LOCUS       NM_001008822            1687 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus keratin 25 (Krt25), mRNA.
ACCESSION   NM_001008822 XM_220938
VERSION     NM_001008822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Yu,X., Chen,F., Ni,C., Zhang,G., Zheng,L., Zhang,J., Li,C.,
            Sandilands,A., Yao,Z. and Li,M.
  TITLE     A Missense Mutation within the Helix Termination Motif of KRT25
            Causes Autosomal Dominant Woolly Hair/Hypotrichosis
  JOURNAL   J Invest Dermatol 138 (1), 230-233 (2018)
   PUBMED   28899683
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Zernov,N.V., Skoblov,M.Y., Marakhonov,A.V., Shimomura,Y.,
            Vasilyeva,T.A., Konovalov,F.A., Abrukova,A.V. and Zinchenko,R.A.
  TITLE     Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a
            Mutation in the Keratin 25 Gene Expressed in Hair Follicles
  JOURNAL   J Invest Dermatol 136 (6), 1097-1105 (2016)
   PUBMED   26902920
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Choi,H.I., Choi,G.I., Kim,E.K., Choi,Y.J., Sohn,K.C., Lee,Y.,
            Kim,C.D., Yoon,T.J., Sohn,H.J., Han,S.H., Kim,S., Lee,J.H. and
            Lee,Y.H.
  TITLE     Hair greying is associated with active hair growth
  JOURNAL   Br J Dermatol 165 (6), 1183-1189 (2011)
   PUBMED   21916889
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 12, 2022 this sequence version replaced NM_001008822.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004028.1, SRR26360190.502914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984036, SAMN17050747
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               JAXUCZ010000010.1  84770721-84771197   c
            478-560             JAXUCZ010000010.1  84770330-84770412   c
            561-717             JAXUCZ010000010.1  84769000-84769156   c
            718-879             JAXUCZ010000010.1  84766152-84766313   c
            880-1005            JAXUCZ010000010.1  84765942-84766067   c
            1006-1223           JAXUCZ010000010.1  84765154-84765371   c
            1224-1291           JAXUCZ010000010.1  84764301-84764368   c
            1292-1687           JAXUCZ010000010.1  84763573-84763968   c
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1687
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /note="keratin 25"
                     /db_xref="GeneID:303519"
                     /db_xref="RGD:1359097"
     exon            1..477
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1401
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /note="K25; CK-25; cytokeratin-25; type I inner root
                     sheath-specific keratin-K25irs1; K25A; keratin-25A; type I
                     keratin KA38; keratin 25, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 25"
                     /protein_id="NP_001008822.1"
                     /db_xref="GeneID:303519"
                     /db_xref="RGD:1359097"
                     /translation="MSLRLSSGSKRSYARPSTGSLRGASFGAANACGVAGIGSGFSCA
                     FGSSSTGGNTGVANSCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLDNVQALQEANAD
                     LEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIITSTTSNANAVLQIDNARLT
                     ADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHK
                     EEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSAS
                     LQQQITEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCTQL
                     AQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCLLIGGDEGACKS
                     SSYKSKDYTSGNAGNQSKDSPKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN"
     exon            478..560
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            561..717
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            718..879
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1005
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1223
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1291
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1687
                     /gene="Krt25"
                     /gene_synonym="Ka38; Krt25A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggcact ctattctgac tttcaaggac acagtcctgc gacacgcttg ccctgaaatc
       61 atgtctcttc gcctctccag tggatccaag aggtcctatg ctcgtcccag cacaggatcg
      121 ctcaggggcg ccagctttgg tgctgcaaat gcttgtggcg tagcaggcat tggaagtggc
      181 ttctcctgcg cctttgggag cagctccaca ggaggaaaca cgggtgtggc caactcctgt
      241 gctggcttca ctgtgaatga ggggggcctc ctctccggca atgagaaggt gaccatgcag
      301 aacctcaatg accgcctggc ctcctacctg gataatgtac aagcacttca ggaggccaac
      361 gctgacctgg agcagaagat caagggctgg tatgaaaaat ttggacctgg gtcatgccgc
      421 ggtctcgatc atgactacag tagatacttc cccatcattg atgatcttaa aaaccagatc
      481 atcacttcca ccaccagcaa tgccaatgcc gttctgcaga ttgacaatgc caggctcacg
      541 gctgatgact tcagactcaa gtacgaaaac gagctggccc tccaccagag cgtagaggct
      601 gacgtgaacg ggctgcgcag ggttctggat gaaatcaccc tgtgccgcac tgacctggag
      661 attcagtacg aaaccctgag tgaggaactg acttacctca agaagaacca caaagaggaa
      721 atgcaggctc tgcagtgcgc agccggaggt aatgtgaatg tggagatgaa cgcagccccc
      781 ggcgtggacc tcaccgtcct gctgaacaac atgcgagccg agtacgaggc cctggctgag
      841 cagaaccgca gggacgccga ggcctggttc caagagaaga gcgcttcgct gcagcagcag
      901 atcaccgagg acgtgggcgc caccacctca gccaggaatg agctgacgga aatgaaacgt
      961 acgctccaaa ccttggagat tgaactacag tctctcctgg ccacgaaaca ctctctggag
     1021 tgctccctga cggagaccga gggcaactac tgcacgcagc tggctcagat ccaggctcag
     1081 atcagcgccc tggaggagca gctgcaccag gtgaggacgg agaccgaggg ccagaagctg
     1141 gaatatgagc agctgctgaa cgtcaaggcc cacctggaga aggagatcga gacctactgc
     1201 ctcctcatag gaggagacga gggggcctgt aagtcttcga gttacaagtc taaagattac
     1261 acctctggaa acgcgggaaa ccaaagcaaa gattccccca aagccatagt ggttaagaaa
     1321 gtcctagagg aggtggacca acgcagcaag attctaacca ctaggctcca ctccctggaa
     1381 gagaaatctc aaagcaatta gcaaagatca tgagcaaaca aagaagaaaa aaagcttcag
     1441 agaagacaag gcgtgaaatg cgtctgggaa atgagcaagc ctatgggaaa aaaaaaaaaa
     1501 aaaagaaatg tctgtcctgt tgtcttctgt tcctttctcc ttctgagcca gcagcagcag
     1561 cagcagcagc agcagaactc cccatccatc tggtgggatg ttgcttgcaa atgaacgcca
     1621 gggctcaccc gattacccta cagccatctg ttagctgttc cttccagtca ataaacctcc
     1681 cttgagc
//
