keratin 5, type II; keratin 8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 5"
                     /protein_id="NP_899162.2"
                     /db_xref="GeneID:369017"
                     /db_xref="RGD:727894"
                     /translation="MSRQSSVSFRSGGSRSFSAASAITPSVSRTTFSSVSRSGGGGGR
                     VSLGGAYGAGGYGSRSLYNVGGSKRISFSSGGGSFRNQFGAGAGGGYGFGGGAGSGFG
                     FGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRV
                     RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTIKQNLDPLFEQY
                     INNLRRQLDGVMGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVD
                     AAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSI
                     IAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRL
                     RSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQ
                     ELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSLSSGYGGRSNIGYGS
                     GLGSGIGGFASDIGPLLNRRGLGSGLSVGGSGFSASSGQGGGFSSGGGSSSSVKFVST
                     TSSSRRSFKS"
     exon            631..845
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            846..906
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1002
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1167
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1293
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1514
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1549
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..2185
                     /gene="Krt5"
                     /gene_synonym="CK-5; K5; Krt2-5; Sak57"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagccac ccacagcgtc ccgttgaacg ccgacctccc tgccaccagc gccccgtgct
       61 cttgctcctc caggaacaaa caccatcatg tctcgccagt ccagtgtgtc cttccgaagc
      121 gggggcagcc gctctttcag cgccgcttct gccatcaccc catctgtctc tcgtaccacc
      181 ttcagctcgg tgtcccgcag tggtggtggt ggtggcaggg tcagccttgg tggcgcttac
      241 ggagccgggg gctatggcag ccgaagcctg tacaatgtgg ggggctccaa aaggatctcc
      301 ttcagttctg gcggaggtag cttcaggaac caatttggtg ccggtgctgg aggcggctat
      361 ggctttggag gaggagcagg cagtggattc ggctttggtg gtggagctgg cagtggcttt
      421 ggcttcggtg gtggagctgg ctttggtggt ggctatggtg gagctggctt ccctgtgtgc
      481 ccccctggtg gcatccaaga ggtcaccgtt aaccagaatc tcctcacacc cctgaacctg
      541 caaatcgatc ccaccatcca gcgggtcagg actgaggaga gggagcagat caagaccctc
      601 aacaacaagt ttgcctcctt catcgacaag gtgcggttcc tggagcagca gaacaaggtc
      661 ctggacacca aatggaccct gctgcaggag cagggcacca agaccataaa gcagaacctg
      721 gatccgttgt ttgaacagta cattaacaac ctccgtagac agctggatgg ggtcatgggg
      781 gagaggggcc gcctggactc ggagctgagg aacatgcagg atctggtgga ggactacaag
      841 aacaagtacg aggatgagat caacaagcgt accacggctg agaatgaatt cgtgatgttg
      901 aagaaggatg tggacgcggc ctacatgaac aaggtggagc tagaagctaa ggttgatgcc
      961 ctaatggacg agatcaactt catgaagatg ttctttgatg cggagctgtc ccagatgcag
     1021 acacatgtct ctgacacatc tgtggtcctc tccatggaca acaaccgtag cctggacctg
     1081 gacagcatca tcgctgaggt caaggcccag tatgaggaca ttgccaaccg cagccgaaca
     1141 gaggctgagt cctggtacca gaccaagtac gaggagctgc agcagacagc cggccggcac
     1201 ggagatgacc tccgcaacac caagcatgag atctcagaga tgaaccggat gatccagagg
     1261 ctgagatccg agatcgacaa tgtcaagaag cagtgtgcca acctccagaa tgccatcgcc
     1321 gaggctgagc agcgtgggga gctggctctc aaggatgcca gaaacaagct gactgagctg
     1381 gaggaggccc tgcagaaggc caagcaggac atggcccggc tgctgcgcga gtaccaggag
     1441 ctcatgaaca ccaagctggc cctggatgtg gagatcgcca cctacaggaa gctgctggag
     1501 ggagaggagt gcaggctgag tggagaagga gttggaccag tcaacatctc tgtcgtcact
     1561 aacagcctct cttctggcta tggaggaaga agcaacattg gctatggctc tggcttgggc
     1621 agtggcattg gcggttttgc ctcagatatc ggcccactct tgaacaggcg cggtttgggt
     1681 agtgggctca gtgtgggggg ctccggcttc agtgcaagca gtggtcaagg tgggggtttc
     1741 agcagtggtg gtggcagcag ctccagtgtc aaatttgtct ccaccacctc ctcctcccgg
     1801 aggagcttca agagctaaga agaacctgct ccaagaccct ggccttcacg ggcagcccca
     1861 ggcccacaga gactgcatct tctaggcagt cccccagacc aagtcttctt tttttctgga
     1921 gagtagtcta gaccatgcct gctgcaaaac cacatgcttt ggttcctgga agggaataaa
     1981 tcccaacttc tggcctcccc atgcctcagt tcttcatctt gttccaagtc agtacctacg
     2041 tgtgttcttt gataacccag acatccaaat tgttgtagaa cgtaaaccac caaagcagac
     2101 cccaccccca ccctggcacc caccttaact ctgtcctggt tctgacgtcc tccagactgt
     2161 gtccaataaa gcttttataa tataa
//
