LOCUS       NM_001008806            2127 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus keratin 4 (Krt4), mRNA.
ACCESSION   NM_001008806 XM_235686
VERSION     NM_001008806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Sakamoto,K., Aragaki,T., Morita,K., Kawachi,H., Kayamori,K.,
            Nakanishi,S., Omura,K., Miki,Y., Okada,N., Katsube,K., Takizawa,T.
            and Yamaguchi,A.
  TITLE     Down-regulation of keratin 4 and keratin 13 expression in oral
            squamous cell carcinoma and epithelial dysplasia: a clue for
            histopathogenesis
  JOURNAL   Histopathology 58 (4), 531-542 (2011)
   PUBMED   21371075
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Samen,U., Eikmanns,B.J., Reinscheid,D.J. and Borges,F.
  TITLE     The surface protein Srr-1 of Streptococcus agalactiae binds human
            keratin 4 and promotes adherence to epithelial HEp-2 cells
  JOURNAL   Infect Immun 75 (11), 5405-5414 (2007)
   PUBMED   17709412
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Ness,S.L., Edelmann,W., Jenkins,T.D., Liedtke,W., Rustgi,A.K. and
            Kucherlapati,R.
  TITLE     Mouse keratin 4 is necessary for internal epithelial integrity
  JOURNAL   J Biol Chem 273 (37), 23904-23911 (1998)
   PUBMED   9727004
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Wang,D.Y., Xiang,Y.Y., Tanaka,M., Shen,Q. and Sugimura,H.
  TITLE     Identification of cytokeratin subspecies altered in rat
            experimental esophageal tumors by subtractive cloning
  JOURNAL   Cancer Lett 108 (1), 119-127 (1996)
   PUBMED   8950218
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Rugg,E.L., McLean,W.H., Allison,W.E., Lunny,D.P., Macleod,R.I.,
            Felix,D.H., Lane,E.B. and Munro,C.S.
  TITLE     A mutation in the mucosal keratin K4 is associated with oral white
            sponge nevus
  JOURNAL   Nat Genet 11 (4), 450-452 (1995)
   PUBMED   7493030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 7, 2020 this sequence version replaced NM_001008806.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK003985.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16676809
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               JAXUCZ010000007.1  134930160-134930713 c
            555-769             JAXUCZ010000007.1  134928755-134928969 c
            770-830             JAXUCZ010000007.1  134927782-134927842 c
            831-926             JAXUCZ010000007.1  134927290-134927385 c
            927-1091            JAXUCZ010000007.1  134926722-134926886 c
            1092-1217           JAXUCZ010000007.1  134926457-134926582 c
            1218-1432           JAXUCZ010000007.1  134925760-134925974 c
            1433-1467           JAXUCZ010000007.1  134925511-134925545 c
            1468-2127           JAXUCZ010000007.1  134924753-134925412 c
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2127
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /note="keratin 4"
                     /db_xref="GeneID:315323"
                     /db_xref="RGD:1359272"
     exon            1..554
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1646
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /note="cytokeratin-4; type-II keratin Kb4; keratin 4, type
                     II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 4"
                     /protein_id="NP_001008806.2"
                     /db_xref="GeneID:315323"
                     /db_xref="RGD:1359272"
                     /translation="MISRQSSVRGVSRGFSSGSAVAGGVKRVAFSSASMSGGAGRCSS
                     GGFGSRSLYNLGGHKSISMSVAGSCQGGGYGGAGGFGVGGYGAGFGAGGFGGGFGGSF
                     NGRGGPGFPVCPAGGIQEVTINQSLLTPLQVEIDPEIQKIRTAEREQIKTLNNKFASF
                     IDKVRFLEQQNKVLETKWNLLQQQTTTTSPRNLDPFFETYINALRKNLDTLSNDKGRL
                     QSELKLMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKD
                     EINFMRVLYEAELSQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQYEEIARKSKAE
                     VESWYQIKVQQLQMSADQHGDSLKSTKNEISELNRMIQRIRSEIENIKKQTLQASVAD
                     AEQRGELALKDAYTKRADLETALQKAKEDLARLMRDYQELMNVKLALDVEIATYRKLL
                     EGEECRMSGECKSAVSISVVGGSASIGGSGGIGLGLGSGFGSGSCSGSGFGFGGGIYG
                     SSGTKITSSATITKRSPR"
     exon            555..769
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..830
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..926
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1091
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1217
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1432
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1467
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2127
                     /gene="Krt4"
                     /gene_synonym="CK-4; K4; Kb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcaggacc tagctcttgc ttcgcttcgg ttctacgctc gtcgcagctg cctcatctct
       61 cagccatgat ctccagacag tcaagcgtcc gcggagtctc ccggggcttt agcagtggct
      121 cagctgttgc cggtggagtc aagcgggtgg ccttcagctc agcctccatg tctgggggtg
      181 ccgggcgctg ctcctctggg ggtttcggca gcaggagtct ttacaacctc gggggtcaca
      241 agagtatctc catgagcgtg gctgggtcct gccaaggcgg tggctacggc ggtgccggag
      301 gcttcggtgt tggaggatac ggtgctgggt ttggtgccgg tggttttggc ggtggctttg
      361 gaggctcctt caacggccga ggcggtcctg gtttccctgt ctgtcctgct ggaggtattc
      421 aggaagtcac catcaaccag agcctgctga cacctcttca ggtggaaatt gacccagaga
      481 tccagaaaat ccgcacagca gagcgcgagc agatcaagac cctcaacaac aaatttgctt
      541 ccttcatcga caaggtgcgg tttttagagc aacagaacaa agtcctggag accaaatgga
      601 acctcctcca gcagcagaca accaccacat cccccagaaa cctggatcct ttctttgaga
      661 cgtacatcaa cgccttaagg aagaacctgg acactttgag caatgacaaa ggtcgcctac
      721 agtcagagct gaagctcatg caggacagtg tggaggactt caagaccaag tatgaggaag
      781 agatcaacaa gcgcacagct gcagagaacg actttgtggt cctcaagaaa gatgtggatg
      841 ctgcttacat gatcaaggtg gagttagagg ccaaaatgga aagccttaag gatgagatca
      901 acttcatgag agtcctctat gaagcggagc tgtcccagat gcagacacat gtctcagaca
      961 catctgtggt gctgtccatg gataataacc ggaacctgga cctggacggc atcatcgctg
     1021 aggtccgagc ccagtatgag gagattgctc ggaagagcaa ggctgaggtt gagtcctggt
     1081 accagatcaa ggtccagcag ctccagatgt cagctgacca gcacggagat agcctgaaga
     1141 gcaccaagaa tgagatctca gaactcaaca ggatgatcca gaggatacgg tccgagattg
     1201 agaacatcaa gaagcagact ctgcaggcat ctgtggctga tgcagagcaa cgtggagagc
     1261 tggccctcaa agatgcctac accaaacgcg cagacctgga gactgcactg cagaaggcca
     1321 aggaggacct ggcccggctg atgagggact accaggagct catgaatgtc aagctggccc
     1381 tggatgtgga gatcgccacc taccgcaagc tactggaggg cgaggagtgc aggatgtctg
     1441 gagaatgcaa gagtgctgtg agcatctccg tagttggtgg cagtgccagc attggtggca
     1501 gcggtggcat cggccttggc ctgggtagcg gttttggctc tggttcctgt tctggaagtg
     1561 gcttcggatt tggtggcggt atttatggca gctctggtac caagatcacc tcttccgcca
     1621 ccatcaccaa gagatcccca cgatagacaa gacaggatcc tgatggcctt cagccctgat
     1681 atctcttgtg tatccttcac ttcaccccct acccccagtc ttccttcctg gtgctcatct
     1741 tgttagtctc cctcctctgc cttggttcct cagttccagg atgaccttct tggccatggt
     1801 gtggcctctg tcctcctgga gcctcgtagc ttcttctcaa cttgggccga gtgacccccc
     1861 tgcatgggag gggtgtctga tttcacccca atggacagag ggaatgaaga gcaggaactc
     1921 cttctgcaga agtacagggt cactctcggc ccctccagtc acaccagccc ccacctgatc
     1981 ctggacatcc atctgctaca acgacactca ttctccatcc cctgacagca acgggctctg
     2041 tccggttgag acaaagactg cttggtgtcc tgttcagccc tgctcctctc tctactcatc
     2101 cccaataaaa atgctttttg tcattca
//
